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The Importance of Hypoxia-Inducible Factors (HIF-1 and HIF-2) for the Pathophysiology of Inflammatory Bowel Disease

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Prebiotic Impacts of Soybean Residue (Okara) on Eubiosis/Dysbiosis Condition of the Gut and the Possible Effects on Liver and Kidney Functions

Swallah, M. S., Fan, H., Wang, S., Yu, H., & Piao, C. (2021) · Molecules · doi:10.3390/molecules26020326 · Cited by 86

HIF1α-regulated glycolysis promotes activation-induced cell death and IFN-γ induction in hypoxic T cells

Shen, H., Ojo, O. A., Ding, H., Mullen, L. J., Xing, C., Hossain, M. I., Yassin, A., Shi, V. Y., Lewis, Z., Podgórska, E., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-53593-8 · Cited by 90

Epigenetic Repression of DNA Mismatch Repair by Inflammation and Hypoxia in Inflammatory Bowel Disease–Associated Colorectal Cancer

Edwards, R. A., Witherspoon, M., Wang, K., Afrasiabi, K., Pham, T. T., Birnbaumer, L., & Lipkin, S. M. (2009) · Cancer Research · doi:10.1158/0008-5472.can-09-1285 · Cited by 80

Therapeutic Manipulation of the HIF Hydroxylases

Nagel, S., Talbot, N. P., Mecinović, J., Smith, T. G., Buchan, A. M., & Schofield, C. J. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2711 · Cited by 77

Butyrate Does Not Protect Against Inflammation-induced Loss of Epithelial Barrier Function and Cytokine Production in Primary Cell Monolayers From Patients With Ulcerative Colitis

Vancamelbeke, M., Laeremans, T., Vanhove, W., Arnauts, K., Ramalho, A. S., Farré, R., Cleynen, I., Ferrante, M., & Vermeire, S. (2019) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjz064 · Cited by 77

Conditioned mesenchymal stem cells produce pleiotropic gut trophic factors

Watanabe, S., Arimura, Y., Nagaishi, K., Isshiki, H., Onodera, K., Nasuno, M., Yamashita, K., Idogawa, M., Naishiro, Y., Murata, M., et al. (2013) · Journal of Gastroenterology · doi:10.1007/s00535-013-0901-3 · Cited by 76

Short‐chain fatty acids affect the development of inflammatory bowel disease through intestinal barrier, immunology, and microbiota: A promising therapy?

Peng, K., Xia, S., Xiao, S., & Yu, Q. (2022) · Journal of Gastroenterology and Hepatology · doi:10.1111/jgh.15970 · Cited by 80

Hypoxia-inducible factor (HIF) network: insights from mathematical models

Cavadas, M. A. S., Nguyen, L. K., & Cheong, A. (2013) · Cell Communication and Signaling · doi:10.1186/1478-811x-11-42 · Cited by 81

The role of mucosal barriers in human gut health

Seo, K., Seo, J.-M., Yeun, J., Choi, H., Kim, Y., & Chang, S.-Y. (2021) · Archives of Pharmacal Research · doi:10.1007/s12272-021-01327-5 · Cited by 76

Hydroxylase Inhibition Abrogates TNF-α–Induced Intestinal Epithelial Damage by Hypoxia-Inducible Factor-1–Dependent Repression of FADD

Hindryckx, P., De Vos, M., Jacques, P., Ferdinande, L., Peeters, H., Olievier, K., Bogaert, S., Brinkman, B., Vandenabeele, P., Elewaut, D., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1002541 · Cited by 73

Interplay of Hypoxia and A2B Adenosine Receptors in Tissue Protection

Koeppen, M., Eckle, T. D. L. G., & Eltzschig, H. K. (2011) · Advances in pharmacology · doi:10.1016/b978-0-12-385526-8.00006-0 · Cited by 73

Hypoxia-inducible factor plays a gut-injurious role in intestinal ischemia reperfusion injury

Kannan, K. B., Colorado, I., Reino, D. C., Palange, D., Lu, Q., Qin, X., Abungu, B., Watkins, A. C., Caputo, F. J., Xu, D.-Z., et al. (2010) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00459.2010 · Cited by 73

Epithelial Hypoxia-Inducible Factor 2 α Facilitates the Progression of Colon Tumors through Recruiting Neutrophils

Triner, D. A., Xue, X., Schwartz, A. J., Jung, I., Colacino, J. A., & Shah, Y. M. (2016) · Molecular and Cellular Biology · doi:10.1128/mcb.00481-16 · Cited by 74

New therapeutic avenues in ulcerative colitis: thinking out of the box

Torres, J., Danese, S., & Colombel, J. (2013) · Gut · doi:10.1136/gutjnl-2012-303959 · Cited by 74

Induction of CD36 and Thrombospondin-1 in Macrophages by Hypoxia-Inducible Factor 1 and Its Relevance in the Inflammatory Process

Ortiz‐Masiá, D., Díez, I., Calatayud, S., Hernández, C., Cosín‐Roger, J., Hinojosa, J., Esplugues, J. V., & Barrachina, M. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0048535 · Cited by 77

HIF‐dependent induction of apical CD55 coordinates epithelial clearance of neutrophils

Louis, N. A., Hamilton, K. E., Kong, T., & Colgan, S. P. (2005) · The FASEB Journal · doi:10.1096/fj.04-3251com · Cited by 72

Mucosal protection by hypoxia‐inducible factor (HIF) prolyl hydroxylase inhibition

Keeley, S., Furuta, G. T., & Colgan, S. P. (2008) · The FASEB Journal · doi:10.1096/fasebj.22.1_supplement.328.3 · Cited by 3

Mucosal Protection by Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibition

Robinson, A., Keely, S., Karhausen, J., Gerich, M. E., Furuta, G. T., & Colgan, S. P. (2008) · Gastroenterology · doi:10.1053/j.gastro.2007.09.033 · Cited by 368

Hypoxia-Inducible Factor Augments Experimental Colitis Through an MIF–Dependent Inflammatory Signaling Cascade

Shah, Y. M., Ito, S., Morimura, K., Chen, C., Yim, S., Haase, V. H., & Gonzalez, F. J. (2008) · Gastroenterology · doi:10.1053/j.gastro.2008.03.009 · Cited by 168

Hypoxia and gastrointestinal disease

Taylor, C. T., & Colgan, S. P. (2007) · Journal of Molecular Medicine · doi:10.1007/s00109-007-0277-z · Cited by 313

Hypoxia-Inducible Factor 1–Dependent Induction of Intestinal Trefoil Factor Protects Barrier Function during Hypoxia

Furuta, G. T., Turner, J. R., Taylor, C. T., Hershberg, R. M., Comerford, K., Narravula, S., Podolsky, D. K., & Colgan, S. P. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.9.1027 · Cited by 449