Regulated Intramembrane Proteolysis
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APP undergoes regulated intramembrane proteolysis.
“The cellular trafficking of APP is complex, as APP undergoes regulated intramembrane proteolysis (Brown et al., 2000).”
From LRAD3, A Novel Low-Density Lipoprotein Receptor Family Member That Modulates Amyloid Precursor Protein Trafficking (2011) · cites this paper as Brown et al., 2000
Cites
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Soluble protein oligomers in neurodegeneration: lessons from the Alzheimer's amyloid β-peptide
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Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
Hotamisligil, G. S. (2010) · Cell · doi:10.1016/j.cell.2010.02.034 · Cited by 2,802 · see citing works
Obesity and the regulation of energy balance
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Neurotrophins and their receptors: A convergence point for many signalling pathways
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From endoplasmic-reticulum stress to the inflammatory response
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ER Stress Induces Cleavage of Membrane-Bound ATF6 by the Same Proteases that Process SREBPs
Ye, J., Rawson, R. B., Komuro, R., Chen, X., Davé, U. P., Prywes, R., Brown, M. S., & Goldstein, J. L. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00133-7 · Cited by 1,871 · see citing works
Self-citationA Century of Cholesterol and Coronaries: From Plaques to Genes to Statins
Goldstein, J. L., & Brown, M. S. (2015) · Cell · doi:10.1016/j.cell.2015.01.036 · Cited by 1,233 · see citing works
Self-citationA Transcriptively Active Complex of APP with Fe65 and Histone Acetyltransferase Tip60
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Trafficking and Proteolytic Processing of APP
Haass, C., Kaether, C., Thinakaran, G., & Sisodia, S. (2012) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a006270 · Cited by 1,075 · see citing works
Crucial Step in Cholesterol Homeostasis
Yang, T., Espenshade, P. J., Wright, M. E., Yabe, D., Gong, Y., Aebersold, R., Goldstein, J. L., & Brown, M. S. (2002) · Cell · doi:10.1016/s0092-8674(02)00872-3 · Cited by 987 · see citing works
Self-citationMitochondrial Aβ: a potential focal point for neuronal metabolic dysfunction in Alzheimer's disease
Caspersen, C., Wang, N., Yao, J., Sosunov, A., Chen, X., Lustbader, J. W., Xu, H. W., Stern, D., McKhann, G., & Du Yan, S. (2005) · The FASEB Journal · doi:10.1096/fj.05-3735fje · Cited by 738 · see citing works
Regulation of Sterol Synthesis in Eukaryotes
Espenshade, P. J., & Hughes, A. L. (2007) · Annual Review of Genetics · doi:10.1146/annurev.genet.41.110306.130315 · Cited by 593 · see citing works
γ-Secretase, notch, Aβ and alzheimer's disease: Where do the presenilins fit in?
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The SREBP Pathway in Drosophila
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CD74 Is a Member of the Regulated Intramembrane Proteolysis-processed Protein Family
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APP Function and Lipids: A Bidirectional Link
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The mitochondrial rhomboid protease PSARL is a new candidate gene for type 2 diabetes
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De Strooper, B., & Karran, E. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00057-w · Cited by 36 · see citing works
Covalent fragment inhibits intramembrane proteolysis
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- Authors
- Brown, M. S., Ye, J., Rawson, R. B., & Goldstein, J. L.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Goldstein, Joseph L
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2000-02
- Volume
- 100
- Issue
- 4
- Pages
- 391-398
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2004465970
- Cited by
- 1,329
- References
- 1
- Citations by year
- 2026: 11 · 2025: 20 · 2024: 19 · 2023: 17 · 2022: 27 · 2021: 31 · 2020: 32 · 2019: 35 · 2018: 35 · 2017: 27 · 2016: 37 · 2015: 46 · 2014: 48 · 2013: 53 · 2012: 60
- FWCI
- 12.55
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (HL-20948, P01HL020948)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- regulated intramembrane proteolysis, proteolytic enzymes, membrane proteins, proteolytic processing, conceptual convergence, G proteins, receptor-mediated endocytosis, introns
- MeSH terms
- Animals, Bacteria, DNA-Binding Proteins, Endoribonucleases, Humans, Membrane Proteins, Nuclear Proteins, Endopeptidases, Transcription Factors, Amyloid beta-Protein Precursor, Protein Serine-Threonine Kinases, Protein Folding, CCAAT-Enhancer-Binding Proteins, Sterol Regulatory Element Binding Protein 1
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