The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1.
Open accessAbstract
Insulin resistance is often associated with atherosclerotic diseases in subjects with obesity and impaired glucose tolerance. This study examined the effects of insulin resistance on coronary risk factors in IRS-1 deficient mice, a nonobese animal model of insulin resistance. Blood pressure and plasma triglyceride levels were significantly higher in IRS-1 deficient mice than in normal mice. Impaired endothelium-dependent vascular relaxation was also observed in IRS-1 deficient mice. Furthermore, lipoprotein lipase activity was lower than in normal mice, suggesting impaired lipolysis to be involved in the increase in plasma triglyceride levels under insulin-resistant conditions. Thus, insulin resistance plays an important role in the clustering of coronary risk factors which may accelerate the progression of atherosclerosis in subjects with insulin resistance.
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Cites
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“The mechanism associated with hypertension in insulin resistance with hyperinsulinemia may be related to skeletal muscle blood flow and relative skeletal muscle fiber type (22), vascular endothelial function (23), increased renal sodium reabsorption secondary to hyperinsulinemia (24), increased activity of the sympath…”
BackgroundLillioja, S., Young, A. A., Culter, C. L., Ivy, J. L., Abbott, W. G., Zawadzki, J. K., Yki-Järvinen, H., Christin, L., Secomb, T. W., & Bogardus, C. (1987) · Journal of Clinical Investigation · doi:10.1172/jci113088 · Cited by 782
Cited by
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IRS proteins and the common path to diabetes
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Autonomous Control of Cell and Organ Size by CHICO, a Drosophila Homolog of Vertebrate IRS1–4
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FROM MICE TO MEN: Insights into the Insulin Resistance Syndromes
Biddinger, S. B., & Kahn, C. R. (2006) · Annual Review of Physiology · doi:10.1146/annurev.physiol.68.040104.124723 · Cited by 706
Metadata
- Authors
- Abe, H., Yamada, N., Kamata, K., Kuwaki, T., Shimada, M., Osuga, J., Shionoiri, F., Yahagi, N., Kadowaki, T., Tamemoto, H., Ishibashi, S., Yazaki, Y., & Makuuchi, M.
- Venue
- Journal of Clinical Investigation
- Published
- 1998-04-15
- Volume
- 101
- Issue
- 8
- Pages
- 1784-1788
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2052961933
- Cited by
- 229
- References
- 9
- FWCI
- 10.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1. https://app.cochat.ai/papers/10.1172/jci1594
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- Abe, H., Yamada, N., Kamata, K., Kuwaki, T., Shimada, M., Osuga, J., Shionoiri, F., Yahagi, N., Kadowaki, T., Tamemoto, H., Ishibashi, S., Yazaki, Y., & Makuuchi, M. (1998). Hypertension, hypertriglyceridemia, and impaired endothelium-dependent vascular relaxation in mice lacking insulin receptor substrate-1. Journal of Clinical Investigation. https://doi.org/10.1172/jci1594
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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