The DOI matches its Crossref record; 83 of the 83 references it cites were found in a registry or an index.
The survival kinases Akt and Pim as potential pharmacological targets
Open accessAbstract
The Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed cell death by phosphorylating substrates that regulate both apoptosis and cellular metabolism. The PI3K-dependent activation of the Akt kinases and the JAK/STAT-dependent induction of the Pim kinases are examples of partially overlapping survival kinase pathways. Pharmacological manipulation of such kinases could have a major impact on the treatment of a wide variety of human diseases including cancer, inflammatory disorders, and ischemic diseases.
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Cites
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Cited by
Mebratu, Y., & Tesfaigzi, Y. (2009) · Cell Cycle · doi:10.4161/cc.8.8.8147 · Cited by 957
Visfatin, an Adipocytokine with Proinflammatory and Immunomodulating Properties
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Regulated cell death and inflammation: an auto-amplification loop causes organ failure
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For better or for worse: the role of Pim oncogenes in tumorigenesis
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Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation
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Metadata
- Authors
- Amaravadi, R.
- Venue
- Journal of Clinical Investigation
- Published
- 2005-10-01
- Volume
- 115
- Issue
- 10
- Pages
- 2618-2624
- ISSN
- 0021-9738 (ISSN-L)
- OpenAlex
- W2151410975
- Cited by
- 408
- References
- 83
- FWCI
- 9.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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