Cited by 686Neutrophil, Myeloperoxidase and Oxidative MechanismsNitric Oxide and Endothelin EffectsRedox biology and oxidative stress

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.

Open access

Clancy, R M, Leszczynska-Piziak, J, Abramson, S B·1992·Journal of Clinical Investigation

DOI 10.1172/jci115929PMC PMC329973

Open this paper in CoChat — free account Open PDF

Abstract

Nitric oxide provokes vasodilation and inhibits platelet aggregation. We examined the effect of nitric oxide on superoxide anion production by three sources: activated intact neutrophils, xanthine oxidase/hypoxanthine, and the NADPH oxidase. Nitric oxide significantly inhibited the generation of superoxide anion by neutrophils exposed to either FMLP (10(-7)M) or PMA (150 ng/ml) (IC50 = 30 microM). To determine whether the effect of nitric oxide on the respiratory burst was due to simple scavenging of O2+, kinetic studies that compared effects on neutrophils and the cell-free xanthine oxidase system were performed. Nitric oxide inhibited O2+ produced by xanthine oxidase only when added simultaneously with substrate, consistent with the short half-life of NO in oxygenated solution. In contrast, the addition of nitric oxide to neutrophils 20 min before FMLP resulted in the inhibition of O2+ production, which suggests formation of a stable intermediate. The effect of nitric oxide on the cell-free NADPH oxidase superoxide-generating system was also examined: The addition of NO before arachidonate activation (t = -6 min) significantly inhibited superoxide anion production. Nitric oxide did not inhibit O2+ when added at NADPH initiation (t = 0). Treatment of the membrane but not cytosolic component of the oxidase was sufficient to inhibit O2+ generation. The data suggest that nitric oxide inhibits neutrophil O2+ production via direct effects on membrane components of the NADPH oxidase. This action must occur before the assembly of the activated complex.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci115929

Cites

54 of 54 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Grynkiewicz, G., Poenie, M., & Tsien, R. Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83641-4 · Cited by 21,562
Isolation of mononuclear cells and granulocytes from human blood.
Bøyum, A. (1968) · Scandinavian Journal of Clinical and Laboratory Investigation · Cited by 9,585
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.
Bøyum, A. (1968) · PubMed · Cited by 5,263
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786
Nitric oxide: an endogenous modulator of leukocyte adhesion.
Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,036
Localization of nitric oxide synthase indicating a neural role for nitric oxide
Bredt, D. S., Hwang, P. M., & Snyder, S. H. (1990) · Nature · doi:10.1038/347768a0 · Cited by 2,981
Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.
Garg, U. C., & Hassid, A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114081 · Cited by 2,154

Show all 54 references

Sorted by citations

Items 301–400 of 686

NO● Represses the Oxygenation of Arachidonoyl PE by 15LOX/PEBP1: Mechanism and Role in Ferroptosis
Mikulska‐Ruminska, K., Anthonymuthu, T. S., Levkina, A., Shrivastava, I. H., Kapralov, A. A., Bayır, H., Kagan, V. E., & Bahar, İ. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105253 · Cited by 41
Biological therapy of strontium-substituted bioglass for soft tissue wound-healing: Responses to oxidative stress in ovariectomised rats
Jebahi, S., Oudadesse, H., Jardak, N., Khayat, I., Keskes, H., Khabir, A., Rebai, T., Feki, H. E., & Feki, A. E. (2013) · Annales Pharmaceutiques Françaises · doi:10.1016/j.pharma.2013.05.003 · Cited by 42
Intrarenal Administration of Molsidomine, a Molecule Releasing Nitric Oxide, Reduces Renal Ischemia-Reperfusion Injury in Rats
Rodríguez-Peña, A. B., García‐Criado, F. J., Eleno, N., Arévalo, M. A., & López-Novoa, J. M. (2004) · American Journal of Transplantation · doi:10.1111/j.1600-6143.2004.00560.x · Cited by 42
Expression of the inducible nitric oxide synthase (iNOS) in human leukocytes: responses to running exercise
Niess, A. M., Sommer, M., Schlotz, E., Northoff, H., Dickhuth, H., & Fehrenbach, E. (2000) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200007000-00006 · Cited by 42
Blood cardioplegia enhanced with nitric oxide donor SPM-5185 counteracts postischemic endothelial and ventricular dysfunction
Nakanishi, K., Zhao, Z., Vinten‐Johansen, J., Hudspeth, D. A., McGee, D. S., & Hammon, J. W. (1995) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(95)70198-2 · Cited by 42
Nanomedicine‐Based Therapeutics for Myocardial Ischemic/Reperfusion Injury
Li, X., Ou, W., Xie, M., Yang, J., Li, Q., & Li, T. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202300161 · Cited by 40
Nitric oxide release in the peripheral blood during hemodialysis
Rysz, J., Luciak, M., Kędziora, J., Błaszczyk, J., & Sibińska, E. (1997) · Kidney International · doi:10.1038/ki.1997.36 · Cited by 41
Donors of nitric oxide mimic effects of ischaemic preconditioning on reperfusion induced arrhythmias in isolated rat heart
Bilińska, M., Ma̧czewski, M., & Berȩsewicz, A. (1996) · Molecular and Cellular Biochemistry · doi:10.1007/bf00240058 · Cited by 41
Gene transfer of nitric oxide synthase
Niebauer, J., Dulak, J., Chan, J. R., Tsao, P. S., & Cooke, J. P. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00304-6 · Cited by 41
Oxygen-Dependent Reversible Inhibition of Mitochondrial Respiration by Nitric Oxide.
Takehara, Y., Nakahara, H., Inai, Y., Yabuki, M., Hamazaki, K., Yoshioka, T., Inoue, M., Horton, A. A., & Utsumi, K. (1996) · Cell Structure and Function · doi:10.1247/csf.21.251 · Cited by 40
Nitric oxide reduces hydrogen peroxide production from human polymorphonuclear neutrophils
Forslund, T., & Sundqvist, T. (1995) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.1995.tb01518.x · Cited by 40
Interactive role of nitric oxide and superoxide anion in neutrophil-mediated endothelial cell injury
Kausalya, S., & Nath, J. (1998) · Journal of Leukocyte Biology · doi:10.1002/jlb.64.2.185 · Cited by 40
Differential nitric oxide synthase expression during hepaticischemia-reperfusion
Serracino‐Inglott, F., Virlos, I. T., Habib, N. A., Williamson, R. C. N., & Mathie, R. T. (2003) · The American Journal of Surgery · doi:10.1016/s0002-9610(03)00075-8 · Cited by 39
Lung injury following pulmonary resection in the isolated, blood‐perfused rat lung
Williams, E. A., Quinlan, G. J., Anning, P. B., Goldstraw, P. G., & Evans, T. W. (1999) · European Respiratory Journal · doi:10.1034/j.1399-3003.1999.14d04.x · Cited by 39
Protective and Therapeutic Effect of Molsidomine on Bleomycin-Induced Lung Fibrosis in Rats
Kılıç, T., Parlakpınar, H., Polat, A., Taşlıdere, E., Vardı, N., Sarihan, M. E., Ermis, H., & Tanbek, K. (2014) · Inflammation · doi:10.1007/s10753-014-9841-1 · Cited by 38
Modulation of the K+ Channels Encoded by the Human Ether-a-Gogo-Related Gene-1 (hERG1) by Nitric Oxide
Taglialatela, M., Pannaccione, A., Iossa, S., Castaldo, P., & Annunziato, L. (1999) · Molecular Pharmacology · doi:10.1124/mol.56.6.1298 · Cited by 38
Ginsenoside Re increases fertile and asthenozoospermic infertile human sperm motility by induction of nitric oxide synthase
Zhang, H., Zhou, Q., Li, X., Xie, Y., Duan, X., Min, F.-L., Liu, B., & Yuan, Z.-G. (2006) · Archives of Pharmacal Research · doi:10.1007/bf02974276 · Cited by 38
Supplement of Nitric Oxide Attenuates Neutrophil-Mediated Reperfusion Injury
Fukuda, H., Sawa, Y., Kadoba, K., Taniguchi, K., Shimazaki, Y., & Matsuda, H. (1995) · Circulation · doi:10.1161/01.cir.92.9.413 · Cited by 38
Local l -Arginine Delivery After Balloon Angioplasty Reduces Monocyte Binding and Induces Apoptosis
Niebauer, J., Schwarzacher, S. P., Hayase, M., Wang, B., Kernoff, R. S., Cooke, J. P., & Yeung, A. C. (1999) · Circulation · doi:10.1161/01.cir.100.17.1830 · Cited by 38
Tissue Kallikrein and Kinin Infusion Rescues Failing Myocardium After Myocardial Infarction
Yao, Y., Yin, H. H., Shen, B., Chao, L., & Chao, J. (2007) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2007.04.009 · Cited by 37
Cytoprotective role of nitric oxide associated with Hsp70 expression in neonatal obstructive nephropathy
Manucha, W. A., & Vallés, P. G. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.01.005 · Cited by 37
Antioxidant Supplementation Enhances Neutrophil Oxidative Burst in Trained Runners Following Prolonged Exercise
Robson, P. J., Bouic, P. J., & Myburgh, K. H. (2003) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.13.3.369 · Cited by 37
Absence of Nitrate Tolerance After Long-Term Treatment with Ramipril: An Endothelium-Dependent Mechanism
Berkenboom, G. M., Fontaine, D. J., Unger, P., Baldassarre, S., Preumont, N., & Fontaine, J. (1999) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199910000-00011 · Cited by 37
Nitric oxide in the liver: Physiopathological roles
Suzuki, H., Menegazzi, M., de Prati, A. C., Mariotto, S., & Armato, U. (1995) · Advances in Neuroimmunology · doi:10.1016/0960-5428(95)00024-0 · Cited by 37
Nitric Oxide Inactivates Xanthine Dehydrogenase and Xanthine Oxidase in Interferon-γ-Stimulated Macrophages
Rinaldo, J. E., Clark, M. A., Parinello, J., & Shepherd, V. L. (1994) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.11.5.7524568 · Cited by 37
Deferoxamine reduces and nitric oxide synthase inhibition increases neutrophil-mediated myotube injury
McLoughlin, T. J., Tsivitse, S. K., Edwards, J. A., Aiken, B. A., & Pizza, F. X. (2003) · Cell and Tissue Research · doi:10.1007/s00441-003-0767-4 · Cited by 38
Nitric Oxide and Redox Signaling in Allergic Airway Inflammation
Reynaert, N. L., Ckless, K., Wouters, E. F. �., van der Vliet, A., & Janssen-Heininger, Y. M. W. (2004) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.129 · Cited by 38
Nitric oxide‐mediated augmentation of neutrophil reactive oxygen and nitrogen species formation: Critical use of probes
Kumar, S., Patel, S., Jyoti, A., Keshari, R. S., Verma, A. R., Barthwal, M. K., & Dikshit, M. (2010) · Cytometry Part A · doi:10.1002/cyto.a.20975 · Cited by 36
Protective role of nitric oxide-mediated inflammatory response against lipid peroxidation in ultraviolet B-irradiated skin
Lee, S., Lee, J., Jung, J. E., Lee, H.-W., Chun, S. D., Kang, I. K., Won, Y., & Kim, Y. P. (2000) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2000.03409.x · Cited by 36
Role of nitric oxide in progression and regression of atherosclerosis.
Cooke, J. P. (1996) · PubMed · Cited by 36
The reported clinical utility of taurine in ischemic disorders may reflect a down-regulation of neutrophil activation and adhesion
McCarty, M. F. (1999) · Medical Hypotheses · doi:10.1054/mehy.1998.0760 · Cited by 36
SHORT-TERM ???PRECONDITIONING??? WITH INHALED NITRIC OXIDE PROTECTS RABBIT LUNGS AGAINST ISCHEMIA-REPERFUSION INJURY1
tte, H. S., Witzenrath, M., Mayer, K., Rosseau, S., Seeger, W., & Grimminger, F. (2001) · Transplantation · doi:10.1097/00007890-200110270-00005 · Cited by 36
Restenosis after Coronary Angioplasty: Pathogenesis of Neointimal Thickening Initiated by Endothelial Loss
Shirotani, M., Yui, Y., & Kawai, C. (1993) · Endothelium · doi:10.3109/10623329309100951 · Cited by 36
Neuronal Nitric Oxide Synthase-Rescue of Dystrophin/Utrophin Double Knockout Mice does not Require nNOS Localization to the Cell Membrane
Wehling-Henricks, M., & Tidball, J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025071 · Cited by 37
Investigation of the essential role of platelet-tumor cell interactions in metastasis progression using an agent-based model
Uppal, A., Wightman, S. C., Ganai, S., Weichselbaum, R. R., & An, G. C. (2014) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-11-17 · Cited by 35
Attenuation of lung graft reperfusion injury by a nitric oxide donor
Bhabra, M. S., Hopkinson, D. N., Shaw, T. E., & Hooper, T. L. (1997) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(97)70330-1 · Cited by 35
Modulation by Nitric Oxide of Cerebral Neutrophil Accumulation after Transient Focal Ischemia in Rats
Parmentier‐Batteur, S., Margaill, I., & Plotkine, M. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200005000-00007 · Cited by 35
Role of curcumin in ameliorating hypertension and associated conditions: a mechanistic insight
Joshi, P., Joshi, S., Semwal, D. K., Verma, K., Dwivedi, J., & Sharma, S. K. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04447-8 · Cited by 35
RETRACTED ARTICLE: The role of nitric oxide during healing of trauma to the skeletal muscle
Filippin, L. I., Cuevas, M. J., Lima‐Cabello, E., Marroni, N. P., González‐Gallego, J., & Xavier, R. M. (2010) · Inflammation Research · doi:10.1007/s00011-010-0277-2 · Cited by 34
Retracted
Measurement of methemoglobin formation from oxyhemoglobin a real-time, continuous assay of nitric oxide release by human polymorphonuclear leukocytes
Lärfars, G., & Gyllenhammar, H. (1995) · Journal of Immunological Methods · doi:10.1016/0022-1759(95)00074-k · Cited by 34
Beneficial effects of nitric oxide inhalation on pulmonary bacterial clearance
Jean, D., Maître, B., Tankovic, J., Meignan, M. A., Adnot, S., Brun‐Buisson, C., HARF, A., & Delclaux, C. (2002) · Critical Care Medicine · doi:10.1097/00003246-200202000-00029 · Cited by 34
Ventilation–Perfusion Mismatch after Lung Ischemia–Reperfusion: Protective Effect of Nitric Oxide
Hermle, G., Schütte, H., WALMRATH, D., Geiger, K. K., Seeger, W., & Grimminger, F. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.4.9808034 · Cited by 34
Attenuated Nitric Oxide Synthase Activity and Protein Expression Accompany Intestinal Ischemia/Reperfusion Injury in Rats
Khanna, A. K., Rossman, J. E., Fung, H., & Caty, M. G. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.2266 · Cited by 34
Low-Dose Nitric Oxide Inhalation During Initial Reperfusion Enhances Rat Lung Graft Function
Ms, B., Hopkinson, D. N., Shaw, T. E., & Hooper, T. L. (1997) · The Annals of Thoracic Surgery · doi:10.1016/s0003-4975(96)01019-3 · Cited by 34
Interleukin 1-induced production of nitric oxide inhibits benzenetriol-mediated oxidative injury in rat hepatocytes
Kuo, P. C., & Abe, K. Y. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90286-4 · Cited by 34
Prevention of Nitrate Tolerance by Long-Term Treatment with Statins
Fontaine, D. J., Otto, A., Fontaine, J., & Berkenboom, G. M. (2003) · Cardiovascular Drugs and Therapy · doi:10.1023/a:1025383601304 · Cited by 33
Nitric oxide and endothelin relationship in intestinal ischemia/reperfusion injury
Durakbaşa, Ç. U., Dağlı, T. E., Mouni, H., Haklar, G., Bilsel, A. S., Yüksel, M., & Aktan, A. Ö. (1998) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/s0952-3278(98)90099-0 · Cited by 33
Nitric oxide/redox-based signalling as a therapeutic target for penile disorders
Burnett, A. L. “., Musicki, B., Jin, L., & Bivalacqua, T. J. (2006) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.10.3.445 · Cited by 33
Recipient iNOS but Not eNOS Deficiency Reduces Luminal Narrowing in Tracheal Allografts
Minamoto, K., & Pinsky, D. J. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20012135 · Cited by 33
Is Atherosclerosis an Arginine Deficiency Disease?
Cooke, J. P. (1998) · Journal of Investigative Medicine · doi:10.1177/170882679804600811 · Cited by 33
Effects of Cytokines and Other Inflammatory Mediators on Human Acute Pancreatitis
Gloor, B., Reber, H. A., & B, R. H. E. O. C. A. O. I. M. O. H. A. P. J. I. C. M. 1.-3. G. (1998) · Journal of Intensive Care Medicine · doi:10.1046/j.1525-1489.1998.00305.x · Cited by 33
Nitric oxide and endothelin in the development of cardiac allograft vasculopathy. Potential targets for therapeutic interventions
Liu, Z., Wildhirt, S. M., Weismüller, S., Schulze, C. J., Conrad, N., & Reichart, B. (1998) · Atherosclerosis · doi:10.1016/s0021-9150(98)00106-3 · Cited by 33
The role of nitric oxide in lipoxin A4‐induced polymorphonuclear neutrophil‐dependent cytotoxicity to human vascular endothelium in vitro
Bratt, J., & Gyllenhammar, H. (1995) · Arthritis & Rheumatism · doi:10.1002/art.1780380609 · Cited by 33
Cardioprotective Effects of Red Blood Cells on Ischemia and Reperfusion Injury in Isolated Rat Heart: Release of Nitric Oxide as a Potential Mechanism
Yang, B., Nichols, W. W., & Mehta, J. L. (1996) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/107424849600100405 · Cited by 32
Evaluation of neutrophil functions after experimental abdominal surgical trauma
Shijo, H., Iwabuchi, K., Hosoda, S., Watanabe, H., Nagaoka, I., & Sakakibara, N. (1998) · Inflammation Research · doi:10.1007/s000110050278 · Cited by 32
Glutathione Reverses Endothelial Damage From Peroxynitrite, the Byproduct of Nitric Oxide Degradation, in Crystalloid Cardioplegia
Nakamura, M., Thourani, V. H., Ronson, R. S., Velez, D. A., L, X., Katzmark, S. L., Robinson, J. A., Schmarkey, L. S., Zhao, Z., Wang, N., et al. (2000) · Circulation · doi:10.1161/01.cir.102.suppl_3.iii-332 · Cited by 32
Changing gears in the course of glomerulonephritis by shifting superoxide to nitric oxide-dominated chemistry
Pfeilschifter, J. M., Beck, K., Eberhardt, W., & Huwiler, A. (2002) · Kidney International · doi:10.1046/j.1523-1755.2002.00225.x · Cited by 32
Nitric Oxide Inhibits Microvascular Protein Leakage Induced by Leukocyte Adhesion-Independent and Adhesion-Dependent Inflammatory Mediators
Johnston, B., Gaboury, J. P., Suematsu, M., & Kubes, P. (1999) · Microcirculation · doi:10.1080/713773949 · Cited by 32
Inhaled NO reduces leukocyte-endothelial cell interactions and myocardial dysfunction in endotoxemic rats
Nevière, R., Guery, B. P., Mordon, S. R., Zerimech, F., Charré, S., Wattel, F., & Chopin, C. (2000) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2000.278.6.h1783 · Cited by 31
Effect of Sodium Nitrite on Ischaemia and Reperfusion-Induced Arrhythmias in Anaesthetized Dogs: Is Protein S-Nitrosylation Involved?
Kovács, M., Kiss, A., Gönczi, M., Miskolczi, G., Seprényi, G., Kaszaki, J., Kohr, M. J., Murphy, E., & Végh, Á. (2015) · PLoS ONE · doi:10.1371/journal.pone.0122243 · Cited by 29
Roles of nitric oxide synthases in platelet-activating factor-induced intestinal necrosis in rats
Qu, X., Rozenfeld, R. A., Huang, W., Sun, X., Tan, X., & Hsueh, W. (1999) · Critical Care Medicine · doi:10.1097/00003246-199902000-00043 · Cited by 30
Expression of VCAM-1 in rabbit iliac arteries is associated with vasodilator dysfunction of regenerated endothelium following balloon injury
Krejcy, K., Schwarzacher, S. P., Ferber, W., Plesch, C., Cybulsky, M. I., & Weidinger, F. F. (1996) · Atherosclerosis · doi:10.1016/0021-9150(95)05747-1 · Cited by 30
Antineutrophil cytoplasm antibody-induced neutrophil nitric oxide production is nitric oxide synthase independent
Tse, W. Y., Williams, J. M., Pall, A. A., Wilkes, M., Savage, C. O. S., & Adu, D. (2001) · Kidney International · doi:10.1046/j.1523-1755.2001.059002593.x · Cited by 30
Aerosolized PGE1, PGI2and nitroprusside protect against vascular leakage in lung ischaemia-reperfusion
Schütte, H., Löckinger, A., Seeger, W., & Grimminger, F. (2001) · European Respiratory Journal · doi:10.1183/09031936.01.00070001 · Cited by 30
L-NAME aggravates pulmonary oxygen toxicity in rats
Capellier, G., Maupoil, V., Boillot, A., Kantelip, J., Rochette, L., Regnard, J., & Barale, F. (1996) · European Respiratory Journal · doi:10.1183/09031936.96.09122531 · Cited by 30
Circulating NOS3 Modulates Left Ventricular Remodeling following Reperfused Myocardial Infarction
Gorressen, S., Stern, M., van de Sandt, A. M., Cortese-Krott, M. M., Ohlig, J., Rassaf, T., Gödecke, A., Fischer, J. W., Heusch, G., Merx, M. W., et al. (2015) · PLOS ONE · doi:10.1371/journal.pone.0120961 · Cited by 29
The role of endothelium and endogenous vasoactive substances in sepsis.
Kotsovolis, G., & Kallaras, K. (2010) · PubMed Central · Cited by 29
High oxidative stress adversely affects NFκB mediated induction of inducible nitric oxide synthase in human neutrophils: Implications in chronic myeloid leukemia
Singh, A. K., Awasthi, D., Dubey, M., Nagarkoti, S., Kumar, A., Chandra, T., Barthwal, M. K., Tripathi, A. K., & Dikshit, M. (2016) · Nitric Oxide · doi:10.1016/j.niox.2016.06.002 · Cited by 29
Cerebrovascular inflammation after brief episodic hypoxia: modulation by neuronal and endothelial nitric oxide synthase
Altay, T., Gonzales, E. R., Park, T. S., & Gidday, J. M. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00798.2003 · Cited by 29
Pulmonary Macrophage Inhibition and Inhaled Nitric Oxide Attenuate Lung Ischemia-Reperfusion Injury
Gazoni, L. M., Tribble, C. G., Zhao, M. Q., Unger, E. B., Farrar, R. A., Ellman, P. I., Fernández, L. G., Laubach, V. E., & Kron, I. L. (2007) · The Annals of Thoracic Surgery · doi:10.1016/j.athoracsur.2007.02.036 · Cited by 28
S-nitroso human serum albumin given after LPS challenge reduces acute lung injury and prolongs survival in a rat model of endotoxemia
Jakubowski, A., Максимович, Н. Е., Olszanecki, R., Gębska, A., Gasser, H., Podesser, B. K., Hallström, S., & Chłopicki, S. (2008) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-008-0351-2 · Cited by 28
Kallikrein gene transfer reduces renal fibrosis, hypertrophy, and proliferation in DOCA-salt hypertensive rats
Xia, C., Bledsoe, G., Chao, L., & Chao, J. (2005) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.00427.2004 · Cited by 28
The Potential Role of Erythropoietin in Chronic Heart Failure: From the Correction of Anemia to Improved Perfusion and Reduced Apoptosis?
Timmer, S. A. J., Boer, K. D., Knaapen, P., Götte, M., & van Rossum, A. C. (2008) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2008.10.024 · Cited by 27
Characterization of Nitric Oxide Consumption Pathways by Normal, Chronic Granulomatous Disease and Myeloperoxidase-Deficient Human Neutrophils
Clark, S., Coffey, M. J., Maclean, R., Collins, P. W., LEWIS, M. J., Cross, A. R., & O’Donnell, V. B. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.10.5889 · Cited by 27
Effects of changing the availability of the substrate for nitric oxide synthase by l-arginine administration on coronary vasomotor tone in angina patients with angiographically narrowed and in patients with normal coronary arteries
Tousoulis, D., Davies, G. J., Tentolouris, C. A., Crake, T., Katsimaglis, G., Stefanadis, C., & Toutouzas, P. C. (1998) · The American Journal of Cardiology · doi:10.1016/s0002-9149(98)00563-3 · Cited by 28
Delayed Administration of Inhaled Nitric Oxide Preserves Alveolar-Capillary Membrane Integrity in Porcine Gram-negative Sepsis
Bloomfield, G. L. (1997) · Archives of Surgery · doi:10.1001/archsurg.1997.01430250067016 · Cited by 28
Erythropoietin in the intensive care unit: beyond treatment of anemia
Patel, N. S. A., Collino, M., Yaqoob, M. M., & Thiemermann, C. (2011) · Annals of Intensive Care · doi:10.1186/2110-5820-1-40 · Cited by 27
Pharmacological Preconditioning With Hyperbaric Oxygen: Can This Therapy Attenuate Myocardial Ischemic Reperfusion Injury and Induce Myocardial Protection via Nitric Oxide?
Yogaratnam, J. Z., Laden, G., Guvendik, L., Cowen, M., Cale, A. R. J., & Griffin, S. C. (2007) · Journal of Surgical Research · doi:10.1016/j.jss.2007.09.003 · Cited by 27
Rho-kinase as a therapeutic target in vascular diseases: Striking nitric oxide signaling
Kolluru, G. K., Majumder, S., & Chatterjee, S. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.09.002 · Cited by 27
l-Arginine, a nitric oxide precursor, attenuates ischemia-reperfusion injury by inhibiting inositol-1,4,5-triphosphate
Mizuno, T., Watanabe, M., Sakamoto, T., & Sunamori, M. (1998) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(98)70376-9 · Cited by 27
l-Arginine in coronary atherosclerosis
Tentolouris, C. A., Tousoulis, D., Goumas, G., Stefanadis, C., Davies, G., & Toutouzas, P. C. (2000) · International Journal of Cardiology · doi:10.1016/s0167-5273(00)00320-x · Cited by 27
Inhibition of the yeast metal reductase heme protein fre1 by nitric oxide (NO): a model for inhibition of NADPH oxidase by NO
Shinyashiki, M., Pan, C. G., Lopez, B., & Fukuto, J. M. (2004) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2004.05.031 · Cited by 27
Neutrophil sequestration in the lung following acute aortic occlusion starts during ischaemia and can be attenuated by tumour necrosis factor and nitric oxide blockade
Tassiopoulos, A. K., HAKIM, T. S., Finck, C. M., Pedoto, A. C., Hodell, M., Landas, S. K., & McGraw, D. J. (1998) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/s1078-5884(98)80089-0 · Cited by 27
Are soluble factors relevant for polymorphonuclear leukocyte dysregulation in septicemia?
Wenisch, C., & Graninger, W. B. (1995) · Clinical and Diagnostic Laboratory Immunology · doi:10.1128/cdli.2.2.241-245.1995 · Cited by 27
Nitric oxide attenuates insulin- or IGF-I-stimulated aortic smooth muscle cell motility by decreasing H2O2levels: essential role of cGMP
Zhuang, D., Ceacareanu, A. C., Lin, Y., Ceacareanu, B., Dixit, M., Chapman, K. E., Waters, C. M., Rao, G. N., & Hassid, A. (2004) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01118.2003 · Cited by 27
Modulation of endothelin and nitric oxide: A rational approach to improve canine hepatic microcirculation
Dhar, D. K., Yamanoi, A., Ohmori, H., Nakashima, Y., Yamamoto, A., Osama, E., Kubota, H., Kohno, H., & Nagasue, N. (1998) · Hepatology · doi:10.1002/hep.510280327 · Cited by 27
Endothelium-Derived Relaxing Factor
Cooke, J. P., & Tsao, P. S. (1996) · Humana Press eBooks · doi:10.1007/978-1-4612-0231-8_1 · Cited by 27
RETRACTION: Opposite Effects of Pre- and Postischemic Treatments with Nitric Oxide Donor on Ischemia/Reperfusion-Induced Renal Injury
Nakajima, A., Ueda, K., Takaoka, M., Yoshimi, Y., & Matsumura, Y. (2006) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.092049 · Cited by 27
Retracted
The role of nitric oxide, superoxide and peroxynitrite in the anti‐arrhythmic effects of preconditioning and peroxynitrite infusion in anaesthetized dogs
Kiss, A., Juhász, L., Seprényi, G., Kupai, K., Kaszaki, J., & Végh, Á. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00774.x · Cited by 25
Reversal of iron-induced nephrotoxicity in rats by molsidomine, a nitric oxide donor
Gupta, A. K., Sharma, S., & Chopra, K. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.08.041 · Cited by 26
Exogenous nitric oxide causes overexpression of TGF-β1 and overproduction of extracellular matrix in human coronary smooth muscle cells
Schmidt, A. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00322-5 · Cited by 26
Dual role of endogenous nitric oxide in tumor necrosis factor shock: induced NO tempers oxidative stress
Cauwels, A., Bultinck, J., & Brouckaert, P. (2005) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5142-z · Cited by 25
Role of nitric oxide in pathological responses of the lung to exposure to environmental/occupational agents
Zeidler-Erdely, P. C., & Castranova, V. (2004) · Redox Report · doi:10.1179/135100004225003879 · Cited by 26
Independent and Combined Effects of Prolonged Inhaled Nitric Oxide and Oxygen on Lung Inflammation in Newborn Piglets
Ekekezie, I. I., Thibeault, D. W., Zwick, D. L., Rezaiekhaligh, M. H., Mabry, S. M., Morgan, R. E., Norberg, M., & Truog, W. E. (1999) · Neonatology · doi:10.1159/000014193 · Cited by 26
New Approaches to the Prevention of Atherosclerosis
Naito, M., Hayashi, T., & Iguchi, A. (1995) · Drugs · doi:10.2165/00003495-199550030-00003 · Cited by 26
Nitric Oxide and Acetaminophen-Mediated Oxidative Injury: Modulation of Interleukin-1-induced Nitric Oxide Synthesis in Cultured Rat Hepatocytes
Kuo, P. C., Schroeder, R. A., & Loscalzo, J. (1997) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)36888-0 · Cited by 26
Necessary Role of Ceramides in the Human Microvascular Endothelium During Health and Disease
SenthilKumar, G., Katunaric, B., Zirgibel, Z., Lindemer, B. J., Jaramillo-Torres, M. J., Bordas-Murphy, H., Schulz, M. E., Pearson, P. J., & Freed, J. K. (2023) · Circulation Research · doi:10.1161/circresaha.123.323445 · Cited by 25
Neuroprotective effects of protein tyrosine phosphatase 1B inhibitor on cerebral ischemia/reperfusion in mice
Sun, M., Izumi, H., Shinoda, Y., & Fukunaga, K. (2018) · Brain Research · doi:10.1016/j.brainres.2018.04.029 · Cited by 25
Enhanced oxidative stress in kidneys of salt-sensitive hypertension: role of sensory nerves
Wang, Y., Chen, A. F., & Wang, D. H. (2006) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00529.2006 · Cited by 25
Bradykinin prevents postischemic leukocyte adhesion and emigration and attenuates microvascular barrier disruption
Shigematsu, S., Ishida, S., Gute, D. C., & Korthuis, R. J. (1999) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1999.277.1.h161 · Cited by 25

Authors: Clancy, R. M., Leszczynska-Piziak, J., & Abramson, S. B.
Affiliations: NYU Langone Health (US)
ORCID: Clancy, R M
Abramson, S B
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1992-09-01
Volume: 90
Issue: 3
Pages: 1116-1121
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci115929
PMC: PMC329973
OpenAlex: W2139533485
Cited by: 686
References: 54
Citations by year: 2026: 1 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 9 · 2016: 6 · 2015: 11 · 2014: 10 · 2013: 5 · 2012: 9
FWCI: 13.70
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: nitric oxide, neutrophils, superoxide production, NADPH oxidase, respiratory burst, fMLP, PMA, arachidonic acid, oxygen radical scavenging
MeSH terms: Calcium, Cells, Cultured, Humans, NADH, NADPH Oxidoreductases, Neutrophils, Nitric Oxide, Superoxides, Xanthine Oxidase, Cell Degranulation, NADPH Oxidases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks