Perspectives series: Cell adhesion in vascular biology. Smooth muscle migration in atherosclerosis and restenosis
Open accessAbstract
Cell Adhesion in Vascular BiologyLesions of atherosclerosis are only found in the intima, and the smooth muscle cells (SMC) 1 comprising these lesions are clonal.These two simple facts imply that formation of the intima, presumably by migration of cells from the media, is a key event in the early stages of atherosclerosis.There is also a lot of interest (1), although less data, in the possibility that smooth muscle migration and proliferation are critical in later stages of the disease and, particularly, in restenosis after angioplasty.This review will discuss possible critical roles for migration in the origin and progression of atherosclerotic lesions.
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Neointimal hyperplasia narrows the luminal diameter, leading to decreased blood flow and recurrence of anginal symptoms.
“Neointimal hyperplasia narrows the luminal diameter, leading to decreased blood flow and recurrence of anginal symptoms [196].”
From AMPK, Mitochondrial Function, and Cardiovascular Disease (2020) · cites this paper as [196]
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The Intima: Soil for Atherosclerosis and Restenosis
Schwartz, S., Deblois, D., & O'Brien, E. (1995) · Circulation Research · doi:10.1161/01.res.77.3.445 · Cited by 1,080 · see citing works
Self-citationReceptor-Ligand Interaction Between CD44 and Osteopontin (Eta-1)
Weber, G. F., Ashkar, S., Glimcher, M. J., & Cantor, H. (1996) · Science · doi:10.1126/science.271.5248.509 · Cited by 950 · see citing works
PDGF-A signaling is a critical event in lung alveolar myofibroblast development and alveogenesis
Boström, H., Willetts, K., Pekny, M., Levéen, P., Lindahl, P., Hedstrand, H., Pekna, M., Hellström, M., Gebre-Medhin, S., Schalling, M., et al. (1996) · Cell · doi:10.1016/s0092-8674(00)81270-2 · Cited by 864 · see citing works
Biomechanical activation: an emerging paradigm in endothelial adhesion biology.
Gimbrone, M. A., Nagel, T., & Topper, J. N. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119346 · Cited by 346 · see citing works
DeRuiter, M. C., Poelmann, R. E., van Munsteren, J. C., Mironov, V., Markwald, R. R., & Groot, A. C. G. (1997) · Circulation Research · doi:10.1161/01.res.80.4.444 · Cited by 332 · see citing works
Smooth muscle migration in atherosclerosis and restenosis.
Schwartz, S. M. (1997) · PubMed · Cited by 322 · see citing works
Self-citationLowery, M. C., Morris, C. A., Ewart, A. K., Brothman, L. J., Zhu, X., Leonard, C. O., Carey, J. C., Keating, M. T., & Brothman, A. R. (1995) · PubMed Central · Cited by 307 · see citing works
Bendeck, M. P., Irvin, C. A., & Reidy, M. A. (1996) · Circulation Research · doi:10.1161/01.res.78.1.38 · Cited by 301 · see citing works
Adhesive interactions of sickle erythrocytes with endothelium.
Hebbel, R. P. (1997) · PubMed · Cited by 263 · see citing works
Effects of fluid dynamic forces on vascular cell adhesion.
Κωνσταντόπουλος, Κ., & McIntire, L. V. (1996) · Journal of Clinical Investigation · doi:10.1172/jci119088 · Cited by 261 · see citing works
Remodeling of Coronary Arteries in Human and Nonhuman Primates
Clarkson, T. B. (1994) · JAMA · doi:10.1001/jama.1994.03510280051032 · Cited by 248 · see citing works
α v β 3 Integrin Expression in Normal and Atherosclerotic Artery
Hoshiga, M., Alpers, C. E., Smith, L. L., Giachelli, C. M., & Schwartz, S. M. (1995) · Circulation Research · doi:10.1161/01.res.77.6.1129 · Cited by 225 · see citing works
Self-citationChoi, E. T., Engel, L., Callow, A. D., et al. (1994) · Journal of Vascular Surgery · doi:10.1016/s0741-5214(94)70127-x · Cited by 194 · see citing works
Monoclonality of smooth muscle cells in human atherosclerosis.
Murry, C. E., Gipaya, C. T., Bartosek, T., Benditt, E. P., & Schwartz, S. M. (1997) · Europe PMC (PubMed Central) · Cited by 192 · see citing works
Self-citationInhibition of integrin function by a cyclic RGD-containing peptide prevents neointima formation.
Matsuno, H., Stassen, J. M., Vermylen, J., et al. (1994) · Circulation · doi:10.1161/01.cir.90.5.2203 · Cited by 170 · see citing works
Vascular Smooth Muscle α v β 3 Integrin Mediates Arteriolar Vasodilation in Response to RGD Peptides
Mogford, J. E., Davis, G. E., Platts, S. H., & Meininger, G. A. (1996) · Circulation Research · doi:10.1161/01.res.79.4.821 · Cited by 154 · see citing works
Role of CD44 in the reaction of vascular smooth muscle cells to arterial wall injury.
Jain, M. K., He, Q. W., Lee, W. S., Kashiki, S., Foster, L. C., Tsai, J. C.-S., Lee, M. E., & Haber, E. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118455 · Cited by 133 · see citing works
Gotwals, P. J., Chi-Rosso, G., Lindner, V., et al. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118693 · Cited by 117 · see citing works
Acute lung injury fibroblast migration and invasion of a fibrin matrix is mediated by CD44.
Svee, K., White, J. G., Vaillant, P., Jessurun, J., Roongta, U. V., Krumwiede, M., Johnson, D., & Henke, C. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118970 · Cited by 114 · see citing works
The extracellular matrix as a cell cycle control element in atherosclerosis and restenosis.
Assoian, R. K., & Marcantonio, E. E. (1997) · Europe PMC (PubMed Central) · Cited by 106 · see citing works
Therapeutic inhibition of carbohydrate-protein interactions in vivo.
Lowe, J. B., & Ward, P. A. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119244 · Cited by 102 · see citing works
Liaw, L., Lombardi, D. M., Almeida, M., Schwartz, S. M., deBlois, D., & Giachelli, C. M. (1997) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.17.1.188 · Cited by 101 · see citing works
Self-citationLi, J., Sensebé, L., Hervé, P., et al. (1995) · PubMed · Cited by 44 · see citing works
An origin for smooth muscle cells from endothelium?
Mw, M., & Sm, S. (1997) · PubMed · Cited by 40 · see citing works
Clyman, R. I., Goetzman, B. W., Chen, Y. Q., et al. (1996) · Pediatric Research · doi:10.1203/00006450-199608000-00004 · Cited by 34 · see citing works
Expression of osteopontin in the head process late in gastrulation in the rat
Thayer, J. M., Giachelli, C. M., Mirkes, P. E., et al. (1995) · Journal of Experimental Zoology · doi:10.1002/jez.1402720309 · Cited by 24 · see citing works
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Research works printed but not linked: 1
- Bennett, M.R., V. Lindner, D. deBlois, M.A. Reidy, and S.M. Schwartz. 1997. The effect of antisense C-MYC oligonucleotides on the rat carotid artery: dissecting the mechanism of action. Arterioscler. Thromb. In press.
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AMPK, Mitochondrial Function, and Cardiovascular Disease
Wu, S., & Zou, M.-H. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21144987 · Cited by 286 · see citing works
Nitric oxide, a protective molecule in the cardiovascular system
Lei, J., Vodovotz, Y., Tzeng, E., & Billiar, T. R. (2013) · Nitric Oxide · doi:10.1016/j.niox.2013.09.004 · Cited by 184 · see citing works
Lee, H.-Y., Chung, J.-W., Youn, S.-W., Kim, J.-Y., Park, K.-W., Koo, B.-K., Oh, B.-H., Park, Y.-B., Chaqour, B., Walsh, K., et al. (2007) · Circulation Research · doi:10.1161/01.res.0000257945.97958.77 · Cited by 107 · see citing works
Nitric Oxide (NO) and Obstructive Sleep Apnea (OSA)
Haight, J. S. J., & Djupesland, P. G. (2003) · Sleep and Breathing · doi:10.1007/s11325-003-0053-4 · Cited by 75 · see citing works
- Authors
- Schwartz, S. M.
- Affiliations
- University of Washington (US)
- Corresponding author
- Schwartz, S M
- ORCID
- Schwartz, S M
- Venue
- Journal of Clinical Investigation
- Published
- 1997-06-15
- Volume
- 99
- Issue
- 12
- Pages
- 2814-2816
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC508129
- OpenAlex
- W1999983218
- Cited by
- 206
- References
- 26
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 7 · 2019: 2 · 2018: 7 · 2017: 2 · 2016: 8 · 2015: 8 · 2014: 4 · 2013: 10 · 2012: 3
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Keywords
- cell adhesion, vascular smooth muscle cells, smooth muscle cell migration, atherosclerosis, restenosis, angioplasty, smooth muscle cell proliferation, vascular biology
- MeSH terms
- Arteriosclerosis, Cell Adhesion, Cell Movement, Humans, Muscle, Smooth, Vascular, Cell Adhesion Molecules
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