Nitric oxide, a protective molecule in the cardiovascular system
Abstract
Nitric oxide (NO) is an intra- and inter-signaling molecule that regulates vessel dilatation, neuronal transmission, cardiac contraction, immunomodulation, and stem cell differentiation and proliferation. NO plays an important protective role in the cardiovascular system. NO inhibits smooth muscle cells proliferation and migration; enhances proliferation and migration of endothelial cell and inhibits apoptosis; suppresses platelet aggregation; and prevents platelet, leukocyte and monocyte adhesion to endothelium. NO exerts an inhibitory effect on the development of intimal hyperplasia in mechanically or immunologically injured vessel. New therapeutic approaches aimed at enhancing NO bioavailability or assisting delivery of NO locally may help patients with cardiovascular disease.
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The blockade of mitochondrial ROS by rotenone was shown to prevent NOX1 activation.
“The blockade of mitochondrial ROS by rotenone was shown to prevent NOX1 activation (FIGURE 17) (564).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [564]
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Peroxynitrite has potent pulmonary vasodilator activity in the rat
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- Authors
- Lei, J., Vodovotz, Y., Tzeng, E., & Billiar, T. R.
- Affiliations
- University of Pittsburgh (US)
- Corresponding author
- Lei, Jing
- Venue
- Nitric Oxide
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 35
- Pages
- 175-185
- ISSN
- 1089-8603 (ISSN-L)
- OpenAlex
- W1981691650
- Cited by
- 184
- References
- 205
- Citations by year
- 2026: 6 · 2025: 7 · 2024: 13 · 2023: 11 · 2022: 16 · 2021: 13 · 2020: 16 · 2019: 15 · 2018: 20 · 2017: 18 · 2016: 14 · 2015: 18 · 2014: 14 · 2013: 1 · 2012: 1
- FWCI
- 1.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nitric Oxide (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- cardioprotection, intimal hyperplasia, smooth muscle cell proliferation, endothelial cell proliferation, platelet aggregation, leukocyte adhesion, NO bioavailability, signal transduction
- MeSH terms
- Animals, Cardiovascular Agents, Cell Adhesion, Endothelium, Vascular, Humans, Nitric Oxide, Platelet Aggregation, Protective Agents, Myocytes, Smooth Muscle, Endothelial Cells, Mice
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