Cited by 212Bacterial biofilms and quorum sensingCystic Fibrosis Research AdvancesInfections and bacterial resistance

The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.

Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions

Open access

Yoon, S. S.·2006·Journal of Clinical Investigation

Open this paper in CoChat — free account Open PDF

Abstract

Mucoid, mucA mutant Pseudomonas aeruginosa cause chronic lung infections in cystic fibrosis (CF) patients and are refractory to phagocytosis and antibiotics. Here we show that mucoid bacteria perish during anaerobic exposure to 15 mM nitrite (NO2) at pH 6.5, which mimics CF airway mucus. Killing required a pH lower than 7, implicating formation of nitrous acid (HNO2) and NO, that adds NO equivalents to cellular molecules. Eighty-seven percent of CF isolates possessed mucA mutations and were killed by HNO2 (3-log reduction in 4 days). Furthermore, antibiotic-resistant strains determined were also equally sensitive to HNO2. More importantly, HNO2 killed mucoid bacteria (a) in anaerobic biofilms; (b) in vitro in ultrasupernatants of airway secretions derived from explanted CF patient lungs; and (c) in mouse lungs in vivo in a pH-dependent fashion, with no organisms remaining after daily exposure to HNO2 for 16 days. HNO2 at these levels of acidity and NO2 also had no adverse effects on cultured human airway epithelia in vitro. In summary, selective killing by HNO2 may provide novel insights into the important clinical goal of eradicating mucoid P. aeruginosa from the CF airways.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1172/jci24684

Cites

60 of 60 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids
Green, L. C., Wagner, D. A., Glogowski, J. A., Skipper, P. L., Wishnok, J. S., & Tannenbaum, S. R. (1982) · Analytical Biochemistry · doi:10.1016/0003-2697(82)90118-x · Cited by 12,061
Flagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development
O'Toole, G. A., & Kolter, R. (1998) · Molecular Microbiology · doi:10.1046/j.1365-2958.1998.01062.x · Cited by 2,697
Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia
Govan, J. R. W., & Deretic, V. P. (1996) · Microbiological Reviews · doi:10.1128/mr.60.3.539-574.1996 · Cited by 1,671
Evidence for Periciliary Liquid Layer Depletion, Not Abnormal Ion Composition, in the Pathogenesis of Cystic Fibrosis Airways Disease
Matsui, H., Grubb, B. R., Tarran, R., Randell, S. H., Gatzy, J. T., Davis, C. W., & Boucher, R. C. (1998) · Cell · doi:10.1016/s0092-8674(00)81724-9 · Cited by 1,168
Effects of reduced mucus oxygen concentration in airway Pseudomonas infections of cystic fibrosis patients
Worlitzsch, D., Tarran, R., Ulrich, M., Schwab, U. E., Cekici, A., Meyer, K. C., Birrer, P., Bellon, G., Berger, J., Weiß, T., et al. (2002) · Journal of Clinical Investigation · doi:10.1172/jci13870 · Cited by 1,151
A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans
Liu, L., Hausladen, A., Zeng, M., Que, L., Heitman, J., & Stamler, J. S. (2001) · Nature · doi:10.1038/35068596 · Cited by 913
The role of pyocyanin in Pseudomonas aeruginosa infection
Lau, G. W., Hassett, D. J., Ran, H., & Kong, F. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.10.002 · Cited by 750
Microbial pathogenesis in cystic fibrosis: mucoid Pseudomonas aeruginosa and Burkholderia cepacia.
Govan, J. R. W., & Deretic, V. P. (1996) · Microbiological Reviews · doi:10.1128/mmbr.60.3.539-574.1996 · Cited by 693
Endogenous Airway Acidification: Implications for Asthma Pathophysiology
HUNT, J. F., Fang, K., Malik, R. K., Snyder, A. H., Malhotra, N. R., Platts‐Mills, T. A. E., & Gaston, B. M. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.3.9911005 · Cited by 649
Pseudomonas aeruginosa Anaerobic Respiration in Biofilms
Yoon, S. S., Hennigan, R. F., Hilliard, G. M., Ochsner, U. A., Parvatiyar, K., Kamani, M. C., Allen, H. L., Dekievit, T., Gardner, P. R., Schwab, U. E., et al. (2002) · Developmental Cell · doi:10.1016/s1534-5807(02)00295-2 · Cited by 587
Self-citation

Flagged first, then by citations

Show all 59 references

Sorted by citations

The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics
Lundberg, J. O., Weitzberg, E., & Gladwin, M. T. (2008) · Nature Reviews Drug Discovery · doi:10.1038/nrd2466 · Cited by 2,739
An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (F e NO) for Clinical Applications
Dweik, R. A., Boggs, P. B., Erzurum, S. C., Irvin, C. G., Leigh, M. W., Lundberg, J. O., Olin, A.-C., Plummer, A. L., & Taylor, D. R. (2011) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.9120-11st · Cited by 2,539
Involvement of Nitric Oxide in Biofilm Dispersal of Pseudomonas aeruginosa
Barraud, N., Hassett, D. J., Hwang, S.-H., Rice, S. A., Kjelleberg, S. J., & Webb, J. S. (2006) · Journal of Bacteriology · doi:10.1128/jb.00779-06 · Cited by 785
Nutritional Cues Control Pseudomonas aeruginosa Multicellular Behavior in Cystic Fibrosis Sputum
Palmer, K. L., Aye, L. M., & Whiteley, M. (2007) · Journal of Bacteriology · doi:10.1128/jb.01138-07 · Cited by 630
Physicochemical properties of mucus and their impact on transmucosal drug delivery
Leal, J., Smyth, H. D. C., & Ghosh, D. (2017) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2017.09.018 · Cited by 560
Antimicrobial susceptibility testing in biofilm-growing bacteria
Macia, M. D., Rojo‐Molinero, E., & Oliver, A. (2014) · Clinical Microbiology and Infection · doi:10.1111/1469-0691.12651 · Cited by 543
T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection
Lee, R. J., Xiong, G., Kofonow, J. M., Chen, B., Lysenko, A., Jiang, P., Abraham, V., Doghramji, L. J., Adappa, N. D., Palmer, J. N., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci64240 · Cited by 542
Applying insights from biofilm biology to drug development — can a new approach be developed?
Bjarnsholt, T., Ciofu, O., Molin, S., Givskov, M., & Høiby, N. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd4000 · Cited by 516
How biology handles nitrite
Maia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401
Chronic rhinosinusitis pathogenesis
Stevens, W. W., Lee, R. J., Schleimer, R. P., & Cohen, N. A. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.10.009 · Cited by 396
P. aeruginosa Biofilms in CF Infection
Wagner, V., & Iglewski, B. H. (2008) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-008-8079-9 · Cited by 292
Biofilm formation to inhibition: Role of zinc oxide-based nanoparticles
Mahamuni-Badiger, P. P., Patil, P. M., Badiger, M. V., Patel, P. R., Gadgil, B. S. T., Pandit, A. S., & Bohara, R. A. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110319 · Cited by 277
Nitric Oxide: A Key Mediator of Biofilm Dispersal with Applications in Infectious Diseases
Barraud, N., Kelso, M. J., Rice, S., & Kjelleberg, S. J. (2014) · Current Pharmaceutical Design · doi:10.2174/1381612820666140905112822 · Cited by 263
Overcoming Nitrite Oxidizing Bacteria Adaptation through Alternating Sludge Treatment with Free Nitrous Acid and Free Ammonia
Duan, H., Ye, L., Lu, X., & Yuan, Z. (2019) · Environmental Science & Technology · doi:10.1021/acs.est.8b06148 · Cited by 252
Slimy partners: the mucus barrier and gut microbiome in ulcerative colitis
Fang, J. C., Wang, H., Zhou, Y., Zhang, H., Zhou, H., & Zhang, X. (2021) · Experimental & Molecular Medicine · doi:10.1038/s12276-021-00617-8 · Cited by 251
Pseudomonas aeruginosa chronic colonization in cystic fibrosis patients
Murray, T. S., Egan, M. E., & Kazmierczak, B. I. (2007) · Current Opinion in Pediatrics · doi:10.1097/mop.0b013e3280123a5d · Cited by 232
The strong biocidal effect of free nitrous acid on anaerobic sewer biofilms
Jiang, G., Gutiérrez, O., & Yuan, Z. (2011) · Water Research · doi:10.1016/j.watres.2011.04.026 · Cited by 223
Free nitrous acid serving as a pretreatment method for alkaline fermentation to enhance short-chain fatty acid production from waste activated sludge
Zhao, J., Wang, D., Li, X., Yang, Q. X., Chen, H., Zhong, Y., & Zeng, G. (2015) · Water Research · doi:10.1016/j.watres.2015.04.012 · Cited by 211
A novel simultaneous partial nitrification Anammox and denitrification (SNAD) with intermittent aeration for cost-effective nitrogen removal from mature landfill leachate
Zhang, F., Peng, Y., Miao, L., Wang, Z., Wang, S., & Li, B. (2016) · Chemical Engineering Journal · doi:10.1016/j.cej.2016.12.105 · Cited by 208
Inhibition of staphylococcal biofilm formation by nitrite
Schlag, S., Nerz, C., Birkenstock, T. A., Altenberend, F., & Götz, F. (2007) · Journal of Bacteriology · doi:10.1128/jb.00598-07 · Cited by 196
Pseudomonas aeruginosa hypoxic or anaerobic biofilm infections within cystic fibrosis airways
Hassett, D. J., Sutton, M. D., Schurr, M. J., Herr, A. B., Caldwell, C. C., & Matu, J. O. (2009) · Trends in Microbiology · doi:10.1016/j.tim.2008.12.003 · Cited by 189
Improving wastewater management using free nitrous acid (FNA)
Duan, H., Gao, S.-H., Li, X., Hamid, N. H. A., Jiang, G., Zheng, M., Bai, X., Bond, P. L., Lu, X., Chislett, M., et al. (2019) · Water Research · doi:10.1016/j.watres.2019.115382 · Cited by 186
Therapeutic Uses of Inorganic Nitrite and Nitrate: From the Past to the Future
Butler, A. R., & Feelisch, M. (2008) · Circulation · doi:10.1161/circulationaha.107.753814 · Cited by 184
Anaerobic physiology of Pseudomonas aeruginosa in the cystic fibrosis lung
Schobert, M., & Jahn, D. (2010) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2010.08.007 · Cited by 164
An efficient and green pretreatment to stimulate short-chain fatty acids production from waste activated sludge anaerobic fermentation using free nitrous acid
Li, X., Zhao, J., Wang, D., Yang, Q. X., Xu, Q., Deng, Y., Yang, W., & Zeng, G. (2015) · Chemosphere · doi:10.1016/j.chemosphere.2015.08.076 · Cited by 160
Enhancing methane production from waste activated sludge using combined free nitrous acid and heat pre-treatment
Wang, Q., Jiang, G., Ye, L., & Yuan, Z. (2014) · Water Research · doi:10.1016/j.watres.2014.06.010 · Cited by 158
Comparison of Biomarkers in Exhaled Breath Condensate and Bronchoalveolar Lavage
Jackson, A. S., Sandrini, A., Campbell, C., Chow, S., Thomas, P. S., & Yates, D. H. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200601-107oc · Cited by 158
Nitrate-Nitrite-Nitric Oxide Pathway: Implications for Anesthesiology and Intensive Care
Weitzberg, E., Hezel, M., Lundberg, J. O., & Warner, D. S. (2010) · Anesthesiology · doi:10.1097/aln.0b013e3181fcf3cc · Cited by 145
Gene expression of Pseudomonas aeruginosa in a mucin-containing synthetic growth medium mimicking cystic fibrosis lung sputum
Fung, C., Naughton, S., Turnbull, L., Tingpej, P., Rose, B. R., Arthur, J. W., Hu, H., Harmer, C. J., Harbour, C., Hassett, D. J., et al. (2010) · Journal of Medical Microbiology · doi:10.1099/jmm.0.019984-0 · Cited by 139
The biofilm‐associated bacterial infections unrelated to indwelling devices
Mirzaei, R., Mohammadzadeh, R., Alikhani, M. Y., Moghadam, M. S., Karampoor, S., Kazemi, S., Barfipoursalar, A., & Yousefimashouf, R. (2020) · IUBMB Life · doi:10.1002/iub.2266 · Cited by 137
Enhanced sludge solubilization and dewaterability by synergistic effects of nitrite and freezing
Sun, F., Xiao, K., Zhu, W., Withanage, N., & Zhou, Y. (2017) · Water Research · doi:10.1016/j.watres.2017.11.066 · Cited by 134
Nutrient Availability as a Mechanism for Selection of Antibiotic Tolerant Pseudomonas aeruginosa within the CF Airway
Hoffman, L. R., Richardson, A. R., Houston, L. S., Kulasekara, H. D., Martens‐Habbena, W., Klausen, M., Burns, J. L., Stahl, D. A., Hassett, D. J., Fang, F. C., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1000712 · Cited by 130
Pseudomonas aeruginosa biofilm infections in cystic fibrosis: insights into pathogenic processes and treatment strategies
Hassett, D. J., Korfhagen, T. R., Irvin, R. T., Schurr, M. J., Sauer, K., Lau, G. W., Sutton, M. D., Yu, H. D., & Høiby, N. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728220903454988 · Cited by 126
Advancement of Gallium and Gallium-Based Compounds as Antimicrobial Agents
Li, F., Liu, F., Huang, K., & Yang, S. (2022) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2022.827960 · Cited by 120
Gaseous nitric oxide to treat antibiotic resistant bacterial and fungal lung infections in patients with cystic fibrosis: a phase I clinical study
Deppisch, C., Herrmann, G., Graepler-Mainka, U., Wirtz, H., Heyder, S., Engel, C., Marschal, M., Miller, C. C., & Riethmüller, J. (2016) · Infection · doi:10.1007/s15010-016-0879-x · Cited by 115
Inorganic nitrite therapy: historical perspective and future directions
Kevil, C. G., Kolluru, G. K., Pattillo, C. B., & Giordano, T. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.042 · Cited by 113
Contribution of Cell Elongation to the Biofilm Formation of Pseudomonas aeruginosa during Anaerobic Respiration
Yoon, M. Y., Lee, K., Park, Y., & Yoon, S. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016105 · Cited by 110
Self-citation
Improving secondary sludge biodegradability using free nitrous acid treatment
Pijuan, M., Wang, Q., Ye, L., & Yuan, Z. (2012) · Bioresource Technology · doi:10.1016/j.biortech.2012.04.016 · Cited by 109
Pseudomonas aeruginosa In Vitro Phenotypes Distinguish Cystic Fibrosis Infection Stages and Outcomes
Mayer-Hamblett, N., Rosenfeld, M., Gibson, R. L., Ramsey, B. W., Kulasekara, H. D., Retsch‐Bogart, G. Z., Morgan, W. J., Wolter, D. J., Pope, C. E., Houston, L. S., et al. (2014) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201404-0681oc · Cited by 106
Gaseous nitric oxide bactericidal activity retained during intermittent high-dose short duration exposure
Miller, C., McMullin, B., Ghaffari, A., Stenzler, A., Pick, N., Roscoe, D. L., Ghahary, A., ROAD, J. D., & Av‐Gay, Y. (2008) · Nitric Oxide · doi:10.1016/j.niox.2008.08.002 · Cited by 106
Sequence diversity of the mucABD locus in Pseudomonas aeruginosa isolates from patients with cystic fibrosis
Bragonzi, A., Wiehlmann, L., Klockgether, J., Cramer, N., Worlitzsch, D., Döring, G., & Tümmler, B. (2006) · Microbiology · doi:10.1099/mic.0.29175-0 · Cited by 102
Iron Acquisition Mechanisms and Their Role in the Virulence of Burkholderia Species
Butt, A. T., & Thomas, M. S. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00460 · Cited by 103
Role of free nitrous acid in the pretreatment of waste activated sludge: Extracellular polymeric substances disruption or cells lysis?
Wu, J., Yang, Q. X., Luo, W., Sun, J. P., Xu, Q., Chen, F., Zhao, J., Yi, K., Wang, X., Wang, D., et al. (2017) · Chemical Engineering Journal · doi:10.1016/j.cej.2017.11.038 · Cited by 98
Nitrate Respiration Protects Hypoxic Mycobacterium tuberculosis Against Acid- and Reactive Nitrogen Species Stresses
Tan, M. P., de Sequeira, P. C., Lin, W. W., Phong, W. Y., Cliff, P. R., Ng, S. H., Lee, B. H., Camacho, L. R., Schnappinger, D., Ehrt, S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013356 · Cited by 99
Proteomic, Microarray, and Signature-Tagged Mutagenesis Analyses of AnaerobicPseudomonas aeruginosaat pH 6.5, Likely Representing Chronic, Late-Stage Cystic Fibrosis Airway Conditions
Platt, M. D., Schurr, M. J., Sauer, K., Vázquez, G. J., Kukavica‐Ibrulj, I., Potvin, É., Lévesque, R. C., Fedynak, A., Brinkman, F. S. L., Schurr, J. R., et al. (2008) · Journal of Bacteriology · doi:10.1128/jb.01683-07 · Cited by 92
Investigation of the algT operon sequence in mucoid and non-mucoid Pseudomonas aeruginosa isolates from 115 Scandinavian patients with cystic fibrosis and in 88 in vitro non-mucoid revertants
Ciofu, O., Lee, B., Johannesson, M., Hermansen, N. O., Meyer, P., & Høiby, N. (2008) · Microbiology · doi:10.1099/mic.0.2007/010421-0 · Cited by 91
BdlA, DipA and Induced Dispersion Contribute to Acute Virulence and Chronic Persistence of Pseudomonas aeruginosa
Li, Y., Petrova, O. E., Su, S., Lau, G. W., Panmanee, W., Na, R., Hassett, D. J., Davies, D. G., & Sauer, K. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004168 · Cited by 87
Biofouling and scaling control of reverse osmosis membrane using one-step cleaning-potential of acidified nitrite solution as an agent
Filloux, E., Wang, J., Pidou, M., Gernjak, W., & Yuan, Z. (2015) · Journal of Membrane Science · doi:10.1016/j.memsci.2015.08.034 · Cited by 82
How Three Self-Secreted Biofilm Exopolysaccharides of Pseudomonas aeruginosa, Psl, Pel, and Alginate, Can Each Be Exploited for Antibiotic Adjuvant Effects in Cystic Fibrosis Lung Infection
Chung, J. H., Eisha, S., Park, S., Morris, A. J., & Martin, I. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108709 · Cited by 80
New Insights into Upper Airway Innate Immunity
Hariri, B. M., & Cohen, N. A. (2016) · American Journal of Rhinology and Allergy · doi:10.2500/ajra.2016.30.4360 · Cited by 81
Nitrite and Nitrite Reductases: From Molecular Mechanisms to Significance in Human Health and Disease
Castiglione, N., Rinaldo, S., Giardina, G., Stelitano, V., & Cutruzzolà, F. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4196 · Cited by 81
Mode of Nitric Oxide Delivery Affects Antibacterial Action
Hall, J. R., Rouillard, K. R., Suchyta, D. J., Brown, M. D., Ahonen, M. J. R., & Schoenfisch, M. H. (2019) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.9b01384 · Cited by 75
Chronic obstructive pulmonary disease (COPD): Evaluation from clinical, immunological and bacterial pathogenesis perspectives
Hassett, D. J., Borchers, M. T., & Panos, R. J. (2014) · The Journal of Microbiology · doi:10.1007/s12275-014-4068-2 · Cited by 78
Nitric Oxide Protects Bacteria from Aminoglycosides by Blocking the Energy-Dependent Phases of Drug Uptake
McCollister, B. D., Hoffman, M. G., Husain, M., & Vázquez‐Torres, A. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01203-10 · Cited by 75
Free nitrous acid pretreatment of wasted activated sludge to exploit internal carbon source for enhanced denitrification
Ma, B., Peng, Y., Wei, Y., Li, B., Bao, P., & Wang, Y. (2014) · Bioresource Technology · doi:10.1016/j.biortech.2014.11.054 · Cited by 71
Two‐pronged survival strategy for the major cystic fibrosis pathogen, Pseudomonas aeruginosa, lacking the capacity to degrade nitric oxide during anaerobic respiration
Yoon, S. S., Karabulut, A., Lipscomb, J. D., Hennigan, R. F., Lymar, S. V., Groce, S. L., Herr, A. B., Howell, M. L., Kiley, P. J., Schurr, M. J., et al. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601787 · Cited by 71
Self-citation
In Vitro Spectrum of Activity of Finafloxacin, a Novel, pH-Activated Fluoroquinolone, under Standard and Acidic Conditions
Stubbings, W., Leow, P., Yong, G. C., Goh, F. Q. Y., Körber-Irrgang, B., Kresken, M., Endermann, R., & Labischinski, H. (2011) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00833-10 · Cited by 71
Microenvironmental characteristics and physiology of biofilms in chronic infections of CF patients are strongly affected by the host immune response
Jensen, P. Ø., Kolpen, M., Kragh, K. N., & Kühl, M. (2017) · Apmis · doi:10.1111/apm.12668 · Cited by 75
A novel siderophore system is essential for the growth of Pseudomonas aeruginosa in airway mucus
Gi, M., Lee, K., Kim, S. C., Yoon, J., Yoon, S. S., & Choi, J. Y. (2015) · Scientific Reports · doi:10.1038/srep14644 · Cited by 70
Self-citation
Determinants of Exhaled Breath Condensate pH in a Large Population With Asthma
Liu, L., Teague, W. G., ERZURUM, S. C., Fitzpatrick, A. M., Mantri, S., Dweik, R. A., Bleecker, E. R., Meyers, D. A., Busse, W. W., Calhoun, W. J., et al. (2010) · CHEST Journal · doi:10.1378/chest.10-0163 · Cited by 68
A novel and simple treatment for control of sulfide induced sewer concrete corrosion using free nitrous acid
Sun, X., Jiang, G., Bond, P. L., Keller, J., & Yuan, Z. (2014) · Water Research · doi:10.1016/j.watres.2014.12.020 · Cited by 67
Contribution of Oxygen-Limiting Conditions to Persistent Infection of Pseudomonas Aeruginosa
Schobert, M., & Tielen, P. (2010) · Future Microbiology · doi:10.2217/fmb.10.16 · Cited by 70
Oral Streptococci and Nitrite-Mediated Interference of Pseudomonas aeruginosa
Scoffield, J. A., & Wu, H. (2014) · Infection and Immunity · doi:10.1128/iai.02396-14 · Cited by 66
Participation of nitric oxide reductase in survival of Pseudomonas aeruginosa in LPS-activated macrophages
柿島, 宏., Shiratsuchi, A., Taoka, A., Nakanishi, Y., & Fukumori, Y. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.02.017 · Cited by 65
Free nitrous acid breaks down extracellular polymeric substances in waste activated sludge
Zhang, T., Wang, Q., Khan, J. H., & Yuan, Z. (2015) · RSC Advances · doi:10.1039/c5ra06080j · Cited by 64
Identification and Antibody-Therapeutic Targeting of Chloramphenicol-Resistant Outer Membrane Proteins in Escherichia coli
Li, H., Lin, X., Wang, S., & Peng, X. (2007) · Journal of Proteome Research · doi:10.1021/pr070307y · Cited by 64
Burn wounds infected by contaminated water: Case reports, review of the literature and recommendations for treatment
Ribeiro, N. F. F., Heath, C. H., Kierath, J., Rea, S. M., Duncan-Smith, M., & Wood, F. M. (2009) · Burns · doi:10.1016/j.burns.2009.03.002 · Cited by 63
Catalase (KatA) Plays a Role in Protection against Anaerobic Nitric Oxide in Pseudomonas aeruginosa
Su, S., Panmanee, W., Wilson, J. J., Mahtani, H. K., Li, Q., VanderWielen, B. D., Makris, T. M., Rogers, M., McDaniel, C. T., Lipscomb, J. D., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091813 · Cited by 62
Nitrite modulates bacterial antibiotic susceptibility and biofilm formation in association with airway epithelial cells
Zemke, A. C., Shiva, S., Burns, J. L., Moskowitz, S. M., Pilewski, J. M., Gladwin, M. T., & Bomberger, J. M. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.08.011 · Cited by 61
Sodium Nitrite-Mediated Killing of the Major Cystic Fibrosis Pathogens Pseudomonas aeruginosa , Staphylococcus aureus , and Burkholderia cepacia under Anaerobic Planktonic and Biofilm Conditions
Major, T. A., Panmanee, W., Mortensen, J. E., Gray, L. D., Hoglen, N., & Hassett, D. J. (2010) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.00379-10 · Cited by 61
The transcription factor DNR from Pseudomonas aeruginosa specifically requires nitric oxide and haem for the activation of a target promoter in Escherichia coli
Castiglione, N., Rinaldo, S., Giardina, G., & Cutruzzolà, F. (2009) · Microbiology · doi:10.1099/mic.0.028027-0 · Cited by 58
Molecular Determinants of the Thickened Matrix in a Dual-Species Pseudomonas aeruginosa and Enterococcus faecalis Biofilm
Lee, K., Lee, K., Kim, D.-G., & Yoon, S. S. (2017) · Applied and Environmental Microbiology · doi:10.1128/aem.01182-17 · Cited by 58
Self-citation
Nitrogen Chemistry and Lung Physiology
Marozkina, N. V., & Gaston, B. M. (2015) · Annual Review of Physiology · doi:10.1146/annurev-physiol-021113-170352 · Cited by 57
It is rocket science – why dietary nitrate is hard to ‘beet’! Part II: further mechanisms and therapeutic potential of the nitrate‐nitrite‐NO pathway
Mills, C. E., Khatri, J., Maskell, P., Odongerel, C., & Webb, A. J. (2016) · British Journal of Clinical Pharmacology · doi:10.1111/bcp.12918 · Cited by 57
Drug Repurposing - Hypothesis, Molecular Aspects and Therapeutic Applications
Badria, F. A.-E. (2020) · IntechOpen eBooks · doi:10.5772/intechopen.83082 · Cited by 52
Activation of Cholera Toxin Production by Anaerobic Respiration of Trimethylamine N-oxide in Vibrio cholerae
Lee, K., Park, Y., Bari, W., Yoon, M. Y., Go, J., Kim, S. C., Lee, H., & Yoon, S. S. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.394932 · Cited by 53
Self-citation
Disruption and eradication of P. aeruginosa biofilms using nitric oxide-releasing chitosan oligosaccharides
Reighard, K. P., Hill, D. B., Dixon, G. A., Worley, B. V., & Schoenfisch, M. H. (2015) · Biofouling · doi:10.1080/08927014.2015.1107548 · Cited by 53
Aerobic Vitamin B12 Biosynthesis Is Essential for Pseudomonas aeruginosa Class II Ribonucleotide Reductase Activity During Planktonic and Biofilm Growth
Crespo, A., Blanco‐Cabra, N., & Torrents, E. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00986 · Cited by 51
A randomized controlled trial of inhaled l-Arginine in patients with cystic fibrosis
Grasemann, H., Tullis, E. D., & Ratjen, F. A. (2013) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2012.12.008 · Cited by 50
Characterising the impact of post‐treatment storage on chemistry and antimicrobial properties of plasma treated water derived from microwave and DBD sources
Niquet, R., Boehm, D., Schnabel, U., Cullen, P. J., Bourke, P., & Ehlbeck, J. (2017) · Plasma Processes and Polymers · doi:10.1002/ppap.201700127 · Cited by 50
Novel experimental Pseudomonas aeruginosa lung infection model mimicking long‐term host–pathogen interactions in cystic fibrosis
Moser, C. E., van Gennip, M., Bjarnsholt, T., Jensen, P. Ø., Lee, B., Hougen, H. P., Calum, H., Ciofu, O., Givskov, M., Molin, S., et al. (2009) · Apmis · doi:10.1111/j.1600-0463.2008.00018.x · Cited by 49
Proteomics of Pseudomonas aeruginosa Australian Epidemic Strain 1 (AES-1) Cultured under Conditions Mimicking the Cystic Fibrosis Lung Reveals Increased Iron Acquisition via the Siderophore Pyochelin
Hare, N. J., Soe, C. Z., Rose, B. R., Harbour, C., Codd, R., Manos, J., & Cordwell, S. J. (2011) · Journal of Proteome Research · doi:10.1021/pr200659h · Cited by 49
Vitamin B 12 -Mediated Restoration of Defective Anaerobic Growth Leads to Reduced Biofilm Formation in Pseudomonas aeruginosa
Lee, K., Go, J., Yoon, M. Y., Park, Y., Kim, S. C., Yong, D., & Yoon, S. S. (2012) · Infection and Immunity · doi:10.1128/iai.06161-11 · Cited by 48
Self-citation
Enhanced solubilization and biochemical methane potential of waste activated sludge by combined free nitrous acid and potassium ferrate pretreatment
Wang, J., Zhang, Z., Ye, X., Pan, X., Lv, N., Fang, H., & Chen, S. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.122376 · Cited by 48
pH-Responsive, Charge-Reversing Layer-by-Layer Nanoparticle Surfaces Enhance Biofilm Penetration and Eradication
Deiss‐Yehiely, E., Cárcamo‐Oyarce, G., Berger, A. G., Ribbeck, K., & Hammond, P. T. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.3c00481 · Cited by 47
Biofilms 2007: Broadened Horizons and New Emphases
Palmer, R. J., Jr., & Stoodley, P. (2007) · Journal of Bacteriology · doi:10.1128/jb.00787-07 · Cited by 48
PEGylation of Tobramycin Improves Mucus Penetration and Antimicrobial Activity against Pseudomonas aeruginosa Biofilms in Vitro
Bahamondez‐Canas, T., Zhang, H., Tewes, F., Leal, J., & Smyth, H. D. C. (2018) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b00011 · Cited by 43
MutS deficiency and activity of the error‐prone DNA polymerase IV are crucial for determining mucA as the main target for mucoid conversion in Pseudomonas aeruginosa
Moyano, A. J., Luján, A. M., Argaraña, C. E., & Smania, A. M. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05675.x · Cited by 43
Denitrification by cystic fibrosis pathogens – Stenotrophomonas maltophilia is dormant in sputum
Kolpen, M., Kragh, K. N., Bjarnsholt, T., Line, L., Hansen, C. R., Eickhardt‐Dalbøge, C. S., Hansen, N., Kühl, M., Høiby, N., & Jensen, P. Ø. (2014) · International Journal of Medical Microbiology · doi:10.1016/j.ijmm.2014.07.002 · Cited by 43
Buffering airway acid decreases exhaled nitric oxide in asthma
Gaston, B. M., Kelly, R., Urban, P., Liu, L., Henderson, E. M., Doctor, A., Teague, W. G., Fitzpatrick, A. M., ERZURUM, S. C., & Hunt, J. F. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2006.06.040 · Cited by 43
Prediction and Analysis of the Protein Interactome in Pseudomonas aeruginosa to Enable Network-Based Drug Target Selection
Zhang, M., Su, S., Bhatnagar, R., Hassett, D. J., & Lu, L. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041202 · Cited by 41
Relative susceptibility of airway organisms to antimicrobial effects of nitric oxide
Workman, A. D., Carey, R. M., Kohanski, M. A., Kennedy, D. W., Palmer, J. N., Adappa, N. D., & Cohen, N. A. (2017) · International Forum of Allergy & Rhinology · doi:10.1002/alr.21966 · Cited by 39
Molecular typing and biological characteristics of Pseudomonas aeruginosa isolated from cystic fibrosis patients in Brazil
Stehling, E. G., Leite, D. D. S., & da Silveira, W. D. (2010) · The Brazilian Journal of Infectious Diseases · doi:10.1016/s1413-8670(10)70094-5 · Cited by 39
Update in Cystic Fibrosis 2006
Accurso, F. J. (2007) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200701-160up · Cited by 39
Adverse events following immunization: perception and evidence
Bonhoeffer, J., & Heininger, U. (2007) · Current Opinion in Infectious Diseases · doi:10.1097/qco.0b013e32811ebfb0 · Cited by 39
Integrating waste activated sludge (WAS) acidification with denitrification by adding nitrite (NO2−)
Wang, B., Wang, S., Li, B., Peng, C., & Peng, Y. (2014) · Biomass and Bioenergy · doi:10.1016/j.biombioe.2014.05.015 · Cited by 37
AnaerobicPseudomonas aeruginosaand other obligately anaerobic bacterial biofilms growing in the thick airway mucus of chronically infected cystic fibrosis patients: an emerging paradigm or “Old Hat”?
Su, S., & Hassett, D. J. (2012) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2012.708025 · Cited by 35
Evidence for Sigma Factor Competition in the Regulation of Alginate Production by Pseudomonas aeruginosa
Yin, Y., Withers, T. R., Wang, X., & Yu, H. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072329 · Cited by 35
Effect of ivacaftor therapy on exhaled nitric oxide in patients with cystic fibrosis
Grasemann, H., Gonska, T. Y., Avolio, J., Klingel, M. L., Tullis, E. D., & Ratjen, F. A. (2015) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2015.07.001 · Cited by 35
When the Party Is Over: a Signal for Dispersal ofPseudomonas aeruginosaBiofilms
Romeo, T. (2006) · Journal of Bacteriology · doi:10.1128/jb.01317-06 · Cited by 35

Authors: Yoon, S. S.
Affiliations: University of Cincinnati (US)
Corresponding author: Yoon, S. S.
ORCID: Yoon, S. S.
Venue: Journal of Clinical Investigation
Publisher: American Society for Clinical Investigation
Published: 2006-01-19
Volume: 116
Issue: 2
Pages: 436-446
ISSN: 0021-9738 (ISSN-L)
DOI: 10.1172/jci24684
PMC: PMC1350997
OpenAlex: W2134475541
Cited by: 212
References: 59
Citations by year: 2026: 2 · 2025: 3 · 2024: 4 · 2023: 5 · 2022: 7 · 2021: 10 · 2020: 9 · 2019: 10 · 2018: 9 · 2017: 11 · 2016: 14 · 2015: 12 · 2014: 19 · 2013: 9 · 2012: 13
FWCI: 5.85
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Clinical Investigation (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Carolina Digital Repository (University of North Carolina at Chapel Hill) (submittedVersion)
YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
UNC Libraries
Funders: U.S. Department of Energy (DEAC-02-98CH10886, -AC02-98 CH 10886, DE-AC02-)
National Institutes of Health (5r01ai040541-05, DE-AC02-98CH10886)
National Institute of General Medical Sciences (GM-69845, R01GM069845)
National Institute of Allergy and Infectious Diseases (AI 40541, R01AI050812)
Basic Energy Sciences (DE-AC02, DEAC0298CH10886, AC02-98CH10886)
Brookhaven National Laboratory (AC-02-98CH10886, DE-AC02- 98CH10886)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
Health Sciences › Medicine › Microbiology (medical) › Infections and bacterial resistance
Keywords: Pseudomonas aeruginosa, cystic fibrosis, nitrite, nitrous acid, nitric oxide, biofilm, airway mucus, pH dependence, antibiotic resistance, chronic lung infection, airway epithelium
MeSH terms: Anaerobiosis, Animals, Bacterial Proteins, Cells, Cultured, Child, Child, Preschool, Cystic Fibrosis, Epithelial Cells, Humans, Hydrogen-Ion Concentration, Infant, Microbial Sensitivity Tests, Mucus, Nitrites, Pseudomonas aeruginosa, Pseudomonas Infections, Sputum, Biofilms, Respiratory Mucosa, Drug Resistance, Bacterial, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Anaerobic killing of mucoid Pseudomonas aeruginosa by acidified nitrite derivatives under cystic fibrosis airway conditions

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks