The DOI matches its Crossref record; 38 of the 38 references it cites were found in a registry or an index.
Central role of mitochondrial aldehyde dehydrogenase and reactive oxygen species in nitroglycerin tolerance and cross-tolerance
Open accessAbstract
Recent studies suggest that mitochondrial aldehyde dehydrogenase (ALDH-2) plays a central role in the process of nitroglycerin (glyceryl trinitrate, GTN) biotransformation in vivo and that its inhibition accounts for mechanism-based tolerance in vitro. The extent to which ALDH-2 contributes to GTN tolerance (impaired relaxation to GTN) and cross-tolerance (impaired endothelium-dependent relaxation) in vivo remain to be elucidated. Rats were treated for three days with GTN. Infusions were accompanied by decreases in vascular ALDH-2 activity, GTN biotransformation, and cGMP-dependent kinase (cGK-I) activity. Further, whereas in control vessels, multiple inhibitors and substrates of ALDH-2 reduced both GTN-stimulation of cGKI and GTN-induced vasodilation, these agents had little effect on tolerant vessels. A state of functional tolerance (in the GTN/cGMP pathway) was recapitulated in cultured endothelial cells by knocking down mitochondrial DNA (ρ0 cells). In addition, GTN increased the production of reactive oxygen species (ROS) by mitochondria, and these increases were associated with impaired relaxation to acetylcholine. Finally, antioxidants/reductants decreased mitochondrial ROS production and restored ALDH-2 activity. These observations suggest that nitrate tolerance is mediated, at least in significant part, by inhibition of vascular ALDH-2 and that mitochondrial ROS contribute to this inhibition. Thus, GTN tolerance may be viewed as a metabolic syndrome characterized by mitochondrial dysfunction.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“However, patients often develop nitrate tolerance (tachyphylaxis) after prolonged use because the reactive oxygen species generated by nitroglycerin can oxidize the thiol group of the mtALDH and result in enzyme dysfunction.111,141–143”
From Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO) (2016) · cites this paper as [142]
Citations
Cites
Heitzer, T., Schlinzig, T., Krohn, K., Meinertz, T., & Münzel, T. (2001) · Circulation · doi:10.1161/hc4601.099485 · Cited by 1,961
Self-citationMünzel, T. F., Sayegh, H. S., Freeman, B. Α., Tarpey, M. M., & Harrison, D. G. (1995) · Journal of Clinical Investigation · doi:10.1172/jci117637 · Cited by 652
Self-citationIdentification of the enzymatic mechanism of nitroglycerin bioactivation
Chen, Z., Zhang, J., & Stamler, J. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122225199 · Cited by 545
Self-citationLincoln, T., Dey, N. B., & Sellak, H. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.3.1421 · Cited by 512
Role for mitochondrial oxidants as regulators of cellular metabolism
Nemoto, S., Takeda, K., Yu, Z.-X., Ferrans, V. J., & Finkel, T. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.19.7311-7318.2000 · Cited by 393
Huang, A., Vita, J. A., Venema, R. C., & Keaney, J. F. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002248200 · Cited by 365
Self-citation[27] Isolation of human cell lines lacking mitochondrial DNA
King, M. P., & Attardi, G. M. (1996) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(96)64029-4 · Cited by 361
Structure of mitochondrial aldehyde dehydrogenase: the genetic component of ethanol aversion
Steinmetz, C. G., Xie, P., Weiner, H., & Hurley, T. D. (1997) · Structure · doi:10.1016/s0969-2126(97)00224-4 · Cited by 327
Oelze, M. W., Mollnau, H., Hoffmann, N., Warnholtz, A., Bodenschatz, M., Smolenski, A., Walter, U., Skatchkov, M. P., Meinertz, T., & Münzel, T. F. (2000) · Circulation Research · doi:10.1161/01.res.87.11.999 · Cited by 253
Self-citationMünzel, T. F., Li, H., Mollnau, H., Hink, U., Matheis, E., Hartmann, M., Oelze, M., Skatchkov, M. P., Warnholtz, A., Duncker, L., et al. (2000) · Circulation Research · doi:10.1161/01.res.86.1.e7 · Cited by 234
Self-citation
Flagged first, then by citations
Research works printed but not linked: 4
- O’Byrne, 2000, J. Pharmacol. Exp. Ther., 292, 326
- Brien, 1988, J. Pharmacol. Exp. Ther., 244, 322
- Needleman, 1966, Mol. Pharmacol., 2, 134
- Needleman, 1965, Mol. Pharmacol., 1, 77
Cited by
Sorted by citations
Items 201–300 of 300
Nitrate-Based Vasodilators Inhibit Multiple Vascular Aldehyde Dehydrogenases
Murphy, T. C., Arntzen, R., & Picklo, M. J. (2005) · Cardiovascular Toxicology · doi:10.1385/ct:5:3:321 · Cited by 15
Mechanisms of Nitrite Reduction in Ischemia in the Cardiovascular System
Webb, A., & Ahluwalia, A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00017-4 · Cited by 15
BiDil (Isosorbide Dinitrate and Hydralazine)
Carmody, M. S., & Anderson, J. R. (2006) · Cardiology in Review · doi:10.1097/01.crd.0000250840.15645.fb · Cited by 15
Garcia-Bou, R., Rocha, M., Apostolova, N., Herance, J. R., Hernández‐Mijares, A., & Víctor, V. M. (2012) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2012.02.013 · Cited by 14
Therapeutic Implications of Nitrite in Hypertension
Ling, W. C., Mustafa, M. R., & Murugan, D. D. (2019) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000771 · Cited by 14
Tissue-specific Gene Expression in Rat Hearts and Aortas in a Model of Vascular Nitrate Tolerance
Csont, T., Murlasits, Z., Ménesi, D., Kelemen, J. Z., Bencsik, P., Pipicz, M., Fekete, V., Zvara, Á., Puskás, L. G., & Ferdinandy, P. (2015) · Journal of Cardiovascular Pharmacology · doi:10.1097/fjc.0000000000000218 · Cited by 14
Daiber, A., & Münzel, T. F. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-411-1_22 · Cited by 14
Self-citationDaiber, A., & Münzel, T. F. (2009) · Methods in molecular biology · doi:10.1007/978-1-60761-411-1_3 · Cited by 14
Self-citationD’Souza, Y., Ji, Y., & Bennett, B. M. (2012) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2012.02220.x · Cited by 13
Nitric Oxide Modulation as a Therapeutic Strategy in Heart Failure
Taylor, A. L. (2012) · Heart Failure Clinics · doi:10.1016/j.hfc.2011.11.002 · Cited by 13
Mu, X., He, K., Sun, H., Zhou, X., Chang, L., Li, X., Chu, W., Qiao, G., & Lu, Y. (2012) · Free Radical Research · doi:10.3109/10715762.2012.749987 · Cited by 16
Lukaszewicz, A., Mebazaa, A., Callebert, J., Matéo, J., Gatecel, C., Kechiche, H., Maistre, G., Carayon, A., Baudin, B., & Payen, D. M. (2005) · Critical Care Medicine · doi:10.1097/01.ccm.0000163233.00458.dd · Cited by 13
Advances in Factors Affecting ALDH2 Activity and its Mechanisms
Liu, Y., Liu, X., & Pan, C. (2024) · Cardiovascular Toxicology · doi:10.1007/s12012-024-09923-9 · Cited by 13
NO and sGC-Stimulating NO Donors
Megson, I. L., & Miller, M. R. (2008) · Handbook of experimental pharmacology · doi:10.1007/978-3-540-68964-5_12 · Cited by 12
Sarr, M., Lobysheva, I. I., Diallo, A. S., Stoclet, J., Schini‐Kerth, V. B., & Müller, B. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.02.037 · Cited by 12
Liu, C., Leung, F. P., Lee, V. W. Y., Lau, C. W., Yao, X., Lü, L., & Huang, Y. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.05.009 · Cited by 12
Hobbs, A. J., & Stasch, J. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-373866-0.00009-5 · Cited by 12
Pharmacologic Options for Treatment of Ischemic Disease
Abrams, J., Schroeder, J. S., Frishman, W. H., & Freedman, J. E. (2007) · Elsevier eBooks · doi:10.1016/b978-1-4160-3358-5.50011-5 · Cited by 12
Coadministration of Carvedilol Attenuates Nitrate Tolerance by Preventing Cytochrome P450 Depletion
Nakahira, A., Minamiyama, Y., Takemura, S., Hirai, H., Sasaki, Y., Okada, S., Funae, Y., & Suehiro, S. (2010) · Circulation Journal · doi:10.1253/circj.cj-10-0149 · Cited by 11
Neither nitrite nor nitric oxide mediate toxic effects of nitroglycerin on mitochondria
Dungel, P., Haindl, S., Behling, T., Mayer, B., Redl, H., & Kozlov, A. V. (2011) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.20389 · Cited by 11
Opelt, M., Wölkart, G., Eroğlu, E., Waldeck‐Weiermair, M., Malli, R., Graier, W. F., Kollau, A., Fassett, J. T., Schrammel, A., Mayer, B., et al. (2018) · Molecular Pharmacology · doi:10.1124/mol.117.110783 · Cited by 11
Vascular function is further impaired in subjects aged 80 years or older
Maruhashi, T., Kajikawa, M., Kishimoto, S., Hashimoto, H., Takaeko, Y., Yamaji, T., Harada, T., Hashimoto, Y., Han, Y., Aibara, Y., et al. (2020) · Hypertension Research · doi:10.1038/s41440-020-0435-z · Cited by 11
Wölkart, G., Beretta, M., Wenzl, M. V., Stessel, H., Schmidt, K., Maeda, N., Mayer, B., & Schrammel, A. (2012) · British Journal of Pharmacology · doi:10.1111/bph.12081 · Cited by 11
New insights into nitroglycerin effects and tolerance: Role of calcitonin gene-related peptide
Peng, J., & Li, Y. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.02.039 · Cited by 11
Nanoliposomal Nitroglycerin Exerts Potent Anti-Inflammatory Effects
Ardekani, S., Scott, H. A., Gupta, S., Eum, S., Yang, X. Q., Brunelle, A. R., Wilson, S. M., Mohideen, U., & Ghosh, K. (2015) · Scientific Reports · doi:10.1038/srep16258 · Cited by 10
Marini, E., Giorgis, M., Leporati, M., Rolando, B., Chegaev, K. Y., Lazzarato, L., Bertinaria, M., Vincenti, M., & Stilo, A. D. (2022) · Antioxidants · doi:10.3390/antiox11010166 · Cited by 10
Mulkareddy, V., Racette, S. B., Coggan, A. R., & Peterson, L. R. (2018) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2018.09.026 · Cited by 10
Perkins, W. J., Taniguchi, M., Warner, D. O., Chini, E. N., & Jones, K. A. (2007) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00368.2006 · Cited by 10
Psychiatric perspectives of brain, behavior, and the immune system.
Stein, M., & Trestman, R. L. (1990) · PubMed · Cited by 10
Tolerability to 1-year treatment with once-daily molsidomine in patients with stable angina
Messin, R., Bruhwyler, J., Dubois, C., Famaey, J. P., & Géczy, J. (2006) · Advances in Therapy · doi:10.1007/bf02850048 · Cited by 9
Synthesis of Some Novel Organic Nitrates and Comparative in Vitro Study of Their Vasodilator Profile
Chegaev, K. Y., Lazzarato, L., Marcarino, P., Stilo, A. D., Fruttero, R., Vanthuyne, N., Roussel, C., & Gasco, A. (2009) · Journal of Medicinal Chemistry · doi:10.1021/jm9002236 · Cited by 9
Nitroglycerin reduces myocardial oxygen consumption during exercise despite vascular tolerance
Parent, R., Leblanc, N., & Lavallée, M. (2005) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00607.2005 · Cited by 9
Neubauer, R., Neubauer, A., Wölkart, G., Schwarzenegger, C., Lang, B., Schmidt, K., Russwurm, M., Koesling, D., Gorren, A. C. F., Schrammel, A., et al. (2013) · Molecular Pharmacology · doi:10.1124/mol.113.086835 · Cited by 9
Physiologie der Koronardurchblutung
Bassenge, E. (2004) · Springer eBooks · doi:10.1007/978-3-642-18649-3_5 · Cited by 9
Nitroglycerin-MediatedS-Nitrosylation of Proteins
Stamler, J. S. (2008) · Circulation Research · doi:10.1161/circresaha.108.184341 · Cited by 9
Self-citationStamm, P., Jabs, A., Oelze, M. W., Mikhed, Y., Kröller‐Schön, S., Welschof, P., Jansen, T., Hausding, M., Kopp, M., Steven, S., et al. (2015) · BMC Pharmacology and Toxicology · doi:10.1186/2050-6511-16-s1-a90 · Cited by 8
Self-citationMessin, R., Carreer-Bruhwyler, F., Dubois, C., Famaey, J. P., & Géczy, J. (2006) · Advances in Therapy · doi:10.1007/bf02850352 · Cited by 8
Mechanisms underlying dysfunction of carotid arteries in genetically hyperlipidemic rabbits
August, M., Wingerter, O., Oelze, M. W., Wenzel, P., Kleschyov, A. L., Daiber, A., Mülsch, A., Münzel, T. F., & Tsilimingas, N. B. (2006) · Nitric Oxide · doi:10.1016/j.niox.2006.02.003 · Cited by 8
Self-citationDaiber, A., & Gori, T. (2008) · Cardiovascular Research · doi:10.1093/cvr/cvn174 · Cited by 8
Self-citationNitric oxide releasing graphene for next-generation therapeutics
Tabish, T. A., & Lygate, C. A. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115676 · Cited by 8
An, Y., Li, Y., Zhang, C., Cong, X., Gao, Y., Wu, L., & Dou, D. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.12.065 · Cited by 7
Pharmacologic Options for Treatment of Ischemic Disease
Schroeder, J. S., Frishman, W. H., Parker, J. D., Angiolillo, D. J., Woods, C. E., & Scirica, B. M. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4557-0101-8.00007-2 · Cited by 7
Alcohol and Aldehyde Dehydrogenases: Molecular Aspects
Danquah, K. O., & Gyamfi, D. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800773-0.00003-3 · Cited by 7
Kaesemeyer, W., & Suvorava, T. (2021) · American Journal of Cardiovascular Drugs · doi:10.1007/s40256-021-00474-w · Cited by 7
Shortall, K., Durack, E., Magner, E., & Soulimane, T. (2021) · Cells · doi:10.3390/cells10123535 · Cited by 7
Zhang, X., Chang, L. F., Zhang, Y., Deng, S., Li, Y., & Peng, J. (2009) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2009.06.043 · Cited by 7
Imanishi, T., Kuroi, A., Ikejima, H., Mochizuki, S., Goto, M., & Akasaka, T. (2007) · Circulation Journal · doi:10.1253/circj.71.1473 · Cited by 7
Kaesemeyer, W., & Suvorava, T. (2022) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/10742484221086091 · Cited by 6
Aminoethyl nitrate – the novel super nitrate?
Bauersachs, J. K. (2009) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2009.00414.x · Cited by 5
Soto, J., Ferrer, F. J. A., Otero, J. C., Peláez, D., & Arenas, J. F. (2010) · Theoretical Chemistry Accounts · doi:10.1007/s00214-010-0802-y · Cited by 5
The effects of nitroglycerine on the redox status of rat erythrocytes and reticulocytes
Marković, S., Ognjanović, B. I., Štajn, A., Žikić, R. V., Saičić, Z. S., Radojičić, R., & Spasić, M. B. (2006) · Physiological Research · doi:10.33549/physiolres.930801 · Cited by 5
Vasiliou, V., Thompson, D. C., & Petersen, D. R. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.99183-9 · Cited by 5
Hamdan, A. M., Mohammedsaleh, Z. M., Aboelnour, A., & El-kannishy, S. M. H. (2022) · Saudi Pharmaceutical Journal · doi:10.1016/j.jsps.2022.07.001 · Cited by 4
Developing New Organic Nitrates for Treating Hypertension
Balarini, C. M., Cruz, J. C., Alves, J. L., França-Silva, M. S., & Braga, V. A. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-809275-0.00010-7 · Cited by 4
The nitric oxide donor RuBPY does not induce in vitro cross-tolerance with acetylcholine
Paulo, M., Grando, M. D., da Silva, R. S., Minshall, R. D., & Bendhack, L. M. (2017) · Nitric Oxide · doi:10.1016/j.niox.2017.05.004 · Cited by 4
Knorr, M., Hausding, M., Pfeffer, A., Jurk, K., Jansen, T., Schwierczek, K., Oelze, M. W., Kröller‐Schön, S., Schulz, E., Wenzel, P., et al. (2014) · Pharmacology · doi:10.1159/000361052 · Cited by 5
Self-citationGutterman, D. D. (2007) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.107.148023 · Cited by 4
Hink, U., Alhamdani, M.-S. S., & Münzel, T. F. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.06.014 · Cited by 4
Self-citationFaponle, A. S., Gauld, J. W., & de Visser, S. P. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083845 · Cited by 3
Cobalt complex based on cyclam for reversible binding of nitric oxide
Siri, O., Tabard, A., Pullumbi, P., & Guilard, R. (2008) · Molecular Simulation · doi:10.1080/08927020802235680 · Cited by 3
Guo, R., Chen, L., Li, L., Guo, X., Sun, J., Xiong, X.-M., Cheng, Z., Li, Y., & Chen, X.-P. (2011) · Pharmacogenetics and Genomics · doi:10.1097/fpc.0b013e328343ea0a · Cited by 3
Semerdzhieva, N. E., Denchev, S. V., & Gospodinova, M. V. (2022) · Cureus · doi:10.7759/cureus.24789 · Cited by 3
Elgharabawy, R. M., Ahmed, A. S., & Al-Najjar, A. H. (2016) · Therapeutics and Clinical Risk Management · doi:10.2147/tcrm.s114469 · Cited by 2
Recent Developments in Vascular Biology
Conklin, D. J. (2014) · Circulation Research · doi:10.1161/circresaha.114.305639 · Cited by 2
Improving the hemocompatibility of catheters via NO release/generation
Wo, Y., Brisbois, E. J., Bartlett, R. H., & Meyerhoff, M. E. (2017) · Elsevier eBooks · doi:10.1016/b978-0-08-100497-5.00013-6 · Cited by 2
Zhang, G., Liu, X., Xu, J. M., Cheng, G., & Jun-tang, X. (2020) · Journal of Comparative Effectiveness Research · doi:10.2217/cer-2019-0099 · Cited by 2
Vasiliou, V., & Petersen, D. R. (2010) · Elsevier eBooks · doi:10.1016/b978-0-08-046884-6.00407-3 · Cited by 2
Sarr, M. (2004) · OpenGrey (Institut de l'Information Scientifique et Technique) · Cited by 2
A Study of the Pathway of Nitric Oxide Production by Nitroglycerin in Trabecular Meshwork Cells
Yoon, S. H., & Kim, J. W. (2013) · Journal of the Korean Ophthalmological Society · doi:10.3341/jkos.2013.54.9.1429 · Cited by 1
Pharmacology of Nitrovasodilators
Münzel, T. F., & Daiber, A. (2017) · Springer eBooks · doi:10.1007/978-3-319-46189-2_15 · Cited by 1
Self-citationLi, Z., Shan, L., & Yu, P. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.06.013 · Cited by 1
Shan, L., Hu, H., Wu, J., Guo, B., & Wang, Y. (2022) · Current Pharmaceutical Analysis · doi:10.2174/1573412918666220831101931 · Cited by 1
Marković, S., Djordjević, N. Z., Milutinović, M. G., Štajn, A. Š., & Spasić, M. B. (2014) · General Physiology and Biophysics · doi:10.4149/gpb_2014018 · Cited by 1
Parajuli, B. (2014) · IUScholarWorks (Indiana University) · doi:10.7912/c2/1848 · Cited by 1
Activation of the trigeminal system in the animal models of migraine
Laborc, K. F. (2023) · doi:10.14232/phd.11677 · Cited by 1
Wendt, M. (2005)
Self-citationSarr, M. (2013) · Journal of Clinical Medicine and Research · doi:10.5897/jcmr12.026
Cole, R., Kalogeropoulos, A. P., Georgiopoulou, V. V., Gheorghiade, M., Quyyumi, A. A., Yancy, C. W., & Butler, J. (2011)
Mouziri, Z. (2014) · TSpace (University of Toronto)
Inorganic nitrite and conduit artery function
Omar, S. A. (2015)
Meet the History 冠攣縮性狭心症の診断と治療 泰江弘文先生に聞く
弘文, 泰., & 章, 山. (2005) · 心臓 · doi:10.11281/shinzo1969.37.11_955
Discovery and characterization of small molecule inhibitors of the aldehyde dehydrogenase 1/2 family
Buchman, C. D. (2016) · IUScholarWorks (Indiana University) · doi:10.7912/c21s46
Münzel, T. F., Daiber, A., & Gori, T. (2011)
Self-citationEFFECT OF NITROGLYCERIN ON IN VITRO MATURATIONOF SHEEP OOCYTES
شبر, A. M. H. S. ع. ا. م. ح., الجعيفري, A. A. I. A. ع. ع. ا. ا., & Fakhrildin, M. B. M.-R. (2011) · IRAQI JOURNAL OF AGRICULTURAL SCIENCES
Observations concerning the mechanism of action of glyceryl trinitrate
Zhou, K. (2018) · TSpace (University of Toronto)
Münzel, T. F., & Post, F. (2007) · Clinical Research in Cardiology Supplements · doi:10.1007/s11789-006-0022-0
Self-citationOdebiyi, O., Badejo, J. A., Alabi, B. A., Ajayi, A. M., Iwalewa, O. E., & FAGBEMI, O. S. (2021) · Nutrire · doi:10.1186/s41110-021-00141-9
Structural and kinetic studies of human aldh7a1 and aldh9a1
Wyatt, J. W. (2021) · doi:10.32469/10355/88060
(2008) · Circulation · doi:10.1161/circulationaha.108.189685
Daiber, A., Coldewey, M., Oelze, M. W., Stalleicken, D., Mülsch, A., & Münzel, T. F. (2006) · Steinkopff eBooks · doi:10.1007/3-7985-1560-3_3
Self-citationIst eine Therapie mit organischen Nitraten heute noch sinnvoll?
Münzel, T. F., & Daiber, A. (2006) · Steinkopff eBooks · doi:10.1007/3-7985-1560-3_2
Self-citationOxidativer Stress und kardiovaskuläre Erkrankungen
Bassenge, E., Daiber, A., & Schneider, H. T. (2006) · Steinkopff eBooks · doi:10.1007/3-7985-1560-3_9
Self-citationde Araújo, N. F., Nóbrega, N. R. C., Costa, D. E. F. D. R., Simplicio, J. A., Ribeiro, N. D. A. R., Tirapelli, C. R., & Bonaventura, D. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.177056
Vasiliou, V., Lisgara, A., Krupenko, S. A., Krupenko, N. I., Alayyoub, M., Petersen, D. R., & Thompson, D. C. (2025) · Elsevier eBooks · doi:10.1016/b978-0-323-95488-4.00287-4
Feng, X., Gao, L., Xu, H., Ye, J., Pang, L., Wang, L., & Song, L. (2025) · Antioxidants · doi:10.3390/antiox14121423
Das, P. P., Medhi, S., Dutta, S., Talukdar, A. J., & Gourinath, S. (2025) · Current Genetic Medicine Reports · doi:10.1007/s40142-025-00227-0
Investigating the role of nitric oxide clones in cardiovascular conditions
Arif, S. (2014) · University of Birmingham Institutional Research Archive (University of Birmingham)
Metadata
- Authors
- Sydow, K., Daiber, A., Oelze, M., Chen, Z., August, M., Wendt, M., Ullrich, V., Mülsch, A., Schulz, E., Keaney, J. F., Stamler, J. S., & Münzel, T.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- Howard Hughes Medical Institute (US)
- University of Konstanz (DE)
- Goethe University Frankfurt (DE)
- Boston University (US)
- Corresponding author
- Münzel, Thomas
- ORCID
- Venue
- Journal of Clinical Investigation
- Published
- 2004-02-01
- Volume
- 113
- Issue
- 3
- Pages
- 482-489
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2172008520
- Cited by
- 300
- References
- 38
- Citations by year
- 2025: 5 · 2024: 3 · 2023: 6 · 2022: 7 · 2021: 7 · 2020: 7 · 2019: 4 · 2018: 10 · 2017: 17 · 2016: 11 · 2015: 11 · 2014: 12 · 2013: 7 · 2012: 18
- FWCI
- 18.50
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Clinical Investigation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Deutsche Forschungsgemeinschaft
- Topics
- Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Eicosanoids and Hypertension Pharmacology
- Keywords
- nitroglycerin tolerance, nitrate tolerance, mitochondrial aldehyde dehydrogenase, reactive oxygen species, endothelium-dependent relaxation, mitochondrial dysfunction, antioxidants, acetylcholine-induced relaxation, vascular smooth muscle
- MeSH terms
- Aldehyde Dehydrogenase, Animals, Aorta, Drug Tolerance, Nitroglycerin, Cyclic GMP, Mitochondria, Myocardium, Vasodilator Agents, Rats, Wistar, Reactive Oxygen Species, Models, Animal, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review