The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.
Insulin resistance and hypersecretion in obesity: European Group for the Study of Insulin Resistance (EGIR)
Open accessAbstract
Insulin resistance and insulin hypersecretion are established features of obesity. Their prevalence, however, has only been inferred from plasma insulin concentrations. We measured insulin sensitivity (as the whole-body insulin-mediated glucose uptake) and fasting posthepatic insulin delivery rate (IDR) with the use of the euglycemic insulin clamp technique in a large group of obese subjects in the database of the European Group for the Study of Insulin Resistance (1,146 nondiabetic, normotensive Caucasian men and women aged 18-85 yr, with a body mass index (BMI) ranging from 15 to 55 kg.m-2). Insulin resistance, defined as the lowest decile of insulin sensitivity in the lean subgroup (608 subjects with a mean BMI of 29 kg.m-2). Insulin sensitivity declined linearly with BMI at an age- and sex-adjusted rate of 1.2 micromol.min-1.kg FFM-1 per BMI unit (95% confidence intervals = 1.0-1.4). Insulin hypersecretion, defined as the upper decile of IDR, was significantly (P<0.0001) more prevalent (38%) than insulin resistance in the obese group. In the whole dataset, IDR rose as a function of both BMI and insulin resistance in a nonlinear fashion. Neither the waist circumference nor the waist-to-hip ratio, indices of body fat distribution, was related to insulin sensitivity after adjustment for age, gender, and BMI; both, however, were positively associated (P<0.001) with insulin hypersecretion, particularly in women. In nondiabetic, normotensive obese subjects, the prevalence of insulin resistance is relatively low, and is exceeded by the prevalence of insulin hypersecretion, particularly in women with central obesity. In the obese with preserved insulin sensitivity, risk for diabetes, cardiovascular risk, and response to treatment may be different than in insulin resistant obesity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Because the great majority of glucose disposal after intravenous glucose administration occurs in muscle, these results provide strong evidence that insulin resistance in muscle is the earliest demonstrable defect in the natural history of type 2 diabetes, but that the development of overt type 2 diabetes occurs only in those individuals whose β-cells are unable to compensate for the defect in”
From Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes (2009) · cites this paper as [48]
Experimental — accuracy not yet measuredIn the citing paper
“Given the strong association between BMI and insulin sensitivity (8), groups with large differences in insulin sensitivity are generally difficult to match for BMI and fat mass, complicating data interpretation.”
From Metabolic flexibility to lipid availability during exercise is enhanced in individuals with high insulin sensitivity (2018) · cites this paper as [8]
In the citing paper
“A similar relationship also exists between BMI and the degree of insulin resistance.22”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [22]
In the citing paper
“one study reported that 19, 34 and 60% of individuals with a BMI of <30, ≥30–35 and >35, respectively, were insulin resistant.22”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [22]
In the citing paper
“It is well established that there is a generally directly proportional relationship between BMI and both fasting and postprandial insulin levels.21,22”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [22]
In the citing paper
“The hyperinsulinemia associated with rising BMI is necessary to overcome insulin resistance and maintain normoglycemia.22”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [22]
In the citing paper
“Insulin hypersecretion also becomes more frequent with increasing BMI;24 28, 49 and 80% of individuals with a BMI of <30, >30–35 and >35, respectively, exhibited insulin hypersecretion.22”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [22]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Increasing Prevalence of Overweight Among US Adults
Kuczmarski, R. J. (1994) · JAMA · doi:10.1001/jama.272.3.205 · Cited by 2,544
Insulin Resistance in Essential Hypertension
Ferrannini, E., Buzzigoli, G., Bonadonna, R., Giorico, M. A., Oleggini, M., Graziadei, L., Pedrinelli, R., Brandi, L., & Bevilacqua, S. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708063170605 · Cited by 2,344
Self-citationHyperinsulinemia as an independent risk factor for ischemic heart disease
Després, J.-P., Lamarche, B., Mauriège, P., Cantin, B., Dagenais, G. R., Moorjani, S., & Lupien, P.-J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604113341504 · Cited by 1,699
Krotkiewski, M., Björntorp, P. A., Sjöström, L., & Smith, U. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111040 · Cited by 1,475
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405
A Prospective Study of Obesity and Risk of Coronary Heart Disease in Women
Manson, J. E., Colditz, G. A., Stampfer, M. J., Willett, W. C., ROSNER, B. A., Monson, R. R., Speizer, F. E., & Hennekens, C. H. (1990) · New England Journal of Medicine · doi:10.1056/nejm199003293221303 · Cited by 1,403
Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., & Shulman, R. G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220403 · Cited by 1,248
Ohlson, L., Larsson, B., Svärdsudd, K., Welin, L., Eriksson, H., Wilhelmsen, L., Björntorp, P., & Tibblin, G. (1985) · Diabetes · doi:10.2337/diab.34.10.1055 · Cited by 1,143
Research works printed but not linked: 1
- [15]15. L. DeGroot, editor. W.B. Saunders Company, Philadel- phia. 2624-2662.
Cited by
Sorted by citations
Items 401–500 of 895
Verkest, K. R., Fleeman, L. M., Rand, J. S., & Morton, J. M. (2010) · Domestic Animal Endocrinology · doi:10.1016/j.domaniend.2010.06.001 · Cited by 35
Ivović, M., Marina, L., Vujović, S., Tančić‐Gajić, M., Stojanovic, M. M., Radonjić, N. V., Gajić, M. M., Soldatović, I., & Micić, D. (2013) · Metabolism · doi:10.1016/j.metabol.2012.12.006 · Cited by 35
“In a large series of Caucasian individuals of all ages, only 19% of subjects with a BMI lower than 30 kg/m were found to be insulin resistant [37].”
BackgroundAder, M., Stefanovski, D., Richey, J. M., Kim, S. P., Kolka, C. M., Ionut, V., Kabir, M., & Bergman, R. N. (2013) · Diabetes · doi:10.2337/db13-1215 · Cited by 35
Markofski, M. M., Flynn, M. G., Carrillo, A. E., Armstrong, C. L. H., Campbell, W. W., & Sedlock, D. A. (2014) · European Journal of Applied Physiology · doi:10.1007/s00421-014-2902-1 · Cited by 37
The effect of dietary fat content on phospholipid fatty acid profile is muscle fiber type dependent
Janovská, A., Hatzinikolas, G., Mano, M. T., & Wittert, G. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00356.2009 · Cited by 35
“HIGH-FAT DIET (HFD) feeding leads to obesity in rodents as well as in humans (15, 17) and, in skeletal muscles, to an increase in the intracellular content of lipids and resistance to the actions of insulin (IR) and leptin.”
BackgroundHigh Resolution Clinical Model-Based Assessment of Insulin Sensitivity
Lotz, T. (2007) · UC Research Repository (University of Canterbury) · doi:10.26021/2196 · Cited by 34
Fernández-Verdejo, R., Bajpeyi, S., Ravussin, E., & Galgani, J. E. (2018) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00126.2018 · Cited by 34
Adipose Tissue Dysfunction: Clinical Relevance and Diagnostic Possibilities
Schrover, I. M., Spiering, W., Leiner, T., & Visseren, F. L. J. (2016) · Hormone and Metabolic Research · doi:10.1055/s-0042-103243 · Cited by 34
“Accordingly, the prevalence of insulin resistance increases when BMI is higher, ranging from 6 % in normal weight subjects (BMI < 25 kg/ m 2 ) to 60–80 % when BMI is > 35 kg/m 2 [11, 39, 51, 52].”
Are all metabolically healthy individuals with obesity at the same risk of diabetes onset?
Navarro‐González, D., Sánchez‐Íñigo, L., Fernández‐Montero, A., Delgado, J. P., & Martínez, J. A. (2016) · Obesity · doi:10.1002/oby.21667 · Cited by 32
“Several epidemiological (24,25) and physiological studies (26-28) have reported that MHO had a comparable risk of diabetes incidence than lean or overweight healthy subjects, while others have reported opposite findings (4-6).”
BackgroundComprehensive functional screening of miRNAs involved in fat cell insulin sensitivity among women
Dahlman, I. A., Belarbi, Y., Laurencikiene, J., Pettersson, A. M. L., Arner, P., & Kulyté, A. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00251.2016 · Cited by 35
Kulyté, A., Ehrlund, A., Arner, P., & Dahlman, I. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178485 · Cited by 34
Silveira, É. A., Rosa, L. P. D. S., Santos, A. S. E. A. D. C., Cardoso, C. K. D. S., & Noll, M. A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17113930 · Cited by 34
“On the other hand, a European study of nondiabetic individuals with different BMI ranges did not find an association between obesity and insulin resistance, where prevalence of insulin resistance was relatively low [51].”
BackgroundPreventing Cardiovascular Complications of Type 2 Diabetes: Focus on Lipid Management
Henry, R. (2001) · Clinical Diabetes · doi:10.2337/diaclin.19.3.113 · Cited by 47
Erdmann, J., Mayr, M., Oppel, U. G., Sypchenko, O., Wagenpfeil, S., & SCHUSDZIARRA, V. (2008) · Regulatory Peptides · doi:10.1016/j.regpep.2008.10.008 · Cited by 33
Racial and etiopathologic dichotomies in insulin hypersecretion and resistance in obese children
Preeyasombat, C., Bacchetti, P., Lazar, A. A., & Lustig, R. H. (2005) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.12.014 · Cited by 34
Measurement of insulin resistance in vivo
Del Prato, S. (1999) · Drugs · doi:10.2165/00003495-199958001-00002 · Cited by 33
"Predictability of body mass index for diabetes: Affected by the presence of metabolic syndrome?"
Hadaegh, F., Bozorgmanesh, M., Safarkhani, M., Khalili, D., & Azizi, F. (2011) · BMC Public Health · doi:10.1186/1471-2458-11-383 · Cited by 33
“In this population-based study we observed that there were small numbers of men and women with normal weight who had MetS, resembling the normal-weight/MetS phenotype described by Ruderman and others [6-8] and modest numbers with obesity but without MetS, resembling the obese/without MetS phenotype described by Brochu…”
MethodGastrointestinal metabolic surgery for the treatment of type 2 diabetes mellitus
Pok, E.-H. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i39.14315 · Cited by 35
Lundbäck, V., Kulyté, A., Strawbridge, R. J., Rydén, M., Arner, P., Marcus, C., & Dahlman, I. A. (2018) · Diabetologia · doi:10.1007/s00125-018-4572-8 · Cited by 34
“Despite these findings, it is still to a large extent unclear how IR develops and only about 25% of obese women are insulin resistant [10].”
BackgroundShih, K., & Kwok, C. (2018) · BMC Pediatrics · doi:10.1186/s12887-018-1025-y · Cited by 38
“Subjects with obesity frequently have basal hyperinsulinemia and an exaggerated response to stimulation by a test meal or glucose attributed to increased insulin secretion and reduced insulin clearance [32, 33].”
BackgroundNasreddine, L., Tamim, H., Mailhac, A. C., & AlBuhairan, F. S. (2018) · BMC Pediatrics · doi:10.1186/s12887-018-1247-z · Cited by 32
“Despite being obese, these individuals do not present any of the traditional cardiometabolic risk factors that are usually associated with obesity [10, 11].”
BackgroundAbe, Y., Kikuchi, T., Nagasaki, K., Hiura, M., Tanaka, Y., Ogawa, Y., & Uchiyama, M. (2007) · Hypertension Research · doi:10.1291/hypres.30.627 · Cited by 33
“Obesity is the most common cause of insulin resistance and hyperinsulinemia (2) and is strongly associated with hypertension, type 2 diabetes mellitus, dyslipidemia and the metabolic syndrome (MS) in childhood.”
BackgroundDiabetes, sugar-coated but harmful to the brain
Starr, V., & Convit, A. J. (2007) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2007.10.007 · Cited by 33
Insulin Resistance Is Associated with Arterial Stiffness Independent of Obesity in Male Adolescents
Lee, J., Lee, D., Im, J., Shim, J., Kim, S.-M., & Lee, H.-R. (2007) · Hypertension Research · doi:10.1291/hypres.30.5 · Cited by 33
Insulin Resistance, Compensatory Hyperinsulinemia, and Coronary Heart Disease: Syndrome X Revisited
Reaven, G. M. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070238 · Cited by 32
Kayser, B. D., Goran, M. I., & Bouret, S. G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0121954 · Cited by 35
“resistance, as 30–40% of individuals with a Body Mass Index greater than 35kg/m(2) have normal insulin sensitivity determined by the hyperinsulinemic-euglycemic clamp [5].”
BackgroundBattault, S., Méziat, C., do Nascimento, A. R., Braud, L., Gayrard, S., Legros, C., Nardi, F. D., Drai, J., Cazorla, O., Thireau, J., et al. (2017) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00217.2017 · Cited by 32
Role of childhood growth on the risk of metabolic syndrome in obese men and women
Salonen, M. K., Kajantie, E., Osmond, C., Forsén, T., Ylihärsilä, H., Paile‐Hyvärinen, M., Barker, D. J. P., & Eriksson, J. G. (2009) · Diabetes & Metabolism · doi:10.1016/j.diabet.2008.08.008 · Cited by 33
“[6] Ferrannini ENA, Bell P, Cavallo-Perin P, Lalic N, Mingrone G.”
Tanaka, Y., Kikuchi, T., Nagasaki, K., Hiura, M., Ogawa, Y., & Uchiyama, M. (2005) · Hypertension Research · doi:10.1291/hypres.28.529 · Cited by 32
“This is a serious public health problem, since childhood obesity, which is the most common cause of hyperinsulinemia and insulin resistance (2), is associated with hypertension (HT), dyslipidemia, type 2 diabetes mellitus (DM), and long-term vascular complications (3−5).”
BackgroundRole of vasoactive factors in the pathogenesis of early changes in diabetic retinopathy
Chakrabarti, S., Cukiernik, M., Hileeto, D., Evans, T., & Chen, S. (2000) · Diabetes/Metabolism Research and Reviews · doi:10.1002/1520-7560(0000)9999:9999 · Cited by 97
Increased Insulin Resistance in Obese Children Who Have Both 972 IRS-1 and 1057 IRS-2 Polymorphisms
Fur, S. L., Stunff, C. L., & Bougneres, P. F. (2002) · Diabetes · doi:10.2337/diabetes.51.2007.s304 · Cited by 32
Fibric acid derivatives in cardiovascular disease prevention: results from the large clinical trials
Robins, S. J., & Bloomfield, H. E. (2006) · Current Opinion in Internal Medicine · doi:10.1097/01.mol.0000236370.27508.9d · Cited by 32
Lopes, H. F., & Egan, B. M. (2006) · Arquivos Brasileiros de Cardiologia · doi:10.1590/s0066-782x2006001700022 · Cited by 33
Paradoxical Associations of Insulin Resistance With Total and Cardiovascular Mortality in Humans
Kim, K.-S., Lee, Y., Lee, I., Kim, D. J., Jacobs, D. R., & Lee, D. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu194 · Cited by 31
Ensling, M., Steinmann, W. C., & Whaley‐Connell, A. T. (2011) · Cardiorenal Medicine · doi:10.1159/000322886 · Cited by 31
Insulin resistance and impaired baroreflex gain during pregnancy
Daubert, D. L., Chung, M., & Brooks, V. L. (2007) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00614.2006 · Cited by 31
“The association between insulin resistance and impaired baroreflex gain in numerous conditions (10, 11, 20, 22, 26, 55) led us to hypothesize that during pregnancy these variables are mechanistically linked.”
BackgroundDetection of Salivary Insulin Following Low versus High Carbohydrate Meals in Humans
Myette‐Côté, É., Baba, K., Brar, R., & Little, J. P. (2017) · Nutrients · doi:10.3390/nu9111204 · Cited by 33
“Obesity is generally accompanied by metabolic impairments including insulin resistance and hyperinsulinemia [23].”
BackgroundGeloneze, B., Pereira, J. A., Pareja, J. C., Lima, M. M. D. O., Lazarin, M. A. C. T., de Souza, I. C. P., Tambascia, M. A., Chaim, É. A., & Muscelli, E. (2009) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302009000200022 · Cited by 31
A mathematical model of the euglycemic hyperinsulinemic clamp
Picchini, U., Gaetano, A. D., Panunzi, S., Ditlevsen, S., & Mingrone, G. (2005) · Theoretical Biology and Medical Modelling · doi:10.1186/1742-4682-2-44 · Cited by 31
Self-citationDietary Glycemic Index and the Risk of Birth Defects
Parker, S. E., Werler, M. M., Shaw, G. M., Anderka, M., Yazdy, M. M., & Study, T. N. B. D. P. (2012) · American Journal of Epidemiology · doi:10.1093/aje/kws201 · Cited by 30
Fasting‐based Estimates of Insulin Sensitivity in Overweight and Obesity: A Critical Appraisal
Ruige, J. B., Mertens, I. L., Bartholomeeusen, E., Dirinck, E. L., Ferrannini, E., & Gaal, L. F. V. (2006) · Obesity · doi:10.1038/oby.2006.142 · Cited by 29
“However, hyperinsulinemia is not synonymous with insulin resistance (25).”
BackgroundSelf-citationGadd45b is required in part for the anti-obesity effect of constitutive androstane receptor (CAR)
Cai, X., Feng, Y., Xu, M., Yu, C., & Xie, W. (2020) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2020.08.015 · Cited by 29
Lerstad, G., Brodin, E. E., Enga, K. F., Jorde, R., Schirmer, H., Njølstad, I., Svartberg, J. B., Brækkan, S. K., & Hansen, J. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12498 · Cited by 29
Pathogenesis and etiology of essential hypertension: role of dietary carbohydrate
Kopp, W. (2004) · Medical Hypotheses · doi:10.1016/j.mehy.2004.10.009 · Cited by 29
Relationships of Insulin Sensitivity with Fatness and Fitness and in Older Men and Women
Ouyang, P., Sung, J., Kelemen, M. D., Hees, P. S., DeRegis, J. R., Turner, K. L., Bacher, A. C., & Stewart, K. J. (2004) · Journal of Women s Health · doi:10.1089/154099904322966164 · Cited by 30
“41 Although the simple measure of BMI was predictive of insulin sensitivity among women in our study, as has been found by others in healthy individuals, 23,24 abdominal obesity was an even stronger predictor of insulin sensitivity.”
Olivarius, N. D. F., Andreasen, A. H., Siersma, V., Richelsen, B., & Beck‐Nielsen, H. (2006) · Diabetologia · doi:10.1007/s00125-006-0328-y · Cited by 29
“This effect of sulfonylureas and insulin could possibly aggravate the insulin-resistance syndrome associated with type 2 diabetes [2, 13, 14] and thereby counteract the otherwise beneficial effects of these agents.”
BackgroundInsulin Resistance and Hyperinsulinemia in Prepubertal Obese Children
Galli‐Τsinopoulou, A., Karamouzis, M., & Nousia‐Arvanitakis, S. (2003) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.2003.16.4.555 · Cited by 29
Reduced circulating endothelial progenitor cell number in healthy young adult hyperinsulinemic men
Dei, A., Spigoni, V., Ardigò, D., Pedrazzi, G., Franzini, L., Derlindati, E., Urbani, S., Monti, L. D., Gnudi, L., & Zavaroni, I. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.11.011 · Cited by 28
Zhang, Y., Xiao, M., Niu, G., & Tan, H. (2005) · Life Sciences · doi:10.1016/j.lfs.2004.12.047 · Cited by 28
Hardy, T. A., Abu-Raddad, E., Pørksen, N. K., & Gaetano, A. D. (2012) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00421.2011 · Cited by 29
Sinaiko, A. R., & Caprio, S. (2012) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2012.01.012 · Cited by 28
Parra, M. D., de Morentin, B. E. M., & Martínez, J. A. (2004) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602078 · Cited by 28
“However, some obese individuals can be insulin sensitive (Ferrannini et al, 1997) and the main factors involved in the progress to insulin resistance are not well known (Helmersson et al, 2004).”
BackgroundChanges in risk factors for cardiovascular disease with body fat loss in obese women
Krebs, J. D., Evans, S., Cooney, L. M., Mishra, G. D., Frühbeck, G., Finer, N., & Jebb, S. A. (2002) · Diabetes Obesity and Metabolism · doi:10.1046/j.1463-1326.2002.00231.x · Cited by 28
Diminished Fibrinolysis and Thrombosis : Clinical Implications for Accelerated Atherosclerosis
Fujii, S., Goto, D., Zaman, T., Ishimori, N., Watano, K., Kaneko, T., Okada, H., Makiguchi, M., Nakagawa, T., & Kitabatake, A. (1998) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat1994.5.76 · Cited by 28
Carantoni, M., Abbasi, F., Azhar, S., Schaaf, P., & Reaven, G. M. (1999) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.84.3.5560 · Cited by 28
Morens, C., Keijzer, M., de Vries, K., Scheurink, A. J. W., & van Dijk, G. (2005) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00774.2004 · Cited by 27
“which occurred with the development of obesity (9) and/or”
BackgroundLichnovská, R., Gwozdziewiczová, S., & Hřebíček, J. (2002) · Cardiovascular Diabetology · doi:10.1186/1475-2840-1-4 · Cited by 27
Abiri, B., Valizadeh, M., Amini, S., Kelishadi, R., & Hosseinpanah, F. (2023) · Obesity Reviews · doi:10.1111/obr.13548 · Cited by 25
“” The identification and characterization of metabolically healthy obesity (MHO) among adults confirm this belief.(3,5,6) In spite of the fact that these individuals are obese, they do not have any of the typical cardiometabolic risk factors related to individuals with obesity.”
BackgroundMezghenna, K., Pomiès, P., Chalançon, A., Castex, F., Leroy, J., Niclauß, N., Nadal, B., Cambier, L., Cazevieille, C., Petit, P., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2264-8 · Cited by 26
“Interestingly, insulin hypersecretion that generally occurs as a compensatory mechanism for the reduced insulin sensitivity associated with obesity [21] has also been found in non-diabetic obese individuals in the absence of insulin resistance [22].”
BackgroundLv, X., Fang, K., Hao, W., Han, Y., Yang, N., & Yu, Q. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s280084 · Cited by 27
Opposing Effects of Angiotensin II on Muscle and Renal Blood Flow under Euglycemic Conditions
Fliser, D., Dikow, R., Demukaj, S., & Ritz, E. (2000) · Journal of the American Society of Nephrology · doi:10.1681/asn.v11112001 · Cited by 26
Effect of Vitamin C on Forearm Blood Flow and Glucose Metabolism in Essential Hypertension
Natali, A., Sironi, A. M., Toschi, E., Camastra, S., Sanna, G., Perissinotto, A., Taddei, S., & Ferrannini, E. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.11.2401 · Cited by 26
Self-citationPacker, M., Lam, C. S. P., Butler, J., Zannad, F. M., Vaduganathan, M., & Borlaug, B. A. (2025) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2025.07.052 · Cited by 28
“105 the hyperinsulinemia that is seen in states of obesity 106, 107 can promote”
Mirzababaei, A., Mozaffari, H., Shab‐Bidar, S., Milajerdi, A., & Djafarian, K. (2018) · Journal of Human Hypertension · doi:10.1038/s41371-018-0146-y · Cited by 25
“Due to the absence of harmonized criteria, studies reported MHO individuals to be 20-30% of obese individuals depending on the definition [48, 49].”
BackgroundClarke, S. L., Reaven, G. M., Leonard, D. S., Barlow, C. E., Haskell, W. L., Willis, B. L., DeFina, L. F., Knowles, J. W., & Maron, D. J. (2020) · The American Journal of Medicine · doi:10.1016/j.amjmed.2019.11.031 · Cited by 26
Evaluation of the prevalence of metabolic obesity and normal weight among the Polish population.
Bednarek-Tupikowska, G., Stachowska, B., Miazgowski, T., Krzyżanowska‐Świniarska, B., Katra, B., Jaworski, M., Kuliczkowska-Płaksej, J., Jokiel-Rokita, A., Tupikowska, M., Bolanowski, M., et al. (2012) · PubMed · Cited by 25
Salinari, S., BERTUZZI, A., Iaconelli, A., Manco, M., & Mingrone, G. (2008) · Diabetologia · doi:10.1007/s00125-008-1007-y · Cited by 26
Self-citationRelationship of fetuin-A levels to weight-dependent insulin resistance and type 2 diabetes mellitus
Erdmann, J., Salmhofer, H., Knauß, A., Mayr, M., Wagenpfeil, S., Sypchenko, O., Luppa, P. B., & SCHUSDZIARRA, V. (2012) · Regulatory Peptides · doi:10.1016/j.regpep.2012.02.004 · Cited by 25
Metabolic Surgery for Type 2 Diabetes with BMI <35 kg/m2
Lebovitz, H. E. (2013) · Obesity Surgery · doi:10.1007/s11695-013-0907-1 · Cited by 26
Bianchi, C., Miccoli, R., Bonadonna, R. C., Giorgino, F., Frontoni, S., Faloia, E., Marchesini, G., Dolci, M. A., Alviggi, L., Gnasso, A., et al. (2010) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2010.03.006 · Cited by 24
Bakker, S. J. L., ter Maaten, J. C., Popp‐Snijders, C., Heine, R. J., & Gans, R. O. B. (1999) · Journal of Hypertension · doi:10.1097/00004872-199917120-00009 · Cited by 25
The incretin effect in obese adolescents with and without type 2 diabetes: impaired or intact?
Aulinger, B. A., Vahl, T. P., Prigeon, R. L., D'Alessio, D. A., & Elder, D. A. (2016) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00496.2015 · Cited by 24
The role of micronutrients on the treatment of diabetes
Younes, S. (2024) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2023.200238 · Cited by 32
Nyholm, M., Gullberg, B., Haglund, B. J. A., Råstam, L., & Lindblad, U. (2008) · International Journal of Obesity · doi:10.1038/sj.ijo.0803725 · Cited by 25
Sbraccia, P., D’Adamo, M., Leonetti, F., Buongiorno, A. M., Silecchia, G., Basso, M. S., Tamburrano, G., Lauro, D., Federici, M., Daniele, N. D., et al. (2002) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2002.01593.x · Cited by 24
“…clamp, was markedly and significantly reduced in the obese group compared to the lean group; however, in accordance with previously reported data (Ferrannini et al., 1997), this difference was greatly attenuated when rates were normalized by free-fatty-mass rather than body weight (Table 1).”
ResultLong-term normalization of insulin sensitivity following biliopancreatic diversion for obesity
Adami, G. F., Cordera, R., Camerini, G. B., Marinari, G. M., & Scopinaro, N. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802618 · Cited by 24
Does C‐reactive protein identify a subclinical metabolic disease in healthy subjects?
Bo, S., Gambino, R., Uberti, B., Mangiameli, M. P., Colosso, G., Repetti, E., Gentile, L., Cassader, M., & Pagano, G. F. (2005) · European Journal of Clinical Investigation · doi:10.1111/j.1365-2362.2005.01490.x · Cited by 24
Selective aspects of the insulin resistance syndrome
Corry, D. B., & Tuck, M. L. (2001) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-200107000-00005 · Cited by 24
McLaughlin, T., Abbasi, F., Lamendola, C. A., Yee, G., Carter, S., & Cushman, S. W. (2018) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2018.09.014 · Cited by 24
Development of Obesity: The Driver and the Passenger
Kopp, W. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s280146 · Cited by 25
Tura, A., Pacini, G., Kautzky‐Willer, A., Gastaldelli, A., DeFronzo, R. A., Ferrannini, E., & Mari, A. (2011) · Metabolism · doi:10.1016/j.metabol.2011.08.001 · Cited by 23
“[20] Ferrannini E, Natali A, Bell P, et al.”
BackgroundSelf-citationMirbolouk, M., Derakhshan, A., Charkhchi, P., Guity, K., Azizi, F., & Hadaegh, F. (2016) · Pediatric Diabetes · doi:10.1111/pedi.12343 · Cited by 23
“These findings can be defensible by the fact that general obesity which BMI is a surrogate of, can be associated with insulin resistance which is the one of pathophysiologic patterns responsible for developing T2D as well as pre-diabetes (32).”
BackgroundHyperinsulinemia or Insulin Resistance: What Impacts the Progression of Alzheimer’s Disease?
Hegde, V. K., Dhurandhar, N. V., & Reddy, P. H. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190808 · Cited by 22
“[51, 53, 58, 59] and that in some populations, primary”
Bevier, W. C., Zisser, H., Palerm, C. C., Finan, D. A., Seborg, D. E., Doyle, F. J., Wollitzer, A. O., & Jovanovic, L. G. (2007) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.727 · Cited by 23
de Souza, A. L., Batista, G. A., & Alegre, S. M. (2016) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2016.10.018 · Cited by 25
Wilken, M. R., Lambert, M. N. T., Christensen, C. B., & Jeppesen, P. B. (2022) · The Review of Diabetic Studies · doi:10.1900/rds.2022.18.42 · Cited by 22
“These factors may activate several inflammatory pathways to cause systematic inflammation and increased secretion of insulin which may result in lipid abnormalities, including lowered HDL and raised LDL and TG [21,22].”
BackgroundAging and “Age-Related” Diseases - What Is the Relation?
Kopp, W. (2024) · Aging and Disease · doi:10.14336/ad.2024.0570 · Cited by 31
Q192R Polymorphism of Paraoxonase 1 Gene Associated with Insulin Resistance in Mexican Children
Alegría‐Torres, J. A., García-Domínguez, M., Cruz, M., & Aradillas-García, C. (2014) · Archives of Medical Research · doi:10.1016/j.arcmed.2014.12.001 · Cited by 22
Goel, R., Misra, A., Kondal, D., Pandey, R. M., Vikram, N. K., Wasir, J. S., Dhingra, V., & Luthra, K. (2008) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2008.03409.x · Cited by 22
Malecki, M., Klupa, T., Wołkow, P. P., Bochenski, J. P., Wanic, K., & Sieradzki, J. (2003) · Diabetes & Metabolism · doi:10.1016/s1262-3636(07)70017-4 · Cited by 22
Insulin resistance in an energy-centered perspective
Wang, P., & Mariman, E. C. M. (2007) · Physiology & Behavior · doi:10.1016/j.physbeh.2007.11.008 · Cited by 21
“Consistent with this theory, obese people, normally with a high plasma non-esterified fatty acids concentration [17], have higher risk to develop insulin resistance [18,19].”
INS VNTR is a QTL for the insulin response to oral glucose in obese children
Santos, C. D., Fallin, M. D., Stunff, C. L., Fur, S. L., & Bougneres, P. F. (2004) · Physiological Genomics · doi:10.1152/physiolgenomics.00024.2003 · Cited by 22
“Obese juveniles, by contrast, can allow examination of primary genetic associations across a wide range of insulin responses, long before impaired glucose tolerance (IGT) or T2D affect insulin-glucose homeostasis (12, 16).”
BackgroundRegulation of Intermediary Metabolism During Fasting and Feeding
DeFronzo, R. A., & Ferrannini, E. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-18907-1.00035-4 · Cited by 22
Self-citationRosenson, R. S., & Reasner, C. A. (2004) · Current Opinion in Cardiology · doi:10.1097/01.hco.0000133111.66486.c6 · Cited by 21
Metabolic syndrome in children
Sinaiko, A. R. (2012) · Jornal de Pediatria · doi:10.2223/jped.2214 · Cited by 22
Preechasuk, L., Khaedon, N., Lapinee, V., Tangjittipokin, W., Srivanichakorn, W., Sriwijitkamol, A., Plengvidhya, N., Likitmaskul, S., & Thongtang, N. (2022) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2022-003145 · Cited by 21
BMI Is the Main Determinant of the Circulating Leptin in Women after Vertical Banded Gastroplasty
Zabrocka, L. K., Raczyńska, S., Goyke, E., Śledziński, Z., & Świerczyński, J. (2004) · Obesity Research · doi:10.1038/oby.2004.57 · Cited by 21
Friedrich, N., Budde, K., Suhre, K., Völker, U., John, U., Felix, S. B., Kroemer, H. K., Grabe, H. J., Völzke, H., Nauck, M. A., et al. (2015) · Metabolomics · doi:10.1007/s11306-015-0795-6 · Cited by 21
Insulin clearance is different in men and women
Jensen, M. D., Nielsen, S., Gupta, N., Basu, R., & Rizza, R. A. (2011) · Metabolism · doi:10.1016/j.metabol.2011.08.009 · Cited by 21
Cox‐York, K. A., Wei, Y., Wang, D., Pagliassotti, M. J., & Foster, M. T. (2014) · Adipocyte · doi:10.4161/21623945.2014.957988 · Cited by 21
Metadata
- Authors
- Ferrannini, E., Natali, A., Bell, P., Cavallo-Perin, P., Lalic, N., & Mingrone, G.
- Affiliations
- Istituto di Fisiologia Clinica (IT)
- Venue
- Journal of Clinical Investigation
- Published
- 1997-09-01
- Volume
- 100
- Issue
- 5
- Pages
- 1166-1173
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC508292
- OpenAlex
- W2036400933
- Cited by
- 898
- References
- 53
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 20 · 2023: 13 · 2022: 20 · 2021: 28 · 2020: 32 · 2019: 26 · 2018: 32 · 2017: 26 · 2016: 26 · 2015: 36 · 2014: 30 · 2013: 36 · 2012: 43
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Funders
- Università degli Studi di Napoli Federico II
- Helsingin Yliopisto
- Universität Heidelberg
- Lunds Universitet
- Università degli Studi di Padova
- National and Kapodistrian University of Athens
- Université de Genève
- Università degli Studi di Torino
- Università degli Studi di Verona
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- insulin resistance, insulin hypersecretion, obesity, insulin sensitivity, body mass index, waist circumference, waist-to-hip ratio, abdominal obesity, sex differences, hyperinsulinemic-euglycemic clamp, type 2 diabetes risk
- MeSH terms
- Insulin Secretion, Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Obesity, Body Mass Index
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
