The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Synthesis of oxytocin in amnion, chorion, and decidua may influence the timing of human parturition.
Open accessAbstract
Despite the widespread clinical use of oxytocin (OT) as a potent and specific stimulant of labor, previous research data have not supported a role for OT in the physiology of normal human parturition. We have demonstrated synthesis of OT mRNA in amnion, chorion, and decidua using Northern blot analysis, ribonuclease protection assays, and in situ hybridization. Probes directed towards both the 3' and 5' ends of the gene have been used. Levels were highest in decidua with considerably less in chorion and amnion and very low levels in placenta. The transcript size in decidua appears to be 60-80 nucleotides smaller than the transcripts in amnion and chorion. OT gene expression in chorio-decidual tissues increased three- to fourfold around the time of labor onset. Estradiol stimulated synthesis of OT mRNA during in vitro incubation. These results support the hypothesis of a paracrine system involving OT and sex steroids within intrauterine tissues wherein significant changes could occur without being reflected in the maternal circulation. Such a paracrine system could rationalize a long-sought role for oxytocin in the physiology of human labor. These data may lead to novel approaches towards prevention or treatment or preterm labor.
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Melton, D. A., Krieg, P. A., Rebagliati, M. R., Maniatis, T., Zinn, K., & Green, M. R. (1984) · Nucleic Acids Research · doi:10.1093/nar/12.18.7035 · Cited by 6,324
Gunning, P., Ponte, P., Okayama, H., Engel, J., Blau, H., & Kedes, L. (1983) · Molecular and Cellular Biology · doi:10.1128/mcb.3.5.787-795.1983 · Cited by 1,196
Romero, R., & Mazor, M. (1988) · Clinical Obstetrics and Gynecology · doi:10.1097/00003081-198809000-00006 · Cited by 714
Romero, R., Sirtori, M., Oyarzun, E., Avila, C., Mazor, M., Callahan, R., Sabo, V., Athanassiadis, A. P., & Hobbins, J. C. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90409-2 · Cited by 678
Oxytocin receptors in the human uterus during pregnancy and parturition
Fuchs, A.-R., Fuchs, F., Husslein, P., & Soloff, M. S. (1984) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(84)90677-x · Cited by 612
Oxytocin Receptors and Human Parturition: A Dual Role for Oxytocin in the Initiation of Labor
Fuchs, A.-R., Fuchs, F., Husslein, P., Soloff, M. S., & Fernström, M. J. (1982) · Science · doi:10.1126/science.6278592 · Cited by 492
Endocrine control of parturition
Thorburn, G. D., & Challis, J. R. (1979) · Physiological Reviews · doi:10.1152/physrev.1979.59.4.863 · Cited by 427
Romero, R., Manogue, K. R., Mitchell, M. D., Wu, Y. K., Oyarzun, E., Hobbins, J. C., & Cerami, A. (1989) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(89)90515-2 · Cited by 426
BRENT, G. A., & HERSHMAN, J. M. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-63-1-1 · Cited by 365
Poly(A), poly(A) binding protein and the regulation of mRNA stability
Bernstein, P., & Ross, J. (1989) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(89)90011-x · Cited by 353
Cited by
The oxytocin receptor system: structure, function, and regulation
Gimpl, G., & Fahrenholz, F. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.629 · Cited by 3,089
Endocrine and Paracrine Regulation of Birth at Term and Preterm*
Challis, J. R. G., Matthews, S. G., Gibb, W., & Lye, S. J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0407 · Cited by 995
Oxytocin is required for nursing but is not essential for parturition or reproductive behavior.
Nishimori, K., Young, L. J., Guo, Q., Wang, Z., Insel, T. R., & Matzuk, M. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11699 · Cited by 734
The role of oxytocin in parturition
BLANKS, A. (2003) · BJOG: An International Journal of Obstetrics and Gynaecology · doi:10.1016/s1470-0328(03)00024-7 · Cited by 296
The magnocellular oxytocin system, the fount of maternity: Adaptations in pregnancy
Russell, J. A., Leng, G., & Douglas, A. J. (2003) · Frontiers in Neuroendocrinology · doi:10.1016/s0091-3022(02)00104-8 · Cited by 295
Metadata
- Authors
- Chibbar, R., Miller, F. D., & Mitchell, B. F.
- Venue
- Journal of Clinical Investigation
- Published
- 1993-01-01
- Volume
- 91
- Issue
- 1
- Pages
- 185-192
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2136191276
- Cited by
- 256
- References
- 54
- FWCI
- 15.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chibbar, R., Miller, F. D., & Mitchell, B. F. (1993). Synthesis of oxytocin in amnion, chorion, and decidua may influence the timing of human parturition. Journal of Clinical Investigation. https://doi.org/10.1172/jci116169
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