Johnson, Randall S.

HIF-1α is essential for myeloid cell-mediated inflammation

Cramer, T., Yamanishi, Y., Clausen, B. E., Förster, I., Pawlinski, R., Mackman, N., Haase, V. H., Jaenisch, R., Corr, M., Nizet, V., et al. (2003) · Cell

Cancer, Hypoxia, and MetabolismImmune cells in cancer

Cited by 2,046

HIF1α and HIF2α: sibling rivalry in hypoxic tumour growth and progression

Keith, B., Johnson, R. S., & Simon, M. C. (2012) · Nature Reviews Cancer

Cancer, Hypoxia, and MetabolismKruppel-like factors research

Cited by 1,693

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

Rius, J., Guma, M., Schachtrup, C., Akassoglou, K., Zinkernagel, A. S., Nizet, V., Johnson, R. S., Haddad, G. G., & Karin, M. (2008) · Nature

NF-κB Signaling PathwaysCancer, Hypoxia, and Metabolism

Cited by 1,614

Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

Araki, E., Lipes, M. A., Patti, M.-E., Brüning, J. C., Haag III, B., Johnson, R. S., & Kahn, C. R. (1994) · Nature

Metabolism, Diabetes, and CancerGrowth Hormone and Insulin-like Growth Factors

Cited by 1,252

HIF transcription factors, inflammation, and immunity

Palazon, A., Goldrath, A. W., Nizet, V., & Johnson, R. S. (2014) · Immunity

Cancer, Hypoxia, and MetabolismImmune cells in cancer

Cited by 1,195

Hypoxia promotes fibrogenesis in vivo via HIF-1 stimulation of epithelial-to-mesenchymal transition

Higgins, D. F., Kimura, K., Bernhardt, W. M., Shrimanker, N., Akai, Y., Hohenstein, B., Saito, Y., Johnson, R. S., Kretzler, M., Cohen, C. D., et al. (2007) · Journal of Clinical Investigation

Chronic Kidney Disease and DiabetesAcute Kidney Injury Research

Cited by 976

Biology of HIF-1α

Weidemann, A., & Johnson, R. S. (2008) · Cell Death & Differentiation

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 941

Regulation of the HIF-1α Level Is Essential for Hematopoietic Stem Cells

Takubo, K., Goda, N., Yamada, W., Iriuchishima, H., Ikeda, E., Kubota, Y., Shima, H., Johnson, R. S., Hirao, A., Suematsu, M., et al. (2010) · Cell Stem Cell

Hematopoietic Stem Cell TransplantationCancer, Hypoxia, and Metabolism

Cited by 891

Hypoxia-induced neutrophil survival is mediated by HIF-1α–dependent NF-κB activity

Walmsley, S. R., Print, C., Farahi, N., Peyssonnaux, C., Johnson, R. S., Cramer, T., Sobolewski, A., Condliffe, A. M., Cowburn, A. S., Johnson, N., et al. (2005) · The Journal of Experimental Medicine

Cancer, Hypoxia, and MetabolismNeutrophil, Myeloperoxidase and Oxidative Mechanisms

Cited by 891

Loss of PTEN facilitates HIF-1-mediated gene expression

Zundel, W., Schindler, C., Haas-Kogan, D., Koong, A., Kaper, F., Chen, E., Gottschalk, A. R., Ryan, H. E., Johnson, R. S., Jefferson, A. B., et al. (2000) · Genes & Development

Cancer, Hypoxia, and MetabolismPI3K/AKT/mTOR signaling in cancer

Cited by 840

Interdependence of hypoxic and innate immune responses

Nizet, V., & Johnson, R. S. (2009) · Nature Reviews Immunology

Cancer, Hypoxia, and MetabolismImmune Response and Inflammation

Cited by 708

Hypoxia-inducible factors enhance the effector responses of CD8(+) T cells to persistent antigen

Doedens, A. L., Phan, A. T., Stradner, M. H., Fujimoto, J. K., Nguyen, J. V., Yang, E., Johnson, R. S., & Goldrath, A. W. (2013) · Nature Immunology

T-cell and B-cell ImmunologyCancer, Hypoxia, and Metabolism

Cited by 660

Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis

Karhausen, J., Furuta, G. T., Tomaszewski, J. E., Johnson, R. S., Colgan, S. P., & Haase, V. H. (2004) · Journal of Clinical Investigation

Inflammatory Bowel DiseaseGut microbiota and health

Cited by 655

Macrophage Expression of Hypoxia-Inducible Factor-1α Suppresses T-Cell Function and Promotes Tumor Progression

Doedens, A. L., Stockmann, C., Rubinstein, M. P., Liao, D., Zhang, N., DeNardo, D. G., Coussens, L. M., Karin, M., Goldrath, A. W., & Johnson, R. S. (2010) · Cancer Research

Immune cells in cancerCancer, Hypoxia, and Metabolism

Cited by 652

Regulation of iron homeostasis by the hypoxia-inducible transcription factors (HIFs)

Peyssonnaux, C., Zinkernagel, A. S., Schuepbach, R. A., Rankin, E., Vaulont, S., Haase, V. H., Nizet, V., & Johnson, R. S. (2007) · Journal of Clinical Investigation

Iron Metabolism and DisordersErythropoietin and Anemia Treatment

Cited by 639

HIF-1 as a target for drug development

Giaccia, A., Siim, B. G., & Johnson, R. S. (2003) · Nature Reviews Drug Discovery

Cancer, Hypoxia, and MetabolismErythropoietin and Anemia Treatment

Cited by 631

Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity

Lee, Y. S., Kim, J.-W., Osborne, O., Oh, D. Y., Sasik, R., Schenk, S., Chen, A., Chung, H., Murphy, A., Watkins, S. M., et al. (2014) · Cell

Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and Metabolism

Cited by 598

Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo

Rankin, E. B., Biju, M. P., Liu, Q., Unger, T. L., Rha, J., Johnson, R. S., Simon, M. C., Keith, B., & Haase, V. H. (2007) · Journal of Clinical Investigation

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 596

An HIF-1α/VEGF-A Axis in Cytotoxic T Cells Regulates Tumor Progression

Palazon, A., Tyrakis, P. A., Macias, D., Veliça, P., Rundqvist, H., Fitzpatrick, S., Vojnovic, N., Phan, A. T., Loman, N., Hedenfalk, I., et al. (2017) · Cancer Cell

Cancer, Hypoxia, and MetabolismCancer Immunotherapy and Biomarkers

Cited by 521

Cutting Edge: Essential Role of Hypoxia Inducible Factor-1α in Development of Lipopolysaccharide-Induced Sepsis

Peyssonnaux, C., Cejudo-Martin, P., Doedens, A., Zinkernagel, A. S., Johnson, R. S., & Nizet, V. (2007) · The Journal of Immunology

Sepsis Diagnosis and TreatmentInflammation biomarkers and pathways

Cited by 480

Acute postnatal ablation of Hif-2 α results in anemia

Gruber, M., Hu, C.-J., Johnson, R. S., Brown, E. J., Keith, B., & Simon, M. C. (2007) · Proceedings of the National Academy of Sciences

Erythropoietin and Anemia TreatmentCancer, Hypoxia, and Metabolism

Cited by 457

S-2-hydroxyglutarate regulates CD8(+) T-lymphocyte fate

Tyrakis, P. A., Palazon, A., Macias, D., Lee, K. L., Phan, A. T., Veliça, P., You, J., Chia, G. S., Sim, J., Doedens, A., et al. (2016) · Nature

T-cell and B-cell ImmunologyCancer, Hypoxia, and Metabolism

Cited by 433

The hypoxic response of tumors is dependent on their microenvironment

Blouw, B., Song, H., Tihan, T., Bosze, J., Ferrara, N., Gerber, H.-P., Johnson, R. S., & Bergers, G. (2003) · Cancer Cell

Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in Cancer

Cited by 408

The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease

Giaccia, A. J., Simon, M. C., & Johnson, R. (2004) · Genes & Development

Cancer, Hypoxia, and MetabolismRedox biology and oxidative stress

Cited by 380