The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Acceleration of type 1 diabetes mellitus in proinsulin 2–deficient NOD mice
Open accessAbstract
Accumulating evidence favors a role for proinsulin as a key autoantigen in diabetes. In the mouse, two proinsulin isoforms coexist. Most studies point to proinsulin 2 as the major isoform recognized by T cells in the NOD mouse. We studied mice in which a null proinsulin 2 mutation was transferred from proinsulin 2-deficient 129 mice onto the NOD background along with 16 genetic markers (including I-A(g7) MHC molecule) associated with diabetes. Intercross mice from the fourth backcross generation showed that proinsulin 2(-/-) mice develop accelerated insulitis and diabetes. The high prevalence of anti-insulin autoantibodies in proinsulin 2(-/-) mice indicates that diabetes acceleration relates to altered recognition of proinsulin. The prevalence of anti-glutamic acid decarboxylase autoantibodies and of sialitis is not increased in proinsulin 2(-/-) mice. We give evidence that proinsulin 2 expression leads to silencing of T cells specific for an epitope shared by proinsulin 1 and proinsulin 2. In the human, alleles located in the VNTR region flanking the insulin gene control beta cell response to glucose and proinsulin expression in the thymus and are key determinants of diabetes susceptibility. Proinsulin 2(-/-) NOD mice provide a model to study the role of thymic expression of insulin in susceptibility to diabetes.
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Cites
Insulin antibodies in insulin-dependent diabetics before insulin treatment
Palmer, J. P., Asplin, C. M., Clemons, P., Lyen, K., Tatpati, O., Raghu, P. K., & Paquette, T. L. (1983) · Science · doi:10.1126/science.6362005 · Cited by 1,078
Pugliese, A., Zeller, M., Fernandez, A., Zalcberg, L. J., Bartlett, R. J., Ricordi, C., Pietropaolo, M., Eisenbarth, G. S., Bennett, S. T., & Patel, D. D. (1997) · Nature Genetics · doi:10.1038/ng0397-293 · Cited by 945
Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
Vafiadis, P., Bennett, S. T., Todd, J. A., Nadeau, J., Grabs, R., Goodyer, C. G., Wickramasinghe, S., Colle, E., & Polychronakos, C. (1997) · Nature Genetics · doi:10.1038/ng0397-289 · Cited by 809 · cited 1×
“mice from diabetes by intranasal or subcutaneous administration of insulin peptide B-(9-23).”
BackgroundIslet cell autoantigens in insulin-dependent diabetes
Atkinson, M. A., & Maclaren, N. K. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116745 · Cited by 129
Cited by
THE NOD MOUSE: A Model of Immune Dysregulation
Anderson, M. S., & Bluestone, J. A. (2005) · Annual Review of Immunology · doi:10.1146/annurev.immunol.23.021704.115643 · Cited by 1,113
Prime role for an insulin epitope in the development of type 1 diabetes in NOD mice
Nakayama, M., Abiru, N., Moriyama, H., Babaya, N., Liu, E., Miao, D., Yu, L., Wegmann, D. R., Hutton, J. C., Elliott, J. F., et al. (2005) · Nature · doi:10.1038/nature03523 · Cited by 758
Self-representation in the thymus: an extended view
Kyewski, B., & Derbinski, J. (2004) · Nature Reviews Immunology · doi:10.1038/nri1436 · Cited by 342
Type 1 diabetes: translating mechanistic observations into effective clinical outcomes
Herold, K. C., Vignali, D. A. A., Cooke, A., & Bluestone, J. A. (2013) · Nature Reviews Immunology · doi:10.1038/nri3422 · Cited by 237
Understanding type 1 diabetes through genetics: advances and prospects
Polychronakos, C., & Li, Q. (2011) · Nature Reviews Genetics · doi:10.1038/nrg3069 · Cited by 226
Metadata
- Authors
- Thébault-Baumont, K., Dubois-Laforgue, D., Krief, P., Briand, J.-P., Halbout, P., Vallon-Geoffroy, K., Morin, J., Laloux, V., Lehuen, A., Carel, J.-C., Jami, J., Muller, S., & Boitard, C.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-03-15
- Volume
- 111
- Issue
- 6
- Pages
- 851-857
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2113799022
- Cited by
- 224
- References
- 4
- FWCI
- 11.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Thébault-Baumont, K., Dubois-Laforgue, D., Krief, P., Briand, J.-P., Halbout, P., Vallon-Geoffroy, K., Morin, J., Laloux, V., Lehuen, A., Carel, J.-C., Jami, J., Muller, S., & Boitard, C. (2003). Acceleration of type 1 diabetes mellitus in proinsulin 2–deficient NOD mice. Journal of Clinical Investigation. https://doi.org/10.1172/jci16584
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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