The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus
Open accessAbstract
Polycystin-1, which is encoded by a gene that is mutated in autosomal dominant polycystic kidney disease (ADPKD), is involved in cell-matrix interactions as well as in ciliary signaling. The precise mechanisms by which it functions, however, remain unclear. Here we find that polycystin-1 undergoes a proteolytic cleavage that releases its C-terminal tail (CTT), which enters the nucleus and initiates signaling processes. The cleavage occurs in vivo in association with alterations in mechanical stimuli. Polycystin-2, the product of the second gene mutated in ADPKD, modulates the signaling properties of the polycystin-1 CTT. These data reveal a novel pathway by which polycystin-1 transmits messages directly to the nucleus.
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Cites
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Self-citationRegulated Intramembrane Proteolysis
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Cited by
Autosomal dominant polycystic kidney disease
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Chapter Two Intraflagellar Transport (IFT)
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Metadata
- Authors
- Chauvet, V., Tian, X., Husson, H., Grimm, D. H., Wang, T., Hieseberger, T., Igarashi, P., Bennett, A. M., Ibraghimov-Beskrovnaya, O., Somlo, S., & Caplan, M. J.
- Venue
- Journal of Clinical Investigation
- Published
- 2004-11-15
- Volume
- 114
- Issue
- 10
- Pages
- 1433-1443
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2097214606
- Cited by
- 294
- References
- 43
- FWCI
- 10.61
- Type
- journal article
- Language
- en
- Open access
- green
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- Chauvet, V., Tian, X., Husson, H., Grimm, D. H., Wang, T., Hieseberger, T., Igarashi, P., Bennett, A. M., Ibraghimov-Beskrovnaya, O., Somlo, S., & Caplan, M. J. (2004). Mechanical stimuli induce cleavage and nuclear translocation of the polycystin-1 C terminus. Journal of Clinical Investigation. https://doi.org/10.1172/jci21753
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