The DOI matches its Crossref record; 40 of the 40 references it cites were found in a registry or an index.
Acid aspiration-induced lung injury in rabbits is mediated by interleukin-8-dependent mechanisms.
Open accessAbstract
Acid aspiration lung injury may be mediated primarily by neutrophils recruited to the lung by acid-induced cytokines. We hypothesized that a major acid-induced cytokine was IL-8 and that a neutralizing anti-rabbit-IL-8 monoclonal antibody (ARIL8.2) would attenuate acid-induced lung injury in rabbits. Hydrochloric acid (pH = 1.5 in 1/3 normal saline) or 1/3 normal saline (4 ml/kg) was instilled into the lungs of ventilated, anesthetized rabbits. The rabbits were studied for 6 or 24 h. In acid-instilled rabbits without the anti-IL-8 monoclonal antibody, severe lung injury developed in the first 6 h; in the long-term experiments, all rabbits died with lung injury between 12 and 14 h. In acid-instilled rabbits given the anti-IL-8 monoclonal antibody (2 mg/kg, intravenously) either as pretreatment (5 min before the acid) or as treatment (1 h after the acid), acid-induced abnormalities in oxygenation and extravascular lung water were prevented and extravascular protein accumulation was reduced by 70%; in the long-term experiments, anti-IL-8 treatment similarly protected lung function throughout the 24-h period. The anti-IL-8 monoclonal antibody also significantly reduced air space neutrophil counts and IL-8 concentrations. This study establishes IL-8 as a critical cytokine for the development of acid-induced lung injury. Neutralization of IL-8 may provide the first useful therapy for this clinically important form of acute lung injury.
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Cited by
Aspiration Pneumonitis and Aspiration Pneumonia
Marik, P. E. (2001) · New England Journal of Medicine · doi:10.1056/nejm200103013440908 · Cited by 1,627
Contribution of Neutrophils to Acute Lung Injury
Grommes, J., & Soehnlein, O. (2011) · Molecular Medicine · doi:10.2119/molmed.2010.00138 · Cited by 1,313
Coperchini, F., Chiovato, L., Croce, L., Magri, F., & Rotondi, M. (2020) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2020.05.003 · Cited by 1,288
The Acute Respiratory Distress Syndrome: Pathogenesis and Treatment
Matthay, M. A., & Zemans, R. L. (2011) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathol-011110-130158 · Cited by 1,077
Self-citationCytokine-mediated inflammation in acute lung injury
Goodman, R. B., Pugin, J., Lee, J. S., & Matthay, M. A. (2003) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(03)00059-5 · Cited by 688
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Metadata
- Authors
- Folkesson, H. G., Matthay, M. A., Hébert, C. A., & Broaddus, V. C.
- Venue
- Journal of Clinical Investigation
- Published
- 1995-07-01
- Volume
- 96
- Issue
- 1
- Pages
- 107-116
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2004446611
- Cited by
- 422
- References
- 40
- FWCI
- 15.14
- Type
- journal article
- Language
- en
- Open access
- bronze
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