Bcl-2–dependent oxidation of pyruvate dehydrogenase-E2, a primary biliary cirrhosis autoantigen, during apoptosis

Determination of glutathione and glutathione disulfide using glutathione reductase and 2-vinylpyridine

Griffith, O. W. (1980) · Analytical Biochemistry · doi:10.1016/0003-2697(80)90139-6 · Cited by 4,628

Molecular characterization of mitochondrial apoptosis-inducing factor

Susin, S. A., Lorenzo, H. K., Zamzami, N., Marzo, I., Snow, B. E., Brothers, G. M., Mangion, J., Jacotot, E., Costantini, P., Loeffler, M., et al. (1999) · Nature · doi:10.1038/17135 · Cited by 4,060

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

Hockenbery, D. M., Oltvai, Z. N., Yin, X., Milliman, C. L., & Korsmeyer, S. J. (1993) · Cell · doi:10.1016/0092-8674(93)80066-n · Cited by 3,402

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

Casciola-Rosen, L. A., Anhalt, G. J., & Rosen, A. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1317 · Cited by 1,723

Consequences of Cell Death

Sauter, B., Albert, M. L., Francisco, L. M., Larsson, M., Somersan, S., & Bhardwaj, N. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.423 · Cited by 1,357

A Discrete Subpopulation of Dendritic Cells Transports Apoptotic Intestinal Epithelial Cells to T Cell Areas of Mesenteric Lymph Nodes

Huang, F., Platt, N., Wykes, M., Major, J. R., Powell, T. J., Jenkins, C. D., & MacPherson, G. G. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.191.3.435 · Cited by 902

Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis

Poupon, R., Lindor, K., Cauch-Dudek, K., Dickson, E., Poupon, R., & Heathcote, E. (1997) · Gastroenterology · doi:10.1016/s0016-5085(97)70183-5 · Cited by 648

Identification and specificity of a cDNA encoding the 70 kd mitochondrial antigen recognized in primary biliary cirrhosis

Gershwin, M. E., Mackay, I. R., Sturgess, A., & Coppel, R. L. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.10.3525 · Cited by 557

Cleavage by Granzyme B Is Strongly Predictive of Autoantigen Status

Casciola-Rosen, L. A., Andrade, F., Ulanet, D., Wong, W. B., & Rosen, A. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.6.815 · Cited by 492

ABERRANT EXPRESSION OF HLA-DR ANTIGENS ON BILEDUCT EPITHELIUM IN PRIMARY BILIARY CIRRHOSIS: RELEVANCE TO PATHOGENESIS

Ballardini, G., Bianchi, F., Doniach, D., Mirakian, R. M., Pisi, E., & Bottazzo, G. (1984) · The Lancet · doi:10.1016/s0140-6736(84)91108-5 · Cited by 488

Primary biliary cirrhosis

Kaplan, M. M., & Gershwin, M. E. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043898 · Cited by 1,144

Primary biliary cirrhosis # †

Lindor, K. D., Gershwin, E. M., Poupon, R., Kaplan, M., Bergasa, N. V., & Heathcote, J. E. (2009) · Hepatology · doi:10.1002/hep.22906 · Cited by 1,099

Primary biliary cirrhosis

Carey, E. J., Ali, A. H., & Lindor, K. D. (2015) · The Lancet · doi:10.1016/s0140-6736(15)00154-3 · Cited by 735

Drug-Induced Liver Injury

Kaplowitz, N. (2004) · Clinical Infectious Diseases · doi:10.1086/381446 · Cited by 402

Primary biliary cirrhosis

Selmi, C., Bowlus, C. L., Gershwin, M. E., & Coppel, R. L. (2011) · The Lancet · doi:10.1016/s0140-6736(10)61965-4 · Cited by 334

Patients With Primary Biliary Cirrhosis React Against A Ubiquitous Xenobiotic–Metabolizing Bacterium

Selmi, C., Balkwill, D. L., Invernizzi, P., Ansari, A. A., Coppel, R. L., Podda, M., Leung, P. S., Kenny, T. P., Van De Water, J., Nantz, M. H., et al. (2003) · Hepatology · doi:10.1053/jhep.2003.50446 · Cited by 312

Primary biliary cirrhosis

Talwalkar, J. A., & Lindor, K. D. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13808-1 · Cited by 300

Drug-Induced Liver Injury: Cascade of Events Leading to Cell Death, Apoptosis or Necrosis

Iorga, A., Dara, L., & Kaplowitz, N. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18051018 · Cited by 305

Pathogenesis of cholestatic liver disease and therapeutic approaches

Hirschfield, G. M., Heathcote, E. J., & Gershwin, M. E. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.09.004 · Cited by 287

The causes of primary biliary cirrhosis: Convenient and inconvenient truths

Gershwin, E. M., & Mackay, I. R. (2007) · Hepatology · doi:10.1002/hep.22042 · Cited by 273

Primary biliary cirrhosis: A 2010 update

Poupon, R. Y. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2009.11.027 · Cited by 273

Physiology of Cholangiocytes

Tabibian, J. H., Masyuk, A. I., Masyuk, T. V., O'Hara, S. P., & LaRusso, N. F. (2013) · Comprehensive Physiology · doi:10.1002/j.2040-4603.2013.tb00495.x · Cited by 52

The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer

Tew, K. D., Manevich, Y., Grek, C. L., Xiong, Y., Uys, J. D. K., & Townsend, D. M. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.013 · Cited by 239

The Spectrum of Achalasia: Lessons From Studies of Pathophysiology and High-Resolution Manometry

Kahrilas, P. J., & Boeckxstaens, G. E. (2013) · Gastroenterology · doi:10.1053/j.gastro.2013.08.038 · Cited by 236

Glutathione S-Transferases in Cancer

Singh, R. R., & Reindl, K. M. (2021) · Antioxidants · doi:10.3390/antiox10050701 · Cited by 245

Apotopes and the biliary specificity of primary biliary cirrhosis†

Lleo, A., Selmi, C., Invernizzi, P., Podda, M., Coppel, R. L., Mackay, I. R., Gores, G. J., Ansari, A. A., Van de Water, J., & Gershwin, M. E. (2009) · Hepatology · doi:10.1002/hep.22736 · Cited by 222

Biliary Apotopes and Anti-Mitochondrial Antibodies Activate Innate Immune Responses in Primary Biliary Cirrhosis†

Lleò, A., Bowlus, C. L., Yang, G., Invernizzi, P., Podda, M., de Water, J. V., Ansari, A. A., Coppel, R. L., Worman, H. J., Gores, G. J., et al. (2010) · Hepatology · doi:10.1002/hep.23783 · Cited by 215

Diagnosis and Management of Primary Biliary Cholangitis

Younossi, Z. M., Bernstein, D., Shiffman, M. L., Kwo, P. Y., Kim, W. R., Kowdley, K. V., & Jacobson, I. M. (2018) · The American Journal of Gastroenterology · doi:10.1038/s41395-018-0390-3 · Cited by 220

S-Glutathionylation: Indicator of Cell Stress and Regulator of the Unfolded Protein Response

Townsend, D. M. (2007) · Molecular Interventions · doi:10.1124/mi.7.6.7 · Cited by 206

Glutathionylation of Mitochondrial Proteins

Hurd, T. R., Costa, N. J., Dahm, C. C., Beer, S. M., Brown, S. E., Filipovska, A., & Murphy, M. P. (2005) · Antioxidants and Redox Signaling · doi:10.1089/ars.2005.7.999 · Cited by 198

Chemical Xenobiotics and Mitochondrial Autoantigens in Primary Biliary Cirrhosis: Identification of Antibodies against a Common Environmental, Cosmetic, and Food Additive, 2-Octynoic Acid

Amano, K., Leung, P. S. C., Rieger, R., Quan, C., Wang, X., Marik, J., Suen, Y. F., Kurth, M. J., Nantz, M. H., Ansari, A. A., et al. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.9.5874 · Cited by 187

Regulation of Mitochondrial Glutathione Redox Status and Protein Glutathionylation by Respiratory Substrates

Garcia, J., Han, D., Sancheti, H., Yap, L.-P., Kaplowitz, N., & Cadenas, E. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.164160 · Cited by 183

Primary biliary cirrhosis

Kumagi, T., & Heathcote, E. J. (2008) · Orphanet Journal of Rare Diseases · doi:10.1186/1750-1172-3-1 · Cited by 182

Primary biliary cirrhosis

Hohenester, S. D., Elferink, R. P. J. O., & Beuers, U. H. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0164-5 · Cited by 178

Changing Nomenclature for PBC: From ‘Cirrhosis’ to ‘Cholangitis’

Beuers, U. H., Gershwin, M. E., Gish, R. G., Invernizzi, P., Jones, D. E., Lindor, K. D., Ma, X., Mackay, I. R., Parés, A. R., Tanaka, A., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.08.031 · Cited by 173

Changing nomenclature for PBC: From ‘cirrhosis’ to ‘cholangitis’

Beuers, U. H., Gershwin, M. E., Gish, R. G., Invernizzi, P., Jones, D. E., Lindor, K. D., Ma, X., Mackay, I. R., Parés, A. R., Tanaka, A., et al. (2015) · Hepatology · doi:10.1002/hep.28140 · Cited by 165

S-Glutathionylation signaling in cell biology: Progress and prospects

Pastore, A., & Piemonte, F. (2012) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2012.03.010 · Cited by 170

Mechanisms of environmental influence on human autoimmunity: A national institute of environmental health sciences expert panel workshop

Selmi, C. F., Leung, P. S. C., Sherr, D. H., Diaz, M., Nyland, J. F., Monestier, M., Rose, N. R., & Gershwin, M. E. (2012) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.05.007 · Cited by 160

Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants

Juran, B. D., Hirschfield, G. M., Invernizzi, P., Atkinson, E. J., Li, Y., Xie, G., Kosoy, R., Ransom, M., Sun, Y., Bianchi, I., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds359 · Cited by 150

The consequences of apoptosis in autoimmunity

Lleò, A., Selmi, C. F., Invernizzi, P., Podda, M., & Gershwin, M. E. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.04.009 · Cited by 140

The Pathogenesis of Primary Biliary Cholangitis: A Comprehensive Review

Lleò, A., Leung, P. S. C., Hirschfield, G. M., & Gershwin, E. M. (2019) · Seminars in Liver Disease · doi:10.1055/s-0039-1697617 · Cited by 142

Immunoglobulin M levels inversely correlate with CD40 ligand promoter methylation in patients with primary biliary cirrhosis

Lleo, A., Liao, J., Invernizzi, P., Zhao, M., Bernuzzi, F., Ma, L., Lanzi, G., Ansari, A. A., Coppel, R. L., Zhang, P., et al. (2012) · Hepatology · doi:10.1002/hep.24630 · Cited by 133

Models of Drug Induced Liver Injury (DILI)—Current Issues and Future Perspectives

Kuna, L., Bozic, I., Kizivat, T., Bojanic, K., Mrso, M., Kralj, E., Smolic, R., Wu, G. Y., & Smolic, M. (2018) · Current Drug Metabolism · doi:10.2174/1389200219666180523095355 · Cited by 127

Hepatoimmunology: A perspective

Mackay, I. R. (2002) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.2002.01063.x · Cited by 131

Protein S-glutathiolation: Redox-sensitive regulation of protein function

Hill, B. G., & Bhatnagar, A. (2011) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2011.07.009 · Cited by 123

Antimitochondrial antibodies in acute liver failure: implications for primary biliary cirrhosis

Leung, P. S. C., Rossaro, L., Davis, P. A., Park, O., Tanaka, A., Kikuchi, K., Miyakawa, H., Norman, G. L., Lee, W., & Gershwin, E. M. (2007) · Hepatology · doi:10.1002/hep.21828 · Cited by 121

Novel therapeutic targets in primary biliary cirrhosis

Dyson, J. K., Hirschfield, G. M., Adams, D. H., Beuers, U., Mann, D. A., Lindor, K. D., & Jones, D. E. J. (2015) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2015.12 · Cited by 120

Pathogenesis of primary biliary cirrhosis

Jones, D. E. (2007) · Postgraduate Medical Journal · doi:10.1136/gut.2007.122150 · Cited by 118

Lack of immunological or molecular evidence for a role of mouse mammary tumor retrovirus in primary biliary cirrhosis

Selmi, C. F., Ross, S. R., Ansari, A. A., Invernizzi, P., Podda, M., Coppel, R. L., & Gershwin, M. E. (2004) · Gastroenterology · doi:10.1053/j.gastro.2004.05.033 · Cited by 108

Steroid and Ursodesoxycholic Acid Combination Therapy in Severe Drug-Induced Liver Injury

Wree, A., Dechêne, A., Herzer, K., Hilgard, P., Syn, W.-K., Gerken, G., & Canbay, A. (2011) · Digestion · doi:10.1159/000322298 · Cited by 93

Phylogenetic and immunological definition of four lipoylated proteins from Novosphingobium aromaticivorans, implications for primary biliary cirrhosis

Padgett, K. A., Selmi, C. F., Kenny, T. P., Leung, P. S. C., Balkwill, D. L., Ansari, A. A., Coppel, R. L., & Gershwin, M. E. (2005) · Journal of Autoimmunity · doi:10.1016/j.jaut.2005.01.012 · Cited by 102

Changing nomenclature for PBC: from ‘cirrhosis’ to ‘cholangitis’

Beuers, U., Gershwin, M. E., Gish, R. G., Invernizzi, P., Jones, D. E. J., Lindor, K., Ma, X., Mackay, I. R., Parés, A., Tanaka, A., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.06.031 · Cited by 97

MicroRNA‐506 promotes primary biliary cholangitis–like features in cholangiocytes and immune activation

Erice, O., Muñoz-Garrido, P., Vaquero, J., Perugorria, M. J., Fernández‐Barrena, M. G., Sáez, E., Santos‐Laso, Á., Arbelaiz, A., Jiménez-Agüero, R., Fernández‐Irigoyen, J., et al. (2017) · Hepatology · doi:10.1002/hep.29533 · Cited by 96

Apoptosis in liver diseases--detection and therapeutic applications.

Ghavami, S., Hashemi, M. M., Kadkhoda, K., Alavian, S. M., Bay, G. H., & Łoś, M. (2005) · PubMed · Cited by 96

T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis

Allina, J., Hu, B., Sullivan, D. M., Fiel, M. I., Thung, S. N., Bronk, S. F., Huebert, R. C., de Water, J. V., LaRusso, N. F., Gershwin, M. E., et al. (2006) · Journal of Autoimmunity · doi:10.1016/j.jaut.2006.11.004 · Cited by 95

Induction of Primary Biliary Cirrhosis in Guinea Pigs following Chemical Xenobiotic Immunization

Leung, P. S. C., Park, O., Tsuneyama, K., Kurth, M. J., Lam, K. S., Ansari, A. A., Coppel, R. L., & Gershwin, M. E. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2651 · Cited by 94

Etiopathogenesis of primary biliary cirrhosis

Lleò, A., Invernizzi, P., Mackay, I. R., Prince, H., Zhong, R., & Gershwin, M. E. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.3328 · Cited by 94

Caspase induction by IgA antimitochondrial antibody: IgA-mediated biliary injury in primary biliary cirrhosis

Matsumura, S., de Water, J. V., Leung, P. S. C., Odin, J. A., Yamamoto, K., Gores, G. J., Mostov, K. E., Ansari, A. A., Coppel, R. L., Shiratori, Y., et al. (2004) · Hepatology · doi:10.1002/hep.20175 · Cited by 94

Th1 cytokine–induced downregulation of PPARγ in human biliary cells relates to cholangitis in primary biliary cirrhosis†

Harada, K., Isse, K., Kamihira, T., Shimoda, S., & Nakanuma, Y. (2005) · Hepatology · doi:10.1002/hep.20705 · Cited by 88

The role of mitochondria in rheumatic diseases

Becker, Y. L. C., Duvvuri, B., Fortin, P. R., Lood, C., & Boilard, E. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00834-z · Cited by 81

Inhibition of Mitochondrial Respiration and Rapid Depletion of Mitochondrial Glutathione by β-Phenethyl Isothiocyanate: Mechanisms for Anti-Leukemia Activity

Chen, G., Chen, Z., Hu, Y., & Huang, P. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4170 · Cited by 89

Natural killer cells regulate T cell immune responses in primary biliary cirrhosis

Shimoda, S., Hisamoto, S., Harada, K., Iwasaka, S., Chong, Y., Nakamura, M., Bekki, Y., Yoshizumi, T., Shirabe, K., Ikegami, T., et al. (2015) · Hepatology · doi:10.1002/hep.28122 · Cited by 82

Overcoming a “Probable” Diagnosis in Antimitochondrial Antibody Negative Primary Biliary Cirrhosis: Study of 100 Sera and Review of the Literature

Bizzaro, N., Covini, G., Rosina, F., Muratori, P., Tonutti, E., Villalta, D., Pesente, F., Alessio, M. G., Tampoia, M., Antico, A., et al. (2012) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-010-8234-y · Cited by 79

Recognition of Granzyme B‐generated autoantigen fragments in scleroderma patients with ischemic digital loss

Schachna, L., Wigley, F. M., Morris, S. M., Gelber, A. C., Rosen, A., & Casciola-Rosen, L. A. (2002) · Arthritis & Rheumatism · doi:10.1002/art.10407 · Cited by 78

Oxidative stress-induced apoptosis of bile duct cells in primary biliary cirrhosis

Salunga, T. L., Cui, Z., Shimoda, S., Zheng, H.-C., Nomoto, K., Kondo, T., Takano, Y., Selmi, C. F., Alpini, G. D., Gershwin, M. E., et al. (2007) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.04.002 · Cited by 76

The role of environmental factors in primary biliary cirrhosis

Selmi, C. F., & Gershwin, M. E. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.05.006 · Cited by 74

Mechanisms of tissue injury in autoimmune liver diseases

Liaskou, E., Hirschfield, G. M., & Gershwin, M. E. (2014) · Seminars in Immunopathology · doi:10.1007/s00281-014-0439-3 · Cited by 74

Update on primary biliary cirrhosis

Invernizzi, P., Selmi, C. F., & Gershwin, M. E. (2010) · Digestive and Liver Disease · doi:10.1016/j.dld.2010.02.014 · Cited by 70

Shaping macrophages function and innate immunity by bile acids: Mechanisms and implication in cholestatic liver diseases

Calmus, Y., & Poupon, R. (2014) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2014.07.007 · Cited by 69

Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis

Sasaki, M., Miyakoshi, M., Sato, Y., & Nakanuma, Y. (2012) · Liver International · doi:10.1111/liv.12049 · Cited by 69

Environment and primary biliary cirrhosis: Electrophilic drugs and the induction of AMA

Leung, P. S. C., Wang, J., Naiyanetr, P., Kenny, T. P., Lam, K. S., Kurth, M. J., & Gershwin, M. E. (2013) · Journal of Autoimmunity · doi:10.1016/j.jaut.2012.12.007 · Cited by 66

Antimitochondrial antibody heterogeneity and the xenobiotic etiology of primary biliary cirrhosis

Chen, R. C. Y., Naiyanetr, P., Shu, S.-A., Wang, J., Yang, G., Kenny, T. P., Guggenheim, K. G., Butler, J. D., Bowlus, C. L., Tao, M., et al. (2012) · Hepatology · doi:10.1002/hep.26157 · Cited by 65

Experimental evidence on the immunopathogenesis of primary biliary cirrhosis

Selmi, C. F., Meda, F., Kasangian, A. A., Invernizzi, P., Tian, Z., Lian, Z., Podda, M., & Gershwin, M. E. (2009) · Cellular and Molecular Immunology · doi:10.1038/cmi.2009.104 · Cited by 63

Pathogenesis of primary biliary cirrhosis

Jones, D. E. (2003) · Journal of Hepatology · doi:10.1016/s0168-8278(03)00270-8 · Cited by 62

Primary biliary cirrhosis: What do autoantibodies tell us?

Hu, C. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i29.3616 · Cited by 61

Autoantibodies in Systemic Lupus Erythematosus Target Mitochondrial RNA

Becker, Y., Marcoux, G., Allaeys, I., Julien, A.-S., Loignon, R.-C., Benk-Fortin, H., Rollet-Labelle, E., Rauch, J., Fortin, P. R., & Boilard, E. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01026 · Cited by 59

Pathogenesis of Primary Biliary Cirrhosis

Jones, D. E. (2008) · Clinics in Liver Disease · doi:10.1016/j.cld.2008.02.004 · Cited by 58

New insights to the immunopathology and autoimmune responses in primary biliary cirrhosis

He, X.-S., Ansari, A. A., Ridgway, W. M., Coppel, R. L., & Gershwin, M. E. (2006) · Cellular Immunology · doi:10.1016/j.cellimm.2006.04.006 · Cited by 58

Apoptosis and the liver: relation to autoimmunity and related conditions

Bai, J., & Odin, J. A. (2003) · Autoimmunity Reviews · doi:10.1016/s1568-9972(02)00125-8 · Cited by 56

Apoptosis induction by eIF5A1 involves activation of the intrinsic mitochondrial pathway

Sun, Z., Cheng, Z., Taylor, C. A., McConkey, B. J., & Thompson, J. E. (2010) · Journal of Cellular Physiology · doi:10.1002/jcp.22100 · Cited by 57

Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: An immunohistochemical study

Sasaki, M., Ikeda, H., & Nakanuma, Y. (2008) · Journal of Autoimmunity · doi:10.1016/j.jaut.2008.03.005 · Cited by 55

Cytoplasmic p53 and Activated Bax Regulate p53-dependent, Transcription-independent Neural Precursor Cell Apoptosis

Geng, Y., Walls, K. C., Ghosh, A. P., Akhtar, R. S., Klocke, B. J., & Roth, K. A. (2009) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.2009.954024 · Cited by 54

Small ubiquitin‐related modifiers

Janka, C., Selmi, C. F., Gershwin, M. E., Will, H., & Sternsdorf, T. (2005) · Hepatology · doi:10.1002/hep.20619 · Cited by 54

Sidechain Biology and the Immunogenicity of Pdc–E2, the Major Autoantigen of Primary Biliary Cirrhosis

Mao, T. K., Davis, P. A., Odin, J. A., Coppel, R. L., & Gershwin, E. M. (2004) · Hepatology · doi:10.1002/hep.20491 · Cited by 52

Role of Cholangiocytes in Primary Biliary Cirrhosis

Lleò, A., Maroni, L., Glaser, S. S., Alpini, G. D., & Marzioni, M. (2014) · Seminars in Liver Disease · doi:10.1055/s-0034-1383727 · Cited by 51

The Pathogenesis of Autoimmune Liver Disease

Arndtz, K., & Hirschfield, G. M. (2016) · Digestive Diseases · doi:10.1159/000444471 · Cited by 54

Research Progress on the Animal Models of Drug-Induced Liver Injury: Current Status and Further Perspectives

Pan, Y., Cao, M., You, D., Qin, G., & Liu, Z. (2019) · BioMed Research International · doi:10.1155/2019/1283824 · Cited by 51

Immunopathogenesis of Primary Biliary Cirrhosis

Nishio, A., Keeffe, E. B., & Gershwin, M. E. (2002) · Seminars in Liver Disease · doi:10.1055/s-2002-34506 · Cited by 51

Increased expression of nuclear envelope gp210 antigen in small bile ducts in primary biliary cirrhosis

Nakamura, M., Takii, Y., Ito, M., Komori, A., Yokoyama, T., Shimizu‐Yoshida, Y., Koyabu, M., Matsuyama, M. M., Mori, T., Kamihira, T., et al. (2005) · Journal of Autoimmunity · doi:10.1016/j.jaut.2005.10.007 · Cited by 50

The unfinished business of primary biliary cirrhosis

Selmi, C. F., Zuin, M. G., & Gershwin, M. E. (2008) · Journal of Hepatology · doi:10.1016/j.jhep.2008.06.006 · Cited by 49

Pluripotent Stem Cell–Derived Hepatocytes: Potential and Challenges in Pharmacology

Szkolnicka, D., Zhou, W., Lucendo‐Villarin, B., & Hay, D. C. (2013) · The Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011112-140306 · Cited by 51

Primary biliary cholangitis: pathogenic mechanisms

Prìeto, J., Bañales, J. M., & Medina, J. F. (2020) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000703 · Cited by 48

B cells and autoimmune liver diseases

Moritoki, Y., Lian, Z., Ohsugi, Y., Ueno, Y., & Gershwin, M. E. (2006) · Autoimmunity Reviews · doi:10.1016/j.autrev.2006.02.006 · Cited by 48

Changing Nomenclature for PBC: From ‘Cirrhosis’ to ‘Cholangitis’

Beuers, U. H., Gershwin, E. M., Gish, R. G., Invernizzi, P., Jones, D. E., Lindor, K. D., Ma, X., Mackay, I. R., Parés, A. R., Tanaka, A., et al. (2015) · The American Journal of Gastroenterology · doi:10.1038/ajg.2015.312 · Cited by 47

Electrophile-modified lipoic derivatives of PDC-E2 elicits anti-mitochondrial antibody reactivity

Naiyanetr, P., Butler, J. D., Meng, L., Pfeiff, J., Kenny, T. P., Guggenheim, K. G., Reiger, R., Lam, K. S., Kurth, M. J., Ansari, A. A., et al. (2011) · Journal of Autoimmunity · doi:10.1016/j.jaut.2011.06.001 · Cited by 48

Primary Biliary Cirrhosis is More Severe in Overweight Patients

Híndi, M., Levy, C., Couto, C. A., Bejarano, P. A., & Mendes, F. D. (2012) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0b013e318261e659 · Cited by 45

Changing nomenclature for PBC: From 'cirrhosis' to 'cholangitis'

Beuers, U., Gershwin, M. E., Gish, R. G., Invernizzi, P., Jones, D. E. J., Lindor, K., Ma, X., Mackay, I. R., Parés, A., Tanaka, A., et al. (2015) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2015.08.001 · Cited by 43

Infectious Agents and Xenobiotics in the Etiology of Primary Biliary Cirrhosis

Selmi, C. F., Santis, M. D., Cavaciocchi, F., & Gershwin, M. E. (2010) · Disease Markers · doi:10.1155/2010/752314 · Cited by 41

Damaged interlobular bile ducts in primary biliary cirrhosis show reduced expression of glutathione-S-transferase-pi and aberrant expression of 4-hydroxynonenal

Tsuneyama, K., Harada, K., Kono, N., Sasaki, M., Saito, T., Gershwin, M. E., Ikemoto, M., Arai, H., & Nakanuma, Y. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00105-8 · Cited by 41

The Clinical Significance of Posttranslational Modification of Autoantigens

Zavala-Cerna, M. G., Martínez-García, E. A., Torres-Bugarı́n, O., Rubio-Jurado, B., Riebeling, C., & Nava, A. (2014) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-014-8424-0 · Cited by 40

Molecular mechanisms of cholangiopathy in primary biliary cirrhosis

Harada, K., & Nakanuma, Y. (2006) · Medical Molecular Morphology · doi:10.1007/s00795-006-0321-z · Cited by 38

Primary biliary cirrhosis and other ductopenic diseases

Burt, A. D. (2002) · Clinics in Liver Disease · doi:10.1016/s1089-3261(02)00010-7 · Cited by 38

The Immunophysiology and Apoptosis of Biliary Epithelial Cells: Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis

Kawata, K., Kobayashi, Y., Gershwin, M. E., & Bowlus, C. L. (2012) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-012-8324-0 · Cited by 39

A ltered A utoantigen S tructure in S j ö gren ’ s S yndrome: I mplications for the P athogenesis of A utoimmune T issue D amage

Rosen, A., & Casciola-Rosen, L. A. (2004) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/154411130401500304 · Cited by 37

Role of the Anion Exchanger 2 in the Pathogenesis and Treatment of Primary Biliary Cirrhosis

Medina, J. F. (2011) · Digestive Diseases · doi:10.1159/000324144 · Cited by 39

Metabolic modeling of muscle metabolism identifies key reactions linked to insulin resistance phenotypes

Nogiec, C., Burkart, A., Dreyfuss, J. M., Lerin, C., Kasif, S., & Patti, M.-E. (2015) · Molecular Metabolism · doi:10.1016/j.molmet.2014.12.012 · Cited by 34

Genes and (auto)immunity in primary biliary cirrhosis

Selmi, C. F., Invernizzi, P., Zuin, M. G., Podda, M., Seldin, M. F., & Gershwin, M. E. (2005) · Genes and Immunity · doi:10.1038/sj.gene.6364248 · Cited by 34

Apoptosis as a mechanism for cell surface expression of the autoantigen pyruvate dehydrogenase complex

Macdonald, P. S., Palmer, J. M., Kirby, J. A., & Jones, D. E. (2004) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.2004.02484.x · Cited by 34

CD8+ T cells undergo activation and programmed death-1 repression in the liver of aged Ae2a,b−/− mice favoring autoimmune cholangitis

Concepcion, A. R., Salas, J. T., Sáez, E., Sarvide, S., Ferrer, A., Portu, A., Uriarte, I., Hervás‐Stubbs, S., Elferink, R. P. J. O., Prìeto, J., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5665 · Cited by 32

Anti-CD16 autoantibodies and delayed phagocytosis of apoptotic cells in primary biliary cirrhosis

Allina, J., Stanca, C. M., Garber, J. J., Hu, B., Sautès‐Fridman, C., Bach, N., & Odin, J. A. (2007) · Journal of Autoimmunity · doi:10.1016/j.jaut.2007.10.003 · Cited by 32

Apotopes and the biliary specificity of primary biliary cirrhosis†

Lleo, A., Selmi, C., Invernizzi, P., Podda, M., Coppel, R. L., Mackay, I. R., Gores, G. J., Ansari, A. A., Van de Water, J., & Gershwin, M. E. (2009) · Hepatology · doi:10.1002/hep.22736 · Cited by 222

Cell-surface expression of pyruvate dehydrogenase complex during apoptosis: A possible route for autoantigen presentation in primary biliary cirrhosis

Macdonald, P. S., Kirby, J. A., & Jones, D. (2002) · Newcastle University ePrints (Newcastle Univesity) · doi:10.25405/ncl.34649289 · Cited by 1

The mitochondrial autoantigen of PBC localizes within apoptotic bodies of human biliary cells

Lleò, A., Selmi, C. F., Invernizzi, P., Coppel, R. L., Mackay, I. R., Gores, G. J., Ansari, A. A., de Water, J. V., Gershwin, M. E., & Podda, M. (2009) · Digestive and Liver Disease · doi:10.1016/j.dld.2008.12.074

Apotopes and innate immune system: Novel players in the primary biliary cirrhosis scenario

Lleò, A., & Invernizzi, P. (2013) · Digestive and Liver Disease · doi:10.1016/j.dld.2013.01.005 · Cited by 27

Sidechain Biology and the Immunogenicity of Pdc–E2, the Major Autoantigen of Primary Biliary Cirrhosis

Mao, T. K., Davis, P. A., Odin, J. A., Coppel, R. L., & Gershwin, E. M. (2004) · Hepatology · doi:10.1002/hep.20491 · Cited by 52