Cited by 686Neutrophil, Myeloperoxidase and Oxidative MechanismsNitric Oxide and Endothelin EffectsRedox biology and oxidative stress

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Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.

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Clancy, R M, Leszczynska-Piziak, J, Abramson, S B·1992·Journal of Clinical Investigation

DOI 10.1172/jci115929PMC PMC329973

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Abstract

Nitric oxide provokes vasodilation and inhibits platelet aggregation. We examined the effect of nitric oxide on superoxide anion production by three sources: activated intact neutrophils, xanthine oxidase/hypoxanthine, and the NADPH oxidase. Nitric oxide significantly inhibited the generation of superoxide anion by neutrophils exposed to either FMLP (10(-7)M) or PMA (150 ng/ml) (IC50 = 30 microM). To determine whether the effect of nitric oxide on the respiratory burst was due to simple scavenging of O2+, kinetic studies that compared effects on neutrophils and the cell-free xanthine oxidase system were performed. Nitric oxide inhibited O2+ produced by xanthine oxidase only when added simultaneously with substrate, consistent with the short half-life of NO in oxygenated solution. In contrast, the addition of nitric oxide to neutrophils 20 min before FMLP resulted in the inhibition of O2+ production, which suggests formation of a stable intermediate. The effect of nitric oxide on the cell-free NADPH oxidase superoxide-generating system was also examined: The addition of NO before arachidonate activation (t = -6 min) significantly inhibited superoxide anion production. Nitric oxide did not inhibit O2+ when added at NADPH initiation (t = 0). Treatment of the membrane but not cytosolic component of the oxidase was sufficient to inhibit O2+ generation. The data suggest that nitric oxide inhibits neutrophil O2+ production via direct effects on membrane components of the NADPH oxidase. This action must occur before the assembly of the activated complex.

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A new generation of Ca2+ indicators with greatly improved fluorescence properties.
Grynkiewicz, G., Poenie, M., & Tsien, R. Y. (1985) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)83641-4 · Cited by 21,722
Isolation of mononuclear cells and granulocytes from human blood.
Bøyum, A. (1968) · Scandinavian Journal of Clinical and Laboratory Investigation · Cited by 9,585
Copper-Zinc Superoxide Dismutase (SOD1) Is Released by Microglial Cells and Confers Neuroprotection against 6-OHDA Neurotoxicity
Polazzi, E., Mengoni, I., Caprini, M., Peña‐Altamira, E., Kurtys, E., & Monti, B. (2012) · Neurosignals · doi:10.1159/000337115 · Cited by 9,023
Apparent hydroxyl radical production by peroxynitrite: Implications for endothelial injury from nitric oxide and superoxide
Beckman, J. S., Beckman, T. W., Chen, J., Marshall, P. A., & Freeman, B. A. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1620 · Cited by 7,029
Isolation of mononuclear cells and granulocytes from human blood. Isolation of monuclear cells by one centrifugation, and of granulocytes by combining centrifugation and sedimentation at 1 g.
Bøyum, A. (1968) · PubMed · Cited by 5,263
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,786
Nitric oxide: an endogenous modulator of leukocyte adhesion.
Kubes, P., Suzuki, M., & Granger, D. N. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4651 · Cited by 3,036
Localization of nitric oxide synthase indicating a neural role for nitric oxide
Bredt, D. S., Hwang, P. M., & Snyder, S. H. (1990) · Nature · doi:10.1038/347768a0 · Cited by 2,981
Peroxynitrite oxidation of sulfhydryls.
Radí, R., Beckman, J. S., Bush, K., & Freeman, B. Α. (1991) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)64313-7 · Cited by 2,492
Nitric oxide-generating vasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells.
Garg, U. C., & Hassid, A. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114081 · Cited by 2,154

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DNA fragmentation in mouse organs during endotoxic shock.
Bohlinger, I., Leist, M., Gantner, F., Angermüller, S., Tiegs, G., & Wendel, A. (1996) · Europe PMC (PubMed Central) · Cited by 128
Nitric oxide regulation of superoxide-dependent lung injury: Oxidant-protective actions of endogenously produced and exogenously administered nitric oxide
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Sato, H., Zhao, Z.-Q., McGee, D. S., Williams, M. W., Hammon, J. W., & Vinten‐Johansen, J. (1995) · Journal of Thoracic and Cardiovascular Surgery · doi:10.1016/s0022-5223(95)70226-1 · Cited by 105
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Ward, C., Wong, T. H., Murray, J., Rahman, I., Haslett, C., Chilvers, E. R., & Rossi, A. G. (2000) · Biochemical Pharmacology · doi:10.1016/s0006-2952(99)00329-9 · Cited by 93
Nitric oxide.
Farrell, A. J., & Blake, D. R. (1996) · Annals of the Rheumatic Diseases · doi:10.1136/ard.55.1.7 · Cited by 93
Toll‐like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat‐inactivated E. coli
Suliman, H. B., Welty‐Wolf, K. E., Carraway, M. S., Schwartz, D. A., Hollingsworth, J. W., & Piantadosi, C. A. (2005) · The FASEB Journal · doi:10.1096/fj.04-3500fje · Cited by 92
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Gutierrez, H. H., Pitt, B. R., Schwarz, M. A., Watkins, S. C., Lowenstein, C. J., Caniggia, I., Chumley, P. H., & Freeman, B. Α. (1995) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1995.268.3.l501 · Cited by 91
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Role of estrogen deficiency in the formation and progression of cerebral aneurysms. Part II: experimental study of the effects of hormone replacement therapy in rats.
Jamous, M., Nagahiro, S., Kitazato, K., Tamura, T., Kuwayama, K., & Satoh, K. (2005) · Journal of Neurosurgery · doi:10.3171/jns.2005.103.6.1052 · Cited by 86
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Nitric oxide: A regulator of mucosal defense and injury
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Self-citation
Kallistatin inhibits TGF-β-induced endothelial–mesenchymal transition by differential regulation of microRNA-21 and eNOS expression
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Nitric oxide inhibits superoxide production by inflammatory polymorphonuclear leukocytes
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Sperm nitric oxide and motility: the effects of nitric oxide synthase stimulation and inhibition
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Reactive oxygen species generation and histamine release by activated mast cells: modulation by nitric oxide synthase inhibition
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Ikenouchi, H., Kangawa, K., Matsuo, H., & Hirata, Y. (1997) · Circulation · doi:10.1161/01.cir.95.9.2318 · Cited by 80
β-Adrenoceptor responses of the airways: For better or worse?
Broadley, K. J. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.12.060 · Cited by 79
Human and Rat Neutrophils Constitutively Express Neural Nitric Oxide Synthase mRNA
Greenberg, S. S., Ouyang, J., Zhao, X., & Giles, T. D. (1998) · Nitric Oxide · doi:10.1006/niox.1998.0176 · Cited by 79
Modulation of Polymorphonuclear Leukocytes Function by Nitric Oxide
Sethi, S., & Dikshit, M. (2000) · Thrombosis Research · doi:10.1016/s0049-3848(00)00320-0 · Cited by 78
Nitric oxide modulates pancreatic basal secretion and response to cerulein in the rat: Effects in acute pancreatitis
Molero, X., Guarner, F., Salas, A., Mourelle, M., Puig‐Diví, V., & Malagelada, J. R. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90150-7 · Cited by 78
Peroxynitrite: cellular pathology and implications in autoimmunity
Ahmad, R., Hussain, A., & Ahsan, H. (2019) · Journal of Immunoassay and Immunochemistry · doi:10.1080/15321819.2019.1583109 · Cited by 76
Nitric Oxide Reversibly Suppresses Xanthine Oxidase Activity
Fukahori, M., Ichimori, K., Ishida, H., Nakagawa, H., & Okino, H. (1994) · Free Radical Research · doi:10.3109/10715769409056572 · Cited by 75
Inhaled nitric oxide attenuates acute lung injury via inhibition of nuclear factor-κB and inflammation
Kang, J. L., Park, W., Pack, I. S., Lee, H. S., Kim, M. J., Lim, C., & Koh, Y. (2002) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00202.2001 · Cited by 76
Superoxide anion production by rabbit thoracic aorta: effect of endothelium-derived nitric oxide
Pagano, P. J., Tornheim, K., & Cohen, R. A. (1993) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1993.265.2.h707 · Cited by 76
Off-target thiol alkylation by the NADPH oxidase inhibitor 3-benzyl-7-(2-benzoxazolyl)thio-1,2,3-triazolo[4,5-d]pyrimidine (VAS2870)
Sun, Q.-A., Hess, D. T., Wang, B., Miyagi, M., & Stamler, J. S. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.046 · Cited by 76
Expression of a muscle‐specific, nitric oxide synthase transgene prevents muscle membrane injury and reduces muscle inflammation during modified muscle use in mice
Nguyen, H. X., & Tidball, J. (2003) · Journal of Physiology · doi:10.1113/jphysiol.2003.040907 · Cited by 86
Dietary supplementation of ginger and turmeric improves reproductive function in hypertensive male rats
Akinyemi, A. J., Adedara, I. A., Thomé, G. R., Morsch, V. M., Rovani, M. T., Mujica, L. K. S., Duarte, T., Duarte, M. M. M. F., Oboh, G., & Schetinger, M. R. C. (2015) · Toxicology Reports · doi:10.1016/j.toxrep.2015.10.001 · Cited by 75
Activation of Peroxisome Proliferator-Activated Receptor γ by Nitric Oxide in Monocytes/Macrophages Down-Regulates p47phox and Attenuates the Respiratory Burst
von Knethen, A., & Brüne, B. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.5.2619 · Cited by 75
The Function of Nitric Oxide in the Immune System
Bogdan, C. (2000) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-57077-3_19 · Cited by 74
Oxidative Stress and Microvessel Barrier Dysfunction
He, P., Talukder, M. A. H., & Gao, F. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00472 · Cited by 79
Inhaled Nitric Oxide Decreases Hyperoxia-Induced Surfactant Abnormality in Preterm Rabbits
Issa, A., Lappalainen, U., Kleinman, M., Bry, K., & Hallman, M. (1999) · Pediatric Research · doi:10.1203/00006450-199902000-00016 · Cited by 72
Nitric oxide regulation of protein trafficking in the cardiovascular system
Lowenstein, C. J. (2007) · Cardiovascular Research · doi:10.1016/j.cardiores.2007.03.024 · Cited by 74
Endothelium-Targeted Gene and Cell-Based Therapies for Cardiovascular Disease
Melo, L. G., Gnecchi, M., Pachori, A. S., Kong, D., Wang, K., Liu, X., Pratt, R. E., & Dzau, V. J. (2004) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000142363.15113.88 · Cited by 74
Effects of inhaled nitric oxide in a mouse model of sepsis-induced acute lung injury*
Razavi, H. M., Werhun, R., Scott, J. A., Weicker, S., Wang, L. F., McCormack, D. G., & Mehta, S. (2002) · Critical Care Medicine · doi:10.1097/00003246-200204000-00026 · Cited by 70
Differing roles of nitric oxide in the pathogenesis of acute edematous versus necrotizing pancreatitis
Werner, J., Rivera, J., Castillo, C. F. F.-D., Lewandrowski, K. B., Adrie, C., Rattner, D. W., & Warshaw, A. L. (1997) · Surgery · doi:10.1016/s0039-6060(97)90178-1 · Cited by 70
Overview of therapies for prevention of restenosis after coronary interventions
Garas, S. M., Huber, P. R., & Scott, N. A. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00168-1 · Cited by 69
Murine Macrophages Use Oxygen- and Nitric Oxide-Dependent Mechanisms To Synthesize S-Nitroso-Albumin and To Kill Extracellular Trypanosomes
Gobert, A. P., Semballa, S., Daulouède, S., Lesthelle, S., Taxile, M., Veyret, B., & Vincendeau, P. (1998) · Infection and Immunity · doi:10.1128/iai.66.9.4068-4072.1998 · Cited by 68
Kinin Infusion Prevents Renal Inflammation, Apoptosis, and Fibrosis via Inhibition of Oxidative Stress and Mitogen-Activated Protein Kinase Activity
Chao, J., Li, H.-J., Yao, Y., Shen, B., Gao, L., Bledsoe, G., & Chao, L. (2007) · Hypertension · doi:10.1161/01.hyp.0000255925.01707.eb · Cited by 68
The physiological role and pharmacological potential of nitric oxide in neutrophil activation
Armstrong, R. A. (2001) · International Immunopharmacology · doi:10.1016/s1567-5769(01)00094-7 · Cited by 68
Role of nitric oxide and tumor necrosis factor on lung injury caused by ischemia/reperfusion of the lower extremities
Tassiopoulos, A. K., Carlin, R. E., Gao, Y., Pedoto, A. C., Finck, C. M., LANDAS, S. K., Tice, D. G., Marx, W. H., HAKIM, T. S., & McGraw, D. J. (1997) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(97)70065-x · Cited by 67
Renal Protective Effect of Molsidomine and l-Arginine in Ischemia-Reperfusion Induced Injury in Rats
Chander, V., & Chopra, K. (2005) · Journal of Surgical Research · doi:10.1016/j.jss.2005.04.023 · Cited by 67
Oxidative stress induces myeloperoxidase expression in endocardial endothelial cells from patients with chronic heart failure
Rocca, G. L., Stefano, A. D., Eleuteri, E., Anzalone, R., Magno, F., Corrao, S., Loria, T., Martorana, A., Gangi, C. D., Colombo, M., et al. (2008) · Basic Research in Cardiology · doi:10.1007/s00395-008-0761-9 · Cited by 67

Authors: Clancy, R. M., Leszczynska-Piziak, J., & Abramson, S. B.
Affiliations: NYU Langone Health (US)
ORCID: Clancy, R M
Abramson, S B
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1992-09-01
Volume: 90
Issue: 3
Pages: 1116-1121
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci115929
PMC: PMC329973
OpenAlex: W2139533485
Cited by: 686
References: 54
Citations by year: 2026: 1 · 2025: 5 · 2024: 5 · 2023: 6 · 2022: 1 · 2021: 3 · 2020: 5 · 2019: 8 · 2018: 6 · 2017: 9 · 2016: 6 · 2015: 11 · 2014: 10 · 2013: 5 · 2012: 9
FWCI: 13.70
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: nitric oxide, neutrophils, superoxide production, NADPH oxidase, respiratory burst, fMLP, PMA, arachidonic acid, oxygen radical scavenging
MeSH terms: Calcium, Cells, Cultured, Humans, NADH, NADPH Oxidoreductases, Neutrophils, Nitric Oxide, Superoxides, Xanthine Oxidase, Cell Degranulation, NADPH Oxidases

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Nitric oxide, an endothelial cell relaxation factor, inhibits neutrophil superoxide anion production via a direct action on the NADPH oxidase.

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