The intersection between aging and cardiovascular disease

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Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r)

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The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms

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Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part I: Aging Arteries: A “Set Up” for Vascular Disease

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Mammalian Sirtuins: Biological Insights and Disease Relevance

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Suppression of Aging in Mice by the Hormone Klotho

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Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

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Extension of murine life span by overexpression of catalase targeted to mitochondria

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The p66shc adaptor protein controls oxidative stress response and life span in mammals

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AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function

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Genomic Instability and Aging-like Phenotype in the Absence of Mammalian SIRT6

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PI3K/AKT/mTOR Pathway in Angiogenesis

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Untitled work

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Sir2 mediates longevity in the fly through a pathway related to calorie restriction

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FOXO transcription factors at the interface between longevity and tumor suppression

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The tor pathway: a target for cancer therapy

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Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

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Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

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Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises

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Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span

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Sirt1 Regulates Aging and Resistance to Oxidative Stress in the Heart

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Influence of TOR kinase on lifespan in C. elegans

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Sirt3 blocks the cardiac hypertrophic response by augmenting Foxo3a-dependent antioxidant defense mechanisms in mice

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Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms

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Effect of 6-Month Calorie Restriction on Biomarkers of Longevity, Metabolic Adaptation, and Oxidative Stress in Overweight Individuals: A Randomized Controlled Trial

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Long-Term Calorie Restriction Is Highly Effective in Reducing the Risk for Atherosclerosis in Humans

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Nrf2–Keap1 regulation of cellular defense mechanisms against electrophiles and reactive oxygen species

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SIRT1 Modulation of the Acetylation Status, Cytosolic Localization, and Activity of LKB1

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Echocardiographically Detected Left Ventricular Hypertrophy: Prevalence and Risk Factors

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Cardiomyopathy of the aging human heart. Myocyte loss and reactive cellular hypertrophy.

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Linking functional decline of telomeres, mitochondria and stem cells during ageing

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AMP-activated protein kinase mediates ischemic glucose uptake and prevents postischemic cardiac dysfunction, apoptosis, and injury

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BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

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Sirt1 Regulates Insulin Secretion by Repressing UCP2 in Pancreatic β Cells

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Disruption of forkhead transcription factor (FOXO) family members in mice reveals their functional diversification

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Identification of a gene responsible for familial Wolff-Parkinson-White syndrome

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AMP-activated protein kinase-deficient mice are resistant to the metabolic effects of resveratrol

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Sirt7 Increases Stress Resistance of Cardiomyocytes and Prevents Apoptosis and Inflammatory Cardiomyopathy in Mice

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Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

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SIRT1 Controls Endothelial Angiogenic Functions During Vascular Growth

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Endothelial aging

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Toward a unified theory of caloric restriction and longevity regulation

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Influence of age, gender, body mass index, and functional capacity on heart rate variability in a cohort of subjects without heart disease

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Regulation of the mPTP by SIRT3-mediated deacetylation of CypD at lysine 166 suppresses age-related cardiac hypertrophy

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Mutations in the gamma2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis

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Inhibition of mTOR Signaling With Rapamycin Regresses Established Cardiac Hypertrophy Induced by Pressure Overload

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Sirt1 Protects the Heart from Ischemia/Reperfusion

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Involvement of Foxo transcription factors in angiogenesis and postnatal neovascularization

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Mitochondrial Oxidative Stress Mediates Angiotensin II–Induced Cardiac Hypertrophy and Gαq Overexpression–Induced Heart Failure

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Impact of age on the cardiovascular response to dynamic upright exercise in healthy men and women

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Effect of Calorie Restriction With or Without Exercise on Insulin Sensitivity, β-Cell Function, Fat Cell Size, and Ectopic Lipid in Overweight Subjects

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Myocyte Death, Growth, and Regeneration in Cardiac Hypertrophy and Failure

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Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

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Overexpression of insulin-like growth factor-1 in mice protects from myocyte death after infarction, attenuating ventricular dilation, wall stress, and cardiac hypertrophy.

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Overexpression of Catalase Targeted to Mitochondria Attenuates Murine Cardiac Aging

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Rapamycin Attenuates Load-Induced Cardiac Hypertrophy in Mice

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Roles of Cardiac Transcription Factors in Cardiac Hypertrophy

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SIRT1 Negatively Regulates the Mammalian Target of Rapamycin

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Senescence and Death of Primitive Cells and Myocytes Lead to Premature Cardiac Aging and Heart Failure

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Acetylation-dependent regulation of endothelial Notch signalling by the SIRT1 deacetylase

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Life and Death of Cardiac Stem Cells

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IGF-1 Overexpression Inhibits the Development of Diabetic Cardiomyopathy and Angiotensin II–Mediated Oxidative Stress

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Deletion of the p66 ^Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet

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The FOXO3a Transcription Factor Regulates Cardiac Myocyte Size Downstream of AKT Signaling

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Improvements in glucose tolerance and insulin action induced by increasing energy expenditure or decreasing energy intake: a randomized controlled trial

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The Deacetylase SIRT1 Promotes Membrane Localization and Activation of Akt and PDK1 During Tumorigenesis and Cardiac Hypertrophy

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Abnormal Angiogenesis in Foxo1 (Fkhr)-deficient Mice

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SirT1 inhibition reduces IGF-I/IRS-2/Ras/ERK1/2 signaling and protects neurons

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Insulin regulation of heart function in aging fruit flies

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Nitric Oxide Activates Telomerase and Delays Endothelial Cell Senescence

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MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae

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