The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester.
Open accessAbstract
Growth factors and tumor promoters have been shown to play a role in intestinal epithelial growth regulation and transformation. In this study, transforming growth factor-alpha (TGF alpha) and the tumor promoter, tetradecanoyl phorbol acetate (TPA), are shown to stimulate the production of eicosanoids by rat intestinal epithelial (RIE-1) cells in culture. A 4.5-kb mRNA, which hybridizes to the mouse cyclooxygenase-2 cDNA probe, is elevated 18-fold within 30 min after TGF alpha or TPA treatment. Stimulation of RIE-1 cells with TGF alpha leads to the increase of a protein (M(r) approximately 69,000), which binds a monospecific antibody to the mouse cyclooxygenase-2 protein. Dexamethasone markedly inhibits the increase of the 4.5-kb mRNA. Pretreatment of TGF alpha or TPA-stimulated RIE-1 cells with dexamethasone or cyclooxygenase inhibitors prevents the increase in eicosanoid production by these cells. Treatment of quiescent RIE-1 cells with TGF alpha stimulates mitogenesis. This mitogenic activity is blocked by pretreating the cells with dexamethasone or cyclooxygenase inhibitors. A mitogen-inducible cyclooxygenase gene is thus shown to be regulated by TGF alpha and TPA in rat intestinal epithelial cells. We suggest that products of an intestinal growth factor-inducible cyclooxygenase may play a role in the regulation of mitogenesis.
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Cited by
Cyclooxygenases: Structural, cellular, and molecular biology
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The role of cyclooxygenases in inflammation, cancer, and development
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Metadata
- Authors
- DuBois, R. N., Awad, J., Morrow, J., Roberts, L. J., & Bishop, P. R.
- Venue
- Journal of Clinical Investigation
- Published
- 1994-02-01
- Volume
- 93
- Issue
- 2
- Pages
- 493-498
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2107833029
- Cited by
- 373
- References
- 33
- FWCI
- 15.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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