Cited by 220Liver Diseases and ImmunityCell death mechanisms and regulationSystemic Lupus Erythematosus Research

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Bcl-2–dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis

Open access

Odin, Joseph A., Huebert, Robert C., Casciola-Rosen, Livia, LaRusso, Nicholas F., Rosen, Antony·2001·Journal of Clinical Investigation

DOI 10.1172/jci200110716PMC PMC203018

Open this paper in CoChat — free account Open PDF

Abstract

The close association between autoantibodies against pyruvate dehydrogenase-E2 (PDC-E2), a ubiquitous mitochondrial protein, and primary biliary cirrhosis (PBC) is unexplained.Many autoantigens are selectively modified during apoptosis, which has focused attention on apoptotic cells as a potential source of "neo-antigens" responsible for activating autoreactive lymphocytes.Since increased apoptosis of bile duct epithelial cells (cholangiocytes) is evident in patients with PBC, we evaluated the effect of apoptosis on PDC-E2.Autoantibody recognition of PDC-E2 by immunofluorescence persisted in apoptotic cholangiocytes and appeared unchanged by immunoblot analysis.PDC-E2 was neither cleaved by caspases nor concentrated into surface blebs in apoptotic cells.In other cell types, autoantibody recognition of PDC-E2, as assessed by immunofluorescence, was abrogated after apoptosis, although expression levels of PDC-E2 appeared unchanged when examined by immunoblot analysis.Both overexpression of Bcl-2 and depletion of glutathione before inducing apoptosis prevented this loss of autoantibody recognition, suggesting that glutathiolation, rather than degradation or loss, of PDC-E2 was responsible for the loss of immunofluorescence signal.We postulate that apoptotic cholangiocytes, unlike other apoptotic cell types, are a potential source of immunogenic PDC-E2 in patients with PBC.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci200110716

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine
Griffith, O. W. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90139-6 · Cited by 4,628
Molecular characterization of mitochondrial apoptosis-inducing factor
Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060
Bcl-2 functions in an antioxidant pathway to prevent apoptosis
Hockenbery, D. M., Oltvai, Z. N., Yin, X., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80066-n · Cited by 3,402
Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.
Casciola-Rosen, L. A., Anhalt, G. J., & Rosen, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1317 · Cited by 1,723
Self-citation
Consequences of Cell Death
Sauter, B., Albert, M. L., Francisco, L. M., Larsson, M., Somersan, S., & Bhardwaj, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.423 · Cited by 1,357
A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes
Huang, F., Platt, N., Wykes, M., Major, J. R., Powell, T. J., Jenkins, C. D., & MacPherson, G. G. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.435 · Cited by 902
Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis
Poupon, R., Lindor, K., Cauch-Dudek, K., Dickson, E., Poupon, R., & Heathcote, E. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70183-5 · Cited by 648
Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis
Gershwin, M. E., Mackay, I. R., Sturgess, A., & Coppel, R. L. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.10.3525 · Cited by 557
Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status
Casciola-Rosen, L. A., Andrade, F., Ulanet, D., Wong, W. B., & Rosen, A. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.6.815 · Cited by 492
Self-citation
ABERRANT EXPRESSION OF HLA-DR ANTIGENS ON BILEDUCT EPITHELIUM IN PRIMARY BILIARY CIRRHOSIS: RELEVANCE TO PATHOGENESIS
Ballardini, G., Bianchi, F., Doniach, D., Mirakian, R. M., Pisi, E., & Bottazzo, G. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91108-5 · Cited by 488
Primary Biliary Cirrhosis
Kaplan, M. M. (1996) · New England Journal of Medicine · doi:10.1056/nejm199611213352107 · Cited by 459
Specific cleavage of the 70-kDa protein component of the U1 small nuclear ribonucleoprotein is a characteristic biochemical feature of apoptotic cell death.
Casciola-Rosen, L. A., Miller, D. K., Anhalt, G. J., & Rosen, A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)47343-7 · Cited by 418
Self-citation
DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.
Casciola-Rosen, L. A., Anhalt, G. J., & Rosen, A. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.6.1625 · Cited by 417
Self-citation
The Caspase-3 Precursor Has a Cytosolic and Mitochondrial Distribution: Implications for Apoptotic Signaling
Mancini, M., Nicholson, D. W., Roy, S., Thornberry, N. A., Peterson, E. P., Casciola-Rosen, L. A., & Rosen, A. (1998) · The Journal of Cell Biology · doi:10.1083/jcb.140.6.1485 · Cited by 409
Self-citation
β cell apoptosis in T cell-mediated autoimmune diabetes
Kurrer, M. O., Pakala, S. V., Hanson, H. L., & Katz, J. D. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.1.213 · Cited by 317
Bcl-2 expression causes redistribution of glutathione to the nucleus
Voehringer, D. W., McConkey, D. J., McDonnell, T. J., Brisbay, S. M., & Meyn, R. E. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.6.2956 · Cited by 300
PRIMARY BILIARY CIRRHOSIS: IDENTIFICATION OF TWO MAJOR M2 MITOCHONDRIAL AUTOANTIGENS
Yeaman, S. J., Danner, D. J., Mutimer, D., Fussey, S. P. M., James, O., & Bassendine, M. F. (1988) · The Lancet · doi:10.1016/s0140-6736(88)91894-6 · Cited by 292
Neonatal beta-cell apoptosis: a trigger for autoimmune diabetes?
Trudeau, J. D., Dutz, J. P., Arany, E. J., Hill, D. J., Fieldus, W. E., & Finegood, D. T. (2000) · Diabetes · doi:10.2337/diabetes.49.1.1 · Cited by 290
Oxidation of a critical thiol residue of the adenine nucleotide translocator enforces Bcl-2-independent permeability transition pore opening and apoptosis
Costantini, P., Belzacq, A.-S., Vieira, H. L., Larochette, N., de Pablo, M. A., Zamzami, N., Susin, S. A., Brenner, C., & Kroemer, G. (2000) · Oncogene · doi:10.1038/sj.onc.1203299 · Cited by 284
The autoepitope of the 74-kD mitochondrial autoantigen of primary biliary cirrhosis corresponds to the functional site of dihydrolipoamide acetyltransferase.
de Water, J. V., Gershwin, M. E., Leung, P. S. C., Ansari, A. A., & Coppel, R. L. (1988) · The Journal of Experimental Medicine · doi:10.1084/jem.167.6.1791 · Cited by 279
Long-term effects of ursodeoxycholic acid in primary biliary cirrhosis: results of a double-blind controlled multicentric trial
Parés, A. R., Caballería, L., Rodés, J., Bruguera, M., Rodrigo, L., García-Plaza, A., Berenguer, J., Rodríguez-Martínez, D., Mercader, J., & Velicia, R. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80216-0 · Cited by 270
Selective cleavage of nuclear autoantigens during CD95 (Fas/APO-1)-mediated T cell apoptosis.
Casiano, C. A., Martin, S. J., Green, D. R., & Tan, E. M. (1996) · The Journal of Experimental Medicine · doi:10.1084/jem.184.2.765 · Cited by 260
Presence of antinucleosome autoantibodies in a restricted set of connective tissue diseases: Antinucleosome antibodies of the IgG3 subclass are markers of renal pathogenicity in systemic lupus erythematosus
Amoura, Z., Koutouzov, S., Chabre, H., Cacoub, P., Amoura, I., Musset, L., Bach, J., & Pietté, J. C. (2000) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200001)43:1 · Cited by 243
Long‐term ursodeoxycholic acid delays histological progression in primary biliary cirrhosis
Angulo, P., Batts, K. P., Therneau, T. M., Jorgensen, R. A., Dickson, R. E., & Lindor, K. D. (1999) · Hepatology · doi:10.1002/hep.510290301 · Cited by 234
Autoimmune Associations in Primary Biliary Cirrhosis
Culp, K., Fleming, C. R., Duffy, J., Baldus, W. P., & Dickson, E. R. (1982) · Mayo Clinic Proceedings · doi:10.1016/s0025-6196(25)18890-3 · Cited by 228
Proteins Phosphorylated during Stress-induced Apoptosis Are Common Targets for Autoantibody Production in Patients with Systemic Lupus Erythematosus
Utz, P. J., Foley, M. H., Schur, P. H., & Anderson, P. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.5.843 · Cited by 219
Identification of Oxidant-Sensitive Proteins: TNF-α Induces Protein Glutathiolation
Sullivan, D. M., Wehr, N. B., Fergusson, M. M., Levine, R. L., & Finkel, T. (2000) · Biochemistry · doi:10.1021/bi0007674 · Cited by 209
A20 Inhibits Cytokine-Induced Apoptosis and Nuclear Factor κB–Dependent Gene Activation in Islets
Grey, S. T., Arvelo, M. B., Hasenkamp, W. M., Bach, F. H., & Ferran, C. J. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.8.1135 · Cited by 208
Release of Cytochrome c from Liver Mitochondria during Permeability Transition
Kantrow, S. P., & Piantadosi, C. A. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6353 · Cited by 197
Immunohistochemical detection of bcl-2 protein in normal and pathological human liver.
Charlotte, F., L’Herminé, A. C., Martin, N., Geleyn, Y., Nollet, M., Gaulard, P., & Zafrani, E. (1994) · PubMed Central · Cited by 188
Molecular mimicry in primary biliary cirrhosis. Evidence for biliary epithelial expression of a molecule cross-reactive with pyruvate dehydrogenase complex-E2.
de Water, J. V., Turchany, J. M., Leung, P. S. C., Lake, J. R., Muñoz, S., Surh, C. D., Coppel, R. L., Ansari, A. A., Nakanuma, Y., & Gershwin, M. E. (1993) · Journal of Clinical Investigation · doi:10.1172/jci116504 · Cited by 179
Release of apoptogenic proteins from the mitochondrial intermembrane space during the mitochondrial permeability transition
Scarlett, J. L., & Murphy, M. P. (1997) · FEBS Letters · doi:10.1016/s0014-5793(97)01391-4 · Cited by 173
Structural requirement for autoreactivity on human pyruvate dehydrogenase-E2, the major autoantigen of primary biliary cirrhosis. Implication for a conformational autoepitope.
Surh, C. D., Coppel, R. L., & Gershwin, M. E. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.144.9.3367 · Cited by 169
Enhanced apoptosis relates to bile duct loss in primary biliary cirrhosis
Harada, K., Ozaki, S., Gershwin, M. E., & Nakanuma, Y. (1997) · Hepatology · doi:10.1002/hep.510260604 · Cited by 167
The autoimmunity-inducing xenobiotic mercury interacts with the autoantigen fibrillarin and modifies its molecular and antigenic properties
Pollard, K. M., Lee, D.-K., Casiano, C. A., Blüthner, M., Johnston, M. M., & Tan, E. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.7.3521 · Cited by 146
Development and characterization of polarized primary cultures of rat intrahepatic bile duct epithelial cells.
Vroman, B. T., & LaRusso, N. F. (1996) · PubMed · Cited by 138
Self-citation
Evidence for the targeting by 2-oxo-dehydrogenase enzymes in the T cell response of primary biliary cirrhosis
de Water, J. V., Ansari, A. A., Surh, C. D., Coppel, R. L., Roche, T. E., Bonkovsky, H. L., Kaplan, M., & Gershwin, M. E. (1991) · The Journal of Immunology · doi:10.4049/jimmunol.146.1.89 · Cited by 136
Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis
Koga, H., Sakisaka, S., Ohishi, M., Sata, M., & Tanikawa, K. (1997) · Hepatology · doi:10.1002/hep.510250505 · Cited by 134
Epitope mapping and reactivity of autoantibodies to the E2 component of 2‐oxoglutarate dehydrogenase complex in primary biliary cirrhosis using recombinant 2‐oxoglutarate dehydrogenase complex
Moteki, S., Leung, P. S., Dickson, E. R., Van Thiel, D. H., Galperin, C., Buch, T., Alarcon-Segovia, D., Kershenobich, D., Kawano, K., Coppel, R. L., et al. (1996) · Hepatology · doi:10.1002/hep.510230307 · Cited by 133
Sequential activation of three distinct ICE‐like activities in Fas‐ligated Jurkat cells
Greidinger, E. L., Miller, D. K., Yamin, T.-T., Casciola-Rosen, L. A., & Rosen, A. (1996) · FEBS Letters · doi:10.1016/0014-5793(96)00678-3 · Cited by 115
Self-citation
Bcl-2 and Bcl-xL block apoptosis as well as necrosis: possible involvement of common mediators in apoptotic and necrotic signal transduction pathways.
Tsujimoto, Y., Shimizu, S., Eguchi, Y., Kamiike, W., & Matsuda, H. (1997) · PubMed · Cited by 111
Mitochondrial Redox Signaling during Apoptosis
Cai, J., & Jones, D. P. (1999) · Journal of Bioenergetics and Biomembranes · doi:10.1023/a:1005423818280 · Cited by 106
Reduction of disulfide bonds during antigen processing: evidence from a thiol-dependent insulin determinant.
Jensen, P. E. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.174.5.1121 · Cited by 95
Expression of Bcl-2 Increases Intracellular Glutathione by Inhibiting Methionine-Dependent GSH Efflux
Meredith, M. J., Cusick, C. L., Soltaninassab, S. R., Sekhar, K. R., Lu, S. C.-L., & Freeman, M. L. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.8998 · Cited by 94
Autoepitope Mapping and Reactivity of Autoantibodies to the Dihydrolipoamide Dehydrogenase–Binding Protein (E3bp) and the Glycine Cleavage Proteins in Primary Biliary Cirrhosis
Dubel, L., Tanaka, A., Leung, P. S. C., de Water, J. V., Coppel, R. L., Roche, T. E., Johanet, C., Motokawa, Y., Ansari, A. A., & Gershwin, E. M. (1999) · Hepatology · doi:10.1002/hep.510290403 · Cited by 78
Hypoxia-mediated druGS FOR RADIATION AND CHEMOTHERAPY
ADAMS, G. E. (1981) · Cancer · doi:10.1002/1097-0142(19810801)48:3 · Cited by 77
Lipoylated and unlipoylated domains of human PDC-E2 as autoantigens in primary biliary cirrhosis: Significance of lipoate attachment
Quinn, J., Diamond, A. G., Palmer, J. M., Bassendine, M. F., James, O., & Yeaman, S. J. (1993) · Hepatology · doi:10.1002/hep.1840180616 · Cited by 70
Primary biliary cirrhosis: further biochemical and immunological characterization of mitochondrial antigens.
Mendel-Hartvig, I., Nelson, B. D., Lööf, L., & Tötterman, T. H. (1985) · PubMed Central · Cited by 51
Autoreactive liver-infiltrating T cells in primary biliary cirrhosis recognize inner mitochondrial epitopes and the pyruvate dehydrogenase complex
Löhr, H. F., Fleischer, B., Gerken, G., Yeaman, S. J., Büschenfelde, K. H. M. Z., & Manns, M. P. (1993) · Journal of Hepatology · doi:10.1016/s0168-8278(05)80276-4 · Cited by 50
Exogenously Provided Peptides of a Self-antigen Can Be Processed into Forms that Are Recognized by Self–T Cells
Barlow, A. K., He, X., & Janeway, C. A. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.9.1403 · Cited by 37
The mitochondrial adenine nucleotide translocator is an antigen in primary biliary cirrhosis.
Schultheiß, H., Berg, P. A., & Klingenberg, M. (1983) · PubMed Central · Cited by 36
Antimitochondrial Antibodies in Kindreds of Patients With Primary Biliary Cirrhosis: Antimitochondrial Antibodies Are Unique to Clinical Disease and Are Absent in Asymptomatic Family Members
Caldwell, S. H., Leung, P. S. C., Spivey, J. R., Prindiville, T. P., de Medina, M. D., Saicheur, T., Rowley, M. J., Reddy, K. R., Coppel, R. L., Jeffers, L. J., et al. (1992) · Hepatology · doi:10.1002/hep.1840160408 · Cited by 35
Enzyme inhibitory autoantibodies to pyruvate dehydrogenase complex in primary biliary cirrhosis differ for mammalian, yeast and bacterial enzymes: Implications for molecular mimicry
Teoh, K., Mackay, I. R., Rowley, M. J., & Fussey, S. P. M. (1994) · Hepatology · doi:10.1002/hep.1840190431 · Cited by 35
Bile duct cells in primary biliary cirrhosis are 'primed' for apoptosis
Graham, A. M., Dollinger, M., Howie, S., & Harrison, D. J. (1998) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-199807000-00005 · Cited by 33
Bcl-2 protein expression in acute and chronic hepatitis, cirrhosis and hepatocellular carcinoma
Nakopoulou, L., Stefanaki, K. S., Vourlakou, C., Manolaki, N., Gakiopoulou, H., & Michalopoulos, G. K. (1999) · Pathology - Research and Practice · doi:10.1016/s0344-0338(99)80089-2 · Cited by 31
Apoptosis and Proliferation of Fibroblasts During Postnatal Skin Development and Scleroderma in the Tight-skin Mouse
Pablos, J. L., Carreira, P. E., Serrano, L., del Castillo, P., & Gómez-Reino, J. J. (1997) · Journal of Histochemistry & Cytochemistry · doi:10.1177/002215549704500509 · Cited by 31
The Role of T Cells in Primary Biliary Cirrhosis
de Water, J. V., Shimoda, S., Niho, Y., Coppel, R. L., Ansari, A. A., & Gershwin, M. E. (1997) · Seminars in Liver Disease · doi:10.1055/s-2007-1007188 · Cited by 29
Glutamate-induced cytotoxicity in PC12 pheochromocytoma cells: role of oxidation of phospholipids, glutathione and protein sulfhydryls revealed by bcl-2 transfection
Tyurin, V. A., Tyurina, Y. Y., Quinn, P. J., Schor, N. F., Balachandran, R., Day, B. W., & Kagan, V. E. (1998) · Molecular Brain Research · doi:10.1016/s0169-328x(98)00181-8 · Cited by 27
T cell responses to natural human proteins in primary biliary cirrhosis
Jones, D. E., Palmer, J. M., Yeaman, S. J., Bassendine, M. F., & Diamond, A. G. (1997) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1997.3101202.x · Cited by 26
Diabetic sera react with the glutamic acid decarboxylase molecule in a dimeric-oligomeric form
Rowley, M. J., Chen, Q. Y., Teoh, K., Zimmet, P., Tuomi, T., Knowles, W. J., & Mackay, I. R. (1996) · Clinical & Experimental Immunology · doi:10.1046/j.1365-2249.1996.d01-827.x · Cited by 11

Research works printed but not linked: 11

Culp, 1982, Mayo Clin Proc, 57, 365
Tsujimoto, 1997, Leukemia, 11(Suppl. 3), 380
Charlotte, 1994, Am J Pathol, 144, 460
Vroman, 1996, Lab Invest, 74, 303
Watson, 1991, Am J Physiol, 261, G229
Alpini, 1998, Am J Physiol, 274, G767
Mendel-Hartvig, 1985, Clin Exp Immunol, 62, 371
Celli, 1998, Am J Physiol, 275, G749
Que, 1997, Am J Physiol, 272, G106
Dini, 2000, Eur J Histochem, 44, 217
Schultheiss, 1983, Clin Exp Immunol, 54, 648

Sorted by citations

Primary biliary cirrhosis
Kaplan, M. M., & Gershwin, M. E. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043898 · Cited by 1,144
Primary biliary cirrhosis # †
Lindor, K. D., Gershwin, E. M., Poupon, R., Kaplan, M., Bergasa, N. V., & Heathcote, J. E. (2009) · Hepatology · doi:10.1002/hep.22906 · Cited by 1,099
Primary biliary cirrhosis
Carey, E. J., Ali, A. H., & Lindor, K. D. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00154-3 · Cited by 735
Drug-Induced Liver Injury
Kaplowitz, N. (2004) · Clinical Infectious Diseases · doi:10.1086/381446 · Cited by 402
Primary biliary cirrhosis
Selmi, C., Bowlus, C. L., Gershwin, M. E., & Coppel, R. L. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61965-4 · Cited by 334

See all 220

Authors: Odin, J. A., Huebert, R. C., Casciola-Rosen, L., LaRusso, N. F., & Rosen, A.
Affiliations: Icahn School of Medicine at Mount Sinai (US)
Mayo Clinic (US)
Johns Hopkins University (US)
Corresponding author: Odin, Joseph A.
ORCID: Odin, Joseph A.
Huebert, Robert C.
Casciola-Rosen, Livia
LaRusso, Nicholas F.
Rosen, Antony
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2001-07-15
Volume: 108
Issue: 2
Pages: 223-232
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci200110716
PMC: PMC203018
OpenAlex: W4249025813
Cited by: 220
References: 60
Citations by year: 2026: 1 · 2025: 4 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 4 · 2020: 7 · 2019: 4 · 2018: 4 · 2017: 10 · 2016: 5 · 2015: 20 · 2014: 9 · 2013: 9 · 2012: 14
FWCI: 7.24
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Diabetes and Digestive and Kidney Diseases (K08DK059653, R01DK024031, T32DK-07832)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 44684, R01AR044684)
National Institute of Dental and Craniofacial Research (R37DE012354, DE12354, R01DE012354)
Topics: Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
Keywords: primary biliary cirrhosis, pyruvate dehydrogenase E2, autoantigens, autoantibodies, apoptosis, Bcl-2, glutathione depletion, bile duct epithelial cells, cholangiocytes, mitochondrial proteins, neoantigens, caspase cleavage
MeSH terms: Autoantibodies, Autoantigens, Bile Ducts, Cell Line, Dithiothreitol, Epithelial Cells, Fluorescent Antibody Technique, Glutathione, Humans, Immune Sera, Liver Cirrhosis, Biliary, Lymphocyte Activation, Mitochondria, Pyruvate Dehydrogenase Complex, Transfection, Immunoblotting, Gene Expression Regulation, Enzymologic, Apoptosis, Genes, bcl-2, Dihydrolipoyllysine-Residue Acetyltransferase

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Bcl-2–dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks