The DOI matches its OpenAlex record; 1 of the 1 references it cites were found in a registry or an index.
Toward transcriptional therapies for the failing heart: chemical screens to modulate genes
Open accessAbstract
In response to acute and chronic stresses, the heart frequently undergoes a remodeling process that is accompanied by myocyte hypertrophy, impaired contractility, and pump failure, often culminating in sudden death. The existence of redundant signaling pathways that trigger heart failure poses challenges for therapeutic intervention. Cardiac remodeling is associated with the activation of a pathological gene program that weakens cardiac performance. Thus, targeting the disease process at the level of gene expression represents a potentially powerful therapeutic approach. In this review, we describe strategies for normalizing gene expression in the failing heart with small molecules that control signal transduction pathways directed at transcription factors and associated chromatin-modifying enzymes.
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Citations
Cites
Czubryt, M. P., McAnally, J., Fishman, G. I., & Olson, E. N. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0337639100 · Cited by 418
Self-citation
Cited by
MEF2: a central regulator of diverse developmental programs
Potthoff, M. J., & Olson, E. N. (2007) · Development · doi:10.1242/dev.008367 · Cited by 834
Self-citationInflammation, Growth Factors, and Pulmonary Vascular Remodeling
Hassoun, P. M., Mouthon, L., Barberà, J. A., Eddahibi, S., Flores, S. C., Grimminger, F., Jones, P. L., Maitland, M. L., Michelakis, E. D., Morrell, N. W., et al. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.04.006 · Cited by 710
Altered microRNA expression in human heart disease
Ikeda, S., Kong, S. W., Lu, J., Bisping, E., Zhang, H., Allen, P. D., Golub, T. R., Pieske, B., & Pu, W. T. (2007) · Physiological Genomics · doi:10.1152/physiolgenomics.00144.2007 · Cited by 616
Zhong, Q., Xiao, X., Qiu, Y., Xu, Z., Chen, C., Chong, B., Zhao, X., Hai, S., Li, S., An, Z., et al. (2023) · MedComm · doi:10.1002/mco2.261 · Cited by 442
BET Bromodomains Mediate Transcriptional Pause Release in Heart Failure
Anand, P., Brown, J. D., Lin, C. Y., Qi, J., Zhang, R., Artero, P. C., Alaiti, M. A., Bullard, J., Alazem, K., Margulies, K. B., et al. (2013) · Cell · doi:10.1016/j.cell.2013.07.013 · Cited by 406
“Notably, stress pathways activated in HF are associated with dynamic remodeling of chromatin (McKinsey and Olson, 2005; Sayed et al., 2013), including global changes in histone acetylation and DNA methylation.”
Metadata
- Authors
- McKinsey, T. A., & Olson, E. N.
- Venue
- Journal of Clinical Investigation
- Publisher
- American Society for Clinical Investigation
- Published
- 2005-03-01
- Volume
- 115
- Issue
- 3
- Pages
- 538-546
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2135960088
- Cited by
- 288
- References
- 1
- FWCI
- 19.73
- Type
- journal article
- Language
- en
- Open access
- bronze
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- McKinsey, T. A., & Olson, E. N. (2005). Toward transcriptional therapies for the failing heart: chemical screens to modulate genes. Journal of Clinical Investigation. https://doi.org/10.1172/jci200524144
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