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Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma.
Open accessAbstract
The mechanism that may cause degenerative fibrotic skin lesions was studied in situ using skin biopsies from patients with systemic sclerosis (SSc), localized scleroderma, or keloids, and at the initial disease stage in the University of California at Davis (UCD) lines 200/206 chickens, which develop a hereditary systemic connective tissue disease resembling human SSc and permit study of disease stages not accessible in humans. Frozen skin sections were analyzed simultaneously for apoptosis by terminal deoxynucleotidyl transferase-mediated FITC-dUTP nick end labeling and indirect immunofluorescence staining of cell markers with tetramethylrhodamine isothiocyanate conjugates. The results showed that endothelial cells are clearly the first cells to undergo apoptosis in the skin of UCD-200/206 chickens, a process that seems to be induced by anti-endothelial cell antibodies. In human fibrotic skin diseases, apoptotic endothelial cells could only be detected in early inflammatory disease stages of SSc and localized scleroderma.
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Cited by
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Yang, J., Chang, E., Cherry, A. M., Bangs, C. D., Oei, Y., Bodnar, A., Bronstein, A., Chiu, C.-P., & Herron, G. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.37.26141 · Cited by 410
Pathogenesis of Systemic Sclerosis
Pattanaik, D., Brown, M., Postlethwaite, B. C., & Postlethwaite, A. E. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00272 · Cited by 405
Pathophysiology of systemic sclerosis: current understanding and new insights
Cutolo, M., Soldano, S., & Smith, V. (2019) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2019.1614915 · Cited by 369
Varga, J., Trojanowska, M., & Kuwana, M. (2017) · Journal of Scleroderma and Related Disorders · doi:10.5301/jsrd.5000249 · Cited by 323
Metadata
- Authors
- Sgonc, R., Gruschwitz, M. S., Dietrich, H., Recheis, H., Gershwin, M. E., & Wick, G.
- Venue
- Journal of Clinical Investigation
- Published
- 1996-08-01
- Volume
- 98
- Issue
- 3
- Pages
- 785-792
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2043271787
- Cited by
- 374
- References
- 0
- FWCI
- 6.90
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma. https://app.cochat.ai/papers/10.1172/jci118851
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- Sgonc, R., Gruschwitz, M. S., Dietrich, H., Recheis, H., Gershwin, M. E., & Wick, G. (1996). Endothelial cell apoptosis is a primary pathogenetic event underlying skin lesions in avian and human scleroderma. Journal of Clinical Investigation. https://doi.org/10.1172/jci118851
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