PI3K integrates the action of insulin and leptin on hypothalamic neurons

Central nervous system control of food intake

Schwartz, M. W., Woods, S. C., Porte, D., Seeley, R. J., & Baskin, D. G. (2000) · Nature · doi:10.1038/35007534 · Cited by 6,451

The phosphoinositide 3-kinase pathway

Cantley, L. C. (2002) · Science · doi:10.1126/science.296.5573.1655 · Cited by 5,621

Generalized lacZ expression with the ROSA26 Cre reporter strain

Soriano, P. (1999) · Nature Genetics · doi:10.1038/5007 · Cited by 5,237

A simplified system for generating recombinant adenoviruses

He, T., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., & Vogelstein, B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.5.2509 · Cited by 3,209

Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus

Cowley, M. A., Smart, J. L., Rubinstein, M., Cerdán, M. G., Diano, S., Horvath, T. L., Cone, R. D., & Low, M. J. (2001) · Nature · doi:10.1038/35078085 · Cited by 2,356

Role of Brain Insulin Receptor in Control of Body Weight and Reproduction

Brüning, J. C., Gautam, D., Burks, D. J., Gillette, J., Schubert, M., Orban, P. C., Klein, R., Krone, W., Müller-Wieland, D., & Kahn, C. R. (2000) · Science · doi:10.1126/science.289.5487.2122 · Cited by 2,235

Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality

Takeda, K., Noguchi, K., Shi, W., Tanaka, T., Matsumoto, M., Yoshida, N., Kishimoto, T., & Akira, S. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3801 · Cited by 1,323

Insulin receptors are widely distributed in the central nervous system of the rat

Havránková, J., Roth, J., & Brownstein, M. (1978) · Nature · doi:10.1038/272827a0 · Cited by 1,116

Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboons

Woods, S. C., Lotter, E. C., McKay, L. D., & Porte, D. (1979) · Nature · doi:10.1038/282503a0 · Cited by 1,114

Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice.

Vaisse, C., Halaas, J. L., Horvath, C. M., Darnell, J. E., Stoffel, M., & Friedman, J. M. (1996) · Nature Genetics · doi:10.1038/ng0996-95 · Cited by 1,086

Cerebrospinal fluid levels of insulin, leptin, and agouti‐related protein in relation to BMI in pregnant women

Gustavsson, C., Andersson-Hall, U. K., Pelanis, A., Karlsson, O., Andersson, L., Svedin, P., Mallard, C. E., Myntti, A., Andréasson, U., Zetterberg, H., et al. (2016) · Obesity · doi:10.1002/oby.21502 · Cited by 10

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Catană, O. M., Nemeş, A. F., Cioboată, R., Toma, C., Mitroi, D. M., Călăraşu, C., & Streba, C. T. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14082611 · Cited by 11

Various transgenic mouse lines to study proopiomelanocortin cells in the brain stem label disparate populations of GABAergic and glutamatergic neurons

Rau, A. R., Hughes, A. R., & Hentges, S. T. (2018) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00047.2018 · Cited by 9

Food intake in early life and epigenetic modifications of pro-opiomelanocortin expression in arcuate nucleus

Benite‐Ribeiro, S. A., Rodrigues, V. A. D. L., & Machado, M. R. F. (2021) · Molecular Biology Reports · doi:10.1007/s11033-021-06340-x · Cited by 9

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Infantes-López, M. I., Nieto-Quero, A., Chaves-Peña, P., Zambrana-Infantes, E. N., Cifuentes, M., Márquez, J., Pedraza, C., & Pérez‐Martín, M. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1190418 · Cited by 9

Effect of agmatine on food intake in mandarin fish (Siniperca chuatsi)

Lv, L., Liang, X., Huang, K., & He, S. (2019) · Fish Physiology and Biochemistry · doi:10.1007/s10695-019-00659-w · Cited by 7

Role of Obesity in Human Health and Disease

Rao, V., & Rao, L. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.90990 · Cited by 8

SH 2‐Containing Inositol 5′‐Phosphatase 2 Selectively Impairs Hypothalamic Insulin Signalling and Regulation of Food Intake in Mice

Ichihara, Y., Wada, T., Soeda, Y., Ishii, Y., Sasahara, M., Tsuneki, H., & Sasaoka, T. (2013) · Journal of Neuroendocrinology · doi:10.1111/jne.12014 · Cited by 8

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Benite‐Ribeiro, S. A., dos Santos, J. M., Soares-Filho, M. C., & Duarte, J. A. (2010) · Annual Review of Biomedical Sciences · doi:10.5016/1806-8774.2010v12p30 · Cited by 8

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Zhang, Y., & Ren, J. T. (2015) · Springer eBooks · doi:10.1007/978-3-319-19821-7_4 · Cited by 8

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Webster, A. N., Becker, J. J., Li, C., Schwalbe, D. C., Kerspern, D., Karolczak, E. O., Bundon, C., Onoharigho, R. A., Crook, M., Jalil, M., et al. (2023) · doi:10.1101/2023.10.31.564990 · Cited by 56

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Anwer, M., & Iqbal, M. (2018) · Indian journal of endocrinology and metabolism · doi:10.4103/ijem.ijem_66_18 · Cited by 7

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Nakano, M. H., Asakawa, A., & Inui, A. (2012) · Indian Journal of Endocrinology and Metabolism · doi:10.4103/2230-8210.105572 · Cited by 7

Central effects of insulin detemir on feeding, body weight, and metabolism in rats

Vasselli, J. R., Pi-Sunyer, X., Wall, D. G., John, C. S., Chapman, C. D., & Currie, P. J. (2017) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00111.2016 · Cited by 7

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Tuttle, M. A., Dalman, M. R., Liu, Q., & Londraville, R. L. (2019) · PeerJ · doi:10.7717/peerj.6848 · Cited by 7

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Balthasar, N. (2009) · Experimental Physiology · doi:10.1113/expphysiol.2008.042226 · Cited by 7

Effects of exercise and dietary intervention on metabolic syndrome markers of inactive premenopausal women

Dunn, S. L. (2009) · UNSWorks (UNSW Sydney) · doi:10.26190/unsworks/22256 · Cited by 7

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Jayarathne, H. S. M., Sullivan, R. P., Stilgenbauer, L., Debarba, L. K., Kuchumov, A., Koshko, L., Scofield, S., Liu, W., Ginsburg, B. C., Miller, R. A., et al. (2024) · GeroScience · doi:10.1007/s11357-024-01214-z · Cited by 8

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Shpakov, A. O., & Derkach, K. V. (2017) · Neuroscience and Behavioral Physiology · doi:10.1007/s11055-017-0426-y · Cited by 6

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Xu, A. W., & Barsh, G. S. (2005) · Nature Neuroscience · doi:10.1038/nn0106-15 · Cited by 6

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Kasbi, N. A., Stopschinski, B. E., Polyak, A. G., Malladi, A. R., Manouchehri, N., Scherer, P. E., & Stüve, O. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms27010168 · Cited by 8

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Tamayo-Molina, Y. S., Giraldo, M. A., Rodríguez, B. A., & Machado, G. (2024) · Scientific Reports · doi:10.1038/s41598-024-77915-4 · Cited by 6

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Mancini, M., Hikima, T., Witkovsky, P., Patel, J. C., Stone, D. W., Affinati, A. H., & Rice, M. E. (2025) · Journal of Neuroscience · doi:10.1523/jneurosci.1539-24.2025 · Cited by 7

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Haspula, D., Cui, Z., Pittala, S., Cui, Y., Lü, H., Xiong, Y., Jin, J. J., Gavrilova, O., Hwang, E., Ajwani, J., et al. (2025) · Science Advances · doi:10.1126/sciadv.adu1670 · Cited by 5

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Gualdrón, A. J., & Ávila, V. Á. (2007) · Revista de la Facultad de Medicina · Cited by 5

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Forzisi, E., Jo, C., Castillo, L., Gaur, A., Lad, P. S., Bortolami, A., Roser, C., Venkateswaran, S., Dutto, S., Selby, M., et al. (2024) · The FASEB Journal · doi:10.1096/fj.202401931r · Cited by 4

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Wei, S., Dong, Y., Wang, Y., Li, G., Zhao, Y., & Zheng, R. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107972 · Cited by 4

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Vakili, O., Klionsky, D. J., Reiter, R. J., Ren, J., Deshpande, A., Ahn, K. S., Cho, W., Hushmandi, K., & Kumar, A. P. (2026) · Autophagy · doi:10.1080/15548627.2026.2636096 · Cited by 7

Associations of the PTEN −9C>G polymorphism with insulin sensitivity and central obesity in Chinese

Qiu, Y., Cao, H., Xie, S., Tong, Y., Zhu, Q., Zhang, F., Lü, Q., Yang, Y., Li, D., Chen, M., et al. (2013) · Gene · doi:10.1016/j.gene.2013.06.026 · Cited by 4

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de Souza, G. O., Teixeira, P. D. S., Câmara, N. O. S., & Donato, J. (2023) · Cells · doi:10.3390/cells12202442 · Cited by 4

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Gallo, R., Teijeiro, A., Angulo-Aguado, M., & Djouder, N. (2024) · iScience · doi:10.1016/j.isci.2024.110259 · Cited by 4

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Cho, C. E. (2014) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2014-0094 · Cited by 4

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Dieterle, V., Herzer, S., Gröne, H., Jennemann, R., & Nordström, V. (2019) · International Journal of Obesity · doi:10.1038/s41366-019-0388-y · Cited by 4

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Chua, S. C. (2009) · Diabetes · doi:10.2337/db08-1646 · Cited by 3

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Li, A. H., & Yang, S. (2023) · Gene Reports · doi:10.1016/j.genrep.2023.101834 · Cited by 3

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Kim, H.-J., Choi, S.-H., Chun, B., & Kim, D.-H. (2011) · Journal of Korean Society of Pediatric Endocrinology · doi:10.6065/jkspe.2011.16.3.139 · Cited by 3

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Woods, S. C., & Seeley, R. J. (2005) · Drug Discovery Today Disease Mechanisms · doi:10.1016/j.ddmec.2005.08.004 · Cited by 3

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Flak, J. N. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.11.019 · Cited by 3

CRISPR/SaCas9 mutagenesis of stromal interaction molecule 1 in proopiomelanocortin neurons increases glutamatergic excitability and protects against diet-induced obesity

Qiu, J., Bosch, M. A., Stincic, T. L., Hunker, A. C., Zweifel, L. S., Rønnekleiv, O. K., & Kelly, M. J. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101645 · Cited by 3

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Lee, E. B., & Ahima, R. S. (2011) · Springer eBooks · doi:10.1007/978-0-387-92271-3_67 · Cited by 3

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Farooqui, A. A. (2016) · Springer eBooks · doi:10.1007/978-3-319-15889-1_1 · Cited by 2

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Jackson, M. B., & Ahima, R. S. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-370-7_3 · Cited by 2

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Dong, Z., Peng, X., Song, X., Li, X., Yang, L., You, B., Dong, D., & Jianbo, Y. (2025) · HORMONES · doi:10.1007/s42000-025-00667-x · Cited by 2

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Woods, S. C., & Cota, D. (2007) · Humana Press eBooks · doi:10.1007/978-1-59745-400-1_3 · Cited by 2

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Reichenbach, A., Stark, R., & Andrews, Z. B. (2013) · Cited by 2

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Bıçak, B., Kökcü, Y., Kecel‐Gunduz, S., Özel, A. E., & Akyüz, S. (2020) · Natural and Engineering Sciences · doi:10.28978/nesciences.691673 · Cited by 2

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Sahu, A. (2006) · Springer eBooks · doi:10.1007/978-0-387-31416-7_4 · Cited by 2

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Oliveira, L. D. C. (2022) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.17.2022.tde-06022023-105659 · Cited by 2

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Lyons, D. J. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813814-4.00011-0 · Cited by 1

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Levin, B. E., & Clegg, D. J. (2006) · Endocrine updates · doi:10.1007/978-0-387-32164-6_5 · Cited by 1

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R∅nnekleiv, O. K., & Kelly, M. J. (2009) · Elsevier eBooks · doi:10.1016/b978-008088783-8.00032-2 · Cited by 9

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Berbari, N. F., Pasek, R. C., & Yoder, B. K. (2012) · Springer eBooks · doi:10.1007/978-94-007-5808-7_6 · Cited by 1

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Cintra, D. E. (2008) · doi:10.47749/t/unicamp.2008.435969 · Cited by 1

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Dhillon, S., Kim, G. L., & Belsham, D. D. (2010) · The Open Neuroendocrinology Journal · Cited by 1

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Olatinwo, M. O., Harp, D., Thompson, W. E., Park, H.-K., & Mathews, R. P. (2010) · Springer eBooks · doi:10.1007/978-1-4419-1607-5_17 · Cited by 1

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Amigó-Correig, M. (2010) · Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona)

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Dellschaft, N. S. (2012) · Nottingham ePrints (University of Nottingham)

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Barrios, V., Burgos‐Ramos, E., & Argente, J. (2013) · doi:10.1002/9781118395318.ch4

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Niswender, K. D. (2008) · Cambridge University Press eBooks · doi:10.1017/cbo9780511541643.005

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Desai, M., Keen‐Rhinehart, E., & Ross, M. G. (2009) · KARGER eBooks · doi:10.1159/000221161

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del Villar, V., & Jesús, M. (2011) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

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Lenglos, C., Calvez, J., & Timofeeva, E. (2014) · Receptors & Clinical Investigation · doi:10.14800/rci.222

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Menegon, L. F. (2007) · doi:10.47749/t/unicamp.2007.419167

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Sinclair, M. S. (2012)

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Picardi, P. K. (2007) · doi:10.47749/t/unicamp.2007.415733

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Ropelle, E. R. (2010) · doi:10.47749/t/unicamp.2010.477520

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Stevens, M. H., & Harnsberger, H. R. (1987) · PubMed Central

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Zampieri, T. T. (2016) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2016.tde-07122015-181252

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Roman, E. A. D. F. R. (2011) · doi:10.47749/t/unicamp.2011.829153

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Neto, A. S., da Cunha, G. B., Saheb, B., Arantes, B. S., Júnior, J. P., Boix, R., da Silva, S., & Buriti, N. A. (2007)

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Pope, S., & Lytle, S. (2015) · Child and Adolescent Psychopharmacology News · doi:10.1521/capn.2015.20.6.1

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de Lartigue, G., & Raybould, H. E. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-382026-6.00073-7

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Woods, S. C. (2006) · Elsevier eBooks · doi:10.1016/b978-012369442-3/50139-2

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Carvalho, K. M. M. B. (2015) · Americanae (AECID Library)

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Grossberg, A. J. (2014) · doi:10.6083/m40r9mc6

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Knight, W. D. (2008)

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Pedroso, J. A. B. (2017) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.42.2017.tde-16052017-142324

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Moran, T. H., & Sakai, R. R. (2012) · Wiley eBooks · doi:10.1002/9781118133880.hop203011

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Losanno, M. R. (2013)

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(2019) · PeerJ · doi:10.7287/peerj.6848v0.2/reviews/2

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(2019) · PeerJ · doi:10.7287/peerj.6848v0.1/reviews/1

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(2019) · PeerJ · doi:10.7287/peerj.6848v0.2/reviews/1

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Alawadi, A. (2020) · doi:10.33915/etd.7957

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