The DOI matches its OpenAlex record; 39 of the 39 references it cites were found in a registry or an index.
Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors
Open accessAbstract
Nonmelanoma skin cancer is one of the most common malignancies in humans. Different therapeutic strategies for the treatment of these tumors are currently being investigated. Given the growth-inhibiting effects of cannabinoids on gliomas and the wide tissue distribution of the two subtypes of cannabinoid receptors (CB(1) and CB(2)), we studied the potential utility of these compounds in anti-skin tumor therapy. Here we show that the CB(1) and the CB(2) receptor are expressed in normal skin and skin tumors of mice and humans. In cell culture experiments pharmacological activation of cannabinoid receptors induced the apoptotic death of tumorigenic epidermal cells, whereas the viability of nontransformed epidermal cells remained unaffected. Local administration of the mixed CB(1)/CB(2) agonist WIN-55,212-2 or the selective CB(2) agonist JWH-133 induced a considerable growth inhibition of malignant tumors generated by inoculation of epidermal tumor cells into nude mice. Cannabinoid-treated tumors showed an increased number of apoptotic cells. This was accompanied by impairment of tumor vascularization, as determined by altered blood vessel morphology and decreased expression of proangiogenic factors (VEGF, placental growth factor, and angiopoietin 2). Abrogation of EGF-R function was also observed in cannabinoid-treated tumors. These results support a new therapeutic approach for the treatment of skin tumors.
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Self-citation
Cited by
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Metadata
- Authors
- Casanova, M., Blázquez, C., Martínez‐Palacio, J., Villanueva, C., Fernández‐Aceñero, M. J., Huffman, J. W., Jorcano, J. L., & Guzmán, M.
- Venue
- Journal of Clinical Investigation
- Publisher
- American Society for Clinical Investigation
- Published
- 2003-01-01
- Volume
- 111
- Issue
- 1
- Pages
- 43-50
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2113996941
- Cited by
- 437
- References
- 39
- FWCI
- 15.16
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Casanova, M., Blázquez, C., Martínez‐Palacio, J., Villanueva, C., Fernández‐Aceñero, M. J., Huffman, J. W., Jorcano, J. L., & Guzmán, M. (2003). Inhibition of skin tumor growth and angiogenesis in vivo by activation of cannabinoid receptors. Journal of Clinical Investigation. https://doi.org/10.1172/jci16116
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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