The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Alpha-melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats.
Open accessAbstract
Reperfusion after ischemia induces cytokines, chemoattractant chemokines, adhesion molecules, and nitric oxide (NO). The resultant neutrophil adherence and NO potentiates renal injury. alpha-Melanocyte-stimulating hormone (alpha-MSH) is a potent anti-inflammatory agent that inhibits neutrophil migration and production of neutrophil chemokines and NO. Since neutrophils and NO promote renal ischemic injury, we sought to determine if alpha-MSH inhibits renal injury in a model of bilateral renal ischemia. alpha-MSH significantly reduced ischemia-induced renal damage, measured by changes in renal histology and plasma blood urea nitrogen and creatinine in mice. alpha-MSH significantly decreased tubule necrosis, neutrophil plugging, and capillary congestion. Delay of alpha-MSH treatment for 6 h after ischemia also significantly inhibited renal damage. alpha-MSH also significantly inhibited ischemic damage in rats. To begin to determine the mechanism of action of alpha-MSH, we measured its effects on mediators of neutrophil trafficking and induction of the inducible isoform of NO synthase-II. alpha-MSH inhibited ischemia-induced increases in mRNA for the murine neutrophil chemokine KC/IL-8. alpha-MSH also inhibited induction of mRNA for the adhesion molecule ICAM-1, which is known to be critical in renal ischemic injury. alpha-MSH inhibited nitration of kidney proteins and induction of NO synthase-II. We conclude: (a) alpha-MSH protects against renal ischemia/reperfusion injury; and (b) it may act, in part, by inhibiting the maladaptive activation of genes that cause neutrophil activation and adhesion, and induction of NO synthase.
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Cites
The cloning of a family of genes that encode the melanocortin receptors
Mountjoy, K. G., Robbins, L. S., Mortrud, M. T., & Cone, R. D. (1992) · Science · doi:10.1126/science.1325670 · Cited by 1,635
Cited by
Mishra, J., Ma, Q., Prada, A., Mitsnefes, M., Zahedi, K., Yang, J., Barasch, J., & Devarajan, P. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000088027.54400.c6 · Cited by 1,749
Aquaporins in the Kidney: From Molecules to Medicine
Nielsen, S., Frøkiær, J., Marples, D., Kwon, T.-H., Agre, P., & Knepper, M. A. (2002) · Physiological Reviews · doi:10.1152/physrev.00024.2001 · Cited by 1,251
Targeting melanocortin receptors as a novel strategy to control inflammation
Catania, A., Gatti, S., Colombo, G., & Lipton, J. M. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.1.1 · Cited by 438
Hu, M.-C., Shi, M., Zhang, J., Quiñones, H., Kuro-o, M., & Moe, O. W. (2010) · Kidney International · doi:10.1038/ki.2010.328 · Cited by 386
The innate immune response in ischemic acute kidney injury
Jang, H. R., & Rabb, H. (2009) · Clinical Immunology · doi:10.1016/j.clim.2008.08.016 · Cited by 358
Metadata
- Authors
- Chiao, H., Kohda, Y., McLeroy, P., Craig, L., Housini, I., & Star, R. A.
- Venue
- Journal of Clinical Investigation
- Published
- 1997-03-15
- Volume
- 99
- Issue
- 6
- Pages
- 1165-1172
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2046149192
- Cited by
- 279
- References
- 1
- FWCI
- 15.42
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Chiao, H., Kohda, Y., McLeroy, P., Craig, L., Housini, I., & Star, R. A. (1997). Alpha-melanocyte-stimulating hormone protects against renal injury after ischemia in mice and rats. Journal of Clinical Investigation. https://doi.org/10.1172/jci119272
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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