The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Oxidatively modified low density lipoprotein is a chemoattractant for human T lymphocytes.
Open accessAbstract
Oxidatively modified low density lipoprotein (Ox-LDL) is a known chemoattractant for monocytes. Here we demonstrate, using a modified Boyden chamber assay, that human peripheral blood T lymphocytes, but not B lymphocytes, also respond chemotactically to Ox-LDL, showing a threefold increase over control and an optimum response at 10 micrograms/ml. Copper and endothelial cell-oxidized LDL and beta-VLDL were used and gave similar results. The activity was not chemokinetic and native LDL possessed no chemoattractant activity. The chemoattractant activity was found to reside in the lipid fraction of Ox-LDL. Lysophosphatidylcholine is a major phospholipid component of Ox-LDL and is known to be chemotactic for monocytes. We show that lysophosphatidylcholine is also chemotactic for T lymphocytes with a maximal fourfold increase at 10 microM. Nonmetabolizable analogues of lysophosphatidylcholine had no such chemotactic effect. Thus, Ox-LDL, by virtue of its lysophosphatidylcholine content, may contribute to the recruitment of both T lymphocytes and monocytes into developing atherosclerotic lesions.
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Cites
A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION
Bligh, E. G., & Dyer, W. J. (1959) · Canadian Journal of Biochemistry and Physiology · doi:10.1139/o59-099 · Cited by 54,751
Cited by
The Response-to-Retention Hypothesis of Early Atherogenesis
Williams, K. J., & Tabas, I. (1995) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.15.5.551 · Cited by 1,413
Hörkkö, S., Bird, D. A., Miller, E., Itabe, H., Leitinger, N., Subbanagounder, G., Berliner, J. A., Friedman, P., Dennis, E. A., Curtiss, L. K., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci4533 · Cited by 559
Lysophosphatidylcholine as a Ligand for the Immunoregulatory Receptor G2A
Kabarowski, J. H. S., Zhu, K., Le, L. Q., Witte, O. N., & Xu, Y. (2001) · Science · doi:10.1126/science.1061781 · Cited by 332
RetractedTherapeutic effects of lysophosphatidylcholine in experimental sepsis
Yan, J.-J., Jung, J.-S., Lee, J.-E., Lee, J., Huh, S.-O., Kim, H.-S., Jung, K. C., Cho, J.-Y., Nam, J.-S., Suh, H.-W., et al. (2004) · Nature Medicine · doi:10.1038/nm989 · Cited by 329
Interleukin 8 and cardiovascular disease
Apostolakis, S., Vogiatzi, K., Amanatidou, V., & Spandidos, D. A. (2009) · Cardiovascular Research · doi:10.1093/cvr/cvp241 · Cited by 285
Metadata
- Authors
- McMurray, H. F., Parthasarathy, S., & Steinberg, D.
- Venue
- Journal of Clinical Investigation
- Published
- 1993-08-01
- Volume
- 92
- Issue
- 2
- Pages
- 1004-1008
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2010757919
- Cited by
- 252
- References
- 1
- FWCI
- 4.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- McMurray, H. F., Parthasarathy, S., & Steinberg, D. (1993). Oxidatively modified low density lipoprotein is a chemoattractant for human T lymphocytes. Journal of Clinical Investigation. https://doi.org/10.1172/jci116605
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
