The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Differentiation and long-term survival of C2C12 myoblast grafts in heart.
Open accessAbstract
We have assessed the ability of skeletal myoblasts to form long-term, differentiated grafts in ventricular myocardium. C2C12 myoblasts were grafted directly into the heart of syngeneic mice. Viable grafts were observed as long as 3 mo after implantation. Immunohistological analyses revealed the presence of differentiated myotubes that stably expressed the skeletal myosin heavy chain isoform. Thymidine uptake studies indicated that virtually all of the grafted skeletal myocytes were withdrawn from the cell cycle by 14 d after grafting. Graft myocytes exhibited ultrastructural characteristics typical of differentiated myotubes. Graft formation and the associated myocardial remodeling did not induce overt cardiac arrhythmia. This study indicates that the myocardium can serve as a stable platform for skeletal myoblast grafts. The long-term survival, differentiated phenotype, and absence of sustained proliferative activity observed in myoblast grafts raise the possibility that similar grafting approaches may be used to replace diseased myocardium. Furthermore, the genetic tractability of myoblasts could provide a useful means for the local delivery of recombinant molecules to the heart.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis
Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617
Bussolino, F., Di Renzo, M. F., Ziche, M., Bocchietto, E., Olivero, M., Naldini, L., Gaudino, G., Tamagnone, L., Coffer, A., & Comoglio, P. M. (1992) · The Journal of cell biology · doi:10.1083/jcb.119.3.629 · Cited by 1,337
Cited by
Laflamme, M. A., & Murry, C. E. (2005) · Nature Biotechnology · doi:10.1038/nbt1117 · Cited by 964
Mechanisms and Models in Heart Failure: A Combinatorial Approach
Mann, D. L. (1999) · Circulation · doi:10.1161/01.cir.100.9.999 · Cited by 773
Unchain my heart: the scientific foundations of cardiac repair
Dimmeler, S., Zeiher, A. M., & Schneider, M. D. (2005) · Journal of Clinical Investigation · doi:10.1172/jci200524283 · Cited by 668
Systems approaches to preventing transplanted cell death in cardiac repair
Robey, T. E., Saiget, M. K., Reinecke, H., & Murry, C. E. (2008) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2008.03.009 · Cited by 404
Oxygen gradients correlate with cell density and cell viability in engineered cardiac tissue
Radisic, M., Malda, J., Epping, E., Geng, W., Langer, R., & Vunjak‐Novakovic, G. (2006) · Biotechnology and Bioengineering · doi:10.1002/bit.20722 · Cited by 399
Metadata
- Authors
- Koh, G. Y., Klug, M. G., Soonpaa, M. H., & Field, L. J.
- Venue
- Journal of Clinical Investigation
- Published
- 1993-09-01
- Volume
- 92
- Issue
- 3
- Pages
- 1548-1554
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2171590261
- Cited by
- 285
- References
- 2
- FWCI
- 11.57
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Differentiation and long-term survival of C2C12 myoblast grafts in heart. https://app.cochat.ai/papers/10.1172/jci116734
- The paper
- Koh, G. Y., Klug, M. G., Soonpaa, M. H., & Field, L. J. (1993). Differentiation and long-term survival of C2C12 myoblast grafts in heart. Journal of Clinical Investigation. https://doi.org/10.1172/jci116734
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
