Islet cell autoantigens in insulin-dependent diabetes

Atkinson, M A; Maclaren, N K

doi:10.1172/jci116745

Cited by 129Diabetes and associated disordersPancreatic function and diabetesT-cell and B-cell Immunology

Islet cell autoantigens in insulin-dependent diabetes

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Atkinson, M A, Maclaren, N K·1993·Journal of Clinical Investigation

DOI 10.1172/jci116745PMC PMC288318

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Abstract

A burgeoning number of antigenic targets of the islet cell autoimmunity in IDD have been identified, and more can be anticipated through improved methods for their identification. The challenge for those investigating the pathogenesis of IDD will be to assign the relative importance of these antigens to the development of the disease, and to resolve whether there is a dominant primary immunologic event that is followed by a series of secondary immunizations to a variety of normally sequestered islet cell antigens in the sequence of pathogenic events that culminate in IDD. One interesting observation that may have potential pathogenic implications is the observation that of all islet cell autoantigens described, only two (i.e., 64 kD/GAD, 38 kD) are reactive in their native configurations, implying that recognition of conformational epitopes is most important. This property argues for primary immunizing agents rather than secondary ones after release of denatured antigens and antigenic recognition through their epitopes. Given the complex and multiple physiological functions of islet cells and the continuous variation in their activity, it is reasonable to speculate that the speed of the progression to IDD could vary between individuals with respect to their insulin needs and the relative activities of their islets. Activated islets may express autoantigens that have only limited expression in quiescent islets. The often times striking variation in the severity of insulitis seen in different islets of a single pancreas may be explained by the level of activity of individual islets. Furthermore, disparity in HLA-DR/DQ associations with disease may involve differences in the immunological recognition of autoantigens. Whereas there is still much to learn, it is clear that disease predictability and disease intervention studies have been enhanced through the identification of the islet cell autoantigens in IDD.

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Identification of the 64K autoantigen in insulin-dependent diabetes as the GABA-synthesizing enzyme glutamic acid decarboxylase
Baekkeskov, S., Aanstoot, H.-J., Christgai, S., Reetz, A., Solimena, M., Cascalho, M., Folli, F., Richter-Olesen, H., & Camilli, P.-D. (1990) · Nature · doi:10.1038/347151a0 · Cited by 1,964 · see citing works
ISLET-CELL ANTIBODIES IN DIABETES MELLITUS WITH AUTOIMMUNE POLYENDOCRINE DEFICIENCIES
Bottazzo, G., Florin-Christensen, A., & Doniach, D. (1974) · The Lancet · doi:10.1016/s0140-6736(74)90140-8 · Cited by 1,469 · see citing works
Insulin antibodies in insulin-dependent diabetics before insulin treatment
Palmer, J. P., Asplin, C. M., Clemons, P., Lyen, K., Tatpati, O., Raghu, P. K., & Paquette, T. L. (1983) · Science · doi:10.1126/science.6362005 · Cited by 1,078 · see citing works
Autoantibodies to GABA-ergic Neurons and Pancreatic Beta Cells in Stiff-Man Syndrome
Solimena, M., Folli, F. B., Aparisi, R., Pozza, G., & Camilli, P. V. D. (1990) · New England Journal of Medicine · doi:10.1056/nejm199005313222202 · Cited by 623 · see citing works
Suppression of diabetes in nonobese diabetic mice by oral administration of porcine insulin.
Zhang, Z. J., Davidson, L., Eisenbarth, G. S., & Weiner, H. L. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.22.10252 · Cited by 561 · see citing works
Autoantibodies in newly diagnosed diabetic children immunoprecipitate human pancreatic islet cell proteins
Bækkeskov, S., Nielsen, J. H., Marner, B., Bilde, T., Ludvigsson, J., & Lernmark, Å. (1982) · Nature · doi:10.1038/298167a0 · Cited by 530 · see citing works
Autoimmunity to two forms of glutamate decarboxylase in insulin-dependent diabetes mellitus
Kaufman, D. L., Erlander, M. G., Clare-Salzler, M., Atkinson, M. A., Maclaren, N. K., & Tobin, A. J. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115573 · Cited by 490 · see citing works
Self-citation
Induction and therapy of autoimmune diabetes in the non-obese diabetic (NOD/Lt) mouse by a 65-kDa heat shock protein.
Elias, D., Markovits, D., Reshef, T., van der Zee, R., & Cohen, I. R. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.4.1576 · Cited by 441 · see citing works
Intraorganellar calcium and pH control proinsulin cleavage in the pancreatic β cell via two distinct site-specific endopeptidases
Davidson, H. W., Rhodes, C. J., & Hutton, J. C. (1988) · Nature · doi:10.1038/333093a0 · Cited by 406 · see citing works
A Bovine Albumin Peptide as a Possible Trigger of Insulin-Dependent Diabetes Mellitus
Karjalainen, J., Martin, J. M., Knip, M., Ilonen, J., Robinson, B. H., Savilahti, E., Akerblom, H. K., & Dosch, H. (1992) · New England Journal of Medicine · doi:10.1056/nejm199207303270502 · Cited by 386 · see citing works
Vaccination against autoimmune mouse diabetes with a T-cell epitope of the human 65-kDa heat shock protein.
Elias, D., Reshef, T., Birk, O. S., van der Zee, R., WALKER, M. D., & Cohen, I. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3088 · Cited by 371 · see citing works
A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus
Karjalainen, J., Martin, J. M., Knip, M., Ilonen, J., Robinson, B. H., Savilahti, E., Åkerblom, H. K., Dosch, H. ‐., Norris, J. M., & Pietropaolo, M. (1994) · Journal of Endocrinological Investigation · doi:10.1007/bf03347751 · Cited by 341 · see citing works
A Randomized Trial of Intensive Insulin Therapy in Newly Diagnosed Insulin-Dependent Diabetes Mellitus
Shah, S. C., Malone, J. I., & Simpson, N. E. (1989) · New England Journal of Medicine · doi:10.1056/nejm198903023200902 · Cited by 319 · see citing works
Antibodies to a 64,000 Mr human islet cell antigen precede the clinical onset of insulin-dependent diabetes.
Bækkeskov, S., Landin, M., Kristensen, J. K., Srikanta, S., Bruining, G. J., Mandrup-Poulsen, T. R., de Beaufort, C. E., Soeldner, J. S., Eisenbarth, G. S., & Lindgren, F. (1987) · Journal of Clinical Investigation · doi:10.1172/jci112903 · Cited by 315 · see citing works
Insulitis and Diabetes in NOD Mice Reduced by Prophylactic Insulin Therapy
Atkinson, M. A., Maclaren, N. K., & Luchetta, R. (1990) · Diabetes · doi:10.2337/diab.39.8.933 · Cited by 293 · see citing works
Self-citation
A Prospective Study of the Development of Diabetes in Relatives of Patients with Insulin-Dependent Diabetes
Riley, W. J., Maclaren, N. K., Krischer, J. P., Spillar, R. P., Silverstein, J. H., Schatz, D., Schwartz, S., Malone, J. I., Shah, S., Vadheim, C. M., et al. (1990) · New England Journal of Medicine · doi:10.1056/nejm199010253231704 · Cited by 284 · see citing works
Self-citation
Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes
Atkinson, M. A., Campbell, I. L., Gibbs, K., Maclaren, N. K., Kaufman, D. L., Bu, D.-F., Erlander, M. G., Tobin, A. J., & Shah, S. C. (1992) · The Lancet · doi:10.1016/0140-6736(92)91061-c · Cited by 268 · see citing works
Self-citation
γ‐Aminobutyric Acid Outside the Mammalian Brain
Erdö, S. L., & Wolff, J. R. (1990) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1990.tb01882.x · Cited by 261 · see citing works
PREDICTING INSULIN-DEPENDENT DIABETES
Tarn, A., Dean, B., Schwarz, G., Thomas, J. M., Ingram, D., Bottazzo, G. F., & Gale, E. M. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91601-7 · Cited by 260 · see citing works
Reduction of diabetes incidence of BB Wistar rats by early prophylactic insulin treatment of diabetes-prone animals
Gotfredsen, C. F., Buschard, K., & Frandsen, E. (1985) · Diabetologia · doi:10.1007/bf00703140 · Cited by 207 · see citing works
64 000 Mr autoantibodies as predictors of insulin-dependent diabetes
Atkinson, M. A., Maclaren, N. K., Riley, W. J., Sharp, D., & Lacey, P. E. (1990) · The Lancet · doi:10.1016/0140-6736(90)91241-2 · Cited by 203 · see citing works
Self-citation
The insulin secretory granule
Hutton, J. C. (1989) · Diabetologia · doi:10.1007/bf00265542 · Cited by 192 · see citing works
Concentration of Insulin Autoantibodies at Onset of Type I Diabetes: Inverse Log-Linear Correlation With Age
Vardi, P., Ziegler, A. G., Mathews, J. H., Dib, S. A., Keller, R. J., Ricker, A. T., Wolfsdorf, J. I., Herskowitz, R. D., Rabizadeh, A., Eiswnbarth, G. S., et al. (1988) · Diabetes Care · doi:10.2337/diacare.11.9.736 · Cited by 188 · see citing works
T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins
Roep, B. O., Arden, S. D., de vries, R. R. P., & Hutton, J. C. (1990) · Nature · doi:10.1038/345632a0 · Cited by 185 · see citing works
Infant Feeding in Finnish Children <7 yr of Age With Newly Diagnosed IDDM
Virtanen, S. M., Räsänen, L., Aro, A., Lindström, J., Sippola, H., Lounamaa, R., Toivanen, L., Tuomilehto, J. O., Åkerblom, H. K., & Childhood Diabetes in Finland Study Group (1991) · Diabetes Care · doi:10.2337/diacare.14.5.415 · Cited by 161 · see citing works
Identification and Cloning of a Granule Autoantigen (Carboxypeptidase-H) Associated with Type I Diabetes*
Castaño, L. A., RUSSO, E., ZHOU, L., Lipes, M. A., & Eisenbarth, G. S. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-6-1197 · Cited by 156 · see citing works
Are Insulin Autoantibodies Markers for Insulin-Dependent Diabetes Mellitus?
Atkinson, M. A., Maclaren, N. K., Riley, W. J., Winter, W. E., Fisk, D., & Spillar, R. P. (1986) · Diabetes · doi:10.2337/diab.35.8.894 · Cited by 154 · see citing works
Self-citation
Autoimmunity to Insulin, Beta Cell Dysfunction, and Development of Insulin-dependent Diabetes Mellitus
Srikanta, S., Ricker, A. T., McCulloch, D. K., Soeldner, J. S., Eisenbarth, G. S., & Palmer, J. P. (1986) · Diabetes · doi:10.2337/diab.35.2.139 · Cited by 142 · see citing works
Relationship Between Cows' Milk Consumption and Incidence of IDDM in Childhood
Dahl‐Jørgensen, K., Joner, G., & Hanssen, K. F. (1991) · Diabetes Care · doi:10.2337/diacare.14.11.1081 · Cited by 137 · see citing works
"Cytoplasmic" islet cell antibodies. Evidence that the target antigen is a sialoglycoconjugate
Nayak, R. C., Omar, M. A. K., Rabizadeh, A., Srikanta, S., & Eisenbarth, G. S. (1985) · Diabetes · doi:10.2337/diab.34.6.617 · Cited by 127 · see citing works
Cloning and Expression of IDDM-Specific Human Autoantigens
Rabin, D. U., Pleasic, S. M., Palmer-Crocker, R., & Shapiro, J. (1992) · Diabetes · doi:10.2337/diab.41.2.183 · Cited by 124 · see citing works
Islet cell cytoplasmic autoantibody reactivity to glutamate decarboxylase in insulin-dependent diabetes.
Atkinson, M. A., Kaufman, D. L., Newman, D., Tobin, A. J., & Maclaren, N. K. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116192 · Cited by 121 · see citing works
Self-citation
Prognostically Significant Heterogeneity of Cytoplasmic Islet Cell Antibodies in Relatives of Patients with Type I Diabetes
Gianani, R., Pugliese, A., Bonner‐Weir, S., Shiffrin, A. J., Soeldner, J. S., Erlich, H., Awdeh, Z., Alper, C. A., Jackson, R. A., & Eisenbarth, G. S. (1992) · Diabetes · doi:10.2337/diab.41.3.347 · Cited by 113 · see citing works
T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes
Roep, B. O., Kallan, A. A., Hazenbos, W. L. W., de Vries, R. R. P., Bruining, G. J., BAILYES, E. M., Arden, S. D., & Hutton, J. C. (1991) · The Lancet · doi:10.1016/0140-6736(91)93127-u · Cited by 109 · see citing works
Heat-shock protein 65 as a β cell antigen of insulin-dependent diabetes
Jones, D. B., HUNTER, N. R., & Duff, G. W. (1990) · The Lancet · doi:10.1016/0140-6736(90)93390-b · Cited by 109 · see citing works
Recombinant Glutamic Acid Decarboxylase (Representing the Single Isoform Expressed in Human Islets) Detects IDDM-Associated 64,000-Mr Autoantibodies
Karlsen, A. E., Hagopian, W., Petersen, J. S., Boel, E., Dyrberg, T., Grubin, C. E., Michelsen, B. K., Madsen, O. D., & Lernmark, Å. (1992) · Diabetes · doi:10.2337/diab.41.10.1355 · Cited by 99 · see citing works
Binding of Cytoplasmic Islet Cell Antibodies Is Blocked by Human Pancreatic Glycolipid Extracts
Colman, P. G., Nayak, R. C., Campbell, I. L., & Eisenbarth, G. S. (1988) · Diabetes · doi:10.2337/diab.37.5.645 · Cited by 96 · see citing works
Differential Expression of Glutamic Acid Decarboxylase in Rat and Human Islets
Petersen, J. S., Russel, S., Marshall, M. O., Kofod, H., Buschard, K., Cambon, N., Karlsen, A. E., Boel, E., Hagopian, W., Hejnæs, K. R., et al. (1993) · Diabetes · doi:10.2337/diab.42.3.484 · Cited by 96 · see citing works
Purification and Characterization of a Membrane‐Bound Enkephalin‐Forming Carboxypeptidase, “Enkephalin Convertase”
Supattapone, S., Fricker, L. D., & Snyder, S. H. (1984) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1984.tb12705.x · Cited by 93 · see citing works
Inhibition of Glucose Transport into Rat Islet Cells by Immunoglobulins from Patients with New-Onset Insulin-Dependent Diabetes Mellitus
Johnson, J. H., Crider, B. P., McCorkle, K., Alford, M., & Unger, R. H. (1990) · New England Journal of Medicine · doi:10.1056/nejm199003083221003 · Cited by 85 · see citing works
Children with newly diagnosed insulin dependent diabetes mellitus have increased levels of cow's milk antibodies.
Savilahti, E., Åkerblom, H. K., Tainio, V.-M., & Koskimies, S. (1988) · PubMed · Cited by 84 · see citing works
Autoantibodies to the insulin receptor in juvenile onset insulin-dependent diabetes
Maron, R., Elias, D., de Jongh, B. M., Bruining, G. J., van Rood, J. J., Shechter, Y., & Cohen, I. R. (1983) · Nature · doi:10.1038/303817a0 · Cited by 83 · see citing works
Are insulin autoantibodies markers for insulin-dependent diabetes mellitus?
Atkinson, M. A., Maclaren, N. K., Riley, W. J., et al. (1986) · Diabetes · doi:10.2337/diabetes.35.8.894 · Cited by 72 · see citing works
Self-citation
Cellular immunity to human insulin in individuals at high risk for the development of Type I diabetes mellitus
Keller, R. J. (1990) · Journal of Autoimmunity · doi:10.1016/0896-8411(90)90150-q · Cited by 60 · see citing works
Elevated Proinsulin in Healthy Siblings of IDDM Patients Independent of HLA Identity
HARTLING, S. G., Lindgren, F., Dahlqvist, G., Persson, B., & Binder, C. (1989) · Diabetes · doi:10.2337/diab.38.10.1271 · Cited by 57 · see citing works
Recognition of Common Islet Antigen by Autoantibodies From NOD Mice and Humans With IDDM
Karounos, D. G., & Thomas, J. W. (1990) · Diabetes · doi:10.2337/diab.39.9.1085 · Cited by 56 · see citing works
Reactivity to Human Islets and Fetal Pig Proislets by Peripheral Blood Mononuclear Cells From Subjects With Preclinical and Clinical Insulin-Dependent Diabetes
Harrison, L. C., Aizpurua, H. D., Loudovaris, T., Campbell, I. L., Cebon, J. S., Tait, B. D., & Colman, P. G. (1991) · Diabetes · doi:10.2337/diab.40.9.1128 · Cited by 54 · see citing works
Proinsulin autoantibodies are more closely associated with Type 1 (insulin-dependent) diabetes mellitus than insulin autoantibodies
B�hmer, K., Keilacker, H., Kuglin, B., H�binger, A., Bertrams, J., Gries, F. A., & Kolb, H. (1991) · Diabetologia · doi:10.1007/bf00408359 · Cited by 48 · see citing works
Cloning and expression of IDDM-specific human autoantigens
Rabin, D. U., Pleasic, S. M., Palmer-Crocker, R., et al. (1992) · Diabetes · doi:10.2337/diabetes.41.2.183 · Cited by 43 · see citing works
Is insulin-dependent diabetes mellitus environmentally induced?
Maclaren, N., & Atkinson, M. (1992) · New England Journal of Medicine · doi:10.1056/nejm199207303270509 · Cited by 41 · see citing works
Self-citation
Human T cell clones with specificity for insulinoma cell antigens
van Vliet, E., Roep, B. O., Meulenbroek, L., Bruining, G. J., & de Vries, R. R. P. (1989) · European Journal of Immunology · doi:10.1002/eji.1830190136 · Cited by 38 · see citing works
Could bovine serum albumin be the initiating antigen ultimately responsible for the development of insulin dependent diabetes mellitus?
Glerum, M., Robinson, B. H., & Martin, J. M. (1989) · PubMed · Cited by 34 · see citing works
Recombinant glutamic acid decarboxylase (representing the single isoform expressed in human islets) detects IDDM-associated 64,000-M(r) autoantibodies
Karlsen, A. E., Hagopian, W., Petersen, J. S., et al. (1992) · Diabetes · doi:10.2337/diabetes.41.10.1355 · Cited by 33 · see citing works
No evidence for serological autoimmunity to islet cell heat shock proteins in insulin dependent diabetes.
Atkinson, M. A., Holmes, L., Scharp, D. W., Lacy, P. E., & Maclaren, N. K. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115051 · Cited by 32 · see citing works
Self-citation
Differences in Epitope Restriction of Autoantibodies to Native Human Insulin (IAA) and Antibodies to Heterologous Insulin (IA)
Diaz, J.-L., & Wilkin, T. J. (1987) · Diabetes · doi:10.2337/diab.36.1.66 · Cited by 32 · see citing works
64,000-Mr Autoantigen in Type I Diabetes: Evidence Against Its Surface Location on Human Islets
Colman, P. G., Campbell, I. L., Kay, T. W. H., & Harrison, L. C. (1987) · Diabetes · doi:10.2337/diab.36.12.1432 · Cited by 31 · see citing works
Autoimmunity to insulin, beta cell dysfunction, and development of insulin-dependent diabetes mellitus
Srikanta, S., Ricker, A. T., McCulloch, D. K., et al. (1986) · Diabetes · doi:10.2337/diabetes.35.2.139 · Cited by 31 · see citing works
Cellular and subcellular immunolocalization of L-glutamate decarboxylase in rat pancreatic islets.
Garry, D. J., Appel, N. M., Garry, M. G., & Sorenson, R. L. (1988) · Journal of Histochemistry & Cytochemistry · doi:10.1177/36.6.2896676 · Cited by 28 · see citing works
Insulin-specific human T cells. Epitope specificity, major histocompatibility complex restriction, and alloreactivity to a diabetes-associated haplotype.
Miller, G. G., Pollack, M. S., Nell, L. J., & Thomas, J. W. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.11.3622 · Cited by 26 · see citing works
Novel Considerations on the Antibody/Autoantigen System in Type I (insulin-dependent) Diabetes Mellitus
Bottazzo, G. F., Genovese, S., Bosi, E., Dean, B. M., Christie, M. R., & Bonifacio, E. E. (1991) · Annals of Medicine · doi:10.3109/07853899109148089 · Cited by 25 · see citing works
Reactivity to human islets and fetal pig proislets by peripheral blood mononuclear cells from subjects with preclinical and clinical insulin-dependent diabetes
Harrison, L. C., Aizpurua, H. D., Loudovaris, T., et al. (1991) · Diabetes · doi:10.2337/diabetes.40.9.1128 · Cited by 24 · see citing works
Human Monoclonal IgG1 Insulin Autoantibody From Insulin Autoimmune Syndrome Directed at Determinant at Asparagine Site on Insulin B-Chain
Uchigata, Y., Yao, K., Takayama-Hasumi, S., & Hirata, Y. (1989) · Diabetes · doi:10.2337/diab.38.5.663 · Cited by 18 · see citing works
B‐cell Secretion in Non‐diabetics and Insulin‐dependent Diabetics
Hedïng, L. G., Ludvigsson, J., & Kasperska-Czyzykowa, T. (1982) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1982.tb07693.x · Cited by 16 · see citing works
Differences in epitope restriction of autoantibodies to native human insulin (IAA) and antibodies to heterologous insulin (IA)
Diaz, J. L., & Wilkin, T. J. (1987) · Diabetes · doi:10.2337/diabetes.36.1.66 · Cited by 16 · see citing works
Specificity of Monoclonal Anti-Human Insulin Antibodies
Storch, M.-J., Licht, T., Petersen, K.-G., Obermeier, R., & Kerp, L. (1987) · Diabetes · doi:10.2337/diab.36.9.1005 · Cited by 15 · see citing works
Strong Association Between Diabetes and Displacement of Mouse Anti-Rat Insulinoma Cell Monoclonal Antibody by Human Serum In Vitro
Thomas, N. M., Ginsberg‐Fellner, F., & McEvoy, R. C. (1990) · Diabetes · doi:10.2337/diab.39.10.1203 · Cited by 10 · see citing works
No role for 65 kD heat-shock protein in diabetes
Kämpe, O., Velloso, L. A., Andersson, A., Karlsson, A., Atkinson, M. A., Maclaren, N., & Scharp, D. W. (1990) · The Lancet · doi:10.1016/0140-6736(90)92864-e · Cited by 9 · see citing works
Self-citation
A Human Monoclonal Antibody to Insulin
Livneh, A., Avraham, H. K., Elias, D., Sack, J., Cohen, I. R., & Eshhar, Z. (1986) · Diabetes · doi:10.2337/diab.35.1.68 · Cited by 9 · see citing works
Specificity of monoclonal anti-human insulin antibodies
Storch, M. J., Licht, T., Petersen, K. G., et al. (1987) · Diabetes · doi:10.2337/diabetes.36.9.1005 · Cited by 7 · see citing works
A human monoclonal antibody to insulin
Livneh, A., Avraham, H., Elias, D., et al. (1986) · Diabetes · doi:10.2337/diabetes.35.1.68 · Cited by 7 · see citing works
Human monoclonal IgG1 insulin autoantibody from insulin autoimmune syndrome directed at determinant at asparagine site on insulin B-chain
Uchigata, Y., Yao, K., Takayama-Hasumi, S., et al. (1989) · Diabetes · doi:10.2337/diabetes.38.5.663 · Cited by 6 · see citing works
Autoantibodies to the insulin receptor are infrequent findings in Type 1 (insulin-dependent) diabetes mellitus of recent onset
Rochet, N., Sadoul, J., Ferruà, B., Kubar, J., Tanti, J., Bougneres, P. F., Vialettes, B., OBBERGHEN, E. V., MARCHAND‐BRUSTEL, Y. L., & Freychet, P. (1990) · Diabetologia · doi:10.1007/bf00404090 · Cited by 5 · see citing works
Increased Preproinsulin mRNA in Pancreatic Islets Incubated With Islet Cell–Stimulating Antibodies From Serums of Type I Diabetic Patients
Foggensteiner, L., Bone, A. J., Webster, K. A., & Wilkin, T. J. (1990) · Diabetes · doi:10.2337/diab.39.10.1165 · Cited by 3 · see citing works

Flagged first, then by citations

Research works printed but not linked: 2

Bu, D. F., M. G. Erlander, B. C. Hitz, N. J. K. Tillakaratne, D. L. Kauf- man, C. B. Wagner-McPherson, G. A. Evans, and A. J. Tobin. 1993. Two human glutamate decarboxylases, GAD 65 and GAD 67, are each encoded by a single gene. Proc. NatL. Acad. Sci. USA. In press.
Zhang, Z. J., L. Davidsen, G. S. Eisenbarth, H. L. Weiner, and R. S. Weiner. 1991. Suppression ofdiabetes in non obese diabetic mice by oral adminis- tration of porcine insulin. Proc. Natl. Acad. Sci. USA 88:10252-10256.

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Yu, L., Robles, D. T., Abiru, N., Kaur, P., Rewers, M., Kelemen, K., & Eisenbarth, G. S. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.040556697 · Cited by 450 · see citing works
Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Sacks, D. B., Arnold, M., Bakris, G. L., Bruns, D. E., Horvath, A. R., Lernmark, Å., Metzger, B. E., Nathan, D. M., & Kirkman, M. S. (2023) · Diabetes Care · doi:10.2337/dci23-0036 · Cited by 351 · see citing works
Insulin immunization of nonobese diabetic mice induces a protective insulitis characterized by diminished intraislet interferon-gamma transcription.
MUIR, A. B., Peck, A. B., Clare-Salzler, M. J., Song, Y., Cornelius, J., Luchetta, R., Krischer, J. P., & Maclaren, N. K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117707 · Cited by 244 · see citing works
Self-citation
Acceleration of type 1 diabetes mellitus in proinsulin 2–deficient NOD mice
Thébault, K., Dubois-Laforgue, D., Krief, P., Briand, J., Halbout, P., Vallon-Geoffroy, K., Morin, J., Laloux, V., Lehuen, A., Carel, J., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci16584 · Cited by 223 · see citing works
Antigen Targets of Type 1 Diabetes AutoimmunityPreprint
Roep, B. O., & Peakman, M. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007781 · Cited by 212 · see citing works
Intra- and intermolecular spreading of autoimmunity involving the nuclear self-antigens La (SS-B) and Ro (SS-A).
Topfer, F., Gordon, T. P., & McCluskey, J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.3.875 · Cited by 185 · see citing works
Genetic determination of islet cell autoimmunity in monozygotic twin, dizygotic twin, and non-twin siblings of patients with type 1 diabetes: prospective twin study
REDONDO, M. J., Rewers, M., Yu, L., Garg, S. K., Pilcher, C. C., Elliott, R. B., & Eisenbarth, G. S. (1999) · BMJ · doi:10.1136/bmj.318.7185.698 · Cited by 183 · see citing works
Suppression of insulitis in non-obese diabetic (NOD) mice by oral insulin administration is associated with selective expression of interleukin-4 and -10, transforming growth factor-beta, and prostaglandin-E.
Hancock, W. W., Polanski, M., Zhang, J., BLOGG, N. S., & Weiner, H. L. (1995) · Europe PMC (PubMed Central) · Cited by 161 · see citing works
Previous Exposure to Measles, Mumps, and Rubella—but Not Vaccination During Adolescence—Correlates to the Prevalence of Pancreatic and Thyroid Autoantibodies
Lindberg, B. A., Ahlfors, K., Carlsson, A., Ericsson, U., Landin‐Olsson, M., Lernmark, Å., Ludvigsson, J., Sundkvist, G., & Ivarsson, S.-A. (1999) · PEDIATRICS · doi:10.1542/peds.104.1.e12 · Cited by 153 · see citing works
Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus
Sacks, D. B., Arnold, M. A., Bakris, G. L., Bruns, D. E., Horvath, A. R., Lernmark, Å., Metzger, B. E., Nathan, D. M., & Kirkman, M. S. (2023) · Clinical Chemistry · doi:10.1093/clinchem/hvad080 · Cited by 157 · see citing works
Determinant spreading: lessons from animal models and human disease
McCluskey, J., Farris, A. D., Keech, C. L., Purcell, A. W., Rischmueller, M., Kinoshita, G., Reynolds, P., & Gordon, T. P. (1998) · Immunological Reviews · doi:10.1111/j.1600-065x.1998.tb01222.x · Cited by 130 · see citing works
Clinical, Autoimmune, and Genetic Characteristics of Adult-Onset Diabetic Patients With GAD Autoantibodies in Japan (Ehime Study)
Takeda, H., Kawasaki, E., Shimizu, I., Konoue, E., Fujiyama, M., Murao, S., TANAKA, K., Mori, K., Tarumi, Y., Seto, I., et al. (2002) · Diabetes Care · doi:10.2337/diacare.25.6.995 · Cited by 127 · see citing works
Transfer of Diabetes in the NOD-scid Mouse by CD4 T-Cell Clones: Differential Requirement for CD8 T-Cells
Peterson, J. D., & HASKINS, K. M. (1996) · Diabetes · doi:10.2337/diab.45.3.328 · Cited by 119 · see citing works
Recognition of a subregion of human proinsulin by class I-restricted T cells in type 1 diabetic patients
Toma, A., Haddouk, S., Briand, J., Camoin, L., Gahéry‐Ségard, H., Connan, F., Dubois-Laforgue, D., Caillat‐Zucman, S., Guillet, J., Carel, J., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504230102 · Cited by 116 · see citing works
Islet Autoantigens: Structure, Function, Localization, and RegulationPreprint
Arvan, P. R., Pietropaolo, M., Ostrov, D. A., & Rhodes, C. J. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a007658 · Cited by 96 · see citing works
Pathogenesis of insulin-dependent diabetes mellitus
Falorni, A., Kockum, I. S., Sanjeevi, C. B., & Lernmark, Å. (1995) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(95)80803-5 · Cited by 90 · see citing works
CD4+ T Cells from Glutamic Acid Decarboxylase (GAD)65-specific T Cell Receptor Transgenic Mice Are Not Diabetogenic and Can Delay Diabetes Transfer
Tarbell, K. V., Lee, M., Ranheim, E. A., Chao, C. C., Sanna, M. B., Kim, S.-K., Dickie, P., Teyton, L., Davis, M. M., & McDevitt, H. O. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20011845 · Cited by 83 · see citing works
Autoantibody Recognition of COOH-Terminal Epitopes of GAD65 Marks the Risk for Insulin Requirement in Adult-Onset Diabetes Mellitus1
Falorni, A., Gambelunghe, G., Forini, F., Kassi, G., Cosentino, A., Candeloro, P., Bolli, G. B., Brunetti, P., & Calcinaro, F. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.1.6301 · Cited by 77 · see citing works
Dendritic Cells Expressing Transgenic Galectin-1 Delay Onset of Autoimmune Diabetes in Mice
Perone, M. J., Bertera, S., Tawadrous, Z. S., Shufesky, W. J., Piganelli, J. D., Baum, L. G., Trucco, M., & Morelli, A. E. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5278 · Cited by 76 · see citing works
Combined Analysis of GAD65 and ICA512(IA-2) Autoantibodies in Organ and Non-organ-specific Autoimmune Diseases Confers High Specificity for Insulin-dependent Diabetes Mellitus
Pietropaolo, M., Peakman, M., Pietropaolo, S. L., Zanone, M. M., Foley, T. P., BECKER, D. J., & Trucco, M. (1998) · Journal of Autoimmunity · doi:10.1006/jaut.1997.0170 · Cited by 73 · see citing works
Glucose Homeostasis in the Nonobese Diabetic Mouse at the Prediabetic Stage1
Amrani, A., Durant, S., Throsby, M., Coulaud, J., Dardenne, M., & Homo‐Delarche, F. (1998) · Endocrinology · doi:10.1210/endo.139.3.5823 · Cited by 70 · see citing works
Autoantibodies in Human Diabetes
Pietropaolo, M., & Eisenbarth, G. S. (2001) · KARGER eBooks · doi:10.1159/000060541 · Cited by 66 · see citing works
The nature of autoantigens targeted in autoimmune endocrine diseases
Song, Y., Li, Y., & Maclaren, N. K. (1996) · Immunology Today · doi:10.1016/0167-5699(96)10008-6 · Cited by 66 · see citing works
Self-citation
Beyond the Hormone: Insulin as an Autoimmune Target in Type 1 Diabetes
Brezar, V., Carel, J., Boîtard, C., & Mallone, R. (2011) · Endocrine Reviews · doi:10.1210/er.2011-0010 · Cited by 66 · see citing works
Specificity of islet cell autoantibodies and coexistence with other organ specific autoantibodies in type 1 diabetes mellitus
Tsirogianni, A., Pipi, E., & Soufleros, K. (2009) · Autoimmunity Reviews · doi:10.1016/j.autrev.2009.02.019 · Cited by 56 · see citing works
Role of β-Cells in Type 1 Diabetes Pathogenesis
Faideau, B., Larger, É., Lepault, F., Carel, J., & Boîtard, C. (2005) · Diabetes · doi:10.2337/diabetes.54.suppl_2.s87 · Cited by 53 · see citing works
B Cells in Autoimmune Diabetes
Wong, F. S., & Li, W. (2005) · The Review of Diabetic Studies · doi:10.1900/rds.2005.2.121 · Cited by 52 · see citing works
Molecular genetics of diabetes mellitus
Aitman, T. J., & Todd, J. A. (1995) · Baillière s Clinical Endocrinology and Metabolism · doi:10.1016/s0950-351x(95)80655-5 · Cited by 50 · see citing works
Autoimmune diabetes: the role of the islets of langerhans
Homo‐Delarche, F., & Boîtard, C. (1996) · Immunology Today · doi:10.1016/0167-5699(96)10053-8 · Cited by 51 · see citing works
It's Insulin
Wegmann, D. R., & Eisenbarth, G. S. (2000) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0444 · Cited by 48 · see citing works
Diabetes-Related Autoantibodies and Gestational Diabetes
de Leiva, A., Mauricio, D., & Corcoy, R. (2007) · Diabetes Care · doi:10.2337/dc07-s204 · Cited by 48 · see citing works
Antibodies to GAD in Japanese diabetic patients: a multicenter study
Tsuruoka, A., Matsuba, I., Toyota, T., Isshiki, G., Nagataki, S., & Ikeda, Y. (1995) · Diabetes Research and Clinical Practice · doi:10.1016/0168-8227(95)01101-i · Cited by 46 · see citing works
Distinct clinical and laboratory characteristics of latent autoimmune diabetes in adults in relation to type 1 and type 2 diabetes mellitus
Pipi, E. (2014) · World Journal of Diabetes · doi:10.4239/wjd.v5.i4.505 · Cited by 49 · see citing works
Immunobiology of DC in NOD mice
Morel, P. A., Vasquez, A. C., & Feili‐Hariri, M. (1999) · Journal of Leukocyte Biology · doi:10.1002/jlb.66.2.276 · Cited by 45 · see citing works
Active Tolerance Induction and Prevention of Autoimmune Diabetes by Immunogene Therapy Using Recombinant Adenoassociated Virus Expressing Glutamic Acid Decarboxylase 65 Peptide GAD500–585
Han, G., Li, Y., Wang, J., Wang, R., Chen, G., Song, L., Xu, R., Yu, M., Wu, X., Qian, J., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.8.4516 · Cited by 45 · see citing works
T Cell Recognition of Human Pre-Proinsulin Peptides Depends on the Polymorphism at HLA DQ Locus: A Study Using HLA DQ8 and DQ6 Transgenic Mice
Raju, R. P., MUNN, S. R., & David, C. S. (1997) · Human Immunology · doi:10.1016/s0198-8859(97)00212-7 · Cited by 41 · see citing works
GABA Agonists Differentially Modify Blood Glucose Levels of Diabetic Rats
Gomez, R., Asnis, N., Sl, T., & Barros, H. M. T. (1999) · The Japanese Journal of Pharmacology · doi:10.1254/jjp.80.327 · Cited by 40 · see citing works
IgG subclass antibodies to glutamic acid decarboxylase and risk for progression to clinical insulin-dependent diabetes
Couper, J., Harrison, L. C., Aldis, J., Colman, P. G., Honeyman, M. C., & Ferrante, A. (1998) · Human Immunology · doi:10.1016/s0198-8859(98)00040-8 · Cited by 39 · see citing works
Transgenic plants expressing human glutamic acid decarboxylase (GAD65), a major autoantigen in insulin-dependent diabetes mellitus
Porceddu, A., Falorni, A., Ferradini, N., Cosentino, A., Calcinaro, F., Faleri, C., Cresti, M., Lorenzetti, F., Brunetti, P., & Pezzotti, M. (1999) · Molecular Breeding · doi:10.1023/a:1009605729268 · Cited by 38 · see citing works
T-Cell Response to Proinsulin and Insulin in Type 1 and Pretype 1 Diabetes
Dubois‐Laforgue, D., Carel, J., Bougneres, P. F., Guillet, J., & Boîtard, C. (1999) · Journal of Clinical Immunology · doi:10.1023/a:1020558601175 · Cited by 38 · see citing works
Additive Susceptibility to Insulin-Dependent Diabetes Conferred by Hla-Dqb1 and Insulin Genes
She, J., Bui, M. M., Tian, X. H., MUIR, A. B., Wakeland, E. K., Zorovich, B., Zhang, L.-P., Liu, M. C., Thomson, G., & Maclaren, N. K. (1994) · Autoimmunity · doi:10.3109/08916939409007996 · Cited by 38 · see citing works
Self-citation
Tolerance to Proinsulin-2 Is Due to Radioresistant Thymic Cells
Faideau, B., Lotton, C., Lucas, B., Tardivel, I., Elliott, J. F., Boîtard, C., & Carel, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.1.53 · Cited by 37 · see citing works
Developments in the prediction of type 1 diabetes mellitus, with special reference to insulin autoantibodies
Franke, B., Galloway, T. S., & Wilkin, T. J. (2005) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.554 · Cited by 36 · see citing works
MECHANISMS IN ENDOCRINOLOGY: Insulin and type 1 diabetes: immune connections
Čulina, S., Brezar, V., & Mallone, R. (2012) · European Journal of Endocrinology · doi:10.1530/eje-12-0693 · Cited by 33 · see citing works
Toward a cure for type 1 diabetes mellitus: diabetes-suppressive dendritic cells and beyond
Giannoukakis, N., Phillips, B. E., & Trucco, M. (2008) · Pediatric Diabetes · doi:10.1111/j.1399-5448.2008.00401.x · Cited by 33 · see citing works
GM2-1 pancreatic islet ganglioside: identification and characterization of a novel islet-specific molecule
Dotta, F., Previti, M., Lenti, L., Dionisi, S., Casetta, B., D’Erme, M., Eisenbarth, G. S., & Mario, U. D. (1995) · Diabetologia · doi:10.1007/bf00402184 · Cited by 33 · see citing works
Experimental autoimmune insulitis. Induction by T lymphocytes specific for a peptide of proinsulin.
Griffin, A. C., Zhao, W., Wegmann, K. W., & Hickley, W. F. (1995) · PubMed Central · Cited by 31 · see citing works
Effect of Oral and Intravenous Insulin and Glutamic Acid Decarboxylase in NOD Mice
Ramiya, V. K., Shang, X., Wasserfall, C. H., & Maclaren, N. K. (1997) · Autoimmunity · doi:10.3109/08916939708994736 · Cited by 31 · see citing works
Self-citation
Training in large bowel cancer surgery: observations from three prospective regional United Kingdom audits
Aitken, R., Thompson, M. R., Smith, J. A. E., Radcliffe, A. G., Stamatakis, J. D., & Steele, R. J. (1999) · BMJ · doi:10.1136/bmj.318.7185.702 · Cited by 30 · see citing works
ASPECTS OF THE ETIOLOGY, PREDICTION, AND PREVENTION OF INSULIN-DEPENDENT DIABETES MELLITUS IN CHILDHOOD
Sperling, M. A. (1997) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(05)70476-4 · Cited by 30 · see citing works
Roles of the Humoral Response in Coxsackievirus B-Induced Disease
Gauntt, C. J. (1997) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-60687-8_12 · Cited by 28 · see citing works
Localization of gamma-aminobutyric acid and glutamic acid decarboxylase in the pancreas of the nonobese diabetic mouse.
Saravia, F., Faveeuw, C., Blasquez, C., Tappaz, M., Throsby, M., Pelletier, G., Vaudry, H., Dardenne, M., & Homo-Delarche, F. (1996) · Endocrinology · doi:10.1210/endo.137.8.8754779 · Cited by 28 · see citing works
Interaction of genetic and environmental factors in the pathogenesis of insulin-dependent diabetes mellitus
Åkerblom, H. K., Knip, M., Hyöty, H., Reijonen, H., Virtanen, S. M., Savilahti, E., & Ilonen, J. (1997) · Clinica Chimica Acta · doi:10.1016/s0009-8981(96)06441-8 · Cited by 27 · see citing works
Autoantibodies to the GM2-1 Islet Ganglioside and to GAD-65 at Type 1 Diabetes Onset
Dotta, F., Falorni, A., Tiberti, C., Dionisi, S., Anastasi, E., Torresi, P., Lernmark, Å., & Mario, U. D. (1997) · Journal of Autoimmunity · doi:10.1006/jaut.1997.0166 · Cited by 26 · see citing works
Association of Unexplained Infertility with Gonadotropin and Ovarian Antibodies
Shatavi, S. V., Llanes, B., & Luborsky, J. L. (2006) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2006.00428.x · Cited by 26 · see citing works
The effect of the MHC locus on autoantibodies in type 1 diabetes
Qu, H., & Polychronakos, C. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2009.066647 · Cited by 26 · see citing works
Glutamic acid decarboxylase and other autoantigens in IDDM
Nepom, G. T. (1995) · Current Opinion in Immunology · doi:10.1016/0952-7915(95)80055-7 · Cited by 26 · see citing works
Substitution of aspartic acid at β57 with alanine alters MHC class II peptide binding activity but not protein stability: HLA-DQ (α1∗0201, β1∗0302) and (α1∗0201, β1∗0303)
Sato, A. K., Sturniolo, T., Sinigaglia, F., & Stern, L. J. (1999) · Human Immunology · doi:10.1016/s0198-8859(99)00120-2 · Cited by 24 · see citing works
Current Pharmacological Treatment of Type 2 Diabetes Mellitus in Undocumented Migrants: Is It Appropriate for the Phenotype of the Disease?
Fiorini, G., Cortinovis, I., Corrao, G., Franchi, M., Pincelli, A. I., Perotti, M., Rigamonti, A. E., Sartório, A., & Cella, S. G. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17218169 · Cited by 23 · see citing works
Obstacles and opportunities for targeting the effector T cell response in type 1 diabetes
Buckner, J. H., & Nepom, G. T. (2016) · Journal of Autoimmunity · doi:10.1016/j.jaut.2016.02.009 · Cited by 23 · see citing works
Immunization Therapies in the Prevention of Diabetes
Ramiya, V. K., Lan, M. S., Wasserfall, C. H., Notkins, A. L., & Maclaren, N. K. (1997) · Journal of Autoimmunity · doi:10.1006/jaut.1997.0127 · Cited by 23 · see citing works
Self-citation
Self and non-self antigen in diabetic autoimmunity: Molecules and mechanisms
Karges, W., Ilonen, J., Robinson, B. H., & Dosch, H. (1995) · Molecular Aspects of Medicine · doi:10.1016/0098-2997(95)00001-w · Cited by 23 · see citing works
A CD80-Biased CTLA4-Ig Fusion Protein with Superior In Vivo Efficacy by Simultaneous Engineering of Affinity, Selectivity, Stability, and FcRn Binding
Douthwaite, J. A., Moisan, J., Privezentzev, C. V., Soskic, B., Sabbah, S., Cohen, E. S., Collinson, A., England, E., Huntington, C., Kemp, B., et al. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600682 · Cited by 22 · see citing works
The Neuronal Toxic Factor in Serum of Type 1 Diabetic Patients is a Complement‐fixing Autoantibody
Pittenger, G. L., Liu, D., & Vinik, A. (1995) · Diabetic Medicine · doi:10.1111/j.1464-5491.1995.tb00499.x · Cited by 22 · see citing works
HLA‐DRB1, ‐DQA1, ‐DQB1 and DPB1 susceptibility alleles in Cameroonian type 1 diabetes patients and controls
Mbanya, J. C., Sobngwi, E., & Mbanya, D. N. (2001) · European Journal of Immunogenetics · doi:10.1046/j.0960-7420.2001.00247.x · Cited by 21 · see citing works
Identification of a novel type 1 diabetes-specific epitope by screening phage libraries with sera from pre-diabetic patients
Mennuni, C., Santini, C., Lazzaro, D., Dotta, F., Farilla, L., Fierabracci, A., Bottazzo, G. F., Mario, U. D., Cortese, R., & Luzzago, A. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.0946 · Cited by 20 · see citing works
The GM2-1 Ganglioside Islet Autoantigen in Insulin-Dependent Diabetes Mellitus Is Expressed in Secretory Granules and Is Notβ -Cell Specific*
Dotta, F., Previti, M., Neerman‐Arbez, M., Dionisi, S., Cucinotta, D., Lenti, L., Mario, U. D., & Halban, P. A. (1998) · Endocrinology · doi:10.1210/endo.139.1.5708 · Cited by 19 · see citing works
Islet Cell Antibodies Represent Autoimmune Response Against Several Antigens
Månsson, L., Törn, C., & Landin‐Olsson, M. (2001) · Journal of Diabetes Research · doi:10.1155/edr.2001.85 · Cited by 19 · see citing works
The GABA network and the pathogenesis of IDDM
Esposti, M. D., & Mackay, I. R. (1997) · Diabetologia · doi:10.1007/s001250050687 · Cited by 18 · see citing works
Fetal Type Lymphocytes in Insulin Dependent Diabetes Mellitus
Gyarmati, J., Szekeres‐Barthó, J., Fischer, B., & Soltész, G. (1999) · Autoimmunity · doi:10.3109/08916939908994762 · Cited by 18 · see citing works
Multiple Genes/Multiple Autoantigens Role in Type 1 Diabetes
Abiru, N., & Eisenbarth, G. S. (2000) · Clinical Reviews in Allergy & Immunology · doi:10.1385/criai:18:1:27 · Cited by 18 · see citing works
K cells: a novel target for insulin gene therapy for the prevention of diabetes
Corbett, J. A. (2001) · Trends in Endocrinology and Metabolism · doi:10.1016/s1043-2760(01)00400-3 · Cited by 17 · see citing works
Azathioprine Associated T‐Cell Mutations in Insulin‐Dependent Diabetes Mellitus
Falta, M. T., Atkinson, M. A., Allegretta, Vacek, & Albertini (2000) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.2000.00742.x · Cited by 17 · see citing works
Self-citation
T-cell mediated autoimmunity to the insulinoma-associated protein 2 islet tyrosine phosphatase in type 1 diabetes mellitus
Dotta, F., Dionisi, S., Viglietta, V., Tiberti, C., Matteoli, M. C., Cervoni, M., Bizzarri, C., Marietti, G., Testi, M. G., Multari, G., et al. (1999) · European Journal of Endocrinology · doi:10.1530/eje.0.1410272 · Cited by 17 · see citing works
Peptide-specific cytotoxicity of T lymphocytes against glutamic acid decarboxylase and insulin in type 1 diabetes mellitus
Kimura, K., Kawamura, T., Kadotani, S., Inada, H., Niihira, S., & Yamano, T. (2001) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(00)00225-4 · Cited by 16 · see citing works
Oral Tolerance to Insulin and the Insulin B‐Chain.
Maron, R., BLOGG, N. S., Polanski, M., Hancock, W. W., & Weiner, H. L. (1996) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1996.tb21142.x · Cited by 16 · see citing works
Selection ofhprtMutant T Cells as Surrogates for Dividing Cells Reveals a Restricted T Cell Receptor BV Repertoire in Insulin-Dependent Diabetes Mellitus
Falta, M. T., Magin, G. K., Allegretta, M., Steinman, L., Atkinson, M. A., Brostoff, S. W., & Albertini, R. J. (1999) · Clinical Immunology · doi:10.1006/clim.1998.4664 · Cited by 16 · see citing works
Self-citation
Chemical Tools To Monitor and Manipulate Adaptive Immune Responses
Doran, T. M., Sarkar, M., & Kodadek, T. J. (2016) · Journal of the American Chemical Society · doi:10.1021/jacs.6b02954 · Cited by 15 · see citing works
Has GAD a Central Role in Type 1 Diabetes?
Yoon, J.-W., Sherwin, R. S., Kwon, H., & Jun, H. (2000) · Journal of Autoimmunity · doi:10.1006/jaut.2000.0442 · Cited by 15 · see citing works
Pathophysiology of Canine Diabetes
Hoenig, M. E. (1995) · Veterinary Clinics of North America Small Animal Practice · doi:10.1016/s0195-5616(95)50052-x · Cited by 14 · see citing works
Congenital Autoimmune Diabetes Mellitus
Cilio, C., Bosco, A., Moretti, C., Farilla, L., Savignoni, F., Colarizi, P., Multari, G., Mario, U. D., Bucci, G., & Dotta, F. (2000) · New England Journal of Medicine · doi:10.1056/nejm200005183422015 · Cited by 15 · see citing works
Development of new strategies to prevent type 1 diabetes: the role of animal models
Hänninen, A. L. M., Hamilton‐Williams, E. E., & Kurts, C. (2003) · Annals of Medicine · doi:10.1080/07853890310014597 · Cited by 15 · see citing works
Autoantibodies in Type 1 diabetes
Heras, P., Mantzioros, M., Mendrinos, D., Heras, V., Hatzopoulos, A., Xourafas, V., Kritikos, K., & Karagiannis, S. E. (2010) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2010.08.015 · Cited by 14 · see citing works
Stress Response of Pancreatic Islets from Diabetes Prone BB Rats of Different Age
Wachlin, G., Heine, L., Klöting, I., Dunger, A., Hahn, H.-J., & Schmidt, S. (2002) · Autoimmunity · doi:10.1080/0891693021000014989 · Cited by 13 · see citing works
Development of 2 alternative enzyme-linked immunosorbent assays for routine screening of glutamic acid decarboxylase autoantibodies
Villalba, A., Valdez, S. N., Iacono, R. F., & Poskus, E. (2006) · Clinica Chimica Acta · doi:10.1016/j.cca.2006.07.017 · Cited by 13 · see citing works
Prevention of Type 1 Diabetes from Laboratory to Public Health
Flanders, G., Graves, P. M., & Rewers, M. (1999) · Autoimmunity · doi:10.3109/08916939908998537 · Cited by 11 · see citing works
Controversial topics series: Milk proteins and diabetes
Norris, J. M., & Pietropaolo, M. (1999) · Journal of Endocrinological Investigation · doi:10.1007/bf03343611 · Cited by 9 · see citing works
Insulitis and islet-cell antibody formation in rats with experimentally reduced beta-cell mass
Lampeter, E. F., Tubes, M., Klemens, C., Brocker, U., Friemann, J., Kolb‐Bachofen, V., Gries, F. A., & Kolb, H. (1995) · Diabetologia · doi:10.1007/bf00400599 · Cited by 9 · see citing works
Viral elements in autoimmunity of type I diabetes
Pietropaolo, M., & Trucco, M. (1996) · Trends in Endocrinology and Metabolism · doi:10.1016/1043-2760(96)00037-9 · Cited by 9 · see citing works
Prevalence of β-cell and Thyroid Autoantibody Positivity in Schoolchildren during Three-Year Follow-up
Lindberg, B. A., Carlsson, A., Ericsson, U., Kockum, I. S., Lernmark, Å., Landin‐Olsson, M., Sundkvist, G., & Ivarsson, S.-A. (1999) · Autoimmunity · doi:10.3109/08916939908994062 · Cited by 9 · see citing works
Synchrotron fluorescence imaging of individual mouse beta-cells reveals changes in zinc, calcium, and iron in a model of low-grade inflammation
Slepchenko, K. G., Chen, S., Counts, G. P., Corbin, K. L., Colvin, R. A., & Nunemaker, C. S. (2021) · Metallomics · doi:10.1093/mtomcs/mfab051 · Cited by 8 · see citing works
Aleitamento materno e diabetes Mellitus do tipo 1
Macedo, C. L. D., Ferreira, M. C., Naujorks, A. A., Tercziany, A., da Costa, F. J. B., de David, H. C., Nascimento, L. L., Dal'Forno, T. D. O., & Uggeri, T. M. (1999) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27301999000500008 · Cited by 8 · see citing works
HLA-DR-restricted T cell lines from newly diagnosed type 1 diabetic patients specific for insulinoma and normal islet beta cell proteins: lack of reactivity to glutamic acid decarboxylase
Huang, G. C., Tremble, J. M., BAILYES, E. M., Arden, S. D., Kaye, T. B., McGregor, A., & Banga, J. P. (1995) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1995.tb06649.x · Cited by 8 · see citing works
Conversations with GAD
Nepom, G. T. (2003) · Journal of Autoimmunity · doi:10.1016/s0896-8411(03)00031-3 · Cited by 7 · see citing works
Inhibition of Mitochondrial Oxidative Phosphorylation Induces Hyper-Expression of Glutamic Acid Decarboxylase in Pancreatic Islet Cells
Myers, M. A., Georgiou, H. M., Byron, S. K., & Esposti, M. D. (1999) · Autoimmunity · doi:10.3109/08916939908994759 · Cited by 7 · see citing works
HLA-Associated Cellular Response to GAD in Type 2 Diabetes with Antibodies to GAD.
FUKUI, M., Nakamura, N., NAKANO, K., Kajiyama, S., MATSUO, S., Obayashi, H., Ohta, M., Shigeta, M., Shigeta, H., Kitagawa, Y., et al. (2000) · Endocrine Journal · doi:10.1507/endocrj.47.753 · Cited by 6 · see citing works

Authors: Atkinson, M. A., & Maclaren, N. K.
Affiliations: University of Florida (US)
ORCID: Atkinson, M A
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 1993-10-01
Volume: 92
Issue: 4
Pages: 1608-1616
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci116745
PMC: PMC288318
OpenAlex: W2141405570
Cited by: 129
References: 64
Citations by year: 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2016: 3 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 3
FWCI: 1.61
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Diabetes and associated disorders
Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Keywords: type 1 diabetes, type 1 diabetes pathogenesis, islet autoimmunity, glutamic acid decarboxylase, conformational epitopes, insulitis, disease prediction
MeSH terms: Autoantigens, Carboxypeptidases, Diabetes Mellitus, Type 1, Glutamate Decarboxylase, Heat-Shock Proteins, Humans, Islets of Langerhans, Monosaccharide Transport Proteins, Proinsulin, Serum Albumin, Bovine, T-Lymphocytes

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