Cited by 1,359Chemokine receptors and signalingCell Adhesion Molecules ResearchMacrophage Migration Inhibitory Factor

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

Open access

Qin, S, Rottman, J B, Myers, P, Kassam, N, Weinblatt, M, Loetscher, M, Koch, A E, Moser, B, Mackay, C R·1998·Journal of Clinical Investigation

DOI 10.1172/jci1422PMC PMC508621

Open this paper in CoChat — free account

Abstract

T cells infiltrating inflammatory sites are usually of the activated/memory type. The precise mechanism for the positioning of these cells within tissues is unclear. Adhesion molecules certainly play a role; however, the intricate control of cell migration appears to be mediated by numerous chemokines and their receptors. Particularly important chemokines for activated/memory T cells are the CXCR3 ligands IP-10 and Mig and the CCR5 ligands RANTES, macrophage inflammatory protein-1alpha, and macrophage inflammatory protein-1beta. We raised anti-CXCR3 mAbs and were able to detect high levels of CXCR3 expression on activated T cells. Surprisingly, a proportion of circulating blood T cells, B cells, and natural killer cells also expressed CXCR3. CCR5 showed a similar expression pattern as CXCR3, but was expressed on fewer circulating T cells. Blood T cells expressing CXCR3 (and CCR5) were mostly CD45RO+, and generally expressed high levels of beta1 integrins. This phenotype resembled that of T cells infiltrating inflammatory lesions. Immunostaining of T cells in rheumatoid arthritis synovial fluid confirmed that virtually all such T cells expressed CXCR3 and approximately 80% expressed CCR5, representing high enrichment over levels of CXCR3+ and CCR5+ T cells in blood, 35 and 15%, respectively. Analysis by immunohistochemistry of various inflamed tissues gave comparable findings in that virtually all T cells within the lesions expressed CXCR3, particularly in perivascular regions, whereas far fewer T cells within normal lymph nodes expressed CXCR3 or CCR5. These results demonstrate that the chemokine receptor CXCR3 and CCR5 are markers for T cells associated with certain inflammatory reactions, particularly TH-1 type reactions. Moreover, CXCR3 and CCR5 appear to identify subsets of T cells in blood with a predilection for homing to these sites.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci1422

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
Springer, T. A. (1994) · Cell · doi:10.1016/0092-8674(94)90337-9 · Cited by 7,009
Current Protocols in Immunology
(2018) · Current Protocols in Immunology · doi:10.1002/(issn)1934-368x · Cited by 3,574
Lymphocyte Homing and Homeostasis
Butcher, E. C., & Picker, L. J. (1996) · Science · doi:10.1126/science.272.5258.60 · Cited by 2,846
Human Chemokines: An Update
Baggiolini, M., Dewald, B., & Moser, B. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.675 · Cited by 2,193
Self-citation
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
Bleul, C. C., Farzan, M., Choe, H., Parolin, C., Clark‐Lewis, I., Sodroski, J., & Springer, T. A. (1996) · Nature · doi:10.1038/382829a0 · Cited by 1,953
The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
Oberlin, E., Amara, A., Bachelerie, F., Chable-Bessia, C., Virelizier, J., Arenzana‐Seisdedos, F., Schwartz, O., Heard, J., Clark‐Lewis, I., Legler, D. F., et al. (1996) · Nature · doi:10.1038/382833a0 · Cited by 1,652
Self-citation
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
Bleul, C. C., Fuhlbrigge, R. C., Casasnovas, J. M., Aiuti, A., & Springer, T. A. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.3.1101 · Cited by 1,482
Current protocols in immunology
Nezlin, R. S. (1992) · Molecular Immunology · doi:10.1016/0161-5890(92)90114-d · Cited by 1,413
Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES
Schall, T. J., Bacon, K. B., Toy, K. J., & Goeddel, D. V. (1990) · Nature · doi:10.1038/347669a0 · Cited by 1,378
Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes
Loetscher, M., Gerber, B., Loetscher, P., Jones, S. A., Piali, L., Clark-Lewis, I., Baggiolini, M., & Moser, B. (1996) · Journal of Experimental Medicine · doi:10.1084/jem.184.3.963 · Cited by 1,333
Self-citation

Flagged first, then by citations

Show all 39 references

Sorted by citations

Items 401–500 of 1,000

Susceptibility and Response of Human Blood Monocyte Subsets to Primary Dengue Virus Infection
Wong, K. L., Chen, W., Balakrishnan, T., Toh, Y. X., Fink, K., & Wong, S. C. (2012) · PLoS ONE · doi:10.1371/journal.pone.0036435 · Cited by 77
Expression profile of chemokines and chemokine receptors in epithelial cell layers of oral lichen planus
Ichimura, M., Hiratsuka, K., Ogura, N., Utsunomiya, T., Sakamaki, H., Kondoh, T., Abiko, Y., Otake, S., & Yamamoto, M. (2006) · Journal of Oral Pathology and Medicine · doi:10.1111/j.1600-0714.2006.00402.x · Cited by 77
Specificity of T cells in synovial fluid: high frequencies of CD8+ T cells that are specific for certain viral epitopes
Tan, L., Mowat, A. G., Fazou, C., Rostron, T., Roskell, H., Dunbar, P. R., Tournay, C., Romagné, F., Peyrat, M., Houssaint, E., et al. (2000) · Arthritis Research & Therapy · doi:10.1186/ar80 · Cited by 77
Independent Regulation of Chemokine Responsiveness and Cytolytic Function versus CD8+ T Cell Expansion by Dendritic Cells
Watchmaker, P. B., Berk, E., Muthuswamy, R., Mailliard, R. B., Urban, J. A., Kirkwood, J. M., & Kaliński, P. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0902062 · Cited by 76
CCR10 is expressed in cutaneous T‐cell lymphoma
Notohamiprodjo, M., Segerer, S., Huss, R., Hildebrandt, B., Soler, D. F., Djafarzadeh, R., Buck, W., Nelson, P. J., & von Luettichau, I. (2005) · International Journal of Cancer · doi:10.1002/ijc.20922 · Cited by 76
Understanding the immunoangiostatic CXC chemokine network
Balestrieri, M. L., Balestrieri, A., Mancini, F. P., & Claudio Napoli, A. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn029 · Cited by 76
Molecular cues guiding inflammatory responses
Barreiro, O., Martı́n, P., González-Amaro, R., & Sánchez‐Madrid, F. (2010) · Cardiovascular Research · doi:10.1093/cvr/cvq001 · Cited by 77
Early Gene Expression of NK Cell-Activating Chemokines in Mice Resistant toLeishmania major
Vester, B., Müller, K., Solbach, W., & Laskay, T. (1999) · Infection and Immunity · doi:10.1128/iai.67.6.3155-3159.1999 · Cited by 76
Differential roles for CXCR3 in CD4+ and CD8+ T cell trafficking following viral infection of the CNS
Stiles, L. N., Hosking, M., Edwards, R. A., Strieter, R. M., & Lane, T. E. (2006) · European Journal of Immunology · doi:10.1002/eji.200535509 · Cited by 75
Cc–Chemokine Receptor 6 and Its Ligand Macrophage Inflammatory Protein 3α Might Be Involved in the Amplification of Local Necroinflammatory Response in the Liver
Shimizu, Y., Murata, H., Kashii, Y., Hirano, K., Kunitani, H., Higuchi, K., & Watanabe, A. (2001) · Hepatology · doi:10.1053/jhep.2001.26631 · Cited by 75
CCR5-Δ32 mutation is strongly associated with primary sclerosing cholangitis
Eri, R. D., Jonsson, J. R., Pandeya, N., Purdie, D. M., Clouston, A. D., Martin, N. G., Duffy, D. L., Powell, E. E., Fawcett, J., Florin, T. H., et al. (2004) · Genes and Immunity · doi:10.1038/sj.gene.6364113 · Cited by 75
CCR2 expressing CD4+ T lymphocytes are preferentially recruited to the ileum in Crohn's disease
Connor, S. J. (2004) · Gut · doi:10.1136/gut.2003.028225 · Cited by 75
Surface expression of CC- and CXC-chemokine receptors on leucocyte subsets in inflammatory joint diseases
Brühl, H., Wagner, K., Kellner, H., Schattenkirchner, M., Schlöndorff, D., & Mack, M. (2001) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2001.01679.x · Cited by 75
Distinct chemokine receptor and cytokine expression profile in secondary progressive MS
Sørensen, T. L., & Sellebjerg, F. T. (2001) · Neurology · doi:10.1212/wnl.57.8.1371 · Cited by 74
Vitamin D Receptor Agonists Target CXCL10: New Therapeutic Tools for Resolution of Inflammation
Scolletta, S., Colletti, M., Luigi, L. D., & Crescioli, C. (2013) · Mediators of Inflammation · doi:10.1155/2013/876319 · Cited by 73
Cryptococcus gattii Infection Dampens Th1 and Th17 Responses by Attenuating Dendritic Cell Function and Pulmonary Chemokine Expression in the Immunocompetent Hosts
Angkasekwinai, P., Sringkarin, N., Supasorn, O., Fungkrajai, M., Wang, Y., Chayakulkeeree, M., Ngamskulrungroj, P., Angkasekwinai, N., & Pattanapanyasat, K. (2014) · Infection and Immunity · doi:10.1128/iai.01773-14 · Cited by 76
Mechanisms of T cell organotropism
Fu, H., Ward, E. J., & Marelli‐Berg, F. M. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2211-4 · Cited by 76
The CXC Chemokines Gamma Interferon (IFN-γ)-Inducible Protein 10 and Monokine Induced by IFN-γ Are Released during Severe Melioidosis
Lauw, F. N., Simpson, A. J. H., Prins, J. M., van Deventer, S. J. H., Chaowagul, W., White, N. J., & van der Poll, T. (2000) · Infection and Immunity · doi:10.1128/iai.68.7.3888-3893.2000 · Cited by 73
Identification and Molecular Characterization of Rat CXCR3: Receptor Expression and Interferon-Inducible Protein-10 Binding Are Increased in Focal Stroke
Wang, X., Li, X. O., Schmidt, D. B., Foley, J. J., Barone, F. C., Ames, R. S., & Sarau, H. M. (2000) · Molecular Pharmacology · doi:10.1016/s0026-895x(24)23229-6 · Cited by 73
Pathogenesis of Chronic Chagas Disease: Macrophages, Mitochondria, and Oxidative Stress
López, M., Tanowitz, H. B., & Garg, N. J. (2018) · Current Clinical Microbiology Reports · doi:10.1007/s40588-018-0081-2 · Cited by 73
Mechanisms in Allergic Contact Dermatitis
Rustemeyer, T., van Hoogstraten, I. M. W., Blomberg, B. M. E. V., & Scheper, R. J. (2001) · Springer eBooks · doi:10.1007/978-3-662-10302-9_2 · Cited by 72
Prostaglandin E2 Up-Regulates Macrophage-Derived Chemokine Production but Suppresses IFN-Inducible Protein-10 Production by APC
Kuroda, E., Sugiura, T., Okada, K., Zeki, K., & Yamashita, U. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.1650 · Cited by 72
Roles for CXC Chemokine Ligands 10 and 11 in Recruiting CD4+ T Cells to HIV-1-Infected Monocyte-Derived Macrophages, Dendritic Cells, and Lymph Nodes
Foley, J. F., Yu, C., Solow, R., Yacobucci, M., Peden, K., & Farber, J. M. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4892 · Cited by 71
Herpes Simplex Virus and the Chemokines That Mediate the Inflammation
Carr, D. J. J., & Tomanek, L. (2007) · Springer eBooks · doi:10.1007/978-3-540-33397-5_3 · Cited by 71
Chemokines in hepatitis C virus infection: Pathogenesis, prognosis and therapeutics
Wald, O., Weiss, I. D., Galun, E., & Peled, A. (2007) · Cytokine · doi:10.1016/j.cyto.2007.05.013 · Cited by 71
Emerging concepts in autoimmune encephalomyelitis beyond the CD4/TH1 paradigm
Batoulis, H., Addicks, K., & Küerten, S. (2010) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2010.06.006 · Cited by 72
Leukocyte Infiltration, But Not Neurodegeneration, in the CNS of Transgenic Mice with Astrocyte Production of the CXC Chemokine Ligand 10
Boztuǧ, K., Carson, M. J., Pham-Mitchell, N., Asensio, V. C., DeMartino, J. A., & Campbell, I. L. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.3.1505 · Cited by 71
Role of CXCL10 in central nervous system inflammation
McKimmie, C. S., & Michlmayr, D. (2014) · International Journal of Interferon Cytokine and Mediator Research · doi:10.2147/ijicmr.s35953 · Cited by 71
The CC Chemokine Receptor 5 Is Important in Control of Parasite Replication and Acute Cardiac Inflammation following Infection withTrypanosoma cruzi
Hardison, J. L., Wrightsman, R. A., Carpenter, P. M., Kuziel, W. A., Lane, T. E., & Manning, J. E. (2005) · Infection and Immunity · doi:10.1128/iai.74.1.135-143.2006 · Cited by 70
Acute psychological stress alerts the adaptive immune response: Stress-induced mobilization of effector T cells
Atanackovic, D., Schnee, B., Schuch, G., Faltz, C., Schulze, J., Weber, C., Schafhausen, P., Bartels, K., Bokemeyer, C., Brunner-Weinzierl, M. C., et al. (2006) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2006.03.023 · Cited by 70
The Chemokines CCL5, CCL2 and CXCL12 Play Significant Roles in the Migration of Th1 Cells into Rheumatoid Synovial Tissue
Shadidi, K. R., Aarvak, T., Henriksen, J. E., Natvig, J. B., & Thompson, K. M. (2003) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2003.01214.x · Cited by 70
Sputum T lymphocytes in asthma, COPD and healthy subjects have the phenotype of activated intraepithelial T cells (CD69+ CD103+)
Leckie, M. J. (2003) · Thorax · doi:10.1136/thorax.58.1.23 · Cited by 70
The relative activity of CXCR3 and CCR5 ligands in T lymphocyte migration: concordant and disparate activities in vitro and in vivo
Stanford, M. M., & Issekutz, T. B. (2003) · Journal of Leukocyte Biology · doi:10.1189/jlb.1102547 · Cited by 70
Lack of correlation between chemokine receptor and Th1/Th2 cytokine expression by individual memory T cells
Nanki, T., & Lipsky, P. E. (2000) · International Immunology · doi:10.1093/intimm/12.12.1659 · Cited by 70
Regulation and modulation of eosinophil effector functions
Elsner, J., & Kapp, A. (1999) · Allergy · doi:10.1111/all.1999.54.1.15 · Cited by 69
CXCL10 stabilizes T cell–brain endothelial cell adhesion leading to the induction of cerebral malaria
Sorensen, E. W., Lian, J., Ozga, A. J., Miyabe, Y., Ji, S., Bromley, S. K., Mempel, T. R., & Luster, A. D. (2018) · JCI Insight · doi:10.1172/jci.insight.98911 · Cited by 71
The Role of CXCR3 and Associated Chemokines in the Development of Atherosclerosis and During Myocardial Infarction
Szentes, V., Gazdag, M., Szokodi, I., & Dézsi, C. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01932 · Cited by 69
Immune profiles in acute myeloid leukemia bone marrow associate with patient age, T-cell receptor clonality, and survival
Brück, O. E., Dufva, O., Hohtari, H. R., Blom, S., Turkki, R., Ilander, M. M., Kovanen, P. E., Pallaud, C., Ramos, P. M., Lähteenmäki, H., et al. (2020) · Blood Advances · doi:10.1182/bloodadvances.2019000792 · Cited by 71
Coexpression and interaction of CXCL10 and CD26 in mesenchymal cells by synergising inflammatory cytokines: CXCL8 and CXCL10 are discriminative markers for autoimmune arthropathies
Proost, P., Struyf, S., Loos, T., Gouwy, M., Schutyser, E., Conings, R., Ronsse, I., Parmentier, M., Grillet, B. A. M., Opdenakker, G., et al. (2006) · Arthritis Research & Therapy · doi:10.1186/ar1997 · Cited by 69
Phenotypic and functional characterisation of CCR7+ and CCR7- CD4+memory T cells homing to the joints in juvenile idiopathic arthritis
Gattorno, M., Prigione, I., Morandi, F., Gregorio, A., Chiesa, S., Ferlito, F., Favre, A., Uccelli, A., Gambini, C., Martini, A., et al. (2005) · Arthritis Research & Therapy · doi:10.1186/ar1485 · Cited by 69
Relationship between serum RANTES levels and radiological progression in rheumatoid arthritis patients treated with methotrexate.
Boiardi, L., Macchioni, P., Melicòni, R., Pulsatelli, L., Facchini, A., & Salvarani, C. (1999) · PubMed · Cited by 69
Expression of chemokines, CXC chemokine ligand 10 (CXCL10) and CXCR3 in the inflamed islets of patients with recent-onset autoimmune type 1 diabetes
Uno, S., Imagawa, A., Saisho, K., Okita, K., Iwahashi, H., Hanafusa, T., & Shimomura, I. (2010) · Endocrine Journal · doi:10.1507/endocrj.k10e-076 · Cited by 68
Of mice and men: how animal models advance our understanding of T-cell function in RA
Kobezda, T., Ghassemi-Nejad, S., Mikecz, K., Glant, T. T., & Szekanecz, Z. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.205 · Cited by 68
Cytokine-induced human IFN-γ–secreting effector-memory Th cells in chronic autoimmune inflammation
Sattler, A., Wagner, U. G., Rossol, M., Sieper, J., Wu, P., Krause, A., Schmidt, W., Radmer, S., Köhler, S., Romagnani, C., et al. (2008) · Blood · doi:10.1182/blood-2008-02-139147 · Cited by 68
Increased serum levels of interferon-γ-inducible protein 10 and monokine induced by gamma interferon in patients with haemophagocytic lymphohistiocytosis
TAKADA, H., Takahata, Y., Nomura, A., Ohga, S., Mizuno, Y., & Hara, T. (2003) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.2003.02237.x · Cited by 68
IFN-γ-Inducible T Cell α Chemoattractant Is a Potent Stimulator of Normal Human Blood T Lymphocyte Transendothelial Migration: Differential Regulation by IFN-γ and TNF-α
Karkada, M., Ding, Z., Hanly, J. G., & Issekutz, T. B. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6420 · Cited by 68
Interferon lambda-1 (IFN-λ1/IL-29) induces ELR− CXC chemokine mRNA in human peripheral blood mononuclear cells, in an IFN-γ-independent manner
Pekarek, V., Srinivas, S., Eskdale, J., & Gallagher, G. E. (2007) · Genes and Immunity · doi:10.1038/sj.gene.6364372 · Cited by 67
CXCR3 marks CD4+ memory T lymphocytes that are competent to migrate across a human brain microvascular endothelial cell layer
Callahan, M. K., Williams, K. A., Kivisäkk, P., Pearce, D., Stins, M. F., & Ransohoff, R. M. (2004) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2004.05.004 · Cited by 67
Naturally Occurring Deletional Mutation in the C-Terminal Cytoplasmic Tail of CCR5 Affects Surface Trafficking of CCR5
Shioda, T., Nakayama, E. E., Tanaka, Y., Xin, X., Liu, H., Kawana‐Tachikawa, A., Kato, A., Sakai, Y., Nagai, Y., & Iwamoto, A. (2001) · Journal of Virology · doi:10.1128/jvi.75.7.3462-3468.2001 · Cited by 67
Chemokine and chemokine receptors in autoimmunity: the case of primary biliary cholangitis
Choi, J., Selmi, C. F., Leung, P. S. C., Kenny, T. P., Roskams, T., & Gershwin, M. E. (2016) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2016.1147956 · Cited by 67
IL-2 and IL-12 Alter NK Cell Responsiveness to IFN-γ-Inducible Protein 10 by Down-Regulating CXCR3 Expression
Hodge, D. L., Schill, W. B., Wang, J., Blanca, I., Reynolds, D. A., Ortaldo, J. R., & Young, H. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.12.6090 · Cited by 67
Expression of the inflammatory chemokines CCL5, CCL3 and CXCL10 in juvenile idiopathic arthritis, and demonstration of CCL5 production by an atypical subset of CD8+ T cells
Pharoah, D. S., Varsani, H., Tatham, R. W., Newton, K. R., de Jager, W., Prakken, B. J., Klein, N. J., & Wedderburn, L. R. (2006) · Arthritis Research & Therapy · doi:10.1186/ar1913 · Cited by 67
HIV-Infected Langerhans Cells Preferentially Transmit Virus to Proliferating Autologous CD4+ Memory T Cells Located within Langerhans Cell-T Cell Clusters
Sugaya, M., Loré, K., Koup, R. A., Douek, D. C., & Blauvelt, A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.4.2219 · Cited by 67
T cell chemokine receptor expression in human Th1- and Th2-associated diseases.
Campbell, J. D., & HayGlass, K. T. (2000) · PubMed · Cited by 67
Cutting Edge: Species Specificity of the CC Chemokine 6Ckine Signaling Through the CXC Chemokine Receptor CXCR3: Human 6Ckine Is Not A Ligand for the Human or Mouse CXCR3 Receptors
Jenh, C., Cox, M. A., Kaminski, H., Zhang, M., Byrnes, H. D., Fine, J. S., Lundell, D. J., Chou, C., Narula, S. K., & Zavodny, P. J. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3765 · Cited by 67
Evolution and function of chemokine receptors in the immune system of lower vertebrates
Bajoghli, B. (2013) · European Journal of Immunology · doi:10.1002/eji.201343557 · Cited by 68
Human C5aR knock-in mice facilitate the production and assessment of anti-inflammatory monoclonal antibodies
Lee, H., Zahra, D., Vogelzang, A., Newton, R. A., Thatcher, J., Quan, A., So, T., Zwirner, J., Köentgen, F., Padkjær, S. B., et al. (2006) · Nature Biotechnology · doi:10.1038/nbt1248 · Cited by 66
Self-citation
C-C Chemokine Receptor 5 Gene Variants in Relation to Lung Disease in Sarcoidosis
Spagnolo, P., Renzoni, E. A., Wells, A. U., Copley, S. J., Desai, S. R., Sato, H., Grutters, J. C., Abdallah, A. M., Taegtmeyer, A. B., du Bois, R. M., et al. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200412-1707oc · Cited by 66
C-X-C Motif Chemokine Receptor 3 Splice Variants Differentially Activate Beta-Arrestins to Regulate Downstream Signaling Pathways
Smith, J. S., Alagesan, P., Desai, N. K., Pack, T. F., Wu, J., Inoue, A., Freedman, N. J., & Rajagopal, S. (2017) · Molecular Pharmacology · doi:10.1124/mol.117.108522 · Cited by 67
Resident Th1-Like Effector Memory Cells in Pulmonary Recall Responses to Mycobacterium tuberculosis
Walrath, J. R., Zukowski, L., Krywiak, A., & Silver, R. F. (2005) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2005-0060oc · Cited by 66
Induction of monocyte– and T-cell–attracting chemokines in the lung during the generation of idiopathic pneumonia syndrome following allogeneic murine bone marrow transplantation
Panoskaltsis‐Mortari, A., Strieter, R. M., Hermanson, J. R., Fegeding, K. V., Murphy, W. J., Farrell, C. L., Lacey, D. L., & Blazar, B. R. (2000) · Blood · doi:10.1182/blood.v96.3.834 · Cited by 66
CXCR3–/– mice mount an efficient Th1 response but fail to control Leishmania major infection
Rosas, L. E., Barbi, J. J., Lu, B., Fujiwara, Y., Gerard, C. J., Sanders, V. M., & Satoskar, A. R. (2005) · European Journal of Immunology · doi:10.1002/eji.200425422 · Cited by 65
The CXC chemokine receptors of fish: Insights into CXCR evolution in the vertebrates
Zou, J., Redmond, A. K., Qi, Z., Dooley, H. M., & Secombes, C. J. (2015) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2015.01.004 · Cited by 65
Homing chemokines in rheumatoid arthritis.
Loetscher, P., & Moser, B. (2002) · Arthritis Research · doi:10.1186/ar412 · Cited by 65
Self-citation
CCL22‐induced responses are powerfully enhanced by synergy inducing chemokines via CCR4: evidence for the involvement of first β‐strand of chemokine
Sebastiani, S., Danelon, G., Gerber, B. O., & Uguccioni, M. (2005) · European Journal of Immunology · doi:10.1002/eji.200525800 · Cited by 65
Monokine induced by interferon- is induced by receptor activator of nuclear factor B ligand and is involved in osteoclast adhesion and migration
Kwak, H. B. (2004) · Blood · doi:10.1182/blood-2004-07-2534 · Cited by 66
Targeted in vivo expression of IFN-γ-inducible protein 10 induces specific antitumor activity
Yang, X., Chu, Y., Wang, Y., Zhang, R., & Xiong, S. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0306212 · Cited by 65
Chemokine Receptor CCR5 Expression in Conjunctival Epithelium of Patients With Dry Eye Syndrome
Gulati, A. (2006) · Archives of Ophthalmology · doi:10.1001/archopht.124.5.710 · Cited by 65
CXCL10 Production by Human Monocytes in Response to Leishmania braziliensis Infection
Vargas‐Inchaustegui, D. A., Hogg, A. E., Tulliano, G., Llanos‐Cuentas, A., Arévalo, J., Endsley, J. J., & Soong, L. (2009) · Infection and Immunity · doi:10.1128/iai.00959-09 · Cited by 64
The current status and future directions of myxoma virus, a master in immune evasion
Spiesschaert, B., McFadden, G., Hermans, K., Nauwynck, H., & de Walle, G. R. V. (2011) · Veterinary Research · doi:10.1186/1297-9716-42-76 · Cited by 68
Mechanisms of Irritant and Allergic Contact Dermatitis
Rustemeyer, T., van Hoogstraten, I. M. W., Blomberg, B. M. E. V., Gibbs, S., & Scheper, R. J. (2010) · Springer eBooks · doi:10.1007/978-3-642-03827-3_3 · Cited by 66
Interleukin-12 Is Expressed by Infiltrating Macrophages and Synovial Lining Cells in Rheumatoid Arthritis and Osteoarthritis
Sakkas, L. I., Johanson, N. A., Scanzello, C. R., & Platsoucas, C. D. (1998) · Cellular Immunology · doi:10.1006/cimm.1998.1363 · Cited by 64
Endothelial inflammation: the role of differential expression of N-deacetylase/N-sulphotransferase enzymes in alteration of the immunological properties of heparan sulphate
Carter, N. M., Ali, S., & Kirby, J. A. (2003) · Journal of Cell Science · doi:10.1242/jcs.00662 · Cited by 64
Cytokine, activation marker, and chemokine receptor expression by individual CD4+ memory T cells in rheumatoid arthritis synovium
Nanki, T., & Lipsky, P. E. (2000) · Arthritis Research & Therapy · doi:10.1186/ar120 · Cited by 64
CCL5 is a potential bridge between type 1 and type 2 inflammation in asthma
Gauthier, M. C., Kale, S. L., Oriss, T. B., Gorry, M. C., Ramonell, R. P., Dalton, K., Ray, P., Fahy, J. V., Seibold, M. A., Castro, M., et al. (2023) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2023.02.028 · Cited by 63
The Role of CXCR3 in DSS-Induced Colitis
Chami, B., Yeung, A. W. S., van Vreden, C., King, N. J. C., & Bao, S. (2014) · PLoS ONE · doi:10.1371/journal.pone.0101622 · Cited by 63
MMP19 Is Essential for T Cell Development and T Cell-Mediated Cutaneous Immune Responses
Beck, I. M., Rückert, R., Brandt, K., Mueller, M. S., Sadowski, T., Brauer, R., Schirmacher, P., Mentlein, R., & Sedlacek, R. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002343 · Cited by 63
The Female Lower Genital Tract Is a Privileged Compartment with IL-10 Producing Dendritic Cells and Poor Th1 Immunity following Chlamydia trachomatis Infection
Marks, E., Tam, M. A., & Lycke, N. Y. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001179 · Cited by 63
Characterization of the Chemokine CXCL11-Heparin Interaction Suggests Two Different Affinities for Glycosaminoglycans
Severin, I. C., Gaudry, J.-P., Johnson, Z., Kungl, A. J., Jansma, A. L., Gesslbauer, B., Mulloy, B., Power, C., Proudfoot, A. E. I., & Handel, T. M. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.082552 · Cited by 63
ES-62, a filarial nematode-derived immunomodulator with anti-inflammatory potential
Harnett, W., McInnes, I. B., & Harnett, M. M. (2004) · Immunology Letters · doi:10.1016/j.imlet.2004.04.008 · Cited by 63
Fcγ Receptor IIb Strongly Regulates Fcγ Receptor-Facilitated T Cell Activation by Dendritic Cells
van Montfoort, N., Hoen, P. A. C. ’., Mangsbo, S. M., Camps, M. G. M., Boross, P., Melief, C. J. M., OSSENDORP, F. A., & Verbeek, J. S. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103703 · Cited by 67
Immune privilege and HIV‐1 persistence in the CNS
Persidsky, Y., & Poluektova, L. Y. (2006) · Immunological Reviews · doi:10.1111/j.1600-065x.2006.00440.x · Cited by 64
Immunopathogenesis of acute graft-versus-host disease: implications for novel preventive and therapeutic strategies
Zeiser, R., Marks, R., Bertz, H., & Finke, J. (2004) · Annals of Hematology · doi:10.1007/s00277-004-0890-7 · Cited by 63
Influenza virosomes enhance class I restricted CTL induction through CD4+ T cell activation
Schumacher, R., Adamina, M., Zurbriggen, R., Bolli, M., Padovan, E., Zajac, P., Heberer, M., & Spagnoli, G. C. (2003) · Vaccine · doi:10.1016/j.vaccine.2003.08.019 · Cited by 63
Current status of chemokine receptor inhibitors in development
Allegretti, M., Cesta, M. C., Garin, A., & Proudfoot, A. E. I. (2012) · Immunology Letters · doi:10.1016/j.imlet.2012.04.003 · Cited by 62
Lymphoid Follicle Cells in Chronic Obstructive Pulmonary Disease Overexpress the Chemokine Receptor CXCR3
Kelsen, S. G., Aksoy, M. O., Georgy, M., Hershman, R., Ji, R., Li, X., Hurford, M. T., Solomides, C., Chatila, W. M., & Kim, V. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200807-1089oc · Cited by 62
Chemoattraction of T cells expressing CCR5, CXCR3 and CX3CR1 by proximal tubular epithelial cell chemokines
Cockwell, P. (2002) · Nephrology Dialysis Transplantation · doi:10.1093/ndt/17.5.734 · Cited by 62
Blockade of the chemokine receptor, CCR5, reduces the growth of orthotopically injected colon cancer cells via limiting cancerassociated fibroblast accumulation
Tanabe, Y., Sasaki, S., Mukaida, N., & Baba, T. (2016) · Oncotarget · doi:10.18632/oncotarget.10227 · Cited by 62
T-cell activation via CD26 and caveolin-1 in rheumatoid synovium
Ohnuma, K., Inoue, H., Uchiyama, M., Yamochi, T., Hosono, O., Dang, N. H., & Morimoto, C. (2006) · Modern Rheumatology · doi:10.1007/s10165-005-0452-4 · Cited by 62
TNF-α-Induced Secretion of C-C Chemokines Modulates C-C Chemokine Receptor 5 Expression on Peripheral Blood Lymphocytes
Hornung, F., Scala, G., & Lenardo, M. J. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.164.12.6180 · Cited by 62
Pathological Mechanisms and Clinical Features of Eosinophilic Chronic Rhinosinusitis in the Japanese Population
Takeno, S., Hirakawa, K., & Ishino, T. (2010) · Allergology International · doi:10.2332/allergolint.10-rai-0202 · Cited by 61
Effects of Low-Level Laser Therapy on M1-Related Cytokine Expression in Monocytes via Histone Modification
Chen, C., Wang, C., Wang, Y., Liao, W., Chen, Y., Kuo, C., Kuo, H., & Hung, C. (2014) · Mediators of Inflammation · doi:10.1155/2014/625048 · Cited by 63
Lymphocyte Invasion in IC10/Basal-Like Breast Tumors Is Associated with Wild-Type TP53
Quigley, D. A., Silwal‐Pandit, L., Dannenfelser, R., Langerød, A., Vollan, H. K. M., Vaske, C. J., Siegel, J. U., Troyanskaya, O. G., Chin, S., Caldas, C., et al. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0387 · Cited by 61
Noncompetitive Antagonism and Inverse Agonism as Mechanism of Action of Nonpeptidergic Antagonists at Primate and Rodent CXCR3 Chemokine Receptors
Verzijl, D., Storelli, S., Scholten, D. J., Bosch, L., Reinhart, T. A., Streblow, D. N., Tensen, C. P., Fitzsimons, C. P., Zaman, G. J. R., Pease, J. E., et al. (2008) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.134783 · Cited by 61
Hypercholesterolemia induces T cell expansion in humanized immune mice
Proto, J. D., Doran, A. C., Subramanian, M., Wang, H., Zhang, M., Sözen, E., Rymond, C. C., Kuriakose, G., D’Agati, V. D., WINCHESTER, R. J., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci97785 · Cited by 61
CCR5 Blockade Modulates Inflammation and Alloimmunity in Primates
Schröder, C., Pierson, R. N., Nguyen, B.-N. H., Kawka, D. W., Peterson, L. B., Wu, G., Zhang, T., Springer, M. S., Siciliano, S. J., Iliff, S. A., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2289 · Cited by 61
Early Differentiated CD138highMHCII+IgG+ Plasma Cells Express CXCR3 and Localize into Inflamed Kidneys of Lupus Mice
Lacotte, S., Décossas, M., Coz, C. L., Brun, S., Muller, S., & Dumortier, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0058140 · Cited by 60
Human osteoblasts express functional CXC chemokine receptors 3 and 5: Activation by their ligands, CXCL10 and CXCL13, significantly induces alkaline phosphatase and β‐N‐acetylhexosaminidase release
Lisignoli, G., Toneguzzi, S., Piacentini, A., Cattini, L., Lenti, A., Tschon, M., Cristino, S., Grassi, F., & Facchini, A. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10188 · Cited by 60
Chemokine‐receptor expression on T cells in lung compartments of challenged asthmatic patients
Kallinich, T., Schmidt, S., Hamelmann, E. H., Fischer, A., Qin, S., Luttmann, W., Virchow, J. C., & Kroczek, R. A. (2005) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2004.02132.x · Cited by 60
Self-citation
The Natural Killer Complex Regulates Severe Malarial Pathogenesis and Influences Acquired Immune Responses toPlasmodium bergheiANKA
Hansen, D. S., Evans, K. J., D’Ombrain, M. C., Bernard, N. J., Sexton, A., Buckingham, L. A., Scalzo, A. A., & Schofield, L. (2005) · Infection and Immunity · doi:10.1128/iai.73.4.2288-2297.2005 · Cited by 60

Authors: Qin, S., Rottman, J. B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A. E., Moser, B., & Mackay, C. R.
Affiliations: Brigham and Women's Hospital (US)
University of Bern (CH)
Northwestern University (US)
ORCID: Rottman, J B
Weinblatt, M
Moser, B
Mackay, C R
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1998-02-15
Volume: 101
Issue: 4
Pages: 746-754
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci1422
PMC: PMC508621
OpenAlex: W2081596482
Cited by: 1,359
References: 39
Citations by year: 2026: 6 · 2025: 25 · 2024: 11 · 2023: 20 · 2022: 24 · 2021: 33 · 2020: 23 · 2019: 33 · 2018: 32 · 2017: 33 · 2016: 24 · 2015: 46 · 2014: 52 · 2013: 38 · 2012: 45
FWCI: 37.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
Keywords: CXCR3, CCR5, chemokine receptors, T cell subsets, T cell homing, inflammatory cell infiltration, Th1 response, CXCL10, RANTES, CCL22, CCL19, CD45RO, beta1 integrin, T cell migration, lymph node T cells
MeSH terms: Animals, Antibodies, Monoclonal, Chemotaxis, Humans, Immunologic Memory, Inflammation, Leukocytes, Lymphocyte Activation, Lymphocytes, Mice, Inbred BALB C, Synovial Fluid, Tumor Cells, Cultured, Biomarkers, T-Lymphocyte Subsets, Chemokines, Receptors, Chemokine, Receptors, CCR5, Chemokines, CXC, Mice, Chemokine CXCL10, Receptors, CXCR3

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks