The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy.
Open accessAbstract
To determine whether IGF-1 opposes the stimulation of myocyte death in the surviving myocardium after infarction, transgenic mice overexpressing human IGF-1B in myocytes (FVB.Igf+/-) and wild-type littermates at 1.5 and 2.5 mo of age were subjected to coronary ligation and killed 7 d later. Myocardial infarction involved an average 50% of the left ventricle, and produced cardiac failure. In the region proximate to infarction, myocyte apoptosis increased 4. 2-fold and 2.1-fold in nontransgenics at 1.5 and 2.5 mo, respectively. Corresponding increases in myocyte necrosis were 1. 8-fold and 1.6-fold. In contrast, apoptotic and necrotic myocyte death did not increase in FVB.Igf+/- mice at either age after infarction. In 2.5-mo-old infarcted nontransgenics, functional impairment was associated with a 29% decrease in wall thickness, 43% increase in chamber diameter, and a 131% expansion in chamber volume. Conversely, the changes in wall thickness, chamber diameter, and cavitary volume were 41, 58, and 48% smaller in infarcted FVB.Igf+/- than in nontransgenics. The differential response to infarction of FVB.Igf+/- mice resulted in an attenuated increase in diastolic wall stress, cardiac weight, and left and right ventricular weight-to-body wt ratios. In conclusion, constitutive overexpression of IGF-1 prevented activation of cell death in the viable myocardium after infarction, limiting ventricular dilation, myocardial loading, and cardiac hypertrophy.
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Pfeffer, M. A., Braunwald, E., Moyé, L. A., Basta, L., Brown, E. J., Cuddy, T. E., Davis, B. R., Geltman, E. M., Goldman, S., Flaker, G. C., et al. (1992) · New England Journal of Medicine · doi:10.1056/nejm199209033271001 · Cited by 5,911
Wall stress and patterns of hypertrophy in the human left ventricle.
Grossman, W., Jones, D., & McLaurin, L. P. (1975) · Journal of Clinical Investigation · doi:10.1172/jci108079 · Cited by 2,403
Apoptosis in the Failing Human Heart
Olivetti, G., Abbi, R., Quaini, F., Kajstura, J., Cheng, W., Nitahara, J. A., Quaini, E., Di Loreto, C., Beltrami, C. A., Krajewski, S., et al. (1997) · New England Journal of Medicine · doi:10.1056/nejm199704173361603 · Cited by 1,673
Self-citationZeng, G., & Quon, M. J. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118871 · Cited by 726
Vasan, R. S., Larson, M. G., Benjamin, E. J., Evans, J. C., & Levy, D. (1997) · New England Journal of Medicine · doi:10.1056/nejm199705083361903 · Cited by 402
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Mobilized bone marrow cells repair the infarcted heart, improving function and survival
Orlic, D., Kajstura, J., Chimenti, S., Limana, F., Jakoniuk, I., Quaini, F., Nadal-Ginard, B., Bodine, D. M., Leri, A., & Anversa, P. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181177898 · Cited by 2,086
Self-citationThe intersection between aging and cardiovascular disease
North, B. J., & Sinclair, D. A. (2012) · Circulation Research · doi:10.1161/circresaha.111.246876 · Cited by 1,585
Bernardo, B. C., Weeks, K. L., Pretorius, L., & McMullen, J. R. (2010) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2010.04.005 · Cited by 894
Cardiac Stem Cell and Myocyte Aging, Heart Failure, and Insulin-Like Growth Factor-1 Overexpression
Torella, D., Rota, M., Nurzynska, D., Musso, E., Monsen, A., Shiraishi, I., Zias, E., Walsh, K., Rosenzweig, A., Sussman, M. A., et al. (2004) · Circulation Research · doi:10.1161/01.res.0000117306.10142.50 · Cited by 538
Self-citationMyocyte Death, Growth, and Regeneration in Cardiac Hypertrophy and Failure
Nadal-Ginard, B., Kajstura, J., Leri, A., & Anversa, P. (2003) · Circulation Research · doi:10.1161/01.res.0000053618.86362.df · Cited by 503
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Metadata
- Authors
- Li, Q., Li, B., Wang, X., Leri, A., Jana, K. P., Liu, Y., Kajstura, J., Baserga, R., & Anversa, P.
- Venue
- Journal of Clinical Investigation
- Published
- 1997-10-15
- Volume
- 100
- Issue
- 8
- Pages
- 1991-1999
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2038671576
- Cited by
- 500
- References
- 6
- FWCI
- 18.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. https://app.cochat.ai/papers/10.1172/jci119730
- The paper
- Li, Q., Li, B., Wang, X., Leri, A., Jana, K. P., Liu, Y., Kajstura, J., Baserga, R., & Anversa, P. (1997). Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy. Journal of Clinical Investigation. https://doi.org/10.1172/jci119730
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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