The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
C1 inhibitor deficiency: consensus document
Open accessAbstract
Summary: We present a consensus document on the diagnosis and management of C1 inhibitor deficiency, a syndrome characterized clinically by recurrent episodes of angio-oedema. In hereditary angio-oedema, a rare autosomal dominant condition, C1 inhibitor function is reduced due to impaired transcription or production of non-functional protein. The diagnosis is confirmed by the presence of a low serum C4 and absent or greatly reduced C1 inhibitor level or function. The condition can cause fatal laryngeal oedema and features indistinguishable from gastrointestinal tract obstruction. Attacks can be precipitated by trauma, infection and other stimulants. Treatment is graded according to response and the clinical site of swelling. Acute treatment for severe attack is by infusion of C1 inhibitor concentrate and for minor attack attenuated androgens and/or tranexamic acid. Prophylactic treatment is by attenuated androgens and/or tranexamic acid. There are a number of new products in trial, including genetically engineered C1 esterase inhibitor, kallikrein inhibitor and bradykinin B2 receptor antagonist. Individual sections provide special advice with respect to diagnosis, management (prophylaxis and emergency care), special situations (childhood, pregnancy, contraception, travel and dental care) and service specification.
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Cites
(1958) · Journal of the American Pharmaceutical Association (Scientific ed.) · doi:10.1002/jps.3030470133 · Cited by 2,489
A Long-Term Study of Prognosis in Monoclonal Gammopathy of Undetermined Significance
Kyle, R. A., Therneau, T. M., Rajkumar, S. V., Offord, J. R., Larson, D. R., Plevak, M. F., & Melton, L. J. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa01133202 · Cited by 1,475
Agostoni, A., Aygören-Pürsün, E., Binkley, K. E., Blanch, A., Bork, K., Bouillet, L., Bucher, C., Castaldo, A. J., Cicardi, M., Davis, A. E., et al. (2004) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2004.06.047 · Cited by 646
Self-citationHereditary Angioedema: the Clinical Syndrome and Its Management
FRANK, M. M., GELFAND, J. A., & ATKINSON, J. P. (1976) · Annals of Internal Medicine · doi:10.7326/0003-4819-84-5-580 · Cited by 615
AGOSTONI, A., & CICARDI, M. (1992) · Medicine · doi:10.1097/00005792-199207000-00003 · Cited by 610
Treatment of Hereditary Angioedema with Danazol: Reversal of Clinical and Biochemical Abnormalities
Gelfand, J. A., Sherins, R. J., Alling, D. W., & Frank, M. M. (1976) · New England Journal of Medicine · doi:10.1056/nejm197612232952602 · Cited by 607
Hereditary angioedema with normal C1-inhibitor activity in women
Bork, K., Barnstedt, S.-E., Koch, P., & Traupe, H. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02483-1 · Cited by 557
HEREDITARY ANGIO-NEUROTIC ŒDEMA
OSLER, W. (1888) · The American Journal of the Medical Sciences · doi:10.1097/00000441-188804000-00004 · Cited by 509
ASSOCIATION OF ANDROGENIC-ANABOLIC STEROID THERAPY WITH DEVELOPMENT OF HEPATOCELLULAR CARCINOMA
Johnson, F. L., Lerner, K., Siegel, M., Feagler, J., Majerus, P., Hartmann, J., & Thomas, E. D. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92649-9 · Cited by 374
Han, E. D., MacFarlane, R. C., Mulligan, A. N., Scafidi, J., & Davis, A. E. (2002) · Journal of Clinical Investigation · doi:10.1172/jci14211 · Cited by 362
Cited by
Maurer, M., Magerl, M., Ansotegui, I., Aygören‐Pürsün, E., Betschel, S., Bork, K., Bowen, T., Balle Boysen, H., Farkas, H., Grumach, A. S., et al. (2018) · Allergy · doi:10.1111/all.13384 · Cited by 513
Self-citationCaballero, T., Farkas, H., Bouillet, L., Bowen, T., Gompel, A., Fagerberg, C., Bjökander, J., Bork, K., Bygum, A., Cicardi, M., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2011.11.025 · Cited by 254
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Metadata
- Authors
- Gompels, M. M., Lock, R. J., Abinun, M., Bethune, C. A., Davies, G., Grattan, C., Fay, A. C., Longhurst, H. J., Morrison, L., Price, A., Price, M., & Watters, D.
- Venue
- Clinical and Experimental Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-01-26
- Volume
- 139
- Issue
- 3
- Pages
- 379-394
- ISSN
- 0009-9104 (ISSN-L)
- 1365-2249
- OpenAlex
- W2020059900
- Cited by
- 411
- References
- 49
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Gompels, M. M., Lock, R. J., Abinun, M., Bethune, C. A., Davies, G., Grattan, C., Fay, A. C., Longhurst, H. J., Morrison, L., Price, A., Price, M., & Watters, D. (2005). C1 inhibitor deficiency: consensus document. Clinical and Experimental Immunology. https://doi.org/10.1111/j.1365-2249.2005.02726.x
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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