The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Pathogen–Host Interactions in Pseudomonas aeruginosa Pneumonia
Open accessAbstract
Pseudomonas aeruginosa is an important pathogen causing a wide range of acute and chronic infections. P. aeruginosa rarely causes infection in the normal host, but is an efficient opportunistic pathogen causing serious infections in patients who are mechanically ventilated, individuals who are immunocompromised, and patients with malignancies or HIV infection. Among these risk groups, the most vulnerable hosts are neutropenic and patients who are mechanically ventilated. In addition, P. aeruginosa is the most prevalent chronic infection contributing to the pathogenesis of cystic fibrosis. Because of the ubiquitous nature of P. aeruginosa and its ability to develop resistance to antibiotics, it continues to be problematic from a treatment perspective. The pathogenicity of P. aeruginosa is largely caused by multiple bacterial virulence factors and genetic flexibility enabling it to survive in varied environments. Lung injury associated with P. aeruginosa infection results from both the direct destructive effects of the organism on the lung parenchyma and exuberant host immune responses. This article focuses on the major bacterial virulence factors and important aspects of the host immunity that are involved in the pathogenesis of serious P. aeruginosa infection. In addition to antibiotic therapy, strategies directed toward enhancing host defense and/or limiting excessive inflammation could be important to improve outcome in P. aeruginosa lung infections.
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Cites
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Cited by
Pseudomonas aeruginosa : new insights into pathogenesis and host defenses
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Influenza A inhibits Th17-mediated host defense against bacterial pneumonia in mice.
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RSV Mediates Pseudomonas aeruginosa Binding to Cystic Fibrosis and Normal Epithelial Cells
van Ewijk, B. E., Wolfs, T. F. W., Aerts, P. C., Van Kessel, K. P. M., Fleer, A., Kimpen, J. L. L., & Van Der Ent, C. K. (2007) · Pediatric Research · doi:10.1203/pdr.0b013e3180332d1c · Cited by 113
Metadata
- Authors
- Sadikot, R. T., Blackwell, T. S., Christman, J. W., & Prince, A. S.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2005-06-01
- Volume
- 171
- Issue
- 11
- Pages
- 1209-1223
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2109038233
- Cited by
- 799
- References
- 11
- FWCI
- 12.10
- Type
- journal article
- Language
- en
- Open access
- green
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- Sadikot, R. T., Blackwell, T. S., Christman, J. W., & Prince, A. S. (2005). Pathogen–Host Interactions in Pseudomonas aeruginosa Pneumonia. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/rccm.200408-1044so
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
