Pancreatic β-cell dysfunction in polycystic ovary syndrome: the role of metformin

Messer, Caroline; Boston, Raymond; Leroith, Derek; Geer, Eliza; Miller, Joshua D.; Messer, Marcelo; Futterweit, Walter

doi:10.4158/ep11375.or

Cited by 16Ovarian function and disordersPancreatic function and diabetesDiabetes, Cardiovascular Risks, and Lipoproteins

Pancreatic β-cell dysfunction in polycystic ovary syndrome: the role of metformin

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Messer, Caroline, Boston, Raymond, Leroith, Derek, Geer, Eliza, Miller, Joshua D., Messer, Marcelo, Futterweit, Walter·2012·Endocrine Practice

DOI 10.4158/ep11375.orPMC PMC3722880

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Abstract

Objective To determine whether the administration of 6 months of daily metformin treatment in women with polycystic ovary syndrome (PCOS) would significantly improve pancreatic β-cell function as measured by an increase in the disposition index.Methods We enrolled women with PCOS from a private practice and from the Mount Sinai Hospital Endocrinology Clinic. All patients underwent frequently sampled intravenous glucose tolerance tests both on and off 500 to 1000 mg of twice daily metformin. Values of insulin sensitivity, glucose effectiveness, acute insulin response to glucose, and disposition index were calculated for each test. The product of acute insulin response to glucose and insulin sensitivity yielded the disposition index and estimated the degree of β-cell compensation for insulin resistance.Results We enrolled 14 women. We observed no significant changes in insulin sensitivity, glucose effectiveness, or acute insulin response to glucose, disposition index, or distributed glucose at time 0 before or after metformin treatment. Patients with PCOS treated with metformin remained statistically on the same hyperbolic curve, which is consistent with previously reported results of the effect of metformin on β-cell function. In contrast, the proportional change in disposition index correlated significantly with the proportional change in insulin sensitivity. Patients whose insulin sensitivity decreased after treatment showed a proportional decrease in disposition index, while patients whose insulin sensitivity increased showed a proportional increase in disposition index.Conclusions Our findings suggest that acute insulin response to glucose does not proportionately change to match change in insulin sensitivity. Thus, there may be a β-cell defect in women with PCOS.

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From PCOS and nutritional approaches: Differences between lean and obese phenotype (2021) · cites this paper as [41]

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Authors: Messer, C., Boston, R., Leroith, D., Geer, E., Miller, J. D., Messer, M., & Futterweit, W.
Affiliations: University of Pennsylvania (US)
Icahn School of Medicine at Mount Sinai (US)
Columbia University (US)
Corresponding author: Messer, Caroline
ORCID: Geer, Eliza
Miller, Joshua D.
Venue: Endocrine Practice
Publisher: Elsevier BV
Published: 2012-09
Volume: 18
Issue: 5
Pages: 685-693
ISSN: 1530-891X (ISSN-L)
DOI: 10.4158/ep11375.or
PMC: PMC3722880
OpenAlex: W2086786288
Cited by: 16
References: 38
Citations by year: 2024: 2 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2016: 1 · 2015: 2 · 2014: 3 · 2013: 1
FWCI: 2.23
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Endocrine Practice (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007271)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: polycystic ovary syndrome, metformin, beta-cell dysfunction, disposition index, insulin sensitivity, insulin resistance, acute insulin response, glucose effectiveness, insulin sensitivity index, beta-cell compensation
MeSH terms: Blood Glucose, Female, Glucose Tolerance Test, Humans, Insulin Resistance, Metformin, Polycystic Ovary Syndrome, Prospective Studies, Insulin-Secreting Cells

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Pancreatic β-cell dysfunction in polycystic ovary syndrome: the role of metformin

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