The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.
Hepatic expansion of a virus-specific regulatory CD8+ T cell population in chronic hepatitis C virus infection
Open accessAbstract
Regulatory T (T(R)) cells consist of phenotypically and functionally distinct CD4(+) and CD8(+) T cell subsets engaged both in maintaining self-tolerance and in preventing anti-non-self effector responses (microbial, tumor, transplant, and so on) that may be harmful to the host. Here we propose that the proinflammatory function of virus-specific memory effector CCR7(-)CD8(+) T cells, which are massively recruited in the liver, are inefficient (in terms of IFN-gamma production) in patients with chronic hepatitis C virus (HCV) infection because of the concomitant presence of virus-specific CCR7(-)CD8(+) T(R) cells producing considerable amounts of IL-10. These CD8(+) T(R) cells are antigen specific, as they can be stimulated by HCV epitopes and suppress T cell responses that are in turn restored by the addition of neutralizing anti-IL-10. This study provides for the first time to our knowledge direct evidence of the existence of virus-specific CD8(+) T(R) cells that infiltrate the livers of patients with chronic HCV infection, identifies IL-10 as a soluble inhibitory factor mediating suppression, and suggests that these cells play a pivotal role in controlling hepatic effector CD8(+) T cell responses.
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Cites
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Hori, S., Nomura, T., & Sakaguchi, S. (2003) · Science · doi:10.1126/science.1079490 · Cited by 8,187
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
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Viral Immune Evasion Due to Persistence of Activated T Cells Without Effector Function
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Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
Visualizing the generation of memory CD4 T cells in the whole body
Reinhardt, R. L., Khoruts, A., Merica, R., Zell, T., & Jenkins, M. K. (2001) · Nature · doi:10.1038/35065111 · Cited by 1,026
Migratory properties of naive, effector, and memory CD8(+) T cells
Weninger, W., Crowley, M. A., Manjunath, N., & von Andrian, U. H. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.194.7.953 · Cited by 515
Dynamic programming of CD8+ T lymphocyte responses
van Stipdonk, M. J. B., Hardenberg, G., Bijker, M. S., Lemmens, E. E., Droin, N. M., Green, D. R., & Schoenberger, S. P. (2003) · Nature Immunology · doi:10.1038/ni912 · Cited by 401
Cited by
Immunology of hepatitis B virus and hepatitis C virus infection
Rehermann, B., & Nascimbeni, M. (2005) · Nature Reviews Immunology · doi:10.1038/nri1573 · Cited by 1,627
The Liver as an Immunological Organ
Racanelli, V., & Rehermann, B. (2006) · Hepatology · doi:10.1002/hep.21060 · Cited by 1,377
Adaptive immune responses in acute and chronic hepatitis C virus infection
Bowen, D. G., & Walker, C. M. (2005) · Nature · doi:10.1038/nature04079 · Cited by 756
Living in the liver: hepatic infections
Protzer, U., Maini, M. K., & Knolle, P. A. (2012) · Nature Reviews Immunology · doi:10.1038/nri3169 · Cited by 560
Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence
Rehermann, B. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39133 · Cited by 531
Metadata
- Authors
- Accapezzato, D., Francavilla, V., Paroli, M., Casciaro, M., Chircu, L. V., Cividini, A., Abrignani, S., Mondelli, M. U., & Barnaba, V.
- Venue
- Journal of Clinical Investigation
- Published
- 2004-04-01
- Volume
- 113
- Issue
- 7
- Pages
- 963-972
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2102232873
- Cited by
- 303
- References
- 7
- FWCI
- 23.69
- Type
- journal article
- Language
- en
- Open access
- green
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- Accapezzato, D., Francavilla, V., Paroli, M., Casciaro, M., Chircu, L. V., Cividini, A., Abrignani, S., Mondelli, M. U., & Barnaba, V. (2004). Hepatic expansion of a virus-specific regulatory CD8+ T cell population in chronic hepatitis C virus infection. Journal of Clinical Investigation. https://doi.org/10.1172/jci200420515
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
