The DOI matches its OpenAlex record; 59 of the 59 references it cites were found in a registry or an index.
TGF-β1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II
Open accessAbstract
Angiotensin II (Ang II), a potent hypertrophic stimulus, causes significant increases in TGFb1 gene expression. However, it is not known whether there is a causal relationship between increased levels of TGF-beta1 and cardiac hypertrophy. Echocardiographic analysis revealed that TGF-beta1-deficient mice subjected to chronic subpressor doses of Ang II had no significant change in left ventricular (LV) mass and percent fractional shortening during Ang II treatment. In contrast, Ang II-treated wild-type mice showed a >20% increase in LV mass and impaired cardiac function. Cardiomyocyte cross-sectional area was also markedly increased in Ang II-treated wild-type mice but unchanged in Ang II-treated TGF-beta1-deficient mice. No significant levels of fibrosis, mitotic growth, or cytokine infiltration were detected in Ang II-treated mice. Atrial natriuretic factor expression was approximately 6-fold elevated in Ang II-treated wild-type, but not TGF-beta1-deficient mice. However, the alpha- to beta-myosin heavy chain switch did not occur in Ang II-treated mice, indicating that isoform switching is not obligatorily coupled with hypertrophy or TGF-beta1. The Ang II effect on hypertrophy was shown not to result from stimulation of the endogenous renin-angiotensis system. These results indicate that TGF-beta1 is an important mediator of the hypertrophic growth response of the heart to Ang II.
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Cites
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Cardiac Fibrosis: The Fibroblast Awakens
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Cardiac Nonmyocytes in the Hub of Cardiac Hypertrophy
Kamo, T., Akazawa, H., & Komuro, I. (2015) · Circulation Research · doi:10.1161/circresaha.117.305349 · Cited by 171
Cardiokines: recent progress in elucidating the cardiac secretome
Shimano, M., Ouchi, N., & Walsh, K. (2012) · Circulation · doi:10.1161/circulationaha.112.150656 · Cited by 116
Metadata
- Authors
- Schultz, J. E. J., Witt, S. A., Glascock, B. J., Nieman, M. L., Reiser, P. J., Nix, S. L., Kimball, T. R., & Doetschman, T.
- Venue
- Journal of Clinical Investigation
- Publisher
- American Society for Clinical Investigation
- Published
- 2002-03-15
- Volume
- 109
- Issue
- 6
- Pages
- 787-796
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2172011106
- Cited by
- 426
- References
- 59
- FWCI
- 10.17
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: TGF-β1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II. https://app.cochat.ai/papers/10.1172/jci14190
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- Schultz, J. E. J., Witt, S. A., Glascock, B. J., Nieman, M. L., Reiser, P. J., Nix, S. L., Kimball, T. R., & Doetschman, T. (2002). TGF-β1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II. Journal of Clinical Investigation. https://doi.org/10.1172/jci14190
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
