The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation
Open accessAbstract
Different members of the Rel/NF-kappaB family may play different roles in immunity and inflammation. We report here that c-Rel-deficient mice are resistant to autoimmune encephalomyelitis and are defective in Th1, but not Th2 responses. The Th1 deficiency appears to be caused by selective blockade of IL-12 production by c-Rel-deficient antigen-presenting cells, as well as by a complete abrogation of IFN-gamma expression in c-Rel-deficient T cells. Interestingly, c-Rel deficiency does not affect T-bet expression, suggesting that c-Rel may act downstream of T-bet during Th1 cell differentiation. Thus, unlike NF-kappaB1, which selectively regulates Th2 cell differentiation, c-Rel is essential for Th1 cell differentiation and Th1 cell-mediated autoimmune inflammation.
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Das, J., Chen, C.-H., Yang, L., Cohn, L., Ray, P., & Ray, A. (2001) · Nature Immunology · doi:10.1038/83158 · Cited by 518
Distinct roles for the NF-κB1 (p50) and c-Rel transcription factors in inflammatory arthritis
Campbell, I. K., Gerondakis, S., O’Donnell, K., & Wicks, I. P. (2000) · Journal of Clinical Investigation · doi:10.1172/jci8298 · Cited by 168
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Metadata
- Authors
- Hilliard, B. A., Mason, N., Xu, L., Sun, J., Lamhamedi-Cherradi, S.-E., Liou, H.-C., Hunter, C., & Chen, Y. H.
- Venue
- Journal of Clinical Investigation
- Published
- 2002-09-15
- Volume
- 110
- Issue
- 6
- Pages
- 843-850
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2105481942
- Cited by
- 200
- References
- 2
- FWCI
- 4.18
- Type
- journal article
- Language
- en
- Open access
- green
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- Hilliard, B. A., Mason, N., Xu, L., Sun, J., Lamhamedi-Cherradi, S.-E., Liou, H.-C., Hunter, C., & Chen, Y. H. (2002). Critical roles of c-Rel in autoimmune inflammation and helper T cell differentiation. Journal of Clinical Investigation. https://doi.org/10.1172/jci15254
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