Cited by 184Nitric Oxide and Endothelin EffectsCardiovascular Health and Disease PreventionEicosanoids and Hypertension Pharmacology

Nitric oxide, a protective molecule in the cardiovascular system

Lei, Jing, Vodovotz, Yoram, Tzeng, Edith, Billiar, Timothy R.·2013·Nitric Oxide

Abstract

Nitric oxide (NO) is an intra- and inter-signaling molecule that regulates vessel dilatation, neuronal transmission, cardiac contraction, immunomodulation, and stem cell differentiation and proliferation. NO plays an important protective role in the cardiovascular system. NO inhibits smooth muscle cells proliferation and migration; enhances proliferation and migration of endothelial cell and inhibits apoptosis; suppresses platelet aggregation; and prevents platelet, leukocyte and monocyte adhesion to endothelium. NO exerts an inhibitory effect on the development of intimal hyperplasia in mechanically or immunologically injured vessel. New therapeutic approaches aimed at enhancing NO bioavailability or assisting delivery of NO locally may help patients with cardiovascular disease.

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Crossref · 10.1016/j.niox.2013.09.004

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Authors
Lei, J., Vodovotz, Y., Tzeng, E., & Billiar, T. R.
Affiliations
University of Pittsburgh (US)
Corresponding author
Lei, Jing
Venue
Nitric Oxide
Publisher
Elsevier BV
Published
2013-11
Volume
35
Pages
175-185
ISSN
1089-8603 (ISSN-L)
OpenAlex
W1981691650
Cited by
184
References
205
Citations by year
2026: 6 · 2025: 7 · 2024: 13 · 2023: 11 · 2022: 16 · 2021: 13 · 2020: 16 · 2019: 15 · 2018: 20 · 2017: 18 · 2016: 14 · 2015: 18 · 2014: 14 · 2013: 1 · 2012: 1
FWCI
1.73
Type
journal article
Language
en
Open access
closed
Locations
  • Nitric Oxide (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
Keywords
cardioprotection, intimal hyperplasia, smooth muscle cell proliferation, endothelial cell proliferation, platelet aggregation, leukocyte adhesion, NO bioavailability, signal transduction
MeSH terms
Animals, Cardiovascular Agents, Cell Adhesion, Endothelium, Vascular, Humans, Nitric Oxide, Platelet Aggregation, Protective Agents, Myocytes, Smooth Muscle, Endothelial Cells, Mice

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