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Cited by 270

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis.

Open access
Kasama, T, Strieter, R M, Lukacs, N W, Lincoln, P M, Burdick, M D, Kunkel, S L·1995·Journal of Clinical Investigation
DOI 10.1172/jci117993
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Abstract

In the enclosed study we have examined the expression and contribution of specific chemokines, macrophage inflammatory protein 1 alpha (MIP-1 alpha) and macrophage inflammatory protein 2 (MIP-2), and interleukin 10 (IL-10) during the evolution of type II collagen-induced arthritis (CIA). Detectable levels of chemotactic cytokine protein for MIP-1 alpha and MIP-2 were first observed between days 32 and 36, after initial type II collagen challenge, while increases in IL-10 were found between days 36 and 44. CIA mice passively immunized with antibodies directed against either MIP-1 alpha or MIP-2 demonstrated a delay in the onset of arthritis and a reduction of the severity of arthritis. On the contrary, CIA mice receiving neutralizing anti-IL-10 antibodies demonstrated an acceleration of the onset and an increase in the severity of arthritis. Interestingly, anti-IL-10 treatment increased the expression of MIP-1 alpha and MIP-2, as well as increased myeloperoxidase (MPO) activity and leukocyte infiltration in the inflamed joints. These data suggest that MIP-1 alpha and MIP-2 play a crucial role in the initiation and maintenance, while IL-10 appears to play a regulatory role during the development of experimental arthritis.

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Crossref · 10.1172/jci117993

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Metadata

Authors
Kasama, T., Strieter, R. M., Lukacs, N. W., Lincoln, P. M., Burdick, M. D., & Kunkel, S. L.
Venue
Journal of Clinical Investigation
Publisher
American Society for Clinical Investigation
Published
1995-06-01
Volume
95
Issue
6
Pages
2868-2876
ISSN
0021-9738 (ISSN-L)
DOI
10.1172/jci117993
OpenAlex
W2007137447
Cited by
270
References
54
FWCI
15.99
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. https://app.cochat.ai/papers/10.1172/jci117993
The paper
Kasama, T., Strieter, R. M., Lukacs, N. W., Lincoln, P. M., Burdick, M. D., & Kunkel, S. L. (1995). Interleukin-10 expression and chemokine regulation during the evolution of murine type II collagen-induced arthritis. Journal of Clinical Investigation. https://doi.org/10.1172/jci117993

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.