Cited by 243Rheumatoid Arthritis Research and TherapiesT-cell and B-cell ImmunologyImmunotoxicology and immune responses

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis

Open access

Cope, A P, Londei, M, Chu, N R, Cohen, S B, Elliott, M J, Brennan, F M, Maini, R N, Feldmann, M·1994·Journal of Clinical Investigation

DOI 10.1172/jci117394PMC PMC296155

Open this paper in CoChat — free account Open PDF

Abstract

Experiments were designed to test the hypothesis that chronic exposure to tumor necrosis factor alpha (TNF) alters the function of activated T lymphocytes. Pretreatment of tetanus toxoid-specific T cell clones with TNF for up to 16 d impaired rechallenge proliferative responses to antigen in a dose- and time-dependent fashion. IL-2 and PHA responses were preserved. Prolonged treatment with TNF impaired production of IL-2, IL-10, IFN gamma, TNF, and lymphotoxin (LT) following stimulation with immobilized OKT3, and resulted in suboptimal expression of the IL-2R alpha chain (Tac) but not CD3, CD4, or HLA-DR antigens, when compared to untreated control cells. By contrast, pretreatment of T cells for prolonged periods in vitro with neutralizing anti-TNF monoclonal antibodies (mAb) enhanced proliferative responses, increased lymphokine production, and upregulated Tac expression following stimulation with OKT3. To determine whether TNF exerts immunosuppressive effects on T cells in vivo, we studied cell-mediated immunity in patients with active rheumatoid arthritis (RA), before and after treatment with a chimeric anti-TNF mAb. Treatment with anti-TNF restored the diminished proliferative responses of PBMC to mitogens and recall antigens towards normal in all patients tested. These data demonstrate that persistent expression of TNF in vitro and in vivo impairs cell-mediated immune responses.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci117394

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

The american rheumatism association 1987 revised criteria for the classification of rheumatoid arthritis
Arnett, F. C., Edworthy, S. M., Bloch, D. A., McShane, D. J., Fries, J. F., Cooper, N. S., Healey, L. A., Kaplan, S. R., Liang, M. H., Luthra, H. S., et al. (1988) · Arthritis & Rheumatism · doi:10.1002/art.1780310302 · Cited by 19,753
TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties
Mosmann, T. R., & Coffman, R. L. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.001045 · Cited by 7,692
Interleukin 10(IL-10) inhibits cytokine synthesis by human monocytes: an autoregulatory role of IL-10 produced by monocytes.
de Waal Malefyt, R., Abrams, J., Bennett, B., Figdor, C. G., & de Vries, J. E. (1991) · The Journal of experimental medicine · doi:10.1084/jem.174.5.1209 · Cited by 3,762
Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.
Ding, A. H., Nathan, C., & Stuehr, D. J. (1988) · The Journal of Immunology · doi:10.4049/jimmunol.141.7.2407 · Cited by 2,840
The Biology Of Cachectin/TNF: A Primary Mediator Of The Host Response
Beutler, B., & Cerami, A. (1989) · Annual Review of Immunology · doi:10.1146/annurev.iy.07.040189.003205 · Cited by 1,690
Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.
Keffer, J., Probert, L., Cazlaris, H. E., Georgopoulos, S., Kaslaris, E., Kioussis, D., & Kollias, G. A. (1991) · The EMBO Journal · doi:10.1002/j.1460-2075.1991.tb04978.x · Cited by 1,670
Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.
Dinarello, C. A., Cannon, J. G., Wolff, S. M., Bernheim, H. A., Beutler, B., Cerami, A., Figari, I. S., Palladino, M. A., & O'Connor, J. V. (1986) · The Journal of experimental medicine · doi:10.1084/jem.163.6.1433 · Cited by 1,472
Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon.
Pober, J. S., Gimbrone, M. A., Lapierre, L. A., Mendrick, D. L., Fiers, W., Rothlein, R., & Springer, T. A. (1986) · The Journal of Immunology · doi:10.4049/jimmunol.137.6.1893 · Cited by 1,413
The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection
Kindler, V., Sappino, A., Grau, G. E., Piguet, P., & VASSALLI, P. (1989) · Cell · doi:10.1016/0092-8674(89)90676-4 · Cited by 1,239
Cachectin/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts.
Dayer, J., Beutler, B., & Cerami, A. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.162.6.2163 · Cited by 1,208

Show all 60 references

Research works printed but not linked: 1

Hart, P. H., G. F. Vitti, D. R. Burgess, G. A. Whitty, D. S. Piccoli, and J. H. Hamilton. 1989. Potential anti-inflammatory effects of interleukin-4: Suppression of human monocyte tumor necorsis factor a, interleukin-1, and pros- taglandin E2. Proc. Natl. Acad. Sci. USA. 86:3803-3807.

Sorted by citations

Items 101–200 of 243

TNFR1-induced sphingomyelinase activation modulates TCR signaling by impairing store-operated Ca2+ influx
Church, L. D., Hessler, G., Goodall, J. E., Rider, D. A., Workman, C. J., Vignali, D. A. A., BACON, P. A., Gulbins, E., & Young, S. P. (2005) · Journal of Leukocyte Biology · doi:10.1189/jlb.1003456 · Cited by 55
Modulation of T-cell responses by anti-tumor necrosis factor treatments in rheumatoid arthritis: a review
Davignon, J., Rauwel, B., Degboé, Y., Constantin, A., Boyer, J., Kruglov, A., & Cantagrel, A. G. (2018) · Arthritis Research & Therapy · doi:10.1186/s13075-018-1725-6 · Cited by 55
Soluble TNF receptor production by activated T lymphocytes: differential effects of acute and chronic exposure to TNF.
Cope, A. P., Aderka, D., Wallach, D., Kahan, M., Chu, N., Brennan, F. M., & Feldmann, M. (1995) · PubMed Central · Cited by 55
Self-citation
T Cells as Sources and Targets of TNF: Implications for Immunity and Autoimmunity
Chatzidakis, I., & Mamalaki, C. (2010) · Current directions in autoimmunity · doi:10.1159/000289200 · Cited by 54
Nitric oxide production of T lymphocytes is increased in rheumatoid arthritis
Nagy, G., Clark, J. M., Buzás, E. I., Gorman, C., Pásztói, M., Koncz, Á., Falus, A., & Cope, A. P. (2008) · Immunology Letters · doi:10.1016/j.imlet.2008.02.009 · Cited by 51
Self-citation
Heptavalent pneumococcal conjugate vaccine elicits similar antibody response as standard 23-valent polysaccharide vaccine in adult patients with RA treated with immunomodulating drugs
Kapetanovic, M. C., Roseman, C., Jonsson, G. G., & Truedsson, L. (2011) · Clinical Rheumatology · doi:10.1007/s10067-011-1856-5 · Cited by 50
Dual role of anti-TNF therapy: Enhancement of TCR-mediated T cell activation in peripheral blood and inhibition of inflammation in target tissues
Bosè, F., Raeli, L., Garutti, C., Frigerio, E., Cozzi, A., Crimi, M., Caprioli, F., Scavelli, R., Altomare, G. F., Geginat, J., et al. (2011) · Clinical Immunology · doi:10.1016/j.clim.2011.01.015 · Cited by 50
Cytokine and chemokine receptor profile of peripheral blood mononuclear cells during treatment with infliximab in patients with active rheumatoid arthritis
Nissinen, R., Leirisalo-Repo, M., Peltomaa, R., Palosuo, T., & Vaarala, O. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.008599 · Cited by 50
Fluorescence Microplate-Based Assay for Tumor Necrosis Factor Activity Using SYTOX Green Stain
Jones, L. J., & Singer, V. L. (2001) · Analytical Biochemistry · doi:10.1006/abio.2001.5116 · Cited by 49
Lowered Tumor Necrosis Factor Receptors, but Not Increased Insulin Sensitivity, with Infliximab
Rocco, P. D., Manco, M., Rosa, G., Greco, A. V., & Mingrone, G. (2004) · Obesity Research · doi:10.1038/oby.2004.86 · Cited by 49
Immune-mediated adverse effects of biologicals used in the treatment of rheumatic diseases
Borchers, A. T., Leibushor, N., Cheema, G. S., Naguwa, S. M., & Gershwin, M. E. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.08.002 · Cited by 48
Rheumatoid arthritis and its animal models: the role of TNF-α and the possible absence of specific immune reactions
Klareskog, L., & McDevitt, H. O. (1999) · Current Opinion in Immunology · doi:10.1016/s0952-7915(99)00033-3 · Cited by 47
Ankylosing spondylitis and bowel disease
Baeten, D., Keyser, F. D., Mielants, H., & VEYS, E. M. (2002) · Best Practice & Research Clinical Rheumatology · doi:10.1016/s1521-6942(02)90249-4 · Cited by 46
The proportion of Th1 cells, which prevail in gut mucosa, is decreased in inflammatory bowel syndrome
Damme, N. V., Keyser, F. D., Demetter, P., Baeten, D., Mielants, H., Verbruggen, G., Cuvelier, C. A., VEYS, E. M., & Vos, M. D. (2001) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2001.01638.x · Cited by 46
Rheumatoid arthritis synovial T cells regulate transcription of several genes associated with antigen-induced anergy
Ali, M., Ponchel, F., Wilson, K. E., Francis, M. J. D., Wu, X., Verhoef, A., Boylston, A. W., Veale, D. J., Emery, P., Markham, A. F., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci8027 · Cited by 45
Influence of therapy with chimeric monoclonal tumour necrosis factor-alpha antibodies on intracellular cytokine profiles of T lymphocytes and monocytes in rheumatoid arthritis patients
Schuerwegh, A. J. (2003) · British journal of rheumatology · doi:10.1093/rheumatology/keg171 · Cited by 44
Disseminated Mycobacterium avium Complex Infection in AIDS: Immunopathogenic Significance of an Activated Tumor Necrosis Factor System and Depressed Serum Levels of 1,25 Dihydroxyvitamin D
Haug, C. J., Aukrust, P., Lien, E., Müller, F., Espevik, T., & Frøland, S. S. (1996) · The Journal of Infectious Diseases · doi:10.1093/infdis/173.1.259 · Cited by 44
Inhibition of TNF-αReverses the Pathological Resorption Pit Profile of Osteoclasts from Patients with Acute Charcot Osteoarthropathy
Petrova, N. L., Petrov, P. K., EDMONDS, M. E., & Shanahan, C. M. (2015) · Journal of Diabetes Research · doi:10.1155/2015/917945 · Cited by 46
Non-invasive objective and contemporary methods for measuring ocular surface inflammation in soft contact lens wearers – A review
Chao, C., Richdale, K., Jalbert, I., Doung, K., & Gokhale, M. (2017) · Contact Lens and Anterior Eye · doi:10.1016/j.clae.2017.05.008 · Cited by 42
The impact of conventional DMARD and biological therapies on CD4+ cell subsets in rheumatoid arthritis: a follow-up study
Szalay, B., Vásárhelyi, B., Cseh, Á., Tulassay, T., Deák, M., Kovács, L., & Balog, A. (2013) · Clinical Rheumatology · doi:10.1007/s10067-013-2352-x · Cited by 42
Plasma concentrations of IFN-γ and TNF-α in psoriatic patients before and after local treatment with dithranol ointment
Chodorowska, G. (1998) · Journal of the European Academy of Dermatology and Venereology · doi:10.1016/s0926-9959(97)00182-7 · Cited by 41
Safety of Anti-Tumor Necrosis Factor Therapies in Arthritis Patients
Nanau, R. M., & Neuman, M. G. (2014) · Journal of Pharmacy & Pharmaceutical Sciences · doi:10.18433/j3wp4f · Cited by 41
HLA Polymorphisms and T Cells in Rheumatoid Arthritis
Weyand, C. M., & Goronzy, J. J. (1999) · International Reviews of Immunology · doi:10.3109/08830189909043018 · Cited by 41
Immunopathogenesis and immunotherapy in rheumatoid arthritis: an area in transition
Klareskog, L., Rönnelid, J., & Holm, G. (1995) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1995.tb00923.x · Cited by 40
Th2 mediated regulation in RA and the spondyloarthropathies
van Roon, J. A. G., & Bijlsma, J. W. J. (2002) · Annals of the Rheumatic Diseases · doi:10.1136/ard.61.11.951 · Cited by 40
Collagen-Induced Arthritis in TNF Receptor-1-Deficient Mice: TNF Receptor-2 Can Modulate Arthritis in the Absence of TNF Receptor-1
Tada, Y., Ho, A., Koarada, S., Morito, F., Ushiyama, O., Suzuki, N., Kikuchi, Y., Ohta, A., Mak, T. W., & Nagasawa, K. (2001) · Clinical Immunology · doi:10.1006/clim.2001.5027 · Cited by 39
Sarcoid Intermediate Uveitis Following Etanercept Treatment: A Case Report and Review of the Literature
Fonollosa, A., Artaraz, J., Les, Í., Martínez-Berriotxoa, A., Pérez‐Izquierdo, J., López, Á. V., Gardeazaba, J., Berasategui, B., & Martínez-Alday, N. (2011) · Ocular Immunology and Inflammation · doi:10.3109/09273948.2011.623212 · Cited by 39
Polymorphisms within the Tumor Necrosis Factor–α Promoter Region in Patients with HLA-B27–Associated Uveitis
El‐Shabrawi, Y., Wegscheider, B. J., Weger, M., Renner, W., Posch, U., Ulrich, S., Ardjomand, N., & Hermann, J. (2006) · Ophthalmology · doi:10.1016/j.ophtha.2006.01.004 · Cited by 39
Anti-TNF Therapy and Malignancy – A Critical Review
Cohen, R. B., & Dittrich, K. (2001) · Canadian Journal of Gastroenterology · doi:10.1155/2001/403102 · Cited by 39
TNFα blockade in rheumatoid arthritis: Rationale, clinical outcomes and mechanisms of action
Elliott, M. J., Feldmann, M., & Maini, R. N. (1995) · International Journal of Immunopharmacology · doi:10.1016/0192-0561(94)00092-3 · Cited by 38
Self-citation
Onset of systemic lupus erythematosus after conversion of infliximab to adalimumab treatment in rheumatoid arthritis with a pre-existing anti-dsDNA antibody level
van Rijthoven, A. W. A. M., Bijlsma, J. W. J., van Dijk, M. R., Derksen, R. H. W. M., & van Roon, J. A. G. (2006) · Lara D. Veeken · doi:10.1093/rheumatology/kel227 · Cited by 37
Tumour necrosis factor-α enhances intraepithelial lymphocyte proliferation and migration
Ebert, E. C. (1998) · Gut · doi:10.1136/gut.42.5.650 · Cited by 37
Tumor necrosis factor superfamily molecules in acute coronary syndromes
Aukrust, P., Sandberg, W. J., Otterdal, K., Vinge, L. E., Gullestad, L. L., Yndestad, A., Halvorsen, B. L., & Ueland, T. (2010) · Annals of Medicine · doi:10.3109/07853890.2010.523711 · Cited by 35
Enhanced Anti-inflammatory Activity of Peptide–Gold Nanoparticle Hybrids upon Cigarette Smoke Extract Modification through TLR Inhibition and Autophagy Induction
Gao, W., Wang, L., Wang, K., Sun, L., Rao, Y., Ma, A., Zhang, M., Li, Q., & Yang, H. Y. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b10536 · Cited by 34
Exploring the reciprocal relationship between immunity and inflammation in chronic inflammatory arthritis
Cope, A. P. (2003) · British journal of rheumatology · doi:10.1093/rheumatology/keg262 · Cited by 34
Self-citation
NOVEL THERAPIES FOR INFLAMMATORY BOWEL DISEASE
Sands, B. E. (1999) · Gastroenterology Clinics of North America · doi:10.1016/s0889-8553(05)70059-5 · Cited by 33
IL-10 enhances expression of the IL-2 receptor alpha chain on T cells.
Cohen, S. B., Katsikis, P. D., Feldmann, M., & Londei, M. (1994) · PubMed Central · Cited by 33
Self-citation
Multiparameter Phospho-Flow Analysis of Lymphocytes in Early Rheumatoid Arthritis: Implications for Diagnosis and Monitoring Drug Therapy
Galligan, C. L., Siebert, J., Siminovitch, K. A., Keystone, E. C., Bykerk, V. P., Perez, O. D., & Fish, E. N. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006703 · Cited by 32
Signal Transduction Pathways in Chronic Inflammatory Autoimmune Disease: Small GTPases
Reedquist, K. A., & Tak, P. P. (2012) · The Open Rheumatology Journal · doi:10.2174/1874312901206010259 · Cited by 31
Immunological intervention reveals reciprocal roles for tumor necrosis factor-? and interleukin-10 in rheumatoid arthritis and systemic lupus erythematosus
Maini, R. N., Elliott, M. J., Charles, P., & Feldmann, M. (1994) · Springer Seminars in Immunopathology · doi:10.1007/bf00197526 · Cited by 32
Self-citation
TNF Blockade Maintains an IL-10+ Phenotype in Human Effector CD4+ and CD8+ T Cells
Roberts, C. A., Durham, L. E., Fleskens, V., Evans, H. G., & Taams, L. S. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00157 · Cited by 32
Disease modifying treatment and elective surgery in rheumatoid arthritis: the need for more data
Jain, A., Maini, R., & Nanchahal, J. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.017640 · Cited by 30
Self-citation
Inhibitor of Kappa B Epsilon (IκBε) Is a Non-Redundant Regulator of c-Rel-Dependent Gene Expression in Murine T and B Cells
Clark, J. M., Aleksiyadis, K., Martin, A., McNamee, K., Tharmalingam, T., Williams, R. O., Mémet, S., & Cope, A. P. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024504 · Cited by 28
Self-citation
Guidelines for referral and management of systemic lupus erythematosus in adults
Wolfe, F., & Pincus, T. (1999) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199909)42:9 · Cited by 269
Effect of Infliximab on Gene Expression Profiling in Behçet's Disease
Keino, H., Watanabe, T., Taki, W., & Okada, A. A. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-7999 · Cited by 27
MicroRNA-365 alleviates morphine analgesic tolerance via the inactivation of the ERK/CREB signaling pathway by negatively targeting β-arrestin2
Wu, X.-P., She, R.-X., Yang, Y., Xing, Z., Chen, H.-W., & Zhang, Y. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0405-9 · Cited by 27
The Effect of TNF-α Blocker HL036337 and Its Best Concentration to Inhibit Dry Eye Inflammation
Choi, W., Noh, H., Yeo, A., Jang, H., Ahn, H. K., Song, Y. J., & Lee, H. K. (2016) · Korean Journal of Ophthalmology · doi:10.3341/kjo.2016.30.4.302 · Cited by 26
Peptides identify multiple hotspots within the ligand binding domain of the TNF receptor 2.
Hsiao, K.-C., Brissette, R. E., Wang, P., Fletcher, P. W., Rodriguez, V., Lennick, M., Blume, A. J., & Goldstein, N. I. (2003) · Proteome Science · doi:10.1186/1477-5956-1-1 · Cited by 26
The role of cytokines in rheumatoid arthritis. The Croonian Lecture 1995.
Maini, R. N. (1996) · PubMed Central · Cited by 26
Self-citation
Exogenous IL-2 Controls the Balance in Th1, Th17, and Treg Cell Distribution in Patients with Progressive Rheumatoid Arthritis Treated with TNF-Alpha Inhibitors
Kosmaczewska, A., Ciszak, L., Świerkot, J., Szteblich, A., Kosciow, K., & Frydecka, I. (2014) · Inflammation · doi:10.1007/s10753-014-9987-x · Cited by 25
Retinal degeneration in experimental coronavirus retinopathy (ECOR) is associated with increased TNF-α, soluble TNFR2 and altered TNF-α signaling
Hooper, L. C., Chin, M. S., Detrick, B., & Hooks, J. J. (2005) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2005.05.018 · Cited by 24
IFN-γ-induced HLA-DR but not ICAM-1 expression on cultured dermal papilla cells is downregulated by TNF-α
König, A., Happle, R., & Hoffmann, R. (1997) · Archives of Dermatological Research · doi:10.1007/s004030050222 · Cited by 24
Detection ofMycobacterium tuberculosisGroup Organisms in Human and Mouse Joint Tissue by Reverse Transcriptase PCR: Prevalence in Diseased Synovial Tissue Suggests Lack of Specific Association with Rheumatoid Arthritis
Kempsell, K. E., Cox, C. J., McColm, A. A., Bagshaw, J. A., Reece, R., Veale, D. J., Emery, P., Isaacs, J. D., Gaston, H., & Crowe, J. (2001) · Infection and Immunity · doi:10.1128/iai.69.3.1821-1831.2001 · Cited by 24
T cell receptor ζ reconstitution fails to restore responses of T cells rendered hyporesponsive by tumor necrosis factor α
Clark, J. M., Annenkov, A. E., Panesar, M., Isomäki, P., Chernajovsky, Y., & Cope, A. P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0308231100 · Cited by 24
Self-citation
The significance of cytokine-producing B cells in breast tumor-draining lymph nodes
Mehdipour, F., Razmkhah, M., Faghih, Z., Bagheri, M., Talei, A., & Ghaderi, A. A. (2019) · Cellular Oncology · doi:10.1007/s13402-019-00433-3 · Cited by 23
Decreased Expression of the CD3ζ Chain in T Cells Infiltrating the Synovial Membrane of Patients with Osteoarthritis
Sakkas, L. I., Koussidis, G. A., Avgerinos, E. D., Gaughan, J., & Platsoucas, C. D. (2004) · Clinical and Vaccine Immunology · doi:10.1128/cdli.11.1.195-202.2004 · Cited by 23
Adenoviral transgene delivery provides an approach to identifying important molecular processes in inflammation: evidence for heterogenecity in the requirement for NFκB in tumour necrosis factor production
Foxwell, B. M. J., Bondeson, J., Brennan, F., & Feldmann, M. (2000) · Annals of the Rheumatic Diseases · doi:10.1136/ard.59.suppl_1.i54 · Cited by 23
Self-citation
Usefulness of glycosylated ferritin in atypical presentations of adult onset Still's disease
Hamidou, M. A., Denis, M., Barbarot, S., Boutoille, D., Belizna, C. C., & Moël, G. L. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.012484 · Cited by 22
Lymphoid Microstructures in Rheumatoid Synovitis
Weyand, C. M., Braun, A. B., Takemura, S., & Goronzy, J. J. (2000) · KARGER eBooks · doi:10.1159/000060521 · Cited by 21
The CD69 activation pathway in rheumatoid arthritis synovial fluid t cells
Hernández‐García, C., Fernández‐Gutiérrez, B., Morado, I. C., Bañares, A. A., & Jover, J. Á. (1996) · Arthritis & Rheumatism · doi:10.1002/art.1780390803 · Cited by 21
Therapeutic potential of TNFR2 agonists: a mechanistic perspective
Chen, Y., Jiang, M., & Chen, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1209188 · Cited by 19
Alteration of intestinal intraepithelial lymphocytes after massive small bowel resection
Yang, H., Fan, Y., Finaly, R., & Teitelbaum, D. H. (2003) · Journal of Surgical Research · doi:10.1016/s0022-4804(03)00032-5 · Cited by 19
Cytokines and cell regulation
Fridman, W. H., & Tartour, É. (1997) · Molecular Aspects of Medicine · doi:10.1016/s0098-2997(96)00012-x · Cited by 19
The Presumed Hyporesponsive Behavior of Rheumatoid Arthritis T Lymphocytes Can Be Attributed to Spontaneous Ex Vivo Apoptosis rather than Defects in T Cell Receptor Signaling
Abreu, J. R. F., Grabiec, A. M., Krausz, S., Spijker, R., Burakowski, T., Maśliński, W., Eldering, E., Tak, P. P., & Reedquist, K. A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803278 · Cited by 18
Regulation of myeloid cell function and major histocompatibility complex class II expression by tumor necrosis factor
Müeller, R. B., Skapenko, A., Grünke, M., Wendler, J., Stuhlmüller, B., Kalden, J. R., & Schulze‐Koops, H. (2005) · Arthritis & Rheumatism · doi:10.1002/art.20863 · Cited by 16
Role for suppressor T cells in the pathogenesis of autoimmune diseases (including rheumatoid arthritis). Facts and hypotheses.
Berthelot, J., & Maugars, Y. (2004) · Joint, bone, spine : revue du rhumatisme · doi:10.1016/j.jbspin.2003.11.004 · Cited by 20
A Soluble Factor Produced by Lamina Propria Mononuclear Cells Is Required for TNF-α Enhancement of IFN-γ Production by T Cells
Prehn, J., Landers, C. J., & Targan, S. R. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.8.4277 · Cited by 18
Patients with the most advanced rheumatoid arthritis remain with Th1 systemic defects after TNF inhibitors treatment despite clinical improvement
Kosmaczewska, A., Świerkot, J., Ciszak, L., Szteblich, A., Chrobak, A., Karabon, L., Partyka, A., Szechiński, J., Wiland, P., & Frydecka, I. (2013) · Rheumatology International · doi:10.1007/s00296-013-2895-9 · Cited by 17
Chronic TNF-α exposure impairs TCR-signaling via TNF-RII but not TNF-RI
Aspalter, R. M., Wolf, H. M., & Eibl, M. M. (2005) · Cellular Immunology · doi:10.1016/j.cellimm.2005.10.001 · Cited by 17
Rheumatoid arthritis as a bone marrow disorder
Berthelot, J., Bataille, R., Maugars, Y., & Prost, A. (1996) · Seminars in Arthritis and Rheumatism · doi:10.1016/s0049-0172(96)80039-4 · Cited by 17
Vaccination under TNF blockade - less effective, but worthwhile
Aringer, M. (2012) · Arthritis Research & Therapy · doi:10.1186/ar3808 · Cited by 16
Use of a microgravity organ culture dish system to demonstrate the signal dampening effects of modeled microgravity during T cell development
Woods, C. C., Banks, K. E., Lebsack, T. W., White, T. C., Anderson, G. A., MacCallum, T., Gruener, R., & DeLuca, D. (2004) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2004.09.006 · Cited by 15
TNFR2 signaling modulates immunity after allogeneic hematopoietic cell transplantation
Mancusi, A., Álvarez, M., Piccinelli, S., Velardi, A., & Pierini, A. (2019) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2019.05.001 · Cited by 15
The expanding role of IL-7 and thymic stromal lymphopoietin as therapeutic target for rheumatoid arthritis
Pathak, K. (2014) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2014.893295 · Cited by 15
The relative proportions of secreted interleukin-2 and interleukin-10 determine the magnitude of rheumatoid arthritis T-cell proliferation to the recall antigen tuberculin purified protein derivative
Corrigall, V., Garyfallos, A., & Panayi, G. S. (1999) · Lara D. Veeken · doi:10.1093/rheumatology/38.12.1203 · Cited by 15
Platelet and endothelial activation are requisites for the development of antiphospholipid syndrome
Garcia, E. D. R., Rodriguez, C. S., Rodríguez-Martorell, J., Serrano, A., & González, J. A. G. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.010694 · Cited by 14
TNFα Inhibition in MRL/lpr Mice Ameliorates Pulmonary but not Renal Disease
Kim, N., Ussin, L., Cheng, X., Murali, R., & Sullivan, K. E. (2002) · Journal of Autoimmunity · doi:10.1006/jaut.2002.0617 · Cited by 14
Persistent TNF‐α exposure impairs store operated calcium influx in CD4+ T lymphocytes
Church, L. D., Goodall, J. E., Rider, D. A., BACON, P. A., & Young, S. P. (2005) · FEBS Letters · doi:10.1016/j.febslet.2005.01.051 · Cited by 14
Recent advancements in the surface treatments for enhanced biocompatibility and corrosion resistance of titanium-based biomedical implants
Thakur, A., & Kumar, A. (2024) · Applied Chemical Engineering · doi:10.24294/ace.v7i1.2042 · Cited by 13
Maintenance of cytomegalovirus-specific CD4pos T-cell response in rheumatoid arthritis patients receiving anti-tumor necrosis factor treatments
Davignon, J., Boyer, J., Jamard, B., Nigon, D., Constantin, A., & Cantagrel, A. G. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3083 · Cited by 13
Changes in Tear Cytokine Concentrations Following Discontinuation of Soft Contact Lenses—A Pilot Study
Chao, C., Golebiowski, B., Stapleton, F. J., & Richdale, K. (2015) · Eye & Contact Lens Science & Clinical Practice · doi:10.1097/icl.0000000000000182 · Cited by 12
Activation dependent apoptosis of peripheral blood mononuclear cells from patients with rheumatoid arthritis treated with methotrexate
Świerkot, J., Miedzybrodzki, R., Szymaniec, S., & Szechinski, J. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2003.015370 · Cited by 11
Psoriasis onset during infliximab treatment: description of two cases
Volpe, A., Caramaschi, P., Carletto, A., Pieropan, S., Bambara, L. M., & Biasi, D. (2006) · Rheumatology International · doi:10.1007/s00296-006-0144-1 · Cited by 10
High grade heart block in association with SLE
Edwards, C., Mootoo, R., & Bhanji, A. (2004) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2002.005322 · Cited by 10
Changes in T cell effector functions over an 8-year period with TNF antagonists in patients with chronic inflammatory rheumatic diseases
Sauzullo, I., Scrivo, R., Sessa, P., Mengoni, F., Vullo, V., Valesini, G., & Mastroianni, C. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-26097-x · Cited by 10
Alterations in Both the Activatory and Inhibitory Potential of Peripheral Blood CD4+ T Cells in Rheumatoid Arthritis Patients Correlate with Disease Progression
Kosmaczewska, A., Ciszak, L., Świerkot, J., Szteblich, A., Wiland, P., & Frydecka, I. (2013) · Pathology & Oncology Research · doi:10.1007/s12253-013-9687-0 · Cited by 10
TNF-α mediated modulation of T cell development and exacerbation of in vitro T1DM in fetal thymus organ culture
Middlebrook, A. J., Lebsack, T. W., & DeLuca, D. (2007) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.06.002 · Cited by 10
Role of tumor necrosis factor‐α in the regulation of activated synovial T cell growth: Downregulation of synovial T cells in rheumatoid arthritis patients
Lai, N., Lan, J., Yu, C., & Lin, R. (1995) · European Journal of Immunology · doi:10.1002/eji.1830251207 · Cited by 10
Infliximab Does Not Lead to Reduction in the Interferon-gamma and Lymphoproliferative Responses of Patients with Moderate to Severe Psoriasis
Ortigosa, L., da Silva, L. K. A., Duarte, A., Takahashi, M. D. F., & Benard, G. (2014) · Acta Dermato Venereologica · doi:10.2340/00015555-1650 · Cited by 9
Etanercept treatment to enable successful hepatitis C virus clearance in a patient with rheumatoid arthritis.
Jazwinski, A. B., Jezsik, J. A., Ardoin, S. P., McCallum, R. M., & Tillmann, H. L. (2011) · Europe PMC (PubMed Central) · Cited by 9
Thein vivoeffects of tumour necrosis factor blockade on the early cell mediated immune events and syndrome expression in rat adjuvant arthritis
Bush, K., Kirkham, B. W., & Walker, J. S. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01742.x · Cited by 9
Effects of a PEGylated soluble TNF receptor type 1 (PEG sTNF-RI)on cytokine expression in adjuvant arthritis
Bush, K., Walker, J. S., Frazier, J., & Kirkham, B. W. (2002) · Scandinavian Journal of Rheumatology · doi:10.1080/030097402320318378 · Cited by 9
Antibody decay, T cell immunity and breakthrough infections following two SARS-CoV-2 vaccine doses in infliximab- and vedolizumab-treated patientsPreprint
Lin, S., Kennedy, N. A., Saifuddin, A., Sandoval, D. M., Reynolds, C. J., Seoane, R. C., Kottoor, S. H., Pieper, F. P., Lin, K., Butler, D. K., et al. (2021) · medRxiv · doi:10.1101/2021.11.10.21266168 · Cited by 9
Decreased Peripheral Blood T Cell Cytokine Gene Expression in Rheumatoid Arthritis
Constantin, A. (1999) · Scandinavian Journal of Rheumatology · doi:10.1080/03009749950155625 · Cited by 8
Efficacy of HL036 versus Cyclosporine A in the Treatment of Naturally Occurring Canine Keratoconjunctivitis Sicca
Lee, H.-B., Choi, H., Cho, S., Kang, S. H., Ahn, H. K., Song, Y. J., Kim, Y. J., & Son, W. (2018) · Current Eye Research · doi:10.1080/02713683.2018.1461909 · Cited by 8
Restored and Enhanced Memory T Cell Immunity in Rheumatoid Arthritis After TNFα Blocker Treatment
Khanniche, A., Zhou, L., Jiang, B., Song, J., Jin, Y., Yin, J., Wang, S., Ji, P., Shen, H., Wang, Y., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00887 · Cited by 8
TNF-α inhibits the CD3-mediated upregulation of voltage-gated K+ channel (Kv1.3) in human T cells
Pang, B., Zheng, H., Shin, D. H., Jung, K. C., Ko, J. H., Lee, K., Kang, T. M., & Kim, S. J. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.11.162 · Cited by 7
No signs of immunoactivation in the cerebrospinal fluid during treatment with infliximab
Andersson, M., Svenungsson, E., Khademi, M., Lampa, J., Brundin, L., & Wallström, E. (2006) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2006.055194 · Cited by 7
IL-10 and IL-3 synergize to cause proliferation of human T cells.
Cohen, S. B. (1995) · PubMed Central · Cited by 7
Self-citation
Cellular immunity in rheumatoid arthritis
Gaston, H. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-09138-1.00092-9 · Cited by 6

Authors: Cope, A. P., Londei, M., Chu, N. R., Cohen, S. B., Elliott, M. J., Brennan, F. M., Maini, R. N., & Feldmann, M.
Affiliations: Kennedy Institute of Rheumatology (GB)
ORCID: Cope, A P
Feldmann, M
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1994-08-01
Volume: 94
Issue: 2
Pages: 749-760
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci117394
PMC: PMC296155
OpenAlex: W1985680749
Cited by: 243
References: 60
Citations by year: 2026: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 1 · 2019: 9 · 2018: 4 · 2017: 3 · 2016: 5 · 2015: 5 · 2014: 7 · 2013: 7 · 2012: 10
FWCI: 9.33
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Medical Research Council
Topics: Health Sciences › Medicine › Rheumatology › Rheumatoid Arthritis Research and Therapies
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Immunotoxicology and immune responses
Keywords: TNF-α, T cell activation, T cell receptor/CD3 complex, anti-TNF monoclonal antibody, rheumatoid arthritis, cell-mediated immunity, immunosuppression, IL-2 receptor alpha chain, OKT3, lymphokine production, T cell clones
MeSH terms: Antibodies, Monoclonal, Antigen-Presenting Cells, Arthritis, Rheumatoid, Cells, Cultured, Dose-Response Relationship, Drug, HLA-DR Antigens, Humans, Interleukin-2, Lymphocyte Activation, Lymphokines, T-Lymphocytes, Tumor Necrosis Factor-alpha, CD4 Antigens, Receptor-CD3 Complex, Antigen, T-Cell

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Chronic exposure to tumor necrosis factor (TNF) in vitro impairs the activation of T cells through the T cell receptor/CD3 complex; reversal in vivo by anti-TNF antibodies in patients with rheumatoid arthritis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks