Targeted expression of IL-11 in the murine airway causes lymphocytic inflammation, bronchial remodeling, and airways obstruction.
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Interleukin-11 is a pleotropic cytokine produced by lung stromal cells in response to respiratory viruses, cytokines, and histamine. To further define its potential effector functions, the Clara cell 10-kD protein promoter was used to express IL-11 and the airways of the resulting transgene mice were characterized. In contrast to transgene (-) littermates, the airways of IL-11 transgene (+) animals manifest nodular peribronchiolar mononuclear cell infiltrates and impressive airways remodeling with subepithelial fibrosis. The inflammatory foci contained large numbers of B220(+) and MHC Class II(+) cells and lesser numbers of CD3(+), CD4(+), and CD8(+) cells. The fibrotic response contained increased amounts of types III and I collagen, increased numbers of alpha smooth muscle actin and desmin-containing cells and a spectrum of stromal elements including fibroblasts, myofibroblasts, and smooth muscle cells. Physiologic evaluation also demonstrated that 2-mo-old transgene (+) mice had increased airways resistance and non-specific airways hyperresponsiveness to methacholine when compared with their transgene (-) littermates. These studies demonstrate that the targeted expression of IL-11 in the mouse airway causes a B and T cell-predominant inflammatory response, airway remodeling with increased types III and I collagen, the local accumulation of fibroblasts, myofibroblasts, and myocytes, and obstructive physiologic dysregulation. IL-11 may play an important role in the inflammatory and fibrotic responses in viral and/or nonviral human airway disorders.
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Cites
Manipulating the mouse embryo: A laboratory manual
Hogan, B. L. M., Costantini, F. D., & Lacy, E. (1986) · Cited by 4,460 · see citing works
Predominant TH2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma
Robinson, D. S., Hamid, Q. A., Ying, S., Tsicopoulos, A., Barkans, J. R., Bentley, A. M., Corrigan, C. J., Durham, S. R., & Kay, A. B. (1992) · New England Journal of Medicine · doi:10.1056/nejm199201303260504 · Cited by 2,767 · see citing works
Manipulating the mouse embryo: A laboratory manual
Johnson, M. (1986) · Trends in Genetics · doi:10.1016/0168-9525(86)90275-1 · Cited by 2,259 · see citing works
Desmoulière, A., Geinoz, A., Gabbiani, F., & Gabbiani, G. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.122.1.103 · Cited by 2,226 · see citing works
Community study of role of viral infections in exacerbations of asthma in 9–11 year old children
Johnston, S. L., Pattemore, P. K., Sanderson, G., Smith, S., Lampe, F., Josephs, L., Symington, P., Toole, S. O., Myint, S. H., Tyrrell, D. A. J., et al. (1995) · BMJ · doi:10.1136/bmj.310.6989.1225 · Cited by 1,991 · see citing works
Respiratory viruses and exacerbations of asthma in adults
Nicholson, K. G., Kent, J., & Ireland, D. C. (1993) · BMJ · doi:10.1136/bmj.307.6910.982 · Cited by 1,127 · see citing works
Chanock, R. M., Kim, H. W., Brandt, C. D., & Parrott, R. H. (1976) · Springer eBooks · doi:10.1007/978-1-4613-3988-5_17 · Cited by 1,085 · see citing works
An Economic Evaluation of Asthma in the United States
Weiss, K. B., Gergen, P. J., & Hodgson, T. A. (1992) · New England Journal of Medicine · doi:10.1056/nejm199203263261304 · Cited by 997 · see citing works
Corry, D. B., Folkesson, H. G., Warnock, M. L., Erle, D. J., Matthay, M. A., Wiener-Kronish, J. P., & Locksley, R. M. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.183.1.109 · Cited by 723 · see citing works
Myofibroblasts and Subepithelial Fibrosis in Bronchial Asthma
Brewster, C. E. P., Howarth, P. H., Djukanović, R., Wilson, J. W., Holgate, S. T., & Roche, W. R. (1990) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb/3.5.507 · Cited by 662 · see citing works
Paul, S. R., Bennett, F., Calvetti, J., Kelleher, K. S., Wood, C. R., O'Hara, R. M., Leary, A. C., Sibley, B. S., Clark, S., & Williams, D. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.19.7512 · Cited by 651 · see citing works
Mechanics of Respiration in Unanesthetized Guinea Pigs
Amdur, M. O., & Mead, J. (1958) · American Journal of Physiology-Legacy Content · doi:10.1152/ajplegacy.1958.192.2.364 · Cited by 629 · see citing works
Sigurs, N., Bjarnason, R. G., Sigurbergsson, F., Kjellman, B., & Björkstén, B. (1995) · PEDIATRICS · doi:10.1542/peds.95.4.500 · Cited by 628 · see citing works
Ebina, M., Takahashi, T., Chiba, T., & Motomiya, M. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/148.3.720 · Cited by 607 · see citing works
IgG1 plasmacytosis in interleukin 6 transgenic mice
Suematsu, S., Matsuda, T., Aozasa, K., Akira, S., Nakano, N., Ohno, S., Miyazaki, J., Yamamura, K., Hirano, T., & Kishimoto, T. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7547 · Cited by 586 · see citing works
THE PATHOLOGY OF BRONCHIAL ASTHMA
HUBER, H. L. (1922) · Archives of Internal Medicine · doi:10.1001/archinte.1922.00110120002001 · Cited by 544 · see citing works
Interleukin-11: a new cytokine critical for osteoclast development.
Girasole, G., Passeri, G., Jilka, R. L., & Manolagas, S. C. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117130 · Cited by 395 · see citing works
Viruses as precipitants of asthma symptoms. I. Epidemiology
Pattemore, P., Johnston, S. L., & Bardin, P. G. (1992) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1992.tb03094.x · Cited by 326 · see citing works
Distinct types of lung disease caused by functional subsets of antiviral T cells.
Alwan, W. H., Kozlowska, W. J., & Openshaw, P. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.1.81 · Cited by 317 · see citing works
Zhu, Z., Tang, W., Ray, A., Wu, Y., Einarsson, O., Landry, M. L., Gwaltney, J., & Elias, J. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118431 · Cited by 282 · see citing works
Self-citationPattemore, P., Asher, M. I., Harrison, A. C., Mitchell, E. A., Rea, H. H., & Stewart, A. W. (1990) · American Review of Respiratory Disease · doi:10.1164/ajrccm/142.3.549 · Cited by 278 · see citing works
Pulmonary responses to bronchoconstrictor agonists in the mouse
Martin, T. R., Gerard, N. P., Galli, S. J., & Drazen, J. M. (1988) · Journal of Applied Physiology · doi:10.1152/jappl.1988.64.6.2318 · Cited by 243 · see citing works
Einarsson, Ó., Geba, G. P., Zhu, Z., Landry, M. L., & Elias, J. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118514 · Cited by 229 · see citing works
Self-citationZhang, X., Gu, J. J., Lu, Z., Yasukawa, K., Yancopoulos, G. D., Turner, K., SHOYAB, M., Taga, T., Kishimoto, T., & Bataille, R. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1337 · Cited by 229 · see citing works
Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment
Du, X., & Williams, D. (1994) · Blood · doi:10.1182/blood.v83.8.2023.2023 · Cited by 222 · see citing works
The relationship between proved viral bronchiolitis and subsequent wheezing
Rooney, J. C., & WILLIAMS, H. E. (1971) · The Journal of Pediatrics · doi:10.1016/s0022-3476(71)80385-2 · Cited by 214 · see citing works
DiCosmo, B., Geba, G. P., Picarella, D., Elias, J. A., Rankin, J. A., Stripp, B. R., Whitsett, J. A., & Flavell, R. A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117556 · Cited by 208 · see citing works
Self-citationRespiratory syncytial virus-induced cytokine production by a human bronchial epithelial cell line
Noah, T. L., & Becker, S. (1993) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.1993.265.5.l472 · Cited by 205 · see citing works
Interleukin-11: a multifunctional growth factor derived from the hematopoietic microenvironment
Du, X., & Williams, D. (1994) · Blood · doi:10.1182/blood.v83.8.2023.bloodjournal8382023 · Cited by 191 · see citing works
Pack, R. J., Al-Ugaily, L., & Morris, G. (1981) · Europe PMC (PubMed Central) · Cited by 190 · see citing works
National Asthma Education Program
Lenfant, C. J. M., & Hurd, S. S. (1990) · CHEST Journal · doi:10.1378/chest.98.1.226 · Cited by 174 · see citing works
Du, X., Doerschuk, C. M., Orazi, A., & Williams, D. (1994) · Blood · doi:10.1182/blood.v83.1.33.33 · Cited by 165 · see citing works
Fann, M.-J., & Patterson, P. H. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.1.43 · Cited by 160 · see citing works
Epithelial interleukin-11. Regulation by cytokines, respiratory syncytial virus, and retinoic acid.
Elias, J. A., Zheng, T., Einarsson, Ó., Landry, M. L., Trow, T. K., Rebert, N. A., & Panuska, J. R. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31785-4 · Cited by 153 · see citing works
Self-citationThe Pathobiology of Bronchial Asthma
Arm, J. P., & Lee, T. H. (1992) · Advances in immunology · doi:10.1016/s0065-2776(08)60491-5 · Cited by 150 · see citing works
Maier, R., Ganu, V., & Lotz, M. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(20)80573-0 · Cited by 146 · see citing works
cis-acting elements that confer lung epithelial cell expression of the CC10 gene.
Stripp, B. R., Sawaya, P. L., Luse, D. S., Wikenheiser‐Brokamp, K. A., Wert, S. E., Huffman, J. A., Lattier, D. L., Singh, G., Katyal, S. L., & Whitsett, J. A. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)42098-4 · Cited by 142 · see citing works
Cytokine and hormonal stimulation of human osteosarcoma interleukin-11 production
Elias, J. A., Tang, W., & Horowitz, M. C. (1995) · Endocrinology · doi:10.1210/endo.136.2.7835281 · Cited by 114 · see citing works
Self-citationEnhancement of in vitro and in vivo antigen-specific antibody responses by interleukin 11.
Yin, T., Schendel, P. F., & Yang, Y. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.175.1.211 · Cited by 112 · see citing works
Shelhamer, J. H., Levine, S. J., Wu, T., Jacoby, D. B., Kaliner, M. A., & Rennard, S. I. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-123-4-199508150-00008 · Cited by 109 · see citing works
IL-1 and transforming growth factor-beta regulation of fibroblast-derived IL-11.
Elias, J. A., Zheng, T., Whiting, N. L., Trow, T. K., Merrill, W. W., Zitnik, R. J., Ray, P., & Alderman, E. M. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.152.5.2421 · Cited by 101 · see citing works
Self-citationAirway function in sarcoidosis
Levinson, R. S., Metzger, L. F., Stanley, N. N., Kelsen, S. G., Altose, M. D., Cherniack, N. S., & Brody, J. S. (1977) · The American Journal of Medicine · doi:10.1016/0002-9343(77)90349-7 · Cited by 101 · see citing works
Increased Lower Airways Responsiveness Associated with Sinusitis in a Rabbit Model
Brugman, S. M., Larsen, G. L., Henson, P. M., Honor, J., & Irvin, C. G. (1993) · American Review of Respiratory Disease · doi:10.1164/ajrccm/147.2.314 · Cited by 91 · see citing works
Roeb, E., Graeve, L., Hoffmann, R., Decker, K., Edwards, D. R., & Heinrich, P. C. (1993) · Hepatology · doi:10.1002/hep.1840180624 · Cited by 83 · see citing works
Quantitative measurement of bronchial muscle in men with asthma.
Hossain, S. (1973) · PubMed · doi:10.1164/arrd.1973.107.1.99 · Cited by 78 · see citing works
Prevalence of asthma, atopy, and bronchial hyperreactivity in bronchiectasis: a controlled study.
Pang, J. A. C. K., Chan, H. S., & Sung, J. J. �. (1989) · Thorax · doi:10.1136/thx.44.11.948 · Cited by 70 · see citing works
An Economic Evaluation of Asthma in the United States
(1992) · New England Journal of Medicine · doi:10.1056/nejm199208203270821 · Cited by 58 · see citing works
New Insights into Airway Inflammation by Endobronchial Biopsy
Holgate, S. T., Wilson, J. W., & Howarth, P. H. (1992) · American Review of Respiratory Disease · doi:10.1164/ajrccm/145.2_pt_2.s2 · Cited by 52 · see citing works
Castleman, W. L., Sorkness, R. L., Lemanske, R. F., Grasee, G., & Suyemoto, M. M. (1988) · PubMed · Cited by 51 · see citing works
Histamine augments cytokine-stimulated IL-11 production by human lung fibroblasts.
Zheng, T., Nathanson, M. H., & Elias, J. A. (1994) · The Journal of Immunology · doi:10.4049/jimmunol.153.10.4742 · Cited by 49 · see citing works
Self-citationFormaldehyde-Induced Airway Hyperreactivity in Vivo and ex Vivo in Guinea Pigs
Swiecichowski, A. L., Long, K. J., Miller, M. L., & Leikauf, G. D. (1993) · Environmental Research · doi:10.1006/enrs.1993.1063 · Cited by 35 · see citing works
Chanock, R. M., McIntosh, K., Murphy, B. R., & Parrott, R. H. (1991) · Springer eBooks · doi:10.1007/978-1-4615-8138-3_20 · Cited by 31 · see citing works
Epidemiology of Respiratory Viruses in Persons with and without Asthma and COPD
Monto, A. S. (1995) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm/151.5_pt_1.1653 · Cited by 21 · see citing works
Krzyżanowski, M., Sherrill, D. L., & Lebowitz, M. D. (1990) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a115516 · Cited by 19 · see citing works
Du, X., Doerschuk, C. M., Orazi, A., et al. (1994) · Blood · doi:10.1182/blood.v83.1.33.bloodjournal83133 · Cited by 18 · see citing works
Gross, N. J. (1995) · CHEST Journal · doi:10.1378/chest.107.5_supplement.210s · Cited by 12 · see citing works
Disorders of the Intrathoracic Airways
Lazarus, S. C. (2010) · Elsevier eBooks · doi:10.1016/b978-1-4160-4710-0.00044-4 · Cited by 7 · see citing works
Roeb, E. (1993) · Hepatology · doi:10.1016/0270-9139(93)90236-g · Cited by 7 · see citing works
Chronic bronchitis and emphysema
Jariwalla, G. (1985) · Springer eBooks · doi:10.1007/978-94-009-4880-8_5 · Cited by 2 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Luce, J.M. 1994. Bronchiectasis. In Textbook of Respiratory Medicine. 2nd ed. J.F. Murray and J.A. Nadel, editors. W.B. Saunders Co., Philadelphia. 1398-1417.
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Henderson, N. C., Rieder, F., & Wynn, T. A. (2020) · Nature · doi:10.1038/s41586-020-2938-9 · Cited by 1,868 · see citing works
Zhu, Z., Homer, R., Wang, Z., Chen, Q., Geba, G. P., Wang, J., Zhang, Y., & Elias, J. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5909 · Cited by 1,704 · see citing works
Self-citationIL-17 is increased in asthmatic airways and induces human bronchial fibroblasts to produce cytokines
Molet, S., Hamid, Q. A., Davoineb, F., Nutku, E., Tahaa, R., Pagé, N., Olivenstein, R., Elias, J. A., & Chakir, J. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.117929 · Cited by 952 · see citing works
Self-citationLee, C. G., Homer, R. J., Zhu, Z., Lanone, S., Wang, X., Koteliansky, V., Shipley, J. M., Gotwals, P., Noble, P., Chen, Q., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.809 · Cited by 940 · see citing works
Self-citationMurine models of pulmonary fibrosis
Moore, B. B., & Hogaboam, C. M. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00313.2007 · Cited by 800 · see citing works
Inflammatory Mediators of Asthma: An Update
Barnes, P. J., Chung, K. F., & Page, C. P. (1998) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01381-4 · Cited by 712 · see citing works
Elias, J. A., Zhu, Z., Chupp, G. L., & Homer, R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8124 · Cited by 696 · see citing works
Self-citationChung, K. F., & Barnes, P. J. (1999) · Thorax · doi:10.1136/thx.54.9.825 · Cited by 652 · see citing works
Identification of Circulating Fibrocytes as Precursors of Bronchial Myofibroblasts in Asthma
Schmidt, M., Sun, G. Y., Stacey, M. A., Mori, L., & Mattoli, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.1.380 · Cited by 633 · see citing works
Lee, C. G., Link, H., Bałuk, P., Homer, R., Chapoval, S. P., Bhandari, V., Kang, M., Cohn, L. E., Kim, Y. K., McDonald, D. M., et al. (2004) · Nature Medicine · doi:10.1038/nm1105 · Cited by 586 · see citing works
Self-citationThe role of T lymphocytes in the pathogenesis of asthma
Larché, M., Robinson, D. S., & Kay, A. B. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.169 · Cited by 568 · see citing works
Immunologic messenger molecules: Cytokines, interferons, and chemokines
Commins, S. P., Borish, L., & Steinke, J. W. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.07.008 · Cited by 477 · see citing works
The role of allergy in the development of asthma
Holt, P. G., Macaubas, C., Stumbles, P. A., & Sly, P. D. (1999) · Nature · doi:10.1038/35037009 · Cited by 472 · see citing works
Temann, U.-A., Geba, G. P., Rankin, J. A., & Flavell, R. A. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.7.1307 · Cited by 452 · see citing works
Self-citationThe role of lymphocytes in allergic disease
Romagnani, S. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2000.104575 · Cited by 444 · see citing works
Al‐Muhsen, S., Johnson, J. R., & Hamid, Q. A. (2011) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.04.047 · Cited by 414 · see citing works
Interferon γ Induction of Pulmonary Emphysema in the Adult Murine Lung
Wang, Z., Zheng, T., Zhu, Z., Homer, R., Riese, R. J., Chapman, H. A., Shapiro, S. D., & Elias, J. A. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.11.1587 · Cited by 412 · see citing works
Self-citationThe sentinel role of the airway epithelium in asthma pathogenesis
Holgate, S. T. (2011) · Immunological Reviews · doi:10.1111/j.1600-065x.2011.01030.x · Cited by 411 · see citing works
Airway remodeling in asthma: what really matters
Fehrenbach, H., Wagner, C., & Wegmann, M. (2017) · Cell and Tissue Research · doi:10.1007/s00441-016-2566-8 · Cited by 411 · see citing works
Lee, C. G., Cho, S. J., Kang, M., Chapoval, S. P., Lee, P. J., Noble, P. W., Yehualaeshet, T., Lu, B., Flavell, R. A., Milbrandt, J., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040104 · Cited by 365 · see citing works
Self-citationA role for eosinophils in airway remodelling in asthma
Kay, A. B., Phipps, S., & Robinson, D. S. (2004) · Trends in Immunology · doi:10.1016/j.it.2004.07.006 · Cited by 316 · see citing works
Interleukin-11 is a therapeutic target in idiopathic pulmonary fibrosis
Ng, B., Dong, J., D’Agostino, G., Viswanathan, S., Widjaja, A. A., Lim, W.-W., Ko, N. S. J., Tan, J., Chothani, S. P., Huang, B., et al. (2019) · Science Translational Medicine · doi:10.1126/scitranslmed.aaw1237 · Cited by 314 · see citing works
Polarized in vivo expression of IL-11 and IL-17 between acute and chronic skin lesions
Toda, M., Leung, D. Y. M., Molet, S., Boguniewicz, M., Taha, R. A., Christodoulopoulos, P., Fukuda, T., Elias, J. A., & Hamid, Q. A. (2003) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2003.1414 · Cited by 299 · see citing works
Self-citationVirus-induced Airway Hyperresponsiveness and Asthma
Folkerts, G., Busse, W. W., Nijkamp, F. P., Sorkness, R. L., & Gern, J. E. (1998) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.157.6.9707163 · Cited by 264 · see citing works
gp130 at the nexus of inflammation, autoimmunity, and cancer
Silver, J. S., & Hunter, C. A. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0410217 · Cited by 252 · see citing works
Vernooy, J. H. J., Dentener, M. A., van Suylen, R. J., Buurman, W. A., & Wouters, E. F. �. (2002) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.26.1.4652 · Cited by 250 · see citing works
Modeling of fibrotic lung disease using 3D organoids derived from human pluripotent stem cells
Strikoudis, A., Cieślak, A., Loffredo, L., Chen, Y.-W., Patel, N., Saqi, A., Lederer, D. J., & Snoeck, H.-W. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.05.077 · Cited by 242 · see citing works
Interleukin-13 modulates collagen homeostasis in human skin and keloid fibroblasts
Oriente, A., Fedarko, N. S., Pacocha, S. E., Huang, S.-K., Lichtenstein, L. M., & Essayan, D. M. (2000) · The Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35380-7 · Cited by 230 · see citing works
Rhinovirus Replication Causes RANTES Production in Primary Bronchial Epithelial Cells
Schroth, M. K., Grimm, E., Frindt, P., Galagan, D. M., Konno, S.-I., Love, R. B., & Gern, J. E. (1999) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.20.6.3261 · Cited by 223 · see citing works
Prolonged allergen challenge in mice leads to persistent airway remodelling
Mcmillan, S. J., & Lloyd, C. M. (2004) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2004.01895.x · Cited by 220 · see citing works
Aptamers Against Pro- and Anti-Inflammatory Cytokines: A Review
Boshtam, M., Asgary, S., Kouhpayeh, S., Shariati, L., & Khanahmad, H. (2016) · Inflammation · doi:10.1007/s10753-016-0477-1 · Cited by 220 · see citing works
The Enigmatic Cytokine Oncostatin M and Roles in Disease
Richards, C. D. (2013) · ISRN Inflammation · doi:10.1155/2013/512103 · Cited by 206 · see citing works
KIPS, J. C., Anderson, G. P., Fredberg, J. J., Herz, U., Inman, M. D., Jordana, M., Kemeny, D. M., Lötvall, J. O., Pauwels, R., Plopper, C. G., et al. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00026403 · Cited by 205 · see citing works
Busse, W. W., Elias, J. A., Sheppard, D., & Banks-Schlegel, S. P. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.160.3.9902064 · Cited by 202 · see citing works
Self-citationAirway inflammation and remodeling in asthma
Fahy, J. V., Corry, D. B., & Boushey, H. A. (2000) · Current Opinion in Pulmonary Medicine · doi:10.1097/00063198-200001000-00004 · Cited by 196 · see citing works
Zhu, Z., Zheng, T., Lee, C. G., Homer, R., & Elias, J. A. (2002) · Seminars in Cell and Developmental Biology · doi:10.1016/s1084-9521(02)00018-6 · Cited by 194 · see citing works
Self-citationPedroza, M., Le, T. T., Lewis, K., Karmouty‐Quintana, H., To, S., George, A. T., Blackburn, M. R., Tweardy, D. J., & Agarwal, S. K. (2016) · The FASEB Journal · doi:10.1096/fj.15-273953 · Cited by 193 · see citing works
Bergeron, C., Al-Ramli, W., & Hamid, Q. A. (2009) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200808-089rm · Cited by 189 · see citing works
Association of Rhinovirus Infections with Asthma
Gern, J. E., & Busse, W. W. (1999) · Clinical Microbiology Reviews · doi:10.1128/cmr.12.1.9 · Cited by 183 · see citing works
Cook, S. A., & Schäfer, S. (2020) · Annual Review of Medicine · doi:10.1146/annurev-med-041818-011649 · Cited by 176 · see citing works
Waxman, A. B., Einarsson, Ó., Seres, T., Knickelbein, R. G., Warshaw, J. B., Johnston, R. B., Homer, R., & Elias, J. A. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1337 · Cited by 176 · see citing works
Self-citationgp130 CYTOKINE FAMILY AND BONE CELLS
Heymann, D., & Rousselle, A. V. (2000) · Cytokine · doi:10.1006/cyto.2000.0747 · Cited by 172 · see citing works
Moodley, Y. P., Scaffidi, A. K., Misso, N. L., Keerthisingam, C., McAnulty, R. J., Laurent, G. J., Mutsaers, S. E., Thompson, P. J., & Knight, D. A. (2003) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)63658-9 · Cited by 165 · see citing works
Lee, J. H., Kaminski, N., Dolganov, G., Grünig, G., Koth, L. L., Solomon, C., Erle, D. J., & Sheppard, D. (2001) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.25.4.4522 · Cited by 164 · see citing works
Fibroblast-to-myofibroblast transition in bronchial asthma
Michalik, M., Wójcik‐Pszczoła, K., Paw, M., Wnuk, D., Koczurkiewicz, P., Sanak, M., Pękala, E., & Madeja, Z. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2899-4 · Cited by 160 · see citing works
Brinke, A. T., van Dissel, J. T., Sterk, P. J., Zwinderman, A. H., Rabe, K. F., & Bel, E. H. (2001) · Journal of Allergy and Clinical Immunology · doi:10.1067/mai.2001.113047 · Cited by 159 · see citing works
Halwani, R., Al‐Muhsen, S., & Hamid, Q. A. (2010) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2010.06.004 · Cited by 158 · see citing works
Airway Remodeling in Asthma: Unanswered Questions
Elias, J. A. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.supplement_2.a1q4-4 · Cited by 157 · see citing works
Self-citationKuhn, C., Homer, R., Zhu, Z., Ward, N., Flavell, R. A., Geba, G. P., & Elias, J. A. (2000) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.22.3.3690 · Cited by 147 · see citing works
Self-citationIL-11 expression is increased in severe asthma: Association with epithelial cells and eosinophils
Minshall, E., Chakir, J., Laviolette, M., Molet, S., Zhu, Z., Olivenstein, R., Elias, J. A., & Hamid, Q. A. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(00)90070-8 · Cited by 140 · see citing works
Self-citationThe Role of T Lymphocytes in Asthma
Kay, A. B. (2005) · KARGER eBooks · doi:10.1159/000090230 · Cited by 138 · see citing works
Ray, P., Tang, W., Wang, P., Homer, R., Kuhn, C., Flavell, R. A., & Elias, J. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119792 · Cited by 137 · see citing works
Self-citationProteolytic Cleavage Governs Interleukin-11 Trans-signaling
Lokau, J., Nitz, R., Agthe, M., Monhasery, N., Aparicio-Siegmund, S., Schumacher, N., Wolf, J., Möller‐Hackbarth, K., Waetzig, G. H., Grötzinger, J., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.01.053 · Cited by 135 · see citing works
Zhu, Z., Ma, B., Homer, R., Zheng, T., & Elias, J. A. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101512200 · Cited by 135 · see citing works
Self-citationInterleukin-6 and interleukin-11: same same but different
Garbers, C., & Scheller, J. (2013) · Biological Chemistry · doi:10.1515/hsz-2013-0166 · Cited by 134 · see citing works
Blyth, D. I., Wharton, T. F., Pedrick, M. S., Savage, T. J., & Sanjar, S. (2000) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/ajrcmb.23.2.3999 · Cited by 133 · see citing works
Basic mechanisms of development of airway structural changes in asthma: Fig. 1—
Fixman, E. D., Stewart, A. G., & Martin, J. G. (2007) · European Respiratory Journal · doi:10.1183/09031936.00053506 · Cited by 132 · see citing works
Pathological Role of IL-6 in the Experimental Allergic Bronchial Asthma in Mice
Doganci, A., Sauer, K., Karwot, R., & Finotto, S. (2005) · Clinical Reviews in Allergy & Immunology · doi:10.1385/criai:28:3:257 · Cited by 127 · see citing works
Hoyle, G. W., Li, J., Finkelstein, J. B., Eisenberg, T., Liu, J., Lasky, J. A., Athas, G., Morris, G. F., & Brody, A. R. (1999) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)65432-6 · Cited by 127 · see citing works
Drazen, J. M., Finn, P. W., & Sanctis, G. T. D. (1999) · Annual Review of Physiology · doi:10.1146/annurev.physiol.61.1.593 · Cited by 126 · see citing works
Coordination of Immune-Stroma Crosstalk by IL-6 Family Cytokines
West, N. R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01093 · Cited by 119 · see citing works
Airway Remodeling in Asthma: Therapeutic Implications of Mechanisms
Homer, R., & Elias, J. A. (2005) · Physiology · doi:10.1152/physiol.00035.2004 · Cited by 116 · see citing works
Self-citationMetcalfe, R. D., Putoczki, T. L., & Griffin, M. D. W. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01424 · Cited by 112 · see citing works
Bartz, H., BÜNING-PFAUE, F., Türkel, Ö., & SCHAUER, U. (2002) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2002.01927.x · Cited by 106 · see citing works
Kirwan, R. P., Leonard, M. O., Murphy, M., Clark, A. F., & O'Brien, C. J. (2005) · Glia · doi:10.1002/glia.20247 · Cited by 103 · see citing works
Airway Inflammation and Remodeling in Asthma
Zhu, Z., Lee, C. G., Zheng, T., Chupp, G. L., Wang, J., Homer, R., Noble, P. W., Hamid, Q. A., & Elias, J. A. (2001) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.164.supplement_2.2106070 · Cited by 100 · see citing works
Self-citationIL-18 Induces Emphysema and Airway and Vascular Remodeling via IFN-γ, IL-17A, and IL-13
Kang, M., Choi, J., Kim, B. H., Lee, C.-M., Cho, W., Choe, G., Kim, D., Lee, C. G., & Elias, J. A. (2012) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201108-1545oc · Cited by 99 · see citing works
Self-citationPharmacotherapy and airway remodelling in asthma?
Beckett, P. (2003) · Thorax · doi:10.1136/thorax.58.2.163 · Cited by 99 · see citing works
Ng, B., Cook, S. A., & Schäfer, S. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00531-5 · Cited by 98 · see citing works
Mouse models of allergic airway disease
Lloyd, C. M., Gonzalo, J.-Á., Coyle, A. J., & Gutierrez-Ramos, J.-C. (2001) · Advances in immunology · doi:10.1016/s0065-2776(01)77019-8 · Cited by 98 · see citing works
Brusselle, G., Bracke, K. R., Maes, T., D'hulst, A. I., Moerloose, K., Joos, G., & Pauwels, R. (2005) · Pulmonary Pharmacology & Therapeutics · doi:10.1016/j.pupt.2005.06.001 · Cited by 96 · see citing works
Mitchell, C., Provost, K. A., Niu, N., Homer, R., & Cohn, L. E. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100436 · Cited by 96 · see citing works
Self-citationTh-2 cytokines in allergic disease
Robinson, D. S. (2000) · British Medical Bulletin · doi:10.1258/0007142001903625 · Cited by 95 · see citing works
He, C. H., Waxman, A. B., Lee, C. G., Link, H., Rabach, M. E., Ma, B., Chen, Q., Zhu, Z., Zhong, M., Nakayama, K., et al. (2005) · Journal of Clinical Investigation · doi:10.1172/jci23004 · Cited by 92 · see citing works
Self-citationSeyedsadr, M., Wang, Y., Elzoheiry, M., Gopal, S. S., Jang, S., Duran, G., Chervoneva, I., Kasimoglu, E., Wrobel, J. A., Hwang, D., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2221007120 · Cited by 91 · see citing works
Molet, S., Hamid, Q. A., & Hamilos, D. L. (2003) · The Laryngoscope · doi:10.1097/00005537-200310000-00027 · Cited by 91 · see citing works
Complex cytokine regulation of tissue fibrosis
Atamas, S. P. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)02299-3 · Cited by 87 · see citing works
Tang, W., Yang, L., Yang, Y., Leng, S. X., & Elias, J. A. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.10.5506 · Cited by 84 · see citing works
Self-citationUnderstanding the pathogenesis of allergic asthma using mouse models
Leong, K. P., & Huston, D. P. (2001) · Annals of Allergy Asthma & Immunology · doi:10.1016/s1081-1206(10)62201-6 · Cited by 84 · see citing works
Airway fibrosis in rats induced by vanadium pentoxide
Bonner, J. C., Rice, A. B., Moomaw, C. R., & Morgan, D. L. (2000) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2000.278.1.l209 · Cited by 81 · see citing works
CONSEQUENCES OF LONG-TERM INFLAMMATION
Homer, R., & Elias, J. A. (2000) · Clinics in Chest Medicine · doi:10.1016/s0272-5231(05)70270-7 · Cited by 77 · see citing works
Self-citationElevated Vascular Endothelial Growth Factor in Keloids: Relevance to Tissue Fibrosis
Le, A. D., Zhang, Q., Wu, Y., Messadi, D. V., Akhondzadeh, A., Nguyen, A. L., Aghaloo, T. L., Kelly, A., & Bertolami, C. N. (2004) · Cells Tissues Organs · doi:10.1159/000075030 · Cited by 76 · see citing works
Endotoxin responsiveness and subchronic grain dust-induced airway disease
George, C. L. S., Jin, H. L., Wohlford-Lenane, C., O'Neill, M. E., Phipps, J. C., O’Shaughnessy, P. T., Kline, J. N., Thorne, P. S., & Schwartz, D. A. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.280.2.l203 · Cited by 76 · see citing works
Viral and bacterial infections in the development and progression of asthma
Gern, J. E. (2000) · Journal of Allergy and Clinical Immunology · doi:10.1016/s0091-6749(00)90050-2 · Cited by 75 · see citing works
Role of cytokines and chemokines in bronchial hyperresponsiveness and airway inflammation
Riffo‐Vasquez, Y., & Spina, D. (2002) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(02)00217-6 · Cited by 74 · see citing works
Determinants of initiation and progression of idiopathic pulmonary fibrosis
Kottmann, R. M., Hogan, C. M., Phipps, R. P., & Sime, P. J. (2009) · Respirology · doi:10.1111/j.1440-1843.2009.01624.x · Cited by 73 · see citing works
Genovese, T., Cuzzocrea, S., Paola, R. D., Failla, M., Mazzon, E., Sortino, M. A., Frasca, G., Gili, E., Crimi, N., Caputi, A. P., et al. (2005) · Respiratory Research · doi:10.1186/1465-9921-6-58 · Cited by 73 · see citing works
IL-11 Receptor α in the Pathogenesis of IL-13-Induced Inflammation and Remodeling
Chen, Q., Rabach, L. A., Noble, P. W., Zheng, T., Lee, C. G., Homer, R., & Elias, J. A. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.4.2305 · Cited by 73 · see citing works
Self-citationWaxman, A. B., Einarsson, Ó., Seres, T., Knickelbein, R. G., Homer, R., Warshaw, J. B., Johnston, R. B., & Elias, J. A. (1999) · CHEST Journal · doi:10.1378/chest.116.suppl_1.8s · Cited by 72 · see citing works
Self-citationEndogenous IL-11 Signaling Is Essential in Th2- and IL-13–Induced Inflammation and Mucus Production
Lee, C. G., Hartl, D., Matsuura, H., Dunlop, F., Scotney, P. D., Fabri, L., Nash, A. D., Chen, N., Tang, C., Chen, Q., et al. (2008) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2008-0053oc · Cited by 71 · see citing works
Self-citationRole of STAT3 in skin fibrosis and transforming growth factor beta signalling
Pedroza, M., To, S., Assassi, S., Wu, M., Tweardy, D. J., & Agarwal, S. K. (2017) · Rheumatology · doi:10.1093/rheumatology/kex347 · Cited by 71 · see citing works
Fibroblast‐specific IL11 signaling drives chronic inflammation in murine fibrotic lung disease
Ng, B., Dong, J., Viswanathan, S., Widjaja, A. A., Paleja, B. S., Adami, E., Ko, N. S. J., Wang, M., Lim, S., Tan, J., et al. (2020) · The FASEB Journal · doi:10.1096/fj.202001045rr · Cited by 69 · see citing works
Understanding interleukin 11 as a disease gene and therapeutic target
Cook, S. A. (2023) · Biochemical Journal · doi:10.1042/bcj20220160 · Cited by 68 · see citing works
The inflammation–repair cycle in asthma: the pivotal role of the airway epithelium
Holgate (1998) · Clinical & Experimental Allergy · doi:10.1046/j.1365-2222.1998.028s5097.x · Cited by 68 · see citing works
Leng, S. X., & Elias, J. A. (1997) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(97)00017-4 · Cited by 64 · see citing works
Self-citationIL-11 Selectively Inhibits Aeroallergen-Induced Pulmonary Eosinophilia and Th2 Cytokine Production
Wang, J., Homer, R., Hong, L., Cohn, L. E., Lee, C. G., Jung, S. S., & Elias, J. A. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.4.2222 · Cited by 64 · see citing works
Self-citationIL-11 Induces Th17 Cell Responses in Patients with Early Relapsing-Remitting Multiple Sclerosis
Zhang, X., Tao, Y., Chopra, M., Dujmović, I., Jin, J., Tang, Y., Drulovic, J. S., & Markovic‐Plese, S. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1401680 · Cited by 62 · see citing works
Role of Interleukin-17F in Asthma
Kawaguchi, M., Kokubu, F., Fujita, J., Huang, S.-K., & Hizawa, N. (2009) · Inflammation & Allergy - Drug Targets · doi:10.2174/1871528110908050383 · Cited by 61 · see citing works
CCSP modulates airway dysfunction and host responses in an Ova-challenged mouse model
Wang, S., Rosenberger, C. L., Espindola, T. M., Barrett, E. G., Tesfaigzi, Y., Bice, D. E., & Harrod, K. S. (2001) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.2001.281.5.l1303 · Cited by 61 · see citing works
Lim, W., Corden, B., Ng, B., Vanezis, K., D’Agostino, G. A., Widjaja, A. A., Song, W., Xie, C., Su, L., Kwek, X.-Y., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-74944-7 · Cited by 60 · see citing works
- Authors
- Tang, W., Geba, G. P., Zheng, T., Ray, P., Homer, R. J., Kuhn, C., Flavell, R. A., & Elias, J. A.
- Affiliations
- Yale University (US)
- United States Department of Veterans Affairs (US)
- Miriam Hospital (US)
- Brown University (US)
- Venue
- Journal of Clinical Investigation
- Published
- 1996-12-15
- Volume
- 98
- Issue
- 12
- Pages
- 2845-2853
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC507752
- OpenAlex
- W2075223992
- Cited by
- 210
- References
- 59
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 2 · 2023: 6 · 2022: 3 · 2021: 3 · 2020: 7 · 2019: 9 · 2018: 3 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 2 · 2013: 2 · 2012: 5
- FWCI
- 6.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5r01hl054989-03, 5r01hl036708-12)
- National Heart, Lung, and Blood Institute (HL54989, HL-36708)
- National Institute of Allergy and Infectious Diseases (AI-34593)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- interleukin-11, airway inflammation, airway remodeling, airway obstruction, airway hyperresponsiveness, transgenic mice, lymphocytic inflammation, B cells, T cells, subepithelial fibrosis, collagen deposition, myofibroblasts, smooth muscle cells, fibroblasts, airway resistance, methacholine
- MeSH terms
- Airway Obstruction, Airway Resistance, Animals, Cloning, Molecular, Disease Models, Animal, Gene Expression Regulation, Histocytochemistry, Immunohistochemistry, Lung, Mice, Transgenic, Microscopy, Electron, Promoter Regions, Genetic, Proteins, Pulmonary Fibrosis, Uteroglobin, Blotting, Southern, Blotting, Northern, Methacholine Chloride, Interleukin-11, Mice
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