The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Leptin accelerates the onset of puberty in normal female mice.
Open accessAbstract
The fat-derived hormone, leptin, is proposed to serve as an adipostatic signal to the brain to reduce food intake and body weight. In addition to its effects on body weight, chronic leptin treatment restores puberty and fertility to ob/ob mice with total leptin deficiency, and acute treatment substantially corrects hypogonadism in mice starved for 2 d without affecting body weight. Leptin may therefore be a critical signal, linking adiposity and reproduction. Since body weight and adiposity appear to play a critical role in the timing of puberty in humans and rodents, and leptin levels rise with increasing adiposity, we studied the effects of once daily injections of recombinant leptin on the onset of puberty in female mice weaned on day 21 and fed ad libitum. There was a linear increase in body weight during the study period, which was not altered by the dose of leptin used. Mice injected with leptin had an earlier onset of three classic pubertal parameters (i.e., vaginal opening, estrus, and cycling) compared with saline-injected controls. Leptin is the first peripheral molecule demonstrated to accelerate the maturation of the reproductive axis in normal rodents. We propose that leptin is the signal that informs the brain that energy stores are sufficient to support the high energy demands of reproduction, and may be a major determinant of the timing of puberty.
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Cites
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Self-citationThe role of neuropeptide Y in the antiobesity action of the obese gene product
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Genetic Influences on the Timing of Puberty in Mice1
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Cited by
The adolescent brain and age-related behavioral manifestations
Spear, L. P. (2000) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(00)00014-2 · Cited by 5,433
Leptin and the regulation of body weight in mammals
Friedman, J. M., & Halaas, J. L. (1998) · Nature · doi:10.1038/27376 · Cited by 5,405
A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction
Clément, K., Vaisse, C., Lahlou, N., Cabrol, S., Pelloux, V., Cassuto, D., Gourmelen, M., Dina, C., Chambaz, J., Lacorte, J.-M., et al. (1998) · Nature · doi:10.1038/32911 · Cited by 2,346
Leptin Inhibits Bone Formation through a Hypothalamic Relay
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Effects of Recombinant Leptin Therapy in a Child with Congenital Leptin Deficiency
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Metadata
- Authors
- Ahima, R. S., Dushay, J., Flier, S. N., Prabakaran, D., & Flier, J. S.
- Venue
- Journal of Clinical Investigation
- Published
- 1997-02-01
- Volume
- 99
- Issue
- 3
- Pages
- 391-395
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2075767463
- Cited by
- 756
- References
- 6
- FWCI
- 58.57
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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