Impaired glucose homeostasis in insulin-like growth factor binding protein-1 transgenic mice
Open accessAbstract
Transgenic mice that overexpressed IGFBP-1 are hyperinsulinemic in the first week of life and gradually develop fasting hyperglycemia. In adult transgenic mice, the hypoglycemic response to IGF-I but not insulin or des (1-3) IGF-I was attenuated (P < 0.05) compared with wild-type mice. Furthermore, in isolated adipocytes from transgenic mice, the stimulatory effect of IGF-I but not insulin on 2-deoxy-[3H]-glucose uptake was reduced (P < 0.02). In contrast, in isolated soleus muscle, the effects of both IGF-I and insulin on 2-deoxy-3H-glucose uptake and on [3H]-glucose incorporation into glycogen were significantly reduced compared to wild-type mice. The decline in specific activity of the 2-deoxy-3H-glucose, a measure of glucose appearance in the circulation, was more marked in transgenic animals (P < 0.05). In addition, tissue uptake of glucose was significantly higher in diaphragm, heart, intestine, liver, soleus muscle, and adipose tissue from fasting transgenic mice. Plasma concentrations of alanine, lysine, and methionine were also elevated in transgenic mice. These data suggest that overexpression of IGFBP-1 attenuates the hypoglycemic effect of endogenous IGF-I, which is initially compensated for by enhanced pancreatic insulin production. However, in adult mice pancreatic insulin content is reduced, insulin resistance is demonstrable in skeletal muscle and fasting hyperglycemia develops.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
IGFBP1 is elevated in patients with type 2 diabetes and counteracts the hypoglycemic effect of insulin through inhibition of IGF1.
“IGFBP1 is elevated in patients with type 2 diabetes and has been shown to counteract the hypoglycemic effect of insulin through inhibition of IGF1 [224].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [224]
IGFs are regulated by a family of IGF-binding proteins that can bind IGFs with equal or greater affinity than IGF1R.
“IGFs are regulated by a family of IGF-binding proteins (IGFBP) that can bind IGFs with equal or greater affinity than IGF1R [224,225].”
From Hepatokines and metabolism: Deciphering communication from the liver (2021) · cites this paper as [224]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Pathogenesis of NIDDM. A balanced overview.
DeFronzo, R. A., Bonadonna, R. C., & Ferrannini, E. (1992) · Diabetes Care · doi:10.2337/diacare.15.3.318 · Cited by 2,085 · see citing works
Insulin-like Growth Factor Binding Proteins
Rechler, M. M. (1993) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60444-6 · Cited by 759 · see citing works
β-cells in type II diabetes mellitus
Porte, D. (1991) · Diabetes · doi:10.2337/diab.40.2.166 · Cited by 585 · see citing works
Insulin-like growth factors I and II in healthy man.
Guler, H., Zapf, J., Schmid, C., & Froesch, E. R. (1989) · European Journal of Endocrinology · doi:10.1530/acta.0.1210753 · Cited by 534 · see citing works
Fetal growth and impaired glucose tolerance in men and women
Phipps, K. P., Barker, D. J. P., Hales, C. N., Fall, C. H. D., Osmond, C., & Clark, P. M. (1993) · Diabetologia · doi:10.1007/bf00399954 · Cited by 490 · see citing works
Suikkari, A., Koivisto, V. A., Rutanen, E., YKI-JÄRVINEN, H., Karonen, S.-L., & Seppälä, M. T. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-2-266 · Cited by 483 · see citing works
Regulation and Function of Insulin-Like Growth Factor-Binding Protein-1
Lee, P., Conover, C. A., & Powell, D. R. (1993) · Experimental Biology and Medicine · doi:10.3181/00379727-204-43630 · Cited by 390 · see citing works
Brismar, K., Fernqvist‐Forbes, E., Wahren, J., & Hall, K. E. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.3.7521354 · Cited by 345 · see citing works
A New in Vitro Model for the Study of Pancreatic A and B Cells*
PIPELEERS, D. G., Veld, P. I. '., Winkel, M. V. D., Maes, E., Schuit, F. C., & Gepts, W. (1985) · Endocrinology · doi:10.1210/endo-117-3-806 · Cited by 341 · see citing works
Baxter, R. C., & Martin, J. L. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.18.6898 · Cited by 311 · see citing works
Zapf, J., Hauri, C., WALDVOGEL, M., et al. (1986) · Journal of Clinical Investigation · doi:10.1172/jci112500 · Cited by 303 · see citing works
Jacob, R. J., Barrett, E. J., Plewe, G., Fagin, K. D., & Sherwin, R. S. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114072 · Cited by 290 · see citing works
Evolution of β-Cell Dysfunction in the Male Zucker Diabetic Fatty Rat
Tokuyama, Y., Sturis, J., DePaoli, A. M., Takeda, J., Stoffel, M., Tang, J., Sun, X., Polonsky, K. S., & Bell, G. I. (1995) · Diabetes · doi:10.2337/diab.44.12.1447 · Cited by 280 · see citing works
INSULIN-LIKE GROWTH FACTOR-BINDING PROTEIN-1 MODULATES BLOOD GLUCOSE LEVELS
LEWITT, M. S., Denyerf, G. S., Gregory Cooney, J., & Baxter, R. C. (1991) · Endocrinology · doi:10.1210/endo-129-4-2254 · Cited by 261 · see citing works
Baxter, R. C., & Cowell, C. T. C. T. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-3-432 · Cited by 226 · see citing works
Rajkumar, K., Barron, D. J., LEWITT, M. S., et al. (1995) · Endocrinology · doi:10.1210/endo.136.9.7544274 · Cited by 200 · see citing works
Self-citationSuikkari, A., Koivisto, V. A., Koistinen, R. A., Seppälä, M. T., & Yki‐Järvinen, H. (1989) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-68-1-135 · Cited by 199 · see citing works
POGGI, C., MARCHAND‐BRUSTEL, Y. L., Zapf, J., RUDOLF, F. E., & Freychet, P. (1979) · Endocrinology · doi:10.1210/endo-105-3-723 · Cited by 175 · see citing works
Diverse effects of insulin-like growth factor I on glucose, lipid, and amino acid metabolism
Boulware, S. D., Tamborlane, W. V., Matthews, L. S., & Sherwin, R. S. (1992) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1992.262.1.e130 · Cited by 145 · see citing works
Meuli, C., Zapf, J., & Froesch, E. R. (1978) · Diabetologia · doi:10.1007/bf01219425 · Cited by 94 · see citing works
Luo, J., Reid, R. E., & Murphy, L. J. (1990) · Endocrinology · doi:10.1210/endo-127-3-1456 · Cited by 78 · see citing works
Self-citationInsulin-like growth factor-binding protein-1: A role in glucose counterregulation?
LEWITT, M. S., & Baxter, R. C. (1991) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(91)90086-8 · Cited by 70 · see citing works
Murphy, L. J., Seneviratne, C. K., MOREIRA, P., & Reid, R. E. (1991) · Endocrinology · doi:10.1210/endo-128-2-689 · Cited by 64 · see citing works
Self-citationGrowth retardation and hyperglycemia in insulin-like growth factor binding protein-1 transgenic mice
Rajkumar, K. (1995) · Endocrinology · doi:10.1210/en.136.9.4029 · Cited by 62 · see citing works
Self-citationReversion of insulin resistance in the rat during late pregnancy by 72-h glucose infusion
Ramos, P., & Herrera, E. (1995) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1995.269.5.e858 · Cited by 45 · see citing works
Hyperglycemia and impaired glucose tolerance in IGF binding protein-1 transgenic mice
Rajkumar, K., Dheen, S. T., & Murphy, L. J. (1996) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1996.270.4.e565 · Cited by 32 · see citing works
Self-citationLEWITT, M. S., Saunders, H., & Baxter, R. C. (1992) · Endocrinology · doi:10.1210/endo.131.5.1385101 · Cited by 29 · see citing works
Pharmacokinetics and bioavailability of rhIGF-I/IGFBP-3 in the rat and monkey
Adams, S., Moore, J. A., Chu, S., et al. (1995) · Progress in Growth Factor Research · doi:10.1016/0955-2235(95)00003-8 · Cited by 21 · see citing works
Davidson, M. B., Bouch, C., Venkatesan, N., & Karjala, R. G. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.267.6.e808 · Cited by 21 · see citing works
Conjoint IGF-I and Insulin Infusion Shows Diverse Interactive Effects in Diabetic Rats
Tomas, F. M., Knowles, S. E., Owens, P. C., et al. (1996) · Diabetes · doi:10.2337/diab.45.2.170 · Cited by 17 · see citing works
LEWITT, M. S. (1992) · Endocrinology · doi:10.1210/en.131.5.2357 · Cited by 13 · see citing works
Hormonal Regulation of Insulin-Like Growth Factor Binding Protein-1 Expression in the Rat
Murphy, L. J., Luo, J., & Seneviratne, C. K. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5949-4_14 · Cited by 8 · see citing works
Self-citationConjoint IGF-I and insulin infusion shows diverse interactive effects in diabetic rats
Tomas, F., Knowles, S. E., Owens, P. C., et al. (1996) · Diabetes · doi:10.2337/diabetes.45.2.170 · Cited by 6 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Pell, J.M., H.C. Flick-Smith, S. Dye, and R.A. Hill. 1995. Further char- acterization of an IGF-I enhancing antibody: actions on IGF-I-induced hy- poglycemia and interaction with the analogue LR 3 IGF-I. Proc. 3rd Interna- tional Symposium on Insulin-like Growth Factor Binding Proteins. p38 (Abstr.)
Cited by
Sorted by citations
Hepatokines and metabolism: Deciphering communication from the liver
Jensen-Cody, S. O., & Potthoff, M. J. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2020.101138 · Cited by 252 · see citing works
de Wit, N. J., Bosch-Vermeulen, H., de Groot, P. J., Hooiveld, G. J., Bromhaar, M. M. G., Jansen, J., Müller, M., & van der Meer, R. (2008) · BMC Medical Genomics · doi:10.1186/1755-8794-1-14 · Cited by 182 · see citing works
Impaired glucose homeostasis in insulin-like growth factor-binding protein-3-transgenic mice
Silha, J. V., Gui, Y., & Murphy, L. J. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00014.2002 · Cited by 96 · see citing works
Self-citationCentral IGF1 improves glucose tolerance and insulin sensitivity in mice
Hong, H., Cui, Z.-Z., Zhu, L., Fu, S.-P., Rossi, M., Cui, Y.-H., & Zhu, B.-M. (2017) · Nutrition & Diabetes · doi:10.1038/s41387-017-0002-0 · Cited by 54 · see citing works
- Authors
- Rajkumar, K., Krsek, M., Dheen, S. T., & Murphy, L. J.
- Affiliations
- University of Manitoba (CA)
- Venue
- Journal of Clinical Investigation
- Published
- 1996-10-15
- Volume
- 98
- Issue
- 8
- Pages
- 1818-1825
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC507621
- OpenAlex
- W2115140038
- Cited by
- 97
- References
- 33
- Citations by year
- 2026: 1 · 2024: 1 · 2022: 1 · 2021: 2 · 2020: 3 · 2019: 1 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- National University of Singapore (submittedVersion)
- Funders
- Canadian Diabetes Association
- Medical Research Council Canada
- Medical Research Council
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- IGFBP-1, transgenic mice, glucose homeostasis, fasting hyperglycemia, hypoglycemic response, insulin-like growth factor I, insulin resistance, skeletal muscle glucose uptake, adipocytes, glucose appearance, plasma amino acids, hyperinsulinemia
- MeSH terms
- Insulin Secretion, Animals, Blood Glucose, Deoxyglucose, Glucose, Homeostasis, Insulin, Insulin-Like Growth Factor I, Islets of Langerhans, Male, Mice, Transgenic, Insulin-Like Growth Factor Binding Protein 1, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
