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New insights into the pathogenesis of asthma
Open accessAbstract
Historical perspectiveAsthma is a disease whose ability to cause episodic symptomatology has been appreciated since antiquity.Although the fine points of the definition can be debated, it is reasonable to think of asthma as a pulmonary disorder characterized by the generalized reversible obstruction of airflow and to define reversibility as a greater than 12% increase in the patient's forced expiratory volume in 1 second (FEV 1 ) that occurs either spontaneously or with therapy.Airway hyperresponsiveness, an exaggerated bronchospastic response to nonspecific agents such as methacholine and histamine or specific antigens, is the physiologic cornerstone of this disorder.A diagnosis of asthma is established based on a history of recurrent wheeze, cough, or shortness of breath, reversible airway obstruction demonstrated by pulmonary-function testing, and, in cases where questions exist, a methacholine challenge demonstrating airway hyperresponsiveness.It has long been assumed that patients with asthma experience intermittent attacks and have relatively normal lung function during intervening periods.More recent studies have demonstrated that asthma can cause progressive lung impairment and, in some patients, eventuate in partially reversible or irreversible airway obstruction.Any discussion of asthma must take into account the recent increase in its prevalence.Since approximately 1980, the frequency of this disorder has almost doubled.As a result of this "epidemic," asthma now affects approximately 8-10% of the population in the US, is the leading cause of hospitalization among children less than 15 years of age, and costs society billions of dollars annually.This increase in prevalence is not simply due to diagnostic transference or increased diagnostic awareness, since asthma mortality rates have also increased during this interval.
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“Asthma is controlled by Th2 immune response, which leads to the high levels of IgE, airway eosinophilia, and mucus production [18].”
From Picroside II Attenuates Airway Inflammation by Downregulating the Transcription Factor GATA3 and Th2-Related Cytokines in a Mouse Model of HDM-Induced Allergic Asthma (2016) · cites this paper as [18]
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Zhu, Z., Homer, R., Wang, Z., Chen, Q., Geba, G. P., Wang, J., Zhang, Y., & Elias, J. A. (1999) · Journal of Clinical Investigation · doi:10.1172/jci5909 · Cited by 1,730
Self-citationLee, C. G., Homer, R. J., Zhu, Z., Lanone, S., Wang, X., Koteliansky, V., Shipley, J. M., Gotwals, P., Noble, P., Chen, Q., et al. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.6.809 · Cited by 940
Self-citationTreatment of Allergic Asthma with Monoclonal Anti-IgE Antibody
Milgrom, H., Fick, R. B., Su, J. Q., Reimann, J. D., Bush, R. K., Watrous, M. L., & Metzger, W. J. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912233412603 · Cited by 703
Elias, J. A., Zhu, Z., Chupp, G. L., & Homer, R. (1999) · Journal of Clinical Investigation · doi:10.1172/jci8124 · Cited by 696
Self-citationZheng, T., Zhu, Z., Wang, Z., Homer, R., Ma, B., Riese, R. J., Chapman, H. A., Shapiro, S. D., & Elias, J. A. (2000) · Journal of Clinical Investigation · doi:10.1172/jci10458 · Cited by 646
Self-citationDevelopment of Spontaneous Airway Changes Consistent with Human Asthma in Mice Lacking T-bet
Finotto, S., Neurath, M. F., Glickman, J. N., Qin, S., Lehr, H. A., Green, F. H. Y., Ackerman, K. G., Haley, K. J., Galle, P. R., Szabo, S. J., et al. (2002) · Science · doi:10.1126/science.1065544 · Cited by 627
The role of Th1/Th2 polarization in mucosal immunity
Neurath, M. F., Finotto, S., & Glimcher, L. H. (2002) · Nature Medicine · doi:10.1038/nm0602-567 · Cited by 623
Asthma: an epidemic of dysregulated immunity
Umetsu, D. T., McIntire, J. J., Akbari, O., Macaubas, C., & DeKruyff, R. H. (2002) · Nature Immunology · doi:10.1038/ni0802-715 · Cited by 601
Ito, K., Lim, S., Caramori, G., Cosío, B. G., Chung, K. F., Adcock, I. M., & Barnes, P. J. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.132556899 · Cited by 512
A Role for Cysteinyl Leukotrienes in Airway Remodeling in a Mouse Asthma Model
Henderson, W. R., Tang, L.-O., Chu, S.-J., Tsao, S., Chiang, G. K. S., Jones, F., Jonas, M., Pae, C. I., Wang, H., & Chi, E. Y. (2002) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.165.1.2105051 · Cited by 418
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Role of Chitin and Chitinase/Chitinase-Like Proteins in Inflammation, Tissue Remodeling, and Injury
Lee, C. G., Da Silva, C. A., Dela Cruz, C. S., Ahangari, F., Ma, B., Kang, M.-J., He, C.-H., Takyar, S., & Elias, J. A. (2011) · Annual Review of Physiology · doi:10.1146/annurev-physiol-012110-142250 · Cited by 896
Self-citationA sthma : Mechanisms of Disease Persistence and Progression
Cohn, L. E., Elias, J. A., & Chupp, G. L. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104716 · Cited by 809
Self-citationA protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders
Kim, J., Cha, Y., & Surh, Y. (2009) · Mutation research. Fundamental and molecular mechanisms of mutagenesis · doi:10.1016/j.mrfmmm.2009.09.007 · Cited by 692
Lee, C. G., Link, H., Bałuk, P., Homer, R., Chapoval, S. P., Bhandari, V., Kang, M., Cohn, L. E., Kim, Y. K., McDonald, D. M., et al. (2004) · Nature Medicine · doi:10.1038/nm1105 · Cited by 586
Self-citationDisruption of Nrf2 enhances susceptibility to severe airway inflammation and asthma in mice
Rangasamy, T., Guo, J., Mitzner, W. A., Roman, J., Singh, A., Fryer, A. D., Yamamoto, M., Kensler, T. W., Tuder, R. M., Georas, S. N., et al. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20050538 · Cited by 580
A Review on Anti-Inflammatory Activity of Monoterpenes
Sá, R. D. C. D. S. E., Andrade, L., & de Sousa, D. P. (2013) · Molecules · doi:10.3390/molecules18011227 · Cited by 579
IL-13 Activates a Mechanism of Tissue Fibrosis That Is Completely TGF-β Independent
Kaviratne, M., Hesse, M., Leusink, M., Cheever, A. W., Davies, S. J., McKerrow, J. H., Wakefield, L. M., Letterio, J. J., & Wynn, T. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.173.6.4020 · Cited by 370
Lee, C. G., Cho, S. J., Kang, M., Chapoval, S. P., Lee, P. J., Noble, P. W., Yehualaeshet, T., Lu, B., Flavell, R. A., Milbrandt, J., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040104 · Cited by 365
Self-citationZosky, G. R., & Sly, P. D. (2007) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2007.02740.x · Cited by 315
Formaldehyde Exposure and Asthma in Children: A Systematic Review
McGwin, G., Lienert, J., & Kennedy, J. I. (2009) · Environmental Health Perspectives · doi:10.1289/ehp.0901143 · Cited by 283
Decreased Arginine Bioavailability and Increased Serum Arginase Activity in Asthma
Morris, C. R., Poljakovic, M., Lavrisha, L., Machado, L., Kuypers, F. A., & Morris, S. M. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200309-1304oc · Cited by 284
Chitin Is a Size-Dependent Regulator of Macrophage TNF and IL-10 Production
Silva, C. A. D., Chalouni, C. M., Williams, A., Hartl, D., Lee, C. G., & Elias, J. A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802113 · Cited by 282
Self-citationCantero-Recasens, G., Fandos, C., Rubio-Moscardó, F., Valverde, M. A., & Vicente, R. (2009) · Human Molecular Genetics · doi:10.1093/hmg/ddp471 · Cited by 269
Role of Nrf2 and Its Activators in Respiratory Diseases
Liu, Q., Gao, Y., & Ci, X. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/7090534 · Cited by 273
Curcumin use in pulmonary diseases: State of the art and future perspectives
Lelli, D., Sahebkar, A., Johnston, T. P., & Pedone, C. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.11.017 · Cited by 264
Role of A2B adenosine receptor signaling in adenosine-dependent pulmonary inflammation and injury
Sun, C.-X. (2006) · Journal of Clinical Investigation · doi:10.1172/jci27303 · Cited by 253
Lee, K. S., Lee, H. K., Hayflick, J. S., Lee, Y. C., & Puri, K. D. (2006) · The FASEB Journal · doi:10.1096/fj.05-5045com · Cited by 245
Kefir and Health: A Contemporary Perspective
Ahmed, Z., Wang, Y., Ahmad, A., Khan, S. T., Nisa, M., Ahmad, H., & Afreen, A. (2013) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2010.540360 · Cited by 242
Chitinases and chitinase-like proteins in TH2 inflammation and asthma
Elias, J. A., Homer, R., Hamid, Q. A., & Lee, C. G. (2005) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.06.028 · Cited by 235
Self-citationDoerner, A. M., & Zuraw, B. L. (2009) · Respiratory Research · doi:10.1186/1465-9921-10-100 · Cited by 235
Anti-inflammatory effect of thymoquinone in a mouse model of allergic lung inflammation
Gazzar, M. E., Elmezayen, R., Marecki, J. C., Nicolls, M. R., Canastar, A., & Dreskin, S. C. (2006) · International Immunopharmacology · doi:10.1016/j.intimp.2006.02.004 · Cited by 226
Koff, J. L., Shao, M. X. G., Ueki, I. F., & Nadel, J. A. (2008) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00025.2008 · Cited by 232
Mall, M. A. (2008) · Journal of Aerosol Medicine · doi:10.1089/jamp.2007.0659 · Cited by 226
Tissue remodelling in chronic bronchial diseases: from the epithelial to mesenchymal phenotype
Pain, M., Bermúdez, O. M., Lacoste, P., Royer, P., Botturi, K., Tissot, A., Brouard, S., Eickelberg, O., & Magnan, A. (2014) · European Respiratory Review · doi:10.1183/09059180.00004413 · Cited by 212
The Enigmatic Cytokine Oncostatin M and Roles in Disease
Richards, C. D. (2013) · ISRN Inflammation · doi:10.1155/2013/512103 · Cited by 211
Role for macrophage migration inhibitory factor in asthma
Mizue, Y., Ghani, S., Leng, L., McDonald, C., Kong, P. L., Baugh, J. A., Lane, S. J., Craft, J., Nishihira, J., Donnelly, S. C., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0507189102 · Cited by 203
Self-citationAl-Moamary, M. S., Alhaider, S., Al-Hajjaj, M., Ghobain, M. O. A., Idrees, M., Zeitouni, M. O., Alharbi, A. S., Dabbagh, M. A., Al-Matar, H., & Alorainy, H. S. (2012) · Annals of Thoracic Medicine · doi:10.4103/1817-1737.102166 · Cited by 192
Bidirectional interaction of airway epithelial remodeling and inflammation in asthma
Banno, A., Reddy, A. T., Lakshmi, S. P., & Reddy, R. C. (2020) · Clinical Science · doi:10.1042/cs20191309 · Cited by 190
Bonfield, T. L., Koloze, M., Lennon, D. P., Zuchowski, B., Yang, S.-E., & Caplan, A. I. (2010) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00182.2009 · Cited by 188
Trichostatin A attenuates airway inflammation in mouse asthma model
Choi, J., Oh, S. ‐., Kang, M., Kwon, H. J., Oh, G. T., & Kim, D. Y. (2004) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.2004.02006.x · Cited by 183
Lee, M.-Y., Kim, S.-Y., Kwon, O., Oh, S., Lee, H., & Ahn, K. (2009) · International Immunopharmacology · doi:10.1016/j.intimp.2009.01.005 · Cited by 182
Sonic Hedgehog Signaling in the Lung. From Development to Disease
Kugler, M. C., Joyner, A. L., Loomis, C. A., & Munger, J. S. (2014) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2014-0132tr · Cited by 175
Semaphorin 7A plays a critical role in TGF-β1–induced pulmonary fibrosis
Kang, H., Lee, C. G., Homer, R., & Elias, J. A. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20061273 · Cited by 176
Self-citationEosinophils function as antigen-presenting cells
Shi, H. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0404228 · Cited by 170
Cigarette Smoke, Inflammation, and Lung Injury: A Mechanistic Perspective
Bhalla, D. K., Hirata, F., Rishi, A. K., & Gairola, C. G. (2009) · Journal of Toxicology and Environmental Health Part B · doi:10.1080/10937400802545094 · Cited by 165
Hogan, S. P., Seidu, L., Blanchard, C., Groschwitz, K. R., Mishra, A., Karow, M. L., Ahrens, R., Artis, D., Murphy, A. J., Valenzuela, D. M., et al. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.04.039 · Cited by 158
Curcumin and chemokines: mechanism of action and therapeutic potential in inflammatory diseases
Sadeghi, M., Dehnavi, S., Asadirad, A., Xu, S., Majeed, M. A., Jamialahmadi, T., Johnston, T. P., & Sahebkar, A. (2023) · Inflammopharmacology · doi:10.1007/s10787-023-01136-w · Cited by 171
Kang, M., Homer, R., Gallo, A. E., Lee, C. G., Crothers, K. A., Cho, S. J., Rochester, C. L., Cain, H. C., Chupp, G. L., Yoon, H. J., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1948 · Cited by 155
Self-citationInhaled p38α Mitogen-activated Protein Kinase Antisense Oligonucleotide Attenuates Asthma in Mice
Duan, W., Chan, J. H. P., McKay, K., Crosby, J. R., Choo, H. H., Leung, B. P. L., Karras, J. G., & Wong, W. S. F. (2004) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200408-1006oc · Cited by 155
Ochkur, S. I., Jacobsen, E. A., Protheroe, C. A., Biechele, T. L., Pero, R. S., McGarry, M. P., Wang, H., O'Neill, K. R., Colbert, D. C., Colby, T. V., et al. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.12.7879 · Cited by 153
Schneider, D. J., Wu, M., Le, T. T., Cho, S., Brenner, M. B., Blackburn, M. R., & Agarwal, S. K. (2011) · The FASEB Journal · doi:10.1096/fj.11-186098 · Cited by 148
Zhou, Y., Lee, J., Lee, C.-M., Cho, W., Kang, M., Koff, J. L., Yoon, P.-O., Chae, J., Park, H.-O., Elias, J. A., et al. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.356824 · Cited by 147
Self-citationA protective role for the A1 adenosine receptor in adenosine-dependent pulmonary injury
Sun, C.-X., Young, H. W. J., Molina, J. G., Volmer, J. B., Schnermann, J. B., & Blackburn, M. R. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22656 · Cited by 140
Angiogenesis and lymphangiogenesis in bronchial asthma
Detoraki, A., Granata, F., Staibano, S., Rossi, F. W., Marone, G., & Genovese, A. (2010) · Allergy · doi:10.1111/j.1398-9995.2010.02372.x · Cited by 131
Role of mammalian chitinases in inflammatory conditions
Kawada, M., Hachiya, Y., Arihiro, A., & Mizoguchi, E. (2007) · The Keio Journal of Medicine · doi:10.2302/kjm.56.21 · Cited by 133
Hayashi, N., Yoshimoto, T., Izuhara, K., Matsui, K., Tanaka, T., & Nakanishi, K. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706378104 · Cited by 124
Adenosine-Dependent Pulmonary Fibrosis in Adenosine Deaminase-Deficient Mice
Chunn, J. L., Molina, J. G., Mi, T., Xia, Y., Kellems, R. E., & Blackburn, M. R. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.3.1937 · Cited by 127
Antigen-specific CD4+ T cells drive airway smooth muscle remodeling in experimental asthma
Ramos‐Barbón, D., Presley, J. F., Hamid, Q. A., Fixman, E. D., & Martin, J. G. (2005) · Journal of Clinical Investigation · doi:10.1172/jci19711 · Cited by 128
Anti-inflammatory and anti-allergic effects of kefir in a mouse asthma model
Lee, M.-Y., Ahn, K.-S., Kwon, O.-K., Kim, M.-J., Kim, M.-K., Lee, I.-Y., Oh, S.-R., & Lee, H.-K. (2007) · Immunobiology · doi:10.1016/j.imbio.2007.05.004 · Cited by 122
PKCζ at the crossroad of NF-κB and Jak1/Stat6 signaling pathways
Moscat, J., Rennert, P. D., & Díaz-Meco, M. T. (2005) · Cell Death and Differentiation · doi:10.1038/sj.cdd.4401823 · Cited by 121
Anti-inflammatory effects of ivermectin in mouse model of allergic asthma
Yan, S., Ci, X., Chen, N., Chen, C., Li, X., Chu, X., Li, J., & Deng, X. (2011) · Inflammation Research · doi:10.1007/s00011-011-0307-8 · Cited by 120
Lee, C. G., Kang, H.-R., Homer, R., Chupp, G. L., & Elias, J. A. (2006) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200602-017aw · Cited by 115
Self-citationAdenosine signaling and the regulation of chronic lung disease
Zhou, Y., Schneider, D. J., & Blackburn, M. R. (2009) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2009.04.003 · Cited by 116
Kuo, H., Wang, C., Liang, C. D., Yu, H., Huang, C., Wang, L., Hwang, K., & Yang, K. D. (2009) · Pediatric Allergy and Immunology · doi:10.1111/j.1399-3038.2008.00779.x · Cited by 115
Purinergic Signaling in Pulmonary Inflammation
Le, T. T., Berg, N. K., Harting, M. T., Li, X., Eltzschig, H. K., & Yuan, X. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01633 · Cited by 114
Deshpande, D. A., White, T. A., Doğan, S., Walseth, T. F., Panettieri, R. A., & Kannan, M. (2005) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00217.2004 · Cited by 114
Modified Foxp3 mRNA protects against asthma through an IL-10-dependent mechanism
Mays, L. E., Ammon-Treiber, S., Mothes, B., Alkhaled, M., Rottenberger, J., Müller-Hermelink, E. S., Grimm, M., Mezger, M., Beer-Hammer, S., von Stebut, E., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65351 · Cited by 113
Oh, S.-W., Cha, J. Y., Jung, J., Chang, B. C., Kwon, H., Lee, B., & Kim, D.-Y. (2010) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2010.07.026 · Cited by 113
An anti-inflammatory role for a phosphoinositide 3-kinase inhibitor LY294002 in a mouse asthma model
Duan, W., Datiles, A. M. K. A., Leung, B. P. L., Vlahos, C. J., & Wong, W. S. F. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.10.015 · Cited by 111
Sugimoto, T., Ishikawa, Y., Yoshimoto, T., Hayashi, N., Fujimoto, J., & Nakanishi, K. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20031368 · Cited by 111
Bhandari, V., Choo-Wing, R., Chapoval, S. P., Lee, C. G., Tang, C., Kim, Y. K., Ma, B., Bałuk, P., Lin, M. I., McDonald, D. M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601057103 · Cited by 110
Self-citationStigmasterol Modulates Allergic Airway Inflammation in Guinea Pig Model of Ovalbumin-Induced Asthma
Antwi, A. O., Obiri, D. D., & Osafo, N. (2017) · Mediators of Inflammation · doi:10.1155/2017/2953930 · Cited by 108
Ma, B., Zhu, Z., Homer, R., Gerard, C. J., Strieter, R. M., & Elias, J. A. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.3.1872 · Cited by 111
Self-citationMitogen-activated protein kinases as therapeutic targets for asthma
Khorasanizadeh, M., Eskian, M., Gelfand, E. W., & Rezaei, N. (2017) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2017.02.024 · Cited by 107
Anti‐inflammatory effects of apocynin, an inhibitor of NADPH oxidase, in airway inflammation
Kim, S. Y., Moon, K., Jo, H., Jeong, S., Seon, S., Jung, E., Cho, Y. S., Chun, E., & Lee, K. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2011.60 · Cited by 106
RhoA orchestrates glycolysis for TH2 cell differentiation and allergic airway inflammation
Yang, J., Kalim, K. W., Li, Y., Zhang, S., Hinge, A. S., Filippi, M., Zheng, Y., & Guo, F. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.05.004 · Cited by 105
Mitogen‐activated protein kinases and asthma
Pelaia, G., Cuda, G., Vatrella, A., Gallelli, L., Caraglia, M., Marra, M., Abbruzzese, A., Caputi, M., Maselli, R., Costanzo, F. S., et al. (2004) · Journal of Cellular Physiology · doi:10.1002/jcp.20169 · Cited by 105
Role of Early Growth Response-1 (Egr-1) in Interleukin-13-induced Inflammation and Remodeling
Cho, S. J., Kang, M., Homer, R., Kang, H., Zhang, X., Lee, P. J., Elias, J. A., & Lee, C. G. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m506770200 · Cited by 104
Self-citationAirway remodelling in asthma: Current understanding and implications for future therapies
Tang, M. L. K., Wilson, J. W., Stewart, A. G., & Royce, S. G. (2006) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.05.001 · Cited by 101
Kerzerho, J., Maazi, H., Speak, A. O., Szely, N., Lombardi, V., Khoo, B., Geryak, S., Lam, J., Soroosh, P., Snick, J. V., et al. (2012) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2012.09.027 · Cited by 101
Calcium Signaling in Airway Smooth Muscle
Jude, J. A., Wylam, M. E., Walseth, T. F., & Kannan, M. (2007) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200704-047vs · Cited by 100
Moss, A. (2013) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2013.05.009 · Cited by 102
Chong, L., Zhang, W., Nie, Y., Yu, G., Liu, L., Lin, L., Wen, S., Zhu, L., & Li, C. (2014) · Inflammation · doi:10.1007/s10753-014-9873-6 · Cited by 99
SLC26A9-mediated chloride secretion prevents mucus obstruction in airway inflammation
Anagnostopoulou, P., Riederer, B., Duerr, J., Michel, S., Binia, A., Agrawal, R., Liu, X., Kalitzki, K., Xiao, F., Chen, M., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60429 · Cited by 98
Nrf2 reduces allergic asthma in mice through enhanced airway epithelial cytoprotective function
Sussan, T. E., Gajghate, S., Chatterjee, S., Mandke, P., McCormick, S. M., Sudini, K. R., Kumar, S., Breysse, P. N., Diette, G. B., Sidhaye, V. K., et al. (2015) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00398.2014 · Cited by 95
γ-Secretase Inhibitor Reduces Allergic Pulmonary Inflammation by Modulating Th1 and Th2 Responses
Kang, J. H., Kim, B., Uhm, T. G., Lee, S., Lee, G. R., Park, C., & Chung, I. Y. (2009) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200806-893oc · Cited by 95
A review of asthma genetics: gene expression studies and recent candidates.
Malerba, G., & Pignatti, P. F. (2005) · PubMed · Cited by 94
Overview of the pharmacogenetics of asthma treatment
Weiss, S. T., Litonjua, A. A., Lange, C., Lazarus, R. M., Liggett, S. B., Bleecker, E. R., & Tantisira, K. G. (2006) · The Pharmacogenomics Journal · doi:10.1038/sj.tpj.6500387 · Cited by 92
Ma, C., Ma, Z., Fu, Q., & Ma, S. (2013) · Fitoterapia · doi:10.1016/j.fitote.2013.02.014 · Cited by 91
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Metadata
- Authors
- Elias, J. A., Lee, C. G., Zheng, T., Ma, B., Homer, R. J., & Zhu, Z.
- Affiliations
- Yale University (US)
- Corresponding author
- Elias, Jack A.
- Venue
- Journal of Clinical Investigation
- Published
- 2003-02-01
- Volume
- 111
- Issue
- 3
- Pages
- 291-297
- ISSN
- 0021-9738 (ISSN-L)
- PMC
- PMC151878
- OpenAlex
- W2073310243
- Cited by
- 407
- References
- 22
- Citations by year
- 2026: 3 · 2025: 2 · 2024: 7 · 2023: 6 · 2022: 4 · 2021: 12 · 2020: 5 · 2019: 11 · 2018: 9 · 2017: 16 · 2016: 14 · 2015: 22 · 2014: 18 · 2013: 24 · 2012: 21
- FWCI
- 18.25
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Doris Duke Charitable Foundation
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Asthma and respiratory diseases
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Occupational exposure and asthma
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Keywords
- asthma pathogenesis, airway hyperresponsiveness, reversible airway obstruction, methacholine challenge, asthma prevalence, asthma mortality, bronchospasm, history of asthma
- MeSH terms
- Animals, Asthma, Humans, Mice, Transgenic, Models, Biological, Th1 Cells, Th2 Cells, Mice
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