The DOI matches its Crossref record; 114 of the 114 references it cites were found in a registry or an index.
Macrophages and microglia in glioblastoma: heterogeneity, plasticity, and therapy
Open accessAbstract
Glioblastoma (GBM) is the most aggressive tumor in the central nervous system and contains a highly immunosuppressive tumor microenvironment (TME). Tumor-associated macrophages and microglia (TAMs) are a dominant population of immune cells in the GBM TME that contribute to most GBM hallmarks, including immunosuppression. The understanding of TAMs in GBM has been limited by the lack of powerful tools to characterize them. However, recent progress on single-cell technologies offers an opportunity to precisely characterize TAMs at the single-cell level and identify new TAM subpopulations with specific tumor-modulatory functions in GBM. In this Review, we discuss TAM heterogeneity and plasticity in the TME and summarize current TAM-targeted therapeutic potential in GBM. We anticipate that the use of single-cell technologies followed by functional studies will accelerate the development of novel and effective TAM-targeted therapeutics for GBM patients.
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Cites
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Self-citationMacrophage plasticity, polarization, and function in health and disease
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Cited by
Dual roles and therapeutic targeting of tumor-associated macrophages in tumor microenvironments
Xu, J., Ding, L., Mei, J., Hu, Y., Kong, X., Dai, S., Bu, T., Xiao, Q., & Ding, K. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02325-5 · Cited by 389
Immunotherapy for glioblastoma: current state, challenges, and future perspectives
Liu, Y., Zhou, F., Ali, H., Lathia, J. D., & Chen, P. (2024) · Cellular & Molecular Immunology · doi:10.1038/s41423-024-01226-x · Cited by 336
Self-citationMicroglia pack a toolbox for life
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Metadata
- Authors
- Khan, F., Pang, L., Dunterman, M., Lesniak, M. S., Heimberger, A. B., & Chen, P.
- Venue
- Journal of Clinical Investigation
- Published
- 2023-01-03
- Volume
- 133
- Issue
- 1
- ISSN
- 0021-9738 (ISSN-L)
- 1558-8238
- OpenAlex
- W4313427356
- Cited by
- 414
- References
- 114
- FWCI
- 36.82
- Type
- journal article
- Language
- en
- Open access
- gold
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- Khan, F., Pang, L., Dunterman, M., Lesniak, M. S., Heimberger, A. B., & Chen, P. (2023). Macrophages and microglia in glioblastoma: heterogeneity, plasticity, and therapy. Journal of Clinical Investigation. https://doi.org/10.1172/jci163446
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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