Cited by 686Neutrophil, Myeloperoxidase and Oxidative MechanismsNitric Oxide and Endothelin EffectsRedox biology and oxidative stress

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Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.

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Clancy, R M, Leszczynska-Piziak, J, Abramson, S B·1992·Journal of Clinical Investigation

DOI 10.1172/jci115929PMC PMC329973

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Abstract

Nitric oxide provokes vasodilation and inhibits platelet aggregation. We examined the effect of nitric oxide on superoxide anion production by three sources: activated intact neutrophils, xanthine oxidase/hypoxanthine, and the NADPH oxidase. Nitric oxide significantly inhibited the generation of superoxide anion by neutrophils exposed to either FMLP (10(-7)M) or PMA (150 ng/ml) (IC50 = 30 microM). To determine whether the effect of nitric oxide on the respiratory burst was due to simple scavenging of O2+, kinetic studies that compared effects on neutrophils and the cell-free xanthine oxidase system were performed. Nitric oxide inhibited O2+ produced by xanthine oxidase only when added simultaneously with substrate, consistent with the short half-life of NO in oxygenated solution. In contrast, the addition of nitric oxide to neutrophils 20 min before FMLP resulted in the inhibition of O2+ production, which suggests formation of a stable intermediate. The effect of nitric oxide on the cell-free NADPH oxidase superoxide-generating system was also examined: The addition of NO before arachidonate activation (t = -6 min) significantly inhibited superoxide anion production. Nitric oxide did not inhibit O2+ when added at NADPH initiation (t = 0). Treatment of the membrane but not cytosolic component of the oxidase was sufficient to inhibit O2+ generation. The data suggest that nitric oxide inhibits neutrophil O2+ production via direct effects on membrane components of the NADPH oxidase. This action must occur before the assembly of the activated complex.

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A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Grynkiewicz, G., Poenie, M., & Tsien, R. Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83641-4 · Cited by 21,562
Isolation of mononuclear cells and granulocytes from human blood.
Bøyum, A. (1968) · Scandinavian Journal of Clinical and Laboratory Investigation · Cited by 9,585
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.
Bøyum, A. (1968) · PubMed · Cited by 5,263
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786
Nitric oxide: an endogenous modulator of leukocyte adhesion.
Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,036
Localization of nitric oxide synthase indicating a neural role for nitric oxide
Bredt, D. S., Hwang, P. M., & Snyder, S. H. (1990) · Nature · doi:10.1038/347768a0 · Cited by 2,981
Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.
Garg, U. C., & Hassid, A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114081 · Cited by 2,154

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[Inhibitory effect of rat alveolar type II cells on production of superoxide by neutrophils].
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References
(2000) · CRC Press eBooks · doi:10.1201/9781420041521.bmatt
Setting the Scene
Vincent, J. (2006) · Update in intensive care and emergency medicine · doi:10.1007/3-540-30328-6_1
Caracterização da pancreatite aguda induzida por fosfolipases 'A IND. 2' secretorias
Camargo, E. A. (2007) · doi:10.47749/t/unicamp.2007.414392
Interactions of Superoxide Dismutases with Nitric Oxide
Crapo, J. D. (1996) · Springer eBooks · doi:10.1007/978-1-4613-0355-8_27
Association of the 894G>T polymorphism of the endothelial constitutive nitric oxide synthase gene with unstable angina
Iturry-Yamamoto, G. R., Moriguchi, E. H., Zago, A. C., Alho, C. S., & Zago, A. J. (2007) · Brazilian Journal of Medical and Biological Research · doi:10.1590/s0100-879x2007000400005
The Role of the Endothelium in Atherosclerosis
Cooke, J. P. (1997) · Springer eBooks · doi:10.1007/978-3-642-60463-8_17
Cardioprotection with inorganic nitrites
Demeter‐Haludka, V. (2019) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.10172
Peroxynitrite Mediated Oxidations: Spin Trap Studies; Nitration and Hydroxylation of Phenol Result From Different Intermediates; CO(2) Catalyzes the Decomposition of Peroxynitrite.
Lemercier, J.-N. (1997) · doi:10.31390/gradschool_disstheses.6545
Nitric Oxide
Thomas, D. D., Miranda, K. M., Citrin, D. E., Espey, M. G., & Wink, D. A. (2003) · Humana Press eBooks · doi:10.1007/978-1-59259-407-8_2 · Cited by 2
Optimization of photobiomodulation therapy for spinal cord injury: A review
Drew, I. K. M., Harvey, A. R., Wallace, V. P., & Hodgetts, S. I. (2025) · Photochemistry and Photobiology · doi:10.1111/php.70041
Rôles clinico-biologiques du monoxyde d'azote produit par les voies aériennes
Tadié, J. (2010) · doi:10.70675/abd56c0fz6366z441fzb38fze313a5431d89
N-Acetylcysteine in Sepsis
Spies, C., & Reinhart, K. (1994) · Update in intensive care and emergency medicine · doi:10.1007/978-3-642-85036-3_34
Biochemical Regulation of the Microcirculation
Novelli, G. P. (2000) · Springer eBooks · doi:10.1007/978-88-470-2284-3_3
Neural Nitric Oxide Synthase and Neutrophil Function
Greenberg, S. S., Zhao, X., Ouyang, J., & Giles, T. D. (2000) · Birkhäuser Boston eBooks · doi:10.1007/978-1-4612-1328-4_11
Nitric Oxide: A Modulator of the Inflammation Response
Kubes, P. (1997) · Yearbook of intensive care and emergency medicine · doi:10.1007/978-3-662-13450-4_19
Efeito do doador de oxido nitrico S-Nitroso-acetilcisteina sobre a sobre a sinalização celular da angiotensina II em coração e cardiomiocitos de ratos
de Oliveira, F. G. (2005) · doi:10.47749/t/unicamp.2005.393946

Authors: Clancy, R. M., Leszczynska-Piziak, J., & Abramson, S. B.
Affiliations: NYU Langone Health (US)
ORCID: Clancy, R M
Abramson, S B
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1992-09-01
Volume: 90
Issue: 3
Pages: 1116-1121
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci115929
PMC: PMC329973
OpenAlex: W2139533485
Cited by: 686
References: 54
Citations by year: 2026: 1 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 9 · 2016: 6 · 2015: 11 · 2014: 10 · 2013: 5 · 2012: 9
FWCI: 13.70
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: nitric oxide, neutrophils, superoxide production, NADPH oxidase, respiratory burst, fMLP, PMA, arachidonic acid, oxygen radical scavenging
MeSH terms: Calcium, Cells, Cultured, Humans, NADH, NADPH Oxidoreductases, Neutrophils, Nitric Oxide, Superoxides, Xanthine Oxidase, Cell Degranulation, NADPH Oxidases

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Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.

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