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Insulin resistance and hypersecretion in obesity: European Group for the Study of Insulin Resistance (EGIR)
Open accessAbstract
Insulin resistance and insulin hypersecretion are established features of obesity. Their prevalence, however, has only been inferred from plasma insulin concentrations. We measured insulin sensitivity (as the whole-body insulin-mediated glucose uptake) and fasting posthepatic insulin delivery rate (IDR) with the use of the euglycemic insulin clamp technique in a large group of obese subjects in the database of the European Group for the Study of Insulin Resistance (1,146 nondiabetic, normotensive Caucasian men and women aged 18-85 yr, with a body mass index (BMI) ranging from 15 to 55 kg.m-2). Insulin resistance, defined as the lowest decile of insulin sensitivity in the lean subgroup (608 subjects with a mean BMI of 29 kg.m-2). Insulin sensitivity declined linearly with BMI at an age- and sex-adjusted rate of 1.2 micromol.min-1.kg FFM-1 per BMI unit (95% confidence intervals = 1.0-1.4). Insulin hypersecretion, defined as the upper decile of IDR, was significantly (P<0.0001) more prevalent (38%) than insulin resistance in the obese group. In the whole dataset, IDR rose as a function of both BMI and insulin resistance in a nonlinear fashion. Neither the waist circumference nor the waist-to-hip ratio, indices of body fat distribution, was related to insulin sensitivity after adjustment for age, gender, and BMI; both, however, were positively associated (P<0.001) with insulin hypersecretion, particularly in women. In nondiabetic, normotensive obese subjects, the prevalence of insulin resistance is relatively low, and is exceeded by the prevalence of insulin hypersecretion, particularly in women with central obesity. In the obese with preserved insulin sensitivity, risk for diabetes, cardiovascular risk, and response to treatment may be different than in insulin resistant obesity.
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“Because the great majority of glucose disposal after intravenous glucose administration occurs in muscle, these results provide strong evidence that insulin resistance in muscle is the earliest demonstrable defect in the natural history of type 2 diabetes, but that the development of overt type 2 diabetes occurs only in those individuals whose β-cells are unable to compensate for the defect in”
From Skeletal Muscle Insulin Resistance Is the Primary Defect in Type 2 Diabetes (2009) · cites this paper as [48]
Experimental — accuracy not yet measuredIn the citing paper
“Given the strong association between BMI and insulin sensitivity (8), groups with large differences in insulin sensitivity are generally difficult to match for BMI and fat mass, complicating data interpretation.”
From Metabolic flexibility to lipid availability during exercise is enhanced in individuals with high insulin sensitivity (2018) · cites this paper as [8]
In the citing paper
“A similar relationship also exists between BMI and the degree of insulin resistance.22”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [22]
In the citing paper
“one study reported that 19, 34 and 60% of individuals with a BMI of <30, ≥30–35 and >35, respectively, were insulin resistant.22”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [22]
In the citing paper
“It is well established that there is a generally directly proportional relationship between BMI and both fasting and postprandial insulin levels.21,22”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [22]
In the citing paper
“The hyperinsulinemia associated with rising BMI is necessary to overcome insulin resistance and maintain normoglycemia.22”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [22]
In the citing paper
“Insulin hypersecretion also becomes more frequent with increasing BMI;24 28, 49 and 80% of individuals with a BMI of <30, >30–35 and >35, respectively, exhibited insulin hypersecretion.22”
From A review of current trends with type 2 diabetes epidemiology, aetiology, pathogenesis, treatments and future perspectives (2021) · cites this paper as [22]
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Citations
Cites
Role of Insulin Resistance in Human Disease
Reaven, G. M. (1988) · Diabetes · doi:10.2337/diab.37.12.1595 · Cited by 12,154
Glucose clamp technique: a method for quantifying insulin secretion and resistance.
DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425
Increasing Prevalence of Overweight Among US Adults
Kuczmarski, R. J. (1994) · JAMA · doi:10.1001/jama.272.3.205 · Cited by 2,542
Insulin Resistance in Essential Hypertension
Ferrannini, E., Buzzigoli, G., Bonadonna, R., Giorico, M. A., Oleggini, M., Graziadei, L., Pedrinelli, R., Brandi, L., & Bevilacqua, S. (1987) · New England Journal of Medicine · doi:10.1056/nejm198708063170605 · Cited by 2,344
Self-citationHyperinsulinemia as an independent risk factor for ischemic heart disease
Després, J.-P., Lamarche, B., Mauriège, P., Cantin, B., Dagenais, G. R., Moorjani, S., & Lupien, P.-J. (1996) · New England Journal of Medicine · doi:10.1056/nejm199604113341504 · Cited by 1,699
Krotkiewski, M., Björntorp, P. A., Sjöström, L., & Smith, U. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111040 · Cited by 1,475
Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405
A Prospective Study of Obesity and Risk of Coronary Heart Disease in Women
Manson, J. E., Colditz, G. A., Stampfer, M. J., Willett, W. C., ROSNER, B. A., Monson, R. R., Speizer, F. E., & Hennekens, C. H. (1990) · New England Journal of Medicine · doi:10.1056/nejm199003293221303 · Cited by 1,403
Shulman, G. I., Rothman, D. L., Jue, T., Stein, P., DeFronzo, R. A., & Shulman, R. G. (1990) · New England Journal of Medicine · doi:10.1056/nejm199001253220403 · Cited by 1,248
Ohlson, L., Larsson, B., Svärdsudd, K., Welin, L., Eriksson, H., Wilhelmsen, L., Björntorp, P., & Tibblin, G. (1985) · Diabetes · doi:10.2337/diab.34.10.1055 · Cited by 1,143
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- [15]15. L. DeGroot, editor. W.B. Saunders Company, Philadel- phia. 2624-2662.
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Items 701–800 of 895
Pester, M. S., Gonzalez, A., Schmaus, J. A., Wohlgemuth, W. K., McCabe, P. M., Iacobellis, G., Schneiderman, N., & Hurwitz, B. E. (2022) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2022.110785 · Cited by 3
Nutrition in Metabolic Syndrome
Ballesteros-Pomar, M. D. (2006) · Cited by 3
Obesity-Dependent Accumulation of Titanium in the Pancreas of Type 2 Diabetic Donors
Heller, A., Coffman, S. S., & Friedman, K. A. (2019) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.8b00304 · Cited by 3
Castex, F., Leroy, J., Broca, C., Mezghenna, K., Duranton, F., Lavallard, V., Lebreton, F., Gross, R., Wojtusciszyn, A., & Lajoix, A. (2020) · Journal of Diabetes · doi:10.1111/1753-0407.13026 · Cited by 3
The Role of Obesity in Insulin Resistance
Meigs, J. B. (2008) · Humana Press eBooks · doi:10.1007/978-1-60327-116-5_3 · Cited by 4
Elmasry, A. (2001) · Upsala Journal of Medical Sciences · doi:10.3109/2000-1967-170 · Cited by 3
Ogawa, E., Furusyo, N., Murata, M., Ikezaki, H., Ihara, T., Hayashi, T., Toyoda, K., Okada, K., Kainuma, M., Kajiwara, E., et al. (2013) · Journal of Viral Hepatitis · doi:10.1111/jvh.12109 · Cited by 3
Insulin resistance and metabolic parameters in type 2 diabetic patients
Metzler, W., Fischer, S., Köhler, C. U., Pistrosch, F., Kindel, B., & Hanefeld, M. (2002) · European Journal of Internal Medicine · doi:10.1016/s0953-6205(01)00202-3 · Cited by 3
Normandin, É., Doucet, É., RABASA-LHORET, R. P. R., & Brochu, M. (2015) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0451 · Cited by 3
Role of sympathetic overactivity in the pathophysiology of the metabolic syndrome
Egan, B. M., & Julius, S. (2004) · Dialogues in Cardiovascular Medicine · Cited by 3
Bays, H. E., Mandarino, L. J., & DeFronzo, R. A. (2004) · Cited by 3
SHIP2 on pI3K/Akt pathway in palmitic acid stimulated islet β cell.
Liu, Q., Wang, R., Zhou, H., Zhang, L., Cao, Y., Wang, X., & Hao, Y. (2015) · Europe PMC (PubMed Central) · Cited by 3
An Endocrinologist's Perspective
Lebovitz, H. E. (2013) · Cited by 3
A randomized trial of a low-carbohydrate diet for obesity
Foster, G., Wyatt, H. R., & Hill, J. O. (2003) · ACC Current Journal Review · doi:10.1016/s1062-1458(03)00265-4 · Cited by 3
Novel Laboratory Index, Based on Fasting Blood Parameters, Accurately Reflects Insulin Sensitivity
Karczewska‐Kupczewska, M., Nikołajuk, A., Stefanowicz, M., Matulewicz, N., Arnoriaga‐Rodríguez, M., Fernández‐Real, J. M., & Strączkowski, M. (2021) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgab489 · Cited by 3
Nogi, A., Shiwaku, K., Kitajima, K., Yamasaki, M., Anuurad, E., Enkhmaa, B., Yoneyama, T., Hashimoto, M., Kihara, I., YAKURA, C., et al. (2004) · JOURNAL OF THE JAPANESE ASSOCIATION OF RURAL MEDICINE · doi:10.2185/jjrm.53.649 · Cited by 3
Model-Based Therapeutics for Type 1 Diabetes Mellitus
Wong, X. (2008) · UC Research Repository (University of Canterbury) · doi:10.26021/1222 · Cited by 3
Hyperlipidaemia and cardiovascular disease
Cozma, L. S. (2002) · Current Opinion in Lipidology · doi:10.1097/00041433-200204000-00016 · Cited by 3
Snyder, J. E., Jiang, C., Choi, R. H., Morgan, T., Roman, J., Underwood, L., Lucchese, A. M., Montgomery, S. E., Grisanti, L. A., Doliba, N. M., et al. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108388 · Cited by 2
“Interestingly, studies in obese individuals without hypertension or diabetes found that insulin hypersecretion was more prevalent than insulin resistance (11) and proposed to precede insulin resistance.”
Bakija, F. Z., Tolvaj, M., Szijártó, Á., Tokodi, M., Ferencz, A., Lakatos, B. K., Ladányi, Z., Kiss, L. Z., Szelid, Z., Soós, P., et al. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01863-w · Cited by 2
“…earlier studies primarily attributed the connection between increased adiposity and cardiovascular disease mortality to indirect mechanisms, such as the exacerbation of risk factors and chronic conditions, recent fi ndings indicate that direct mechanisms also contribute to this relationship [8, 9].”
Chiriacò, M., Tricò, D., Petrie, J. R., Gabriel, R., Gastaldelli, A., Nolan, J. J., Lalic, N. M., Mingrone, G., Mari, A., & Natali, A. (2025) · Diabetologia · doi:10.1007/s00125-025-06643-9 · Cited by 2
Self-citationTracking the progression to type 2 diabetes with a proportional-derivative insulin secretion model
Othman, N. A., Docherty, P. D., Damanhuri, N. S., & Chase, J. G. (2016) · Control Engineering Practice · doi:10.1016/j.conengprac.2016.10.012 · Cited by 2
Monnard, C. R., & Grasser, E. K. (2019) · European Journal of Nutrition · doi:10.1007/s00394-019-02120-3 · Cited by 2
Age changes in the lipid profile of rats against experimental metabolic syndrome
Kuzmina, I. Y., & Kuzmina, O. (2024) · The Journal of V N Karazin Kharkiv National University series Medicine · doi:10.26565/2313-6693-2024-48-02 · Cited by 4
β-Cell Heterogeneity and Plasticity
Yong, H. J., & Wang, Y. J. (2024) · Advances in anatomy, embryology and cell biology · doi:10.1007/978-3-031-62232-8_3 · Cited by 2
Type 2 Diabetes mellitus in Children and Adolescents: The New Epidemic
Saenger, P. H. (2004) · KARGER eBooks · doi:10.1159/000078292 · Cited by 2
Insulin Resistance in Childhood and Adolescence
Ehehalt, S., & Neu, A. (2011) · KARGER eBooks · doi:10.1159/000327414 · Cited by 2
Viso, M., Porrello, B., Rauseo, D., Reverón, D., Rivas, B., Galdona, E., Rodriguez, L., Rodríguez, Z., Fernández, Y., de León, A. C., et al. (2013) · Redalyc (Universidad Autónoma del Estado de México) · Cited by 2
Ezaki, O. (2011) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.57.383 · Cited by 2
Zawada, A. E., Naskręt, D., Burchardt, P., Niedźwiecki, P., & Wierusz‐Wysocka, B. (2015) · International Journal of Diabetes in Developing Countries · doi:10.1007/s13410-015-0289-0 · Cited by 2
The Bulge, Booze, and the Liver
Adams, L. A., & Angulo, P. (2005) · Clinical Gastroenterology and Hepatology · doi:10.1016/s1542-3565(05)00892-x · Cited by 2
Geluk, C. A., Asselbergs, F. W., & Hillege, H. L. (2005) · ACC Current Journal Review · doi:10.1016/j.accreview.2005.09.018 · Cited by 2
“Microalbuminuria frequently clusters with the metabolic syndrome, which is characterized by a constellation of risk factors, among which insulin resistance, dyslipidemia, hypertension, obesity and endothelial dysfunction.(4-7) Presence of the metabolic syndrome is associated with increased risk for coronary heart dise…”
BackgroundLe syndrome des ovaires polymicrokystiques (SOPMK)
Dewailly, D., Hiéronimus, S., Mirakian, P., & Hugues, J. (2010) · Annales d Endocrinologie · doi:10.1016/j.ando.2009.12.004 · Cited by 2
Type 2 diabetes: the evolution of a disease
Lebovitz, H. E. (2012) · The British Journal of Diabetes · doi:10.1177/1474651412470289 · Cited by 3
Barreto‐Filho, J. A., Consolim‐Colombo, F. M., & Lopes, H. F. (2002) · Cited by 2
Hlaing, Z. T. T., Htway, S. M., & Sein, M. T. (2021) · European Journal of Medical and Health Sciences · doi:10.24018/ejmed.2021.3.1.655 · Cited by 2
Lam, N. N., Murray, R., Docherty, P. D., Morenga, L. T., & Chase, J. G. (2021) · Journal of Diabetes Science and Technology · doi:10.1177/19322968211021602 · Cited by 2
Insulin Resistance and Coronary Heart Disease
Laakso, M., & Kuusisto, J. (2005) · Elsevier eBooks · doi:10.1016/b978-84-8174-892-5.50023-1 · Cited by 2
Vuković, R., & Zdravković, D. (2012) · Medicinski glasnik Specijalna bolnica za bolesti stitaste zlezde i bolesti metabolizma Zlatibor · doi:10.5937/medgla1244075v · Cited by 2
Poirier, P., & Rhéaume, C. (2008) · CRC Press eBooks · doi:10.3109/9781420060850-4 · Cited by 2
Gil, J. E. C., & Spinedi, E. (2017) · Revista Argentina de Endocrinología y Metabolismo · doi:10.1016/j.raem.2017.06.001 · Cited by 6
Lam, N. N., Docherty, P. D., Murray, R., Chase, J. G., & Morenga, L. T. (2020) · IFAC-PapersOnLine · doi:10.1016/j.ifacol.2020.12.661 · Cited by 2
Jamaludin, U. K. (2013) · UMP Institutional Repository (Universiti Malaysia Pahang) · doi:10.26021/3488 · Cited by 2
“…in exercise, healthier diet (Duncan et al. 2003; McAuley et al. 2002; Nishida et al. 2002; Tuomilehto et al. 2001) and weight loss (Camastra et al. 2005; Ferrannini et al. 2005; Ferrannini et al. 1997) are proven to improve sensitivity and thus reduce the prevalence or impact of type 2 diabetes.”
BackgroundCholesterol metabolism in type 2 diabetes
Simonen, P. P. (2002) · Työväentutkimus Vuosikirja · Cited by 2
GENETIC SUSCEPTIBILITY TO THE METABOLIC SYNDROME
Bossé, Y. (2004) · Corpus Université Laval (Université Laval) · Cited by 2
Location Matters: Mitochondrial Arginase 2 as a Treatment for Metabolic Disease?
Stefkovich, M. L., & Titchenell, P. M. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.02.013 · Cited by 2
“1 – 3 A strong correlation exists between insulin resistance and the development of cardiovascular disease.”
BackgroundPreuss, H. G., Mrvichin, N., Kaats, G. R., Preuss, J. M., & Bagchi, D. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-816918-6.00012-3 · Cited by 1
Yan, W., Kan, Z., Wang, L., Yu, Z.-P., Liu, C., Yan, S., & Yang, N. (2025) · Integrative Medicine Research · doi:10.1016/j.imr.2025.101148 · Cited by 1
Silva, L. F. R., Silva, P. H. E., do Carmo, J. O., Garcia, B. C. C., Esteves, E. A., Dias‐Peixoto, M. F., Gripp, F., Chavez, O., Jr., Tricoli, V., Mang, Z. A., et al. (2026) · European Journal of Applied Physiology · doi:10.1007/s00421-026-06131-x · Cited by 1
Daytime sleepiness and specific food cravings: The moderating role of insulin sensitivity
Romaker, E. K., Krueger, M. J., Goldfinger, M., Gonzalez, A., Forster, D. E., Wohlgemuth, W. K., McIntosh, R. C., & Hurwitz, B. E. (2026) · PLoS ONE · doi:10.1371/journal.pone.0343407 · Cited by 2
“Insulin resistance status was defined as a value at or lower than 4.5 mg/kg•min [17].”
InfluentialPıhtılı, A., Çelik, Y., Thunström, E. Ö., & Peker, Y. (2026) · Sleep Medicine · doi:10.1016/j.sleep.2026.108976 · Cited by 1
Does metabolically healthy obesity really exist: going toward new definitions
Rodriguez, C., & Ravussin, É. (2026) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgag247 · Cited by 2
Trapp, S. K. (2015) · VCU Scholars Compass (Virginia Commonwealth University) · doi:10.25772/7dxv-br44 · Cited by 1
The Role of Obesity, Diabetes, and Hypertension in Cleft Lip and Cleft Palate Birth Defects
Kutbi, H. A. (2021) · Digital Commons - USU (Utah State University) · doi:10.26076/72fa-109a · Cited by 1
Fat-Induced Insulin Resistance and Atherosclerosis
Boden, G. H. (2007) · Humana Press eBooks · doi:10.1007/978-1-59259-963-9_49 · Cited by 1
Roy, M. N., Akter, S., Jafarulla, M., Mollah, F. H., Saha, A. R., & Ali, L. (1970) · Journal of Bangladesh Society of Physiologist · doi:10.3329/jbsp.v3i0.1786 · Cited by 1
Bosello, O., & Zamboni, M. M. (2002) · Eating and Weight Disorders - Studies on Anorexia Bulimia and Obesity · doi:10.1007/bf03354434 · Cited by 2
Alboqai, O. K., Suleiman, A., Hourani, H. M. A., Obeidat, B., Abuirmeileh, N. M., El-Qudah, J. M., & Al-Masad, M. (2009) · Diabetologia Croatica · Cited by 1
Comparison of the association with sleep apnoea of obesityversusinsulin resistance
Liu, A., Ariel, D., Lamendola, C. A., Kim, S. H., Abbasi, F., Cardell, J. A., Tomasso, V., Mojaddidi, H., Grove, K., Kushida, C. A., et al. (2015) · European Respiratory Journal · doi:10.1183/13993003.01087-2015 · Cited by 1
Differentially Expressed Proteins in the Pancreas of Diabetic Mice
Qiu, L. (2005) · OhioLink ETD Center (Ohio Library and Information Network) · Cited by 1
Do we need to diagnose normal weight metabolic obesity?
Tyrka, A., Cisowska-Caputa, A., & Olszanecka‐Glinianowicz, M. (2017) · Nutrition Obesity & Metabolic Surgery · doi:10.5114/noms.2017.69833 · Cited by 1
“In the EGIS study the frequency of MONW in the European population was estimated at 10% [4].”
BackgroundExamining the Frequency of Insulin Resistance in Children with Chronic Hepatic Disease
Mirrashidi, F. S., Ilkhanipoor, H., Dehghani, S. M., & Moravej, H. (2019) · Journal of Endocrinology and Diabetes · doi:10.15226/2374-6890/6/2/001128 · Cited by 1
“They showed that insulin sensitivity has a linear relationship with BMI at a particular age and sex [23].”
BackgroundShutova, N. A., Nikolaieva, O. V., Kuzmina, I. Y., Павлова, Е. А., & Sulhdost, I. (2021) · Polish Annals of Medicine · doi:10.29089/2021.21.00179 · Cited by 1
Januszewski, A. S., & Jenkins, A. J. (2022) · Biomarkers in disease · doi:10.1007/978-3-030-81303-1_18-1 · Cited by 1
Januszewski, A. S., & Jenkins, A. J. (2022) · Biomarkers in disease · doi:10.1007/978-3-031-08014-2_18 · Cited by 1
Shriya, A. S. K., Pawar, V. B., & Paul, A. A. (2024) · Current Diabetes Reviews · doi:10.2174/0115733998305019240702095537 · Cited by 2
Trends in mean serum insulin and hyperinsulinemia among US adults without diabetes 1999–2018
Johnson, T. M., & Churilla, J. R. (2025) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2025.109159 · Cited by 1
Role of Mitochondrial Uncoupling Protein 2 (UCP2) in Modulation of Adiposity
Sun, X. (2004) · Cited by 1
Definition, History, and Management of the Metabolic Syndrome and Management Gaps
Vidal, J., & Jiménez, A. (2015) · Springer eBooks · doi:10.1007/978-1-4939-3220-7_1 · Cited by 1
Impact of Bariatric Surgery on Type II Diabetes
Karim, M. A., Naveed, M. J., MacKay, W., & Ali, A. (2013) · Cited by 1
KEJADIAN RESISTENSI INSULIN PADA ANAK OBESITAS USIA 9-12 TAHUN DI KOTA SEMARANG
Asnelviana, H., Sulchan, M., & Panunggal, B. (2017) · Journal of Nutrition College · doi:10.14710/jnc.v6i4.18793 · Cited by 1
Rana, M. M., Bashir, B., AKHTAR, M. S., & Ur-Rehman, A. (2007) · The Professional Medical Journal · doi:10.29309/tpmj/2007.14.02.4900 · Cited by 1
Functional Tests for Assessing Human Beta-Cell Function and Insulin Sensitivity
Lima, M. M. D. O., & Geloneze, B. (2022) · Methods and protocols in food science · doi:10.1007/978-1-0716-2345-9_20 · Cited by 1
Treatment of patients with dyscirculatory encephalopathy on a background of metabolic syndrome
Мищенко, Т. С., Mishchenko, V. М., & Zdesenko, I. V. (2019) · Ukrains kyi Visnyk Psykhonevrolohii · doi:10.36927/2079-0325-v27-is1-2019-3 · Cited by 1
How to consider low serum vitamin D as a risk factor for insulin resistance?
Manco, M., Calvani, M., & Mingrone, G. (2004) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/80.5.1450a · Cited by 1
Self-citationCardiovascular Outcomes in Patients With Hypertension
Poirier, P. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05329 · Cited by 1
Insulin Resistance in Clinical Medicine
Krentz, A. J. (2002) · Wiley eBooks · doi:10.1002/9780470698921.ch2 · Cited by 1
The preservation of insulin sensitivity in obese women without diabetes.
Ngarmukos, C., Chanprasertyothin, S., Puavilai, G., & Ongphiphadhanakul, B. (2008) · PubMed · Cited by 1
Levine, T. B., & Levine, A. B. (2012) · Wiley eBooks · doi:10.1002/9781118480045.ch10 · Cited by 2
THE GENETICS OF INSULIN RESISTANCE IN FAMILIES WITH POLYCYSTIC OVARY SYNDROME
Matar, J. (2006) · D-Scholarship@Pitt (University of Pittsburgh) · Cited by 1
La tolérance au glucose durant l'exercice prolongé et modéré chez la petite fille prépubère
Boisseau, N., Rannou, F., Gratas‐Delamarche, A., Jaffré, C., Bentué‐Ferrer, D., Monnier, M., & Delamarche, P. (1999) · Science & Sports · doi:10.1016/s0765-1597(99)80066-5 · Cited by 1
Studies on microcirculation in insulin resistance
Olausson, J. (2015) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 1
Impact of statins in microalbuminuric subjects with the metabolic syndrome
Geluk, C., Asselbergs, F. W., Hillege, H. L., Bakker, S. J. L., de Jong, Zijlstra, F., & van Gilst, W. H. (2005) · University of Groningen research database (University of Groningen / Centre for Information Technology) · doi:10.1093/eurheart/ehi253 · Cited by 1
Forkhead genes in adipocytes and podocytes
Nilsson, D. (2016) · Gothenburg University Publications Electronic Archive (Gothenburg University) · Cited by 1
Kousar, R. (2009) · Victoria University Research Repository (Victoria University) · Cited by 1
Effects of Weight Loss on Adipose Tissue, Liver and Heart Metabolism in Humans
Viljanen, A. P. M. (2009) · UTUPub (University of Turku)
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Johnston, R. D. (2012) · Nottingham ePrints (University of Nottingham)
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Dellschaft, N. S. (2012) · Nottingham ePrints (University of Nottingham)
Polycystic Ovary Syndrome and Cardiovascular Disease
nder, B., Taner, D., Ylmaz, H., & Muzaffer, M. (2012) · InTech eBooks · doi:10.5772/25519
Methods in the treatment of obesity
López, J. A. F., Remesar, X., & Lamana, M. A. (2000) · Estudis Romànics (Institut d'Estudis Catalans) · doi:10.2436/cs.v0i0.272
Raynor, L. A. (2011) · University of Minnesota Digital Conservancy (University of Minnesota)
TRANSLATIONAL MEDICINE AND ITS IMPACT ON DIABETES DRUG DEVELOPMENT
Calle, R. A., & Taylor, A. E. (2011) · Cambridge University Press eBooks · doi:10.1017/cbo9780511976087.004
Manjrekar, P., Hegde, A., Rukmini, M. S., Rajan, M. G., Shenoy, M. T., & Puneeth, A. (2015) · International Journal of Health & Allied Sciences · doi:10.4103/2278-344x.160869
“Significant correlation was found only between fasting insulin and HOMA‐IR in our study, which is along the lines of many of the older studies.([21,22])”
ResultObese Patient in Intensive Care Unit
Koutsoukou, A., Kyriakopoulou, M., Kotanidou, A. N., & Ekonomidou, F. (2014) · Springer eBooks · doi:10.1007/978-1-4614-8503-2_19-1
Serine/Threonine Protein Phosphatase 5 - a Double-edged Sword - in the Progression towards Diabetes
Grankvist, N. (2012) · Figshare
Boudreaux, M. Y. (2005) · D-Scholarship@Pitt (University of Pittsburgh)
Insulin Signalling and Regulation of Protein Kinase B in Adipocytes
Göransson, O. (2003) · Lund University Publications (Lund University)
Martin, M. D., Giraldi, F. P., & Cavagnini, F. (2010) · Humana Press eBooks · doi:10.1007/978-1-60327-449-4_6
Albai, O., & Timar, R. Z. (2012) · Romanian Journal of Diabetes Nutrition and Metabolic Diseases · doi:10.2478/v10255-012-0004-6
Metadata
- Authors
- Ferrannini, E., Natali, A., Bell, P., Cavallo-Perin, P., Lalic, N., & Mingrone, G.
- Affiliations
- Istituto di Fisiologia Clinica (IT)
- Venue
- Journal of Clinical Investigation
- Published
- 1997-09-01
- Volume
- 100
- Issue
- 5
- Pages
- 1166-1173
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC508292
- OpenAlex
- W2036400933
- Cited by
- 898
- References
- 53
- Citations by year
- 2026: 9 · 2025: 14 · 2024: 20 · 2023: 13 · 2022: 20 · 2021: 28 · 2020: 32 · 2019: 26 · 2018: 32 · 2017: 26 · 2016: 26 · 2015: 36 · 2014: 30 · 2013: 36 · 2012: 43
- FWCI
- 10.82
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion)
- Funders
- Università degli Studi di Napoli Federico II
- Helsingin Yliopisto
- Universität Heidelberg
- Lunds Universitet
- Università degli Studi di Padova
- National and Kapodistrian University of Athens
- Université de Genève
- Università degli Studi di Torino
- Università degli Studi di Verona
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- insulin resistance, insulin hypersecretion, obesity, insulin sensitivity, body mass index, waist circumference, waist-to-hip ratio, abdominal obesity, sex differences, hyperinsulinemic-euglycemic clamp, type 2 diabetes risk
- MeSH terms
- Insulin Secretion, Adolescent, Adult, Aged, Aged, 80 and over, Female, Humans, Insulin, Insulin Resistance, Male, Middle Aged, Obesity, Body Mass Index
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