Mackay, Charles R.

Regulation of inflammatory responses by gut microbiota and chemoattractant receptor GPR43

Maslowski, K. M., Vieira, A. T., Ng, A., Kranich, J., Sierro, F., Yu, D., Schilter, H. C., Rolph, M. S., Mackay, F., Artis, D., et al. (2009) · Nature

Gut microbiota and healthInflammatory Bowel Disease

Cited by 3,241

The role of short chain fatty acids in health and disease

Tan, J., McKenzie, C., Potamitis, M., Thorburn, A. N., Mackay, C. R., & Macia, L. (2014) · Advances in immunology

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 2,425

Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome

Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., Ian McKenzie, C., Hijikata, A., Wong, C., et al. (2015) · Nature Communications

Gut microbiota and healthGastrointestinal motility and disorders

Cited by 1,439

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

Qin, S., Rottman, J. B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A. E., Moser, B., & Mackay, C. R. (1998) · Journal of Clinical Investigation

Chemokine receptors and signalingCell Adhesion Molecules Research

Cited by 1,359

Diet, gut microbiota and immune responses

Maslowski, K. M., & Mackay, C. R. (2011) · Nature Immunology

Gut microbiota and healthAsthma and respiratory diseases

Cited by 1,261

The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes

Bleul, C. C., Wu, L., Hoxie, J. A., Springer, T. A., & Mackay, C. R. (1997) · Proceedings of the National Academy of Sciences

Chemokine receptors and signalingHIV Research and Treatment

Cited by 1,134

High-Fiber Diet and Acetate Supplementation Change the Gut Microbiota and Prevent the Development of Hypertension and Heart Failure in Hypertensive Mice

Marques, F. Z., Nelson, E., Chu, P.-Y., Horlock, D., Fiedler, A., Ziemann, M., Tan, J. K., Kuruppu, S., Rajapakse, N. W., El-Osta, A., et al. (2017) · Circulation

Gut microbiota and healthCardiac Fibrosis and Remodeling

Cited by 1,065

Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

Sallusto, F., Mackay, C. R., & Lanzavecchia, A. (1997) · Science

Chemokine receptors and signalingAsthma and respiratory diseases

Cited by 1,050

Diet, metabolites, and “western-lifestyle” inflammatory diseases

Thorburn, A. N., Macia, L., & Mackay, C. R. (2014) · Immunity

Gut microbiota and healthAdipokines, Inflammation, and Metabolic Diseases

Cited by 879

Gut microbial metabolites facilitate anticancer therapy efficacy by modulating cytotoxic CD8+ T cell immunity

He, Y., Fu, L., Li, Y., Wang, W., Gong, M., Zhang, J., Dong, X., Huang, J., Wang, Q., Mackay, C. R., et al. (2021) · Cell Metabolism

Gut microbiota and healthCancer Immunotherapy and Biomarkers

Cited by 729

T Follicular Helper Cells Express a Distinctive Transcriptional Profile, Reflecting Their Role as Non-Th1/Th2 Effector Cells That Provide Help for B Cells

Chtanova, T., Tangye, S. G., Newton, R., Frank, N., Hodge, M. R., Rolph, M. S., & Mackay, C. R. (2004) · The Journal of Immunology

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 722

Gut microbial metabolites limit the frequency of autoimmune T cells and protect against type 1 diabetes

Mariño, E., Richards, J. L., McLeod, K. H., Stanley, D., Yap, Y. A., Knight, J., McKenzie, C., Kranich, J., Oliveira, A. C., Rossello, F. J., et al. (2017) · Nature Immunology

Gut microbiota and healthT-cell and B-cell Immunology

Cited by 686

Targeting dual-specificity phosphatases: Manipulating MAP kinase signalling and immune responses

Jeffrey, K. L., Camps, M., Rommel, C., & Mackay, C. R. (2007) · Nature Reviews Drug Discovery

Protein Tyrosine PhosphatasesProtein Kinase Regulation and GTPase Signaling

Cited by 533

Dietary metabolites and the gut microbiota: an alternative approach to control inflammatory and autoimmune diseases

Richards, J. L., Yap, Y. A., McLeod, K. H., Mackay, C. R., & Mariño, E. (2016) · Clinical & Translational Immunology

Gut microbiota and healthNutritional Studies and Diet

Cited by 250

Diet-derived short chain fatty acids stimulate intestinal epithelial cells to induce mucosal tolerogenic dendritic cells

Goverse, G., Molenaar, R., Macia, L., Tan, J., Erkelens, M. N., Konijn, T., Knippenberg, M., Cook, E. C. L., Hanekamp, D., Veldhoen, M., et al. (2017) · The Journal of Immunology

Gut microbiota and healthMicrobial Metabolites in Food Biotechnology

Cited by 200