Cited by 1,359Chemokine receptors and signalingCell Adhesion Molecules ResearchMacrophage Migration Inhibitory Factor

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

Open access

Qin, S, Rottman, J B, Myers, P, Kassam, N, Weinblatt, M, Loetscher, M, Koch, A E, Moser, B, Mackay, C R·1998·Journal of Clinical Investigation

DOI 10.1172/jci1422PMC PMC508621

Open this paper in CoChat — free account

Abstract

T cells infiltrating inflammatory sites are usually of the activated/memory type. The precise mechanism for the positioning of these cells within tissues is unclear. Adhesion molecules certainly play a role; however, the intricate control of cell migration appears to be mediated by numerous chemokines and their receptors. Particularly important chemokines for activated/memory T cells are the CXCR3 ligands IP-10 and Mig and the CCR5 ligands RANTES, macrophage inflammatory protein-1alpha, and macrophage inflammatory protein-1beta. We raised anti-CXCR3 mAbs and were able to detect high levels of CXCR3 expression on activated T cells. Surprisingly, a proportion of circulating blood T cells, B cells, and natural killer cells also expressed CXCR3. CCR5 showed a similar expression pattern as CXCR3, but was expressed on fewer circulating T cells. Blood T cells expressing CXCR3 (and CCR5) were mostly CD45RO+, and generally expressed high levels of beta1 integrins. This phenotype resembled that of T cells infiltrating inflammatory lesions. Immunostaining of T cells in rheumatoid arthritis synovial fluid confirmed that virtually all such T cells expressed CXCR3 and approximately 80% expressed CCR5, representing high enrichment over levels of CXCR3+ and CCR5+ T cells in blood, 35 and 15%, respectively. Analysis by immunohistochemistry of various inflamed tissues gave comparable findings in that virtually all T cells within the lesions expressed CXCR3, particularly in perivascular regions, whereas far fewer T cells within normal lymph nodes expressed CXCR3 or CCR5. These results demonstrate that the chemokine receptor CXCR3 and CCR5 are markers for T cells associated with certain inflammatory reactions, particularly TH-1 type reactions. Moreover, CXCR3 and CCR5 appear to identify subsets of T cells in blood with a predilection for homing to these sites.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci1422

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm
Springer, T. A. (1994) · Cell · doi:10.1016/0092-8674(94)90337-9 · Cited by 7,009
Current Protocols in Immunology
(2018) · Current Protocols in Immunology · doi:10.1002/(issn)1934-368x · Cited by 3,574
Lymphocyte Homing and Homeostasis
Butcher, E. C., & Picker, L. J. (1996) · Science · doi:10.1126/science.272.5258.60 · Cited by 2,846
Human Chemokines: An Update
Baggiolini, M., Dewald, B., & Moser, B. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.675 · Cited by 2,193
Self-citation
The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry
Bleul, C. C., Farzan, M., Choe, H., Parolin, C., Clark‐Lewis, I., Sodroski, J., & Springer, T. A. (1996) · Nature · doi:10.1038/382829a0 · Cited by 1,953
The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1
Oberlin, E., Amara, A., Bachelerie, F., Chable-Bessia, C., Virelizier, J., Arenzana‐Seisdedos, F., Schwartz, O., Heard, J., Clark‐Lewis, I., Legler, D. F., et al. (1996) · Nature · doi:10.1038/382833a0 · Cited by 1,652
Self-citation
A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)
Bleul, C. C., Fuhlbrigge, R. C., Casasnovas, J. M., Aiuti, A., & Springer, T. A. (1996) · The Journal of experimental medicine · doi:10.1084/jem.184.3.1101 · Cited by 1,482
Current protocols in immunology
Nezlin, R. S. (1992) · Molecular Immunology · doi:10.1016/0161-5890(92)90114-d · Cited by 1,413
Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES
Schall, T. J., Bacon, K. B., Toy, K. J., & Goeddel, D. V. (1990) · Nature · doi:10.1038/347669a0 · Cited by 1,378
Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes
Loetscher, M., Gerber, B., Loetscher, P., Jones, S. A., Piali, L., Clark-Lewis, I., Baggiolini, M., & Moser, B. (1996) · Journal of Experimental Medicine · doi:10.1084/jem.184.3.963 · Cited by 1,333
Self-citation

Show all 39 references

Sorted by citations

Evolving concepts of rheumatoid arthritis
Firestein, G. S. (2003) · Nature · doi:10.1038/nature01661 · Cited by 3,653
Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing
Chamberlain, G., Fox, J. M., Ashton, B. A., & Middleton, J. (2007) · Stem Cells · doi:10.1634/stemcells.2007-0197 · Cited by 2,432
International Union of Pharmacology. XXII. Nomenclature for Chemokine Receptors
Murphy, P. M., Baggiolini, M., Charo, I. F., Hébert, C. A., Horuk, R., Matsushima, K., Miller, L. H., Oppenheim, J. J., & Power, C. A. (2000) · Pharmacological Reviews · doi:10.1016/s0031-6997(24)01439-x · Cited by 1,817
Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes
Sallusto, F., Lenig, D., Mackay, C. R., & Lanzavecchia, A. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.6.875 · Cited by 1,535
Self-citation
T-Cell Function and Migration — Two Sides of the Same Coin
von Andrian, U. H., & Mackay, C. R. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010053431407 · Cited by 1,429
Self-citation
Chemokines and disease
Gerard, C., & Rollins, B. J. (2001) · Nature Immunology · doi:10.1038/84209 · Cited by 1,357
Lymphocyte traffic control by chemokines
Moser, B., & Loetscher, P. (2001) · Nature Immunology · doi:10.1038/84219 · Cited by 1,253
Self-citation
IFN-γ-Inducible Protein 10 (IP-10; CXCL10)-Deficient Mice Reveal a Role for IP-10 in Effector T Cell Generation and Trafficking
Dufour, J. H., Dziejman, M., Liu, M. T., Leung, J. H., Lane, T. E., & Luster, A. D. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3195 · Cited by 1,075
The Role of Chemokine Receptors in Primary, Effector, and Memory Immune Responses
Sallusto, F., Mackay, C. R., & Lanzavecchia, A. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.593 · Cited by 1,054
Self-citation
CXCR3 ligands: redundant, collaborative and antagonistic functions
Groom, J. R., & Luster, A. D. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2010.158 · Cited by 1,006
Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients
Sørensen, T. L., Tani, M., Jensen, J. S., Pierce, V., Lucchinetti, C. F., Folcik, V. A., Qin, S., Rottman, J., Sellebjerg, F. T., Strieter, R. M., et al. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5150 · Cited by 994
Self-citation
CXCR3 in T cell function
Groom, J. R., & Luster, A. D. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.12.017 · Cited by 1,005
Type 1/Type 2 Immunity in Infectious Diseases
Spellberg, B. J., & Edwards, J. E. (2001) · Clinical Infectious Diseases · doi:10.1086/317537 · Cited by 923
Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses
Sallusto, F., Lanzavecchia, A., & Mackay, C. R. (1998) · Immunology Today · doi:10.1016/s0167-5699(98)01346-2 · Cited by 888
Self-citation
International Union of Basic and Clinical Pharmacology. LXXXIX. Update on the Extended Family of Chemokine Receptors and Introducing a New Nomenclature for Atypical Chemokine Receptors
Bachelerie, F., Ben‐Baruch, A., Burkhardt, A. M., Combadière, C., Farber, J. M., Graham, G. J., Horuk, R., Sparre‐Ulrich, A. H., Locati, M., Luster, A. D., et al. (2013) · Pharmacological Reviews · doi:10.1124/pr.113.007724 · Cited by 888
Chemokines: immunology's high impact factors
Mackay, C. R. (2001) · Nature Immunology · doi:10.1038/84298 · Cited by 842
Self-citation
The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
Campbell, J. J., Haraldsen, G., Pan, J., Rottman, J. B., Qin, S., Ponath, P. D., Andrew, D. P., Warnke, R. A., Ruffing, N., Kassam, N., et al. (1999) · Nature · doi:10.1038/23495 · Cited by 833
Self-citation
CXC chemokines in angiogenesis
Belperio, J. A., Keane, M. P., Arenberg, D. A., Addison, C., Ehlert, J. E., Burdick, M. D., & Strieter, R. M. (2000) · Journal of Leukocyte Biology · doi:10.1189/jlb.68.1.1 · Cited by 822
Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes
Jäger, A., Dardalhon, V., Sobel, R. A., Bettelli, E., & Kuchroo, V. K. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901906 · Cited by 783
Chemokines and chemokine receptors in leukocyte trafficking
Olson, T. S., & Ley, K. F. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00738.2001 · Cited by 670
Kaempferol and inflammation: from chemistry to medicine
Devi, K. P., Malar, D. S., Nabavi, S. F., Sureda, A., Xiao, J., Nabavi, S. M., & Daglia, M. (2015) · Pharmacological Research · doi:10.1016/j.phrs.2015.05.002 · Cited by 619
The immunologic basis for the treatment of psoriasis with new biologic agents
Krueger, J. G. (2002) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2002.120568 · Cited by 594
T Cell Dynamics in HIV-1 Infection
Douek, D. C., Picker, L. J., & Koup, R. A. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141053 · Cited by 579
Neutrophil-Derived Proteins: Selling Cytokines by the Pound
Cassatella, M. A. (1999) · Advances in immunology · doi:10.1016/s0065-2776(08)60791-9 · Cited by 558
Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition)
Cossarizza, A., Chang, H., Radbruch, A., Abrignani, S., Addo, R., Akdis, M., Andrä, I., Andreata, F., Annunziato, F., Arranz, E., et al. (2021) · European Journal of Immunology · doi:10.1002/eji.202170126 · Cited by 531
Role of chemokines in the biology of natural killer cells
Robertson, M. J. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.2.173 · Cited by 515
Chemokine receptors in the central nervous system: role in brain inflammation and neurodegenerative diseases
Cartier, L., Hartley, O., Dubois‐Dauphin, M., & Krause, K. (2004) · Brain Research Reviews · doi:10.1016/j.brainresrev.2004.07.021 · Cited by 520
Pathogenesis of HIV infection: what the virus spares is as important as what it destroys
Grossman, Z., Meier‐Schellersheim, M., Paul, W. E., & Picker, L. J. (2006) · Nature Medicine · doi:10.1038/nm1380 · Cited by 518
Concurrent enteric helminth infection modulates inflammation and gastric immune responses and reduces helicobacter-induced gastric atrophy
Fox, J. G., Beck, P. L., Dangler, C. A., Whary, M. T., Wang, T. C., Shi, H. N., & Nagler‐Anderson, C. (2000) · Nature Medicine · doi:10.1038/75015 · Cited by 489
Radiation-Induced IFN-γ Production within the Tumor Microenvironment Influences Antitumor Immunity
Lugade, A. A., Sorensen, E. W., Gerber, S. A., Moran, J. P., Frelinger, J. G., & Lord, E. M. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.5.3132 · Cited by 485
Human G Protein–Coupled Receptor Gpr-9-6/Cc Chemokine Receptor 9 Is Selectively Expressed on Intestinal Homing T Lymphocytes, Mucosal Lymphocytes, and Thymocytes and Is Required for Thymus-Expressed Chemokine–Mediated Chemotaxis
Zabel, B. A., Agace, W. W., Campbell, J. J., Heath, H., Parent, D., Roberts, A. I., Ebert, E. C., Kassam, N., Qin, S., Zovko, M., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.9.1241 · Cited by 485
Self-citation
B Cells and T Follicular Helper Cells Mediate Response to Checkpoint Inhibitors in High Mutation Burden Mouse Models of Breast Cancer
Hollern, D. P., Xu, N., Thennavan, A., Glodowski, C. R., García‐Recio, S., Mott, K. R., He, X., Garay, J. P., Carey-Ewend, K., Marron, D. L., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.028 · Cited by 480
Differential expression of three T lymphocyte-activating CXC chemokines by human atheroma-associated cells
Mach, F., Sauty, A., Iarossi, A. S., Sukhova, G. K., Neote, K. S., Libby, P., & Luster, A. D. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6993 · Cited by 466
Cutting Edge: Selective Up-Regulation of Chemokine Receptors CCR4 and CCR8 upon Activation of Polarized Human Type 2 Th Cells
D’Ambrosio, D., Iellem, A., Bonecchi, R., Mazzeo, D., Sozzani, S., Mantovani, A., & Sinigaglia, F. (1998) · The Journal of Immunology · doi:10.4049/jimmunol.161.10.5111 · Cited by 461
Expression and Characterization of the Chemokine Receptors CCR2 and CCR5 in Mice
Mack, M., Cihak, J., Simonis, C., Luckow, B., Proudfoot, A. E. I., Plachý, J., Brühl, H., Frink, M., Anders, H., Vielhauer, V., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.7.4697 · Cited by 459
Stromal Cell-Derived Factor-1-CXC Chemokine Receptor 4 Interactions Play a Central Role in CD4+ T Cell Accumulation in Rheumatoid Arthritis Synovium
Nanki, T., Hayashida, K., El-Gabalawy, H. S., Suson, S., Shi, K., Girschick, H. J., Yavuz, S., & Lipsky, P. E. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.11.6590 · Cited by 450
The C-C chemokine receptors CCR4 and CCR8 identify airway T cells of allergen-challenged atopic asthmatics
Panina‐Bordignon, P., Papi, A. A., Mariani, M., Lucia, P. D., Casoni, G. L., Bellettato, C. M., Buonsanti, C., Miotto, D., Mapp, C. E., Villa, A., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci12655 · Cited by 442
The emerging role of epigenetic therapeutics in immuno-oncology
Topper, M. J., Vaz, M., Marrone, K. A., Brahmer, J. R., & Baylin, S. B. (2020) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-019-0266-5 · Cited by 433
Chemokines in Immunity
Yoshie, O., Imai, T., & Nomiyama, H. (2001) · Advances in immunology · doi:10.1016/s0065-2776(01)78002-9 · Cited by 430
Chemokine and Chemokine Receptor Interactions Provide a Mechanism for Selective T Cell Recruitment to Specific Liver Compartments Within Hepatitis C-Infected Liver
Shields, P. L., Morland, C. M., Salmon, M., Qin, S., Hübscher, S. G., & Adams, D. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.163.11.6236 · Cited by 424
Self-citation
CXC chemokines in angiogenesis
Strieter, R. M., Burdick, M. D., Gomperts, B. N., Belperio, J. A., & Keane, M. P. (2005) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2005.04.007 · Cited by 430
Functionally distinct subsets of human FOXP3+ Treg cells that phenotypically mirror effector Th cells
Duhen, T., Duhen, R., Lanzavecchia, A., Sallusto, F., & Campbell, D. J. (2012) · Blood · doi:10.1182/blood-2011-11-392324 · Cited by 413
Cytokines and Chemokines inMycobacterium tuberculosisInfection
Domingo-Gonzalez, R., Prince, O. A., Cooper, A. M., & Khader, S. A. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.tbtb2-0018-2016 · Cited by 434
The Significance of Vasoactive Intestinal Peptide in Immunomodulation
Delgado, M., Pozo, D., & Ganea, D. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.2.7 · Cited by 415
The emerging role of CXCL10 in cancer (Review)
Liu, M., Guo, S., & Stiles, J. K. (2011) · Oncology Letters · doi:10.3892/ol.2011.300 · Cited by 425
Cancer CXC chemokine networks and tumour angiogenesis
Strieter, R. M., Burdick, M. D., Mestas, J., Gomperts, B. N., Keane, M. P., & Belperio, J. A. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.01.006 · Cited by 419
Differential chemokine receptor expression and function in human monocyte subpopulations
Weber, C., Belge, K.-U., von Hundelshausen, P., Draude, G., Steppich, B., Mack, M., Frankenberger, M., Weber, K. S. C., & Ziegler-Heitbrock, H. W. L. (2000) · Journal of Leukocyte Biology · doi:10.1002/jlb.67.5.699 · Cited by 425
Chemokines and T Lymphocytes
Ward, S. G., Bacon, K. B., & Westwick, J. K. (1998) · Immunity · doi:10.1016/s1074-7613(00)80583-x · Cited by 397
Roles of TH1 and TH2 cytokines in a murine model of allergic dermatitis
Spergel, J. M., Mizoguchi, E., Oettgen, H. C., Bhan, A. K., & Geha, R. S. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5669 · Cited by 383
Cell cycle–dependent expression of CXC chemokine receptor 3 by endothelial cells mediates angiostatic activity
Romagnani, P., Annunziato, F., Lasagni, L., Lazzeri, E., Beltrame, C., Francalanci, M., Uguccioni, M., Galli, G., Cosmi, L., Maurenzig, L., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci9775 · Cited by 377
The T Cell-Specific CXC Chemokines IP-10, Mig, and I-TAC Are Expressed by Activated Human Bronchial Epithelial Cells
Sauty, A., Dziejman, M., Taha, R. A., Iarossi, A. S., Neote, K. S., García-Zepeda, E. A., Hamid, Q. A., & Luster, A. D. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.6.3549 · Cited by 373
Donor-Derived Ip-10 Initiates Development of Acute Allograft Rejection
Hancock, W. W., Gao, W., Csizmadia, V., Faia, K. L., Shemmeri, N., & Luster, A. D. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.8.975 · Cited by 373
Chemotactic Responsiveness Toward Ligands for CXCR3 and CXCR4 Is Regulated on Plasma Blasts During the Time Course of a Memory Immune Response
Hauser, A. E., Debes, G. F., Arce, S., Cassese, G., Hamann, A., Radbruch, A., & Manz, R. A. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.169.3.1277 · Cited by 362
Are some breast carcinomas polyclonal in origin?
Heim, S., Teixeira, M. R., & Pandis, N. (2001) · The Journal of Pathology · doi:10.1002/1096-9896(200108)194:4 · Cited by 16
Pyrrolidine dithiocarbamate protects mice from lethal shock induced by LPS or TNF-α
Lauzurica, P., Martı́nez-Martı́nez, S., Marazuela, M., Arco, P. G., Martínez‐A, C., Sánchez‐Madrid, F., & Redondo, J. M. (1999) · European Journal of Immunology · doi:10.1002/(sici)1521-4141(199906)29:06 · Cited by 71
Self-citation
Untitled work
(2003) · PubMed · Cited by 355
The role and therapeutic implications of fibroblast‐like synoviocytes in inflammation and cartilage erosion in rheumatoid arthritis
Noss, E. H., & Brenner, M. B. (2008) · Immunological Reviews · doi:10.1111/j.1600-065x.2008.00648.x · Cited by 359
Bonzo/CXCR6 expression defines type 1–polarized T-cell subsets with extralymphoid tissue homing potential
Kim, C. H., Kunkel, E. J., Boisvert, J., Johnston, B., Campbell, J. J., Genovese, M. C., Greenberg, H. B., & Butcher, E. C. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11902 · Cited by 352
Levels of Interleukin‐1β, ‐8, and ‐10 and RANTES in Gingival Crevicular Fluid and Cell Populations in Adult Periodontitis Patients and the Effect of Periodontal Treatment
Gamonal, J. A., Acevedo, A., Bascones, A., Jorge, O., & Silva, A. H. L. (2000) · Journal of Periodontology · doi:10.1902/jop.2000.71.10.1535 · Cited by 353
Survival of long-lived plasma cells is independent of antigen [In Process Citation]
Manz, R. A. (1998) · International Immunology · doi:10.1093/intimm/10.11.1703 · Cited by 348
Chemokine receptors
Horuk, R. (2001) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(01)00014-4 · Cited by 348
Early commitment of naïve human CD4+ T cells to the T follicular helper (TFH) cell lineage is induced by IL‐12
Ma, C. S., Suryani, S., Avery, D. T., Chan, A., Nanan, R. K. H., Santner‐Nanan, B., Deenick, E. K., & Tangye, S. G. (2009) · Immunology and Cell Biology · doi:10.1038/icb.2009.64 · Cited by 358
Chemokines: signal lamps for trafficking of T and B cells for development and effector function
Kim, C. H., & Broxmeyer, H. E. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.65.1.6 · Cited by 338
EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-γ and IL-2
Lünemann, J. D., Jelčić, I., Roberts, S., Lutterotti, A., Tackenberg, B., Martinꝉ, R., & Münz, C. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072397 · Cited by 348
IL-6 trans-signaling via STAT3 directs T cell infiltration in acute inflammation
McLoughlin, R. M., Jenkins, B. J., Grail, D., Williams, A. S., Fielding, C. A., Parker, C. R., Ernst, M., Topley, N., & Jones, S. A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501794102 · Cited by 340
Chemokines in the systemic organization of immunity
Campbell, D. J., Kim, C. H., & Butcher, E. C. (2003) · Immunological Reviews · doi:10.1034/j.1600-065x.2003.00067.x · Cited by 330
CXCR3 and CCR5 Ligands in Rheumatoid Arthritis Synovium
Patel, D. D., Zachariah, J. P., & Whichard, L. P. (2001) · Clinical Immunology · doi:10.1006/clim.2000.4957 · Cited by 328
Frequent expression of CCR4 in adult T-cell leukemia and human T-cell leukemia virus type 1-transformed T cells
Yoshie, O., Fujisawa, R., Nakayama, T., Harasawa, H., Tago, H., Izawa, D., Hieshima, K., Tatsumi, Y., Matsushima, K., Hasegawa, H., et al. (2002) · Blood · doi:10.1182/blood.v99.5.1505 · Cited by 326
Persistent Induction of the Chemokine Receptor CXCR4 by TGF-β1 on Synovial T Cells Contributes to Their Accumulation Within the Rheumatoid Synovium
Buckley, C. D., Amft, N., Bradfield, P. F., Pilling, D., Ross, E. A., Arenzana‐Seisdedos, F., Amara, A., Curnow, J., Lord, J. M., Scheel‐Toellner, D., et al. (2000) · The Journal of Immunology · doi:10.4049/jimmunol.165.6.3423 · Cited by 325
Overview of the Mechanisms that May Contribute to the Non-Redundant Activities of Interferon-Inducible CXC Chemokine Receptor 3 Ligands
Metzemaekers, M., Vanheule, V., Janssens, R., Struyf, S., & Proost, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01970 · Cited by 335
The Ligands of CXC Chemokine Receptor 3, I-TAC, Mig, and IP10, Are Natural Antagonists for CCR3
Loetscher, P., Pellegrino, A., Gong, J.-H., Mattioli, I., Loetscher, M., Bardi, G., Baggiolini, M., & Clark‐Lewis, I. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m005652200 · Cited by 316
Self-citation
Leukocyte migration and graft-versus-host disease
Wysocki, C., Panoskaltsis‐Mortari, A., Blazar, B. R., & Serody, J. S. (2005) · Blood · doi:10.1182/blood-2004-12-4726 · Cited by 323
Gene Expression and Production of the Monokine Induced by IFN-γ (MIG), IFN-Inducible T Cell α Chemoattractant (I-TAC), and IFN-γ-Inducible Protein-10 (IP-10) Chemokines by Human Neutrophils
Gasperini, S., Marchi, M., Calzetti, F., Laudanna, C., Vicentini, L. M., Olsen, H. S., Murphy, M., Liao, F., Farber, J. M., & Cassatella, M. A. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.8.4928 · Cited by 314
CXCR5 Expressing Human Central Memory CD4 T Cells and Their Relevance for Humoral Immune Responses
Chevalier, N., Jarrossay, D., Ho, E. C., Avery, D. T., Ma, C. S., Yu, D., Sallusto, F., Tangye, S. G., & Mackay, C. R. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002828 · Cited by 326
Self-citation
Glucocorticoids—All-Rounders Tackling the Versatile Players of the Immune System
Strehl, C., Ehlers, L., Gaber, T., & Buttgereit, F. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01744 · Cited by 308
Herpes keratitis
Rowe, A. M., Leger, A. J. S., Jeon, S., Dhaliwal, D. K., Knickelbein, J. E., & Hendricks, R. L. (2012) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2012.08.002 · Cited by 303
IL-1β, IL-6, and RANTES as Biomarkers of Chikungunya Severity
Ng, L. F. P., Chow, A. L., Sun, Y.-J., Kwek, D. J. C., Lim, P., Dimatatac, F., Ng, L. C., Ooi, E. E., Choo, K. H., Her, Z., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004261 · Cited by 302
Cooperation between Th1 and Th2 cells in a murine model of eosinophilic airway inflammation
Randolph, D. A., Stephens, R., Carruthers, C. J. L., & Chaplin, D. (1999) · Journal of Clinical Investigation · doi:10.1172/jci7631 · Cited by 301
Regulation of pulmonary fibrosis by chemokine receptor CXCR3
Jiang, D., Liang, J., Hodge, J. A., Lu, B., Zhu, Z., Yu, S., Fan, J., Gao, Y., Yin, Z., Homer, R., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci16861 · Cited by 303
Active participation of CCR5+CD8+ T lymphocytes in the pathogenesis of liver injury in graft-versus-host disease
Murai, M., Yoneyama, H., Harada, A., Zhang, Y., Vestergaard, C., Guo, B., Suzuki, K., Asakura, H., & Matsushima, K. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6642 · Cited by 298
High CXCR3 expression in synovial mast cells associated with CXCL9 and CXCL10 expression in inflammatory synovial tissues of patients with rheumatoid arthritis
Ruschpler, P., Lorenz, P., Eichler, W., Koczan, D., Hänel, C., Scholz, R., Melzer, C., Thiesen, H., & Stiehl, P. (2003) · Arthritis Research & Therapy · doi:10.1186/ar783 · Cited by 292
CC Chemokine Receptors and Chronic Inflammation—Therapeutic Opportunities and Pharmacological Challenges
White, G. E., Iqbal, A. J., & Greaves, D. R. (2013) · Pharmacological Reviews · doi:10.1124/pr.111.005074 · Cited by 295
Chemokine Receptor Expression Identifies Pre–T Helper (Th)1, Pre–Th2, and Nonpolarized Cells among Human CD4+ Central Memory T Cells
Rivino, L., Messi, M., Jarrossay, D., Lanzavecchia, A., Sallusto, F., & Geginat, J. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040774 · Cited by 298
Expression and regulation of chemokine receptors in human natural killer cells
Inngjerdingen, M., Damaj, B. B., & Maghazachi, A. A. (2001) · Blood · doi:10.1182/blood.v97.2.367 · Cited by 287
Immunosenescent CD8 + T Cells and C-X-C Chemokine Receptor Type 3 Chemokines Are Increased in Human Hypertension
Youn, J., Yu, H. T., Lim, B. J., Koh, M. J., Lee, J., Chang, D.-Y., Choi, Y. S., Lee, S., Kang, S., Jang, Y., et al. (2013) · Hypertension · doi:10.1161/hypertensionaha.113.00689 · Cited by 289
Effector and Regulatory T-cell Subsets in Autoimmunity and Tissue Inflammation
Jäger, A., & Kuchroo, V. K. (2010) · Scandinavian Journal of Immunology · doi:10.1111/j.1365-3083.2010.02432.x · Cited by 296
IP-10 Is Critical for Effector T Cell Trafficking and Host Survival in Toxoplasma gondii Infection
Khan, I. A., MacLean, J. A., Lee, F. S., Casciotti, L., DeHaan, E. N., Schwartzman, J. D., & Luster, A. D. (2000) · Immunity · doi:10.1016/s1074-7613(00)80200-9 · Cited by 281
Histidyl–tRNA Synthetase and Asparaginyl–tRNA Synthetase, Autoantigens in Myositis, Activate Chemokine Receptors on T Lymphocytes and Immature Dendritic Cells
Howard, O. M. Z., Dong, H., Yang, D., Raben, N., Nagaraju, K., Rosen, A., Casciola-Rosen, L. A., Haertlein, M., Kron, M., Yang, D. C. H., et al. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20020186 · Cited by 279
Intracellular Domains of CXCR3 That Mediate CXCL9, CXCL10, and CXCL11 Function
Colvin, R. A., Campanella, G. S. V., Sun, J., & Luster, A. D. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m403595200 · Cited by 276
Expression of the chemokine receptor CXCR3 on neurons and the elevated expression of its ligand IP-10 in reactive astrocytes: in vitro ERK1/2 activation and role in Alzheimer’s disease
Xia, M. Q., Bacskai, B. J., Knowles, R. B., Qin, S. X., & Hyman, B. T. (2000) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(00)00285-x · Cited by 269
Self-citation
Chemokines: attractive mediators of the immune response
Wong, M., & Fish, E. N. (2002) · Seminars in Immunology · doi:10.1016/s1044-5323(02)00123-9 · Cited by 270
Chemokine Receptor Responses on T Cells Are Achieved Through Regulation of Both Receptor Expression and Signaling
Rabin, R. L., Park, M. K., Liao, F., Swofford, R., Stephany, D., & Farber, J. M. (1999) · The Journal of Immunology · doi:10.4049/jimmunol.162.7.3840 · Cited by 266
Multicenter Validation of Urinary CXCL9 as a Risk-Stratifying Biomarker for Kidney Transplant Injury
Hricik, D. E., Nickerson, P. W., Formica, R. N., Poggio, E. D., Rush, D. N., Newell, K. A., Goebel, J., Gibson, I. W., Fairchild, R. L., Riggs, M. R., et al. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12426 · Cited by 265
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility
Kochi, Y., Okada, Y., Suzuki, A., Ikari, K., Terao, C., Takahashi, A., Yamazaki, K., Hosono, N., Myouzen, K., Tsunoda, T., et al. (2010) · Nature Genetics · doi:10.1038/ng.583 · Cited by 268
Multiple sclerosis: a study of CXCL10 and CXCR3 co-localization in the inflamed central nervous system
Sørensen, T. L., Trebst, C., Kivisäkk, P., Klaege, K. L., Majmudar, A., Ravid, R., Lassmann, H., Olsen, D. B., Strieter, R. M., Ransohoff, R. M., et al. (2002) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(02)00097-8 · Cited by 262
Intervention of Thymus and Activation-Regulated Chemokine Attenuates the Development of Allergic Airway Inflammation and Hyperresponsiveness in Mice
Kawasaki, S., Takizawa, H., Yoneyama, H., Nakayama, T., Fujisawa, R., Izumizaki, M., Imai, T., Yoshie, O., Homma, I., Yamamoto, K., et al. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.3.2055 · Cited by 261
Expression of CCR-7, MIP-3β, and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities
Parlato, S., Santini, S. M., Lapenta, C., Pucchio, T. D., Logozzi, M., Spada, M., Giammarioli, A. M., Malorni, W., Fais, S., & Belardelli, F. (2001) · Blood · doi:10.1182/blood.v98.10.3022 · Cited by 259
CXC Chemokines in Cancer Angiogenesis and Metastases
Keeley, E. C., Mehrad, B., & Strieter, R. M. (2010) · Advances in cancer research · doi:10.1016/s0065-230x(10)06003-3 · Cited by 263
T cells expressing the transcription factor PLZF regulate the development of memory-like CD8+ T cells
Weinreich, M. A., Odumade, O. A., Jameson, S. C., & Hogquist, K. A. (2010) · Nature Immunology · doi:10.1038/ni.1898 · Cited by 262
CXCL10 (IFN-γ-Inducible Protein-10) Control of Encephalitogenic CD4+ T Cell Accumulation in the Central Nervous System During Experimental Autoimmune Encephalomyelitis
Fife, B. T., Kennedy, K. J., Paniagua, M. C., Lukacs, N. W., Kunkel, S. L., Luster, A. D., & Karpus, W. J. (2001) · The Journal of Immunology · doi:10.4049/jimmunol.166.12.7617 · Cited by 255

Authors: Qin, S., Rottman, J. B., Myers, P., Kassam, N., Weinblatt, M., Loetscher, M., Koch, A. E., Moser, B., & Mackay, C. R.
Affiliations: Brigham and Women's Hospital (US)
University of Bern (CH)
Northwestern University (US)
ORCID: Rottman, J B
Weinblatt, M
Moser, B
Mackay, C R
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1998-02-15
Volume: 101
Issue: 4
Pages: 746-754
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci1422
PMC: PMC508621
OpenAlex: W2081596482
Cited by: 1,359
References: 39
Citations by year: 2026: 6 · 2025: 25 · 2024: 11 · 2023: 20 · 2022: 24 · 2021: 33 · 2020: 23 · 2019: 33 · 2018: 32 · 2017: 33 · 2016: 24 · 2015: 46 · 2014: 52 · 2013: 38 · 2012: 45
FWCI: 37.11
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Chemokine receptors and signaling
Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
Life Sciences › Immunology and Microbiology › Immunology › Macrophage Migration Inhibitory Factor
Keywords: CXCR3, CCR5, chemokine receptors, T cell subsets, T cell homing, inflammatory cell infiltration, Th1 response, CXCL10, RANTES, CCL22, CCL19, CD45RO, beta1 integrin, T cell migration, lymph node T cells
MeSH terms: Animals, Antibodies, Monoclonal, Chemotaxis, Humans, Immunologic Memory, Inflammation, Leukocytes, Lymphocyte Activation, Lymphocytes, Mice, Inbred BALB C, Synovial Fluid, Tumor Cells, Cultured, Biomarkers, T-Lymphocyte Subsets, Chemokines, Receptors, Chemokine, Receptors, CCR5, Chemokines, CXC, Mice, Chemokine CXCL10, Receptors, CXCR3

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks