The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung.
Open accessAbstract
Previous studies have implicated the novel peptide antibiotic human beta-defensin 1 (hBD-1) in the pathogenesis of cystic fibrosis. We describe in this report the isolation and characterization of the second member of this defensin family, human beta-defensin 2 (hBD-2). A cDNA for hBD-2 was identified by homology to hBD-1. hBD-2 is expressed diffusely throughout epithelia of many organs, including the lung, where it is found in the surface epithelia and serous cells of the submucosal glands. A specific antibody made of recombinant peptide detected hBD-2 in airway surface fluid of human lung. The fully processed peptide has broad antibacterial activity against many organisms, which is salt sensitive and synergistic with lysozyme and lactoferrin. These data suggest the existence of a family of beta-defensin molecules on mucosal surfaces that in the aggregate contributes to normal host defense.
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Cites
A peptide antibiotic from human skin
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Human β-Defensin-1 Is a Salt-Sensitive Antibiotic in Lung That Is Inactivated in Cystic Fibrosis
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Self-citationCystic Fibrosis Airway Epithelia Fail to Kill Bacteria Because of Abnormal Airway Surface Fluid
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Human beta-defensin-1: an antimicrobial peptide of urogenital tissues.
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hBD‐1: a novel β‐defensin from human plasma
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Self-citationEpithelial Antibiotics Induced at Sites of Inflammation
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Self-citationLower respiratory infection and inflammation in infants with newly diagnosed cystic fibrosis
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Cited by
Lung Infections Associated with Cystic Fibrosis
Lyczak, J. B., Cannon, C. L., & Pier, G. B. (2002) · Clinical Microbiology Reviews · doi:10.1128/cmr.15.2.194-222.2002 · Cited by 1,628
Isolation and Characterization of Human μ-Defensin-3, a Novel Human Inducible Peptide Antibiotic
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Antimicrobial peptides: key components of the innate immune system
Pasupuleti, M., Schmidtchen, A., & Malmsten, M. (2012) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2011.594423 · Cited by 799
Pathogen–Host Interactions in Pseudomonas aeruginosa Pneumonia
Sadikot, R. T., Blackwell, T. S., Christman, J. W., & Prince, A. S. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200408-1044so · Cited by 799
Ageitos, J. M., Sánchez-Pérez, A., Calo-Mata, P., & Villa, T. G. (2017) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.09.018 · Cited by 614
Metadata
- Authors
- Bals, R., Wang, X., Wu, Z., Freeman, T., Bafna, V, Zasloff, M., & Wilson, J. M.
- Venue
- Journal of Clinical Investigation
- Published
- 1998-09-01
- Volume
- 102
- Issue
- 5
- Pages
- 874-880
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2058223359
- Cited by
- 577
- References
- 18
- FWCI
- 26.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bals, R., Wang, X., Wu, Z., Freeman, T., Bafna, V, Zasloff, M., & Wilson, J. M. (1998). Human beta-defensin 2 is a salt-sensitive peptide antibiotic expressed in human lung. Journal of Clinical Investigation. https://doi.org/10.1172/jci2410
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