Cited by 426Ovarian function and disordersPancreatic function and diabetesDiabetes, Cardiovascular Risks, and Lipoproteins

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Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus.

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Ehrmann, D A, Sturis, J, Byrne, M M, Karrison, T, Rosenfield, R L, Polonsky, K S·1995·Journal of Clinical Investigation

DOI 10.1172/jci118064PMC PMC185226

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Abstract

The increased prevalence of non-insulin-dependent diabetes mellitus (NIDDM) among women with polycystic ovary syndrome (PCOS) has been ascribed to the insulin resistance characteristic of PCOS. This study was undertaken to determine the role of defects in insulin secretion as well as familial factors to the predisposition to NIDDM seen in PCOS. We studied three groups of women: PCOS with a family history of NIDDM (PCOS FHx POS; n = 11), PCOS without a family history of NIDDM (PCOS FHx NEG; n = 13), and women without PCOS who have a family history of NIDDM (NON-PCOS FHx POS; n = 8). Beta cell function was evaluated during a frequently sampled intravenous glucose tolerance test, by a low dose graded glucose infusion, and by the ability of the beta cell to be entrained by an oscillatory glucose infusion. PCOS FHx POS women were significantly less likely to demonstrate appropriate beta cell compensation for the degree of insulin resistance. The ability of the beta cell to entrain, as judged by the spectral power for insulin secretion rate, was significantly reduced in PCOS FHx POS subjects. In conclusion, a history of NIDDM in a first-degree relative appears to define a subset of PCOS subjects with a greater prevalence of insulin secretory defects. The risk of developing NIDDM imparted by insulin resistance in PCOS may be enhanced by these defects in insulin secretion.

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Spectral Analysis and its Applications.
Freiberger, W. F., Jenkins, G. M., & Watts, D. G. (1969) · Journal of the American Statistical Association · doi:10.2307/2286100 · Cited by 4,990
Classification and diagnosis of diabetes mellitus and other categories of glucose intolerance.
National Diabetes Data Group (1979) · Diabetes · doi:10.2337/diab.28.12.1039 · Cited by 4,909
Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats
Morgan, C. R., & Lazarow, A. (1963) · Diabetes · doi:10.2337/diab.12.2.115 · Cited by 2,197
Profound Peripheral Insulin Resistance, Independent of Obesity, in Polycystic Ovary Syndrome
Dunaif, A., Segal, K. R., Futterweit, W., & Dobrjansky, A. (1989) · Diabetes · doi:10.2337/diab.38.9.1165 · Cited by 1,967
Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose
Bergman, R. N., Phillips, L. S., & Cobelli, C. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110398 · Cited by 1,640
Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of pima indians
Lillioja, S., Mott, D. M., Spraul, M., Ferraro, R., Foley, J. E., Ravussin, E., Knowler, W. C., Bennett, P. H., & Bogardus, C. (1993) · New England Journal of Medicine · doi:10.1056/nejm199312303292703 · Cited by 1,508
Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405
Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study
Martin, B. C., Warram, J. H., Krolewski, A. S., Soeldner, J. S., Kahn, C. R., Martin, B. C., & Bergman, R. N. (1992) · The Lancet · doi:10.1016/0140-6736(92)92814-v · Cited by 1,158
Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents
Warram, J. H., Martin, B. C., Krolewski, A. S., Soeldner, J. S., & Kahn, C. R. (1990) · Annals of Internal Medicine · doi:10.7326/0003-4819-113-12-909 · Cited by 1,038
Toward Physiological Understanding of Glucose Tolerance: Minimal-Model Approach
Bergman, R. N. (1989) · Diabetes · doi:10.2337/diab.38.12.1512 · Cited by 1,001

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Dunaif, J. R. Givens, F. P. Haseltine, and G. R. Merriam, editors. Blackwell Scientific, Cambridge, MA. 347-358.
Dunaif, A., G. Green, and D. Finegood. 1992. Pancreatic beta (B) cell function is normal in insulin resistant women with the polycystic ovary syndrome (PCOS). Proc. Endocrine Soc., 74th Annual Meeting, San Antonio, TX. 280a (Abstr.)
Ehrmann, D. A., M. Byrne, J. Sturis, R. L. Rosenfield, and K. S. Polonsky. 1994. ,8-Cell dysfunction in polycystic ovary syndrome (PCOS): evidence for a genetic basis. Proc. Endocrine Soc., 76th Annual Meeting, Anaheim, CA. 835a(Abstr.)

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Self-citation
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Self-citation
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Gourgari, E., Spanakis, E. K., & Dobs, A. S. (2016) · International Journal of Women s Health · doi:10.2147/ijwh.s104825 · Cited by 14
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Polycystic ovary syndrome in adolescence and early adulthood
Michelmore, K. F. (2000) · Human Fertility · doi:10.1080/1464727002000198771 · Cited by 13
Current Developments in the Molecular Genetics of the Polycystic Ovary Syndrome
Franks, S., Gharani, N., Waterworth, D. M., Batty, S., White, D. M., Williamson, R., & McCarthy, M. I. (1998) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(98)00018-6 · Cited by 13
Insulin Resistance in Polycystic Ovarian Disease
Bhatia, V. (2005) · Southern Medical Journal · doi:10.1097/01.smj.0000177251.15366.85 · Cited by 13
Revisitando o Hirsutismo
Spritzer, P. M. (2002) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302002000200003 · Cited by 10
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Role of GnRH drive in the pathophysiology of polycystic ovary syndrome
Leondires, M. P., & Berga, S. L. (1998) · Journal of Endocrinological Investigation · doi:10.1007/bf03347331 · Cited by 12
Detailed characterisation of circulatory nitric oxide and free radical indices—is there evidence for abnormal cardiovascular homeostasis in young women with polycystic ovary syndrome?
Willis, G., Udiawar, M., Evans, W. D., Blundell, H. L., James, P., & Rees, A. (2014) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1111/1471-0528.12834 · Cited by 12
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Early impaired β-cell function in chinese women with polycystic ovary syndrome.
Tao, T., Li, S., Zhao, A., Mao, X., & Liu, W. (2012) · Europe PMC (PubMed Central) · Cited by 12
Report of the international symposium: polycystic ovary syndrome: first Latin-American consensus
Motta, A. B. (2010) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2009.02259.x · Cited by 12
Tryptophan 64 → arginine polymorphism of β‐3‐adrenergic receptor in Chilean women with polycystic ovary syndrome
Pérez‐Bravo, F., Echiburú, B., Maliqueo, M. A., Santos, J. L., & Sir‐Petermann, T. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02183.x · Cited by 12
Impaired Glucose Metabolism in Women with Polycystic Ovary Syndrome
Vrbíková, J., Fanta, M., Cibula, D., Vondra, K., & Bendlová, B. (2009) · Gynecologic and Obstetric Investigation · doi:10.1159/000232574 · Cited by 11
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New approaches to insulin resistance in polycystic ovarian syndrome
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Løbo, R. A. (2001) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.2001.tb143431.x · Cited by 11
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Le syndrome des ovaires polykystiques (SOPK)
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Mu, L., Zhao, Y., Lai, Y.-C., Li, R., & Qiao, J. (2018) · Clinical Endocrinology · doi:10.1111/cen.13832 · Cited by 10
Levels of circulating insulin cell-free DNA in women with polycystic ovary syndrome – a longitudinal cohort study
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Authors: Ehrmann, D. A., Sturis, J., Byrne, M. M., Karrison, T., Rosenfield, R. L., & Polonsky, K. S.
Affiliations: University of Chicago (US)
ORCID: Sturis, J
Byrne, M M
Karrison, T
Rosenfield, R L
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1995-07-01
Volume: 96
Issue: 1
Pages: 520-527
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci118064
PMC: PMC185226
OpenAlex: W2100224373
Cited by: 426
References: 52
Citations by year: 2025: 1 · 2024: 6 · 2023: 5 · 2022: 12 · 2021: 5 · 2020: 5 · 2019: 9 · 2018: 6 · 2017: 13 · 2016: 11 · 2015: 17 · 2014: 10 · 2013: 12 · 2012: 23
FWCI: 13.28
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (DK 07011-7, T32DK007011)
National Center for Research Resources (RR-00055)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD 06308, R01HD006308)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: polycystic ovary syndrome, insulin secretion, insulin resistance, type 2 diabetes, family history of diabetes, beta-cell function, beta-cell compensation, glucose infusion, insulin secretion rate, insulin sensitivity
MeSH terms: Insulin Secretion, Adult, Blood Glucose, Diabetes Mellitus, Type 2, Female, Glucose, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Polycystic Ovary Syndrome, Testosterone, Body Mass Index

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Insulin secretory defects in polycystic ovary syndrome. Relationship to insulin sensitivity and family history of non-insulin-dependent diabetes mellitus.

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