Cited by 1,269Atherosclerosis and Cardiovascular DiseasesNeutrophil, Myeloperoxidase and Oxidative MechanismsNitric Oxide and Endothelin Effects

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Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.

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Daugherty, A, Dunn, J L, Rateri, D L, Heinecke, J W·1994·Journal of Clinical Investigation

DOI 10.1172/jci117342PMC PMC296328

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Abstract

Oxidatively modified lipoproteins have been implicated in atherogenesis, but the mechanisms that promote oxidation in vivo have not been identified. Myeloperoxidase, a heme protein secreted by activated macrophages, generates reactive intermediates that oxidize lipoproteins in vitro. To explore the potential role of myeloperoxidase in the development of atherosclerosis, we determined whether the enzyme was present in surgically excised human vascular tissue. In detergent extracts of atherosclerotic arteries subjected to Western blotting, a rabbit polyclonal antibody monospecific for myeloperoxidase detected a 56-kD protein, the predicted molecular mass of the heavy subunit. Both the immunoreactive protein and authentic myeloperoxidase bound to a lectin-affinity column; after elution with methyl mannoside their apparent molecular masses were indistinguishable by nondenaturing size-exclusion chromatography. Peroxidase activity in detergent extracts of atherosclerotic lesions likewise bound to a lectin column and eluted with methyl mannoside. Moreover, eluted peroxidase generated the cytotoxic oxidant hypochlorous acid (HOCl), indicating that enzymatically active myeloperoxidase was present in lesions. Patterns of immunostaining of arterial tissue with antihuman myeloperoxidase antibodies were similar to those produced by an antimacrophage antibody, and were especially prominent in the shoulder region of transitional lesions. Intense foci of myeloperoxidase immunostaining also appeared adjacent to cholesterol clefts in lipid-rich regions of advanced atherosclerotic lesions. These findings identify myeloperoxidase as a component of human vascular lesions. Because this heme protein can generate reactive species that damage lipids and proteins, myeloperoxidase may contribute to atherogenesis by catalyzing oxidative reactions in the vascular wall.

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Authors: Daugherty, A., Dunn, J. L., Rateri, D. L., & Heinecke, J. W.
Affiliations: Washington University in St. Louis (US)
ORCID: Daugherty, A
Rateri, D L
Heinecke, J W
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1994-07-01
Volume: 94
Issue: 1
Pages: 437-444
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci117342
PMC: PMC296328
OpenAlex: W2028257547
Cited by: 1,269
References: 88
Citations by year: 2026: 5 · 2025: 15 · 2024: 24 · 2023: 28 · 2022: 39 · 2021: 32 · 2020: 48 · 2019: 47 · 2018: 61 · 2017: 40 · 2016: 40 · 2015: 48 · 2014: 42 · 2013: 50 · 2012: 45
FWCI: 10.54
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health (5r01hd029920-05)
National Heart, Lung, and Blood Institute (HL-17646)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (R01 HD-29920)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: myeloperoxidase, lipoprotein oxidation, atherosclerosis, atherosclerotic plaque, macrophages, hypochlorous acid, oxidized lipoproteins, atherogenesis, heme enzymes, cholesterol clefts, vascular wall
MeSH terms: Arteriosclerosis, Free Radicals, Humans, Hypochlorous Acid, Immunohistochemistry, Lipoproteins, Macrophages, Peroxidase

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Myeloperoxidase, a catalyst for lipoprotein oxidation, is expressed in human atherosclerotic lesions.

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